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Gene: Rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2) Mus musculus
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Symbol: Rapgef2
Name: Rap guanine nucleotide exchange factor (GEF) 2
Description: Exhibits Rap guanyl-nucleotide exchange factor activity. Involved in several processes, including cellular response to cAMP; generation of neurons; and positive regulation of protein phosphorylation. Predicted to localize to several cellular components, including apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Is expressed in embryo; olfactory epithelium; yolk sac endoderm; and yolk sac mesenchyme. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 7. Orthologous to human RAPGEF2 (Rap guanine nucleotide exchange factor 2); PARTICIPATES IN adenosine signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 3,4-methylenedioxymethamphetamine; cyclosporin A; fluoranthene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5830453M24Rik; CNRasGEF; cyclic nucleotide ras GEF; mKIAA0313; neural RAP guanine nucleotide exchange protein; nRapGEP; PDZ domain containing guanine nucleotide exchange factor (GEF) 1; PDZ domain-containing guanine nucleotide exchange factor 1; Pdzgef1; RA-GEF-1; rap guanine nucleotide exchange factor 2; ras/Rap1-associating GEF-1
Orthologs:
Homo sapiens (human) : RAPGEF2 (Rap guanine nucleotide exchange factor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Rapgef2 (Rap guanine nucleotide exchange factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rapgef2 (Rap guanine nucleotide exchange factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : RAPGEF2 (Rap guanine nucleotide exchange factor 2)
Canis lupus familiaris (dog) : RAPGEF2 (Rap guanine nucleotide exchange factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rapgef2 (Rap guanine nucleotide exchange factor 2)
Sus scrofa (pig) : RAPGEF2 (Rap guanine nucleotide exchange factor 2)
Chlorocebus sabaeus (African green monkey) : RAPGEF2 (Rap guanine nucleotide exchange factor 2)
Heterocephalus glaber (naked mole-rat) : Rapgef2 (Rap guanine nucleotide exchange factor 2)
more info ...
Related Pseudogenes: Gm12202   Gm20955  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl379,062,516 - 79,286,517 (-)EnsemblGRCm38mm10GRCm38
GRCm38379,062,511 - 79,286,545 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37378,866,450 - 78,949,797 (-)NCBIGRCm37mm9NCBIm37
MGSCv36379,148,443 - 79,372,981 (-)NCBImm8
MGSCv36379,728,293 - 79,956,813 (-)NCBImm8
Celera379,094,490 - 79,178,178 (-)NCBICelera
Cytogenetic Map3E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Rapgef2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315048
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.