Rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2) - Rat Genome Database

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Gene: Rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2) Mus musculus
Analyze
Symbol: Rapgef2
Name: Rap guanine nucleotide exchange factor (GEF) 2
RGD ID: 1315048
MGI Page MGI
Description: Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to cAMP; and nervous system development. Is active in postsynapse. Is expressed in embryo; olfactory epithelium; yolk sac endoderm; and yolk sac mesenchyme. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 7. Orthologous to human RAPGEF2 (Rap guanine nucleotide exchange factor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5830453M24Rik; CNRa; CNRasGEF; cyclic nucleotide ras GEF; mKIAA0313; neural RAP guanine nucleotide exchange protein; nR; nRapGEP; PDZ domain containing guanine nucleotide exchange factor (GEF) 1; PDZ domain-containing guanine nucleotide exchange factor 1; Pdzgef; Pdzgef1; RA-GEF; RA-GEF-1; rap guanine nucleotide exchange factor 2; ras/Rap1-associating GEF-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm12202   Gm20955  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39378,969,818 - 79,194,681 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl378,969,823 - 79,193,824 (-)EnsemblGRCm39 Ensembl
GRCm38379,062,511 - 79,286,545 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl379,062,516 - 79,286,517 (-)EnsemblGRCm38mm10GRCm38
MGSCv37378,866,450 - 78,949,797 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36379,148,443 - 79,372,981 (-)NCBIMGSCv36mm8
MGSCv36379,728,293 - 79,956,813 (-)NCBIMGSCv36mm8
Celera379,094,490 - 79,178,178 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map334.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
allethrin  (ISO)
amitrole  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP)
caffeine  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP)
cyhalothrin  (ISO)
cypermethrin  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
Enterolactone  (ISO)
fenvalerate  (ISO)
fluoranthene  (EXP)
flutamide  (ISO)
folic acid  (ISO)
folpet  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
gentamycin  (ISO)
hemin  (ISO)
hexadecanoic acid  (ISO)
hydroquinone  (ISO)
lipopolysaccharide  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
permethrin  (ISO)
potassium chromate  (ISO)
propiconazole  (EXP,ISO)
pyrethrins  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
sevoflurane  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (ISO)
taurine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
triacsin C  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (ISO,ISS)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IDA)
blood vessel development  (IMP)
brain-derived neurotrophic factor receptor signaling pathway  (ISO,ISS)
cAMP-mediated signaling  (ISO)
cellular response to cAMP  (IDA,IMP,ISO,ISS)
cellular response to cGMP  (ISO,ISS)
cellular response to nerve growth factor stimulus  (ISO,ISS)
establishment of endothelial barrier  (ISO,ISS)
establishment of endothelial intestinal barrier  (ISO)
forebrain neuron development  (IMP)
G protein-coupled receptor signaling pathway  (IDA,ISO)
microvillus assembly  (ISO)
negative regulation of cell population proliferation  (IMP,ISO)
negative regulation of dendrite morphogenesis  (IMP,ISO)
negative regulation of melanin biosynthetic process  (IMP)
nerve growth factor signaling pathway  (ISO,ISS)
neuron migration  (IMP)
neuron projection development  (IMP,ISO)
neuropeptide signaling pathway  (IDA,ISO)
positive regulation of cAMP-dependent protein kinase activity  (IMP,ISO)
positive regulation of dendritic cell apoptotic process  (IMP,ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA,IMP,ISO)
positive regulation of GTPase activity  (IDA,IMP,ISO,ISS)
positive regulation of neuron migration  (IMP)
positive regulation of neuron projection development  (ISO,ISS)
positive regulation of protein kinase activity  (IDA,ISO,ISS)
positive regulation of vasculogenesis  (IMP)
protein localization to plasma membrane  (ISO)
Rap protein signal transduction  (ISO,ISS)
Ras protein signal transduction  (IBA)
regulation of cell junction assembly  (ISO,ISS)
regulation of modification of postsynaptic structure  (IDA,IEP,IMP)
regulation of synaptic plasticity  (ISO,ISS)
ventricular system development  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal brain development  (IAGP)
abnormal cell adhesion  (IAGP)
abnormal cell migration  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal digestive system development  (IAGP)
abnormal embryonic hematopoiesis  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal heart development  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal liver development  (IAGP)
abnormal retina morphology  (IEA)
abnormal vascular development  (IAGP)
abnormal vasculogenesis  (IAGP)
abnormal visceral yolk sac blood island morphology  (IAGP)
absent erythrocytes  (IAGP)
absent vitelline blood vessels  (IAGP)
anencephaly  (IAGP)
decreased birth body size  (IAGP)
decreased cell proliferation  (IAGP)
decreased common myeloid progenitor cell number  (IAGP)
decreased embryo size  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased exploration in new environment  (IEA)
decreased hematopoietic stem cell number  (IAGP)
delayed embryo turning  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality prior to tooth bud stage  (IEA)
enlarged allantois  (IAGP)
incomplete embryo turning  (IAGP)
increased circulating bilirubin level  (IEA)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
pale liver  (IAGP)
pale yolk sac  (IAGP)
pallor  (IAGP)
preweaning lethality, complete penetrance  (IEA)
small placenta  (IAGP)
spina bifida  (IAGP)
translucent skin  (IAGP)
wavy neural tube  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12465718   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15747579   PMID:16141072   PMID:16141073   PMID:16272156  
PMID:16602821   PMID:16959763   PMID:17826737   PMID:18799693   PMID:19453629   PMID:19635461   PMID:20595512   PMID:21267068   PMID:21677750   PMID:21864586   PMID:21873635   PMID:23800469  
PMID:23885123   PMID:26490870   PMID:27390776   PMID:27507650   PMID:28671696   PMID:28706196   PMID:28917843   PMID:28948210   PMID:29747665   PMID:31040226   PMID:31996307   PMID:32325033  
PMID:32554809   PMID:32581705   PMID:32600317   PMID:32917586   PMID:33268547   PMID:33345400   PMID:37142655   PMID:38236296   PMID:38355793  


Genomics

Comparative Map Data
Rapgef2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39378,969,818 - 79,194,681 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl378,969,823 - 79,193,824 (-)EnsemblGRCm39 Ensembl
GRCm38379,062,511 - 79,286,545 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl379,062,516 - 79,286,517 (-)EnsemblGRCm38mm10GRCm38
MGSCv37378,866,450 - 78,949,797 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36379,148,443 - 79,372,981 (-)NCBIMGSCv36mm8
MGSCv36379,728,293 - 79,956,813 (-)NCBIMGSCv36mm8
Celera379,094,490 - 79,178,178 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map334.91NCBI
RAPGEF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384159,103,079 - 159,360,173 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4159,103,013 - 159,360,174 (+)EnsemblGRCh38hg38GRCh38
GRCh374160,024,231 - 160,281,325 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364160,408,448 - 160,500,752 (+)NCBINCBI36Build 36hg18NCBI36
Celera4157,529,482 - 157,621,655 (+)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4155,939,342 - 156,031,440 (+)NCBIHuRef
CHM1_14160,165,501 - 160,257,796 (+)NCBICHM1_1
T2T-CHM13v2.04162,453,893 - 162,710,940 (+)NCBIT2T-CHM13v2.0
Rapgef2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82166,505,868 - 166,728,139 (-)NCBIGRCr8
mRatBN7.22164,207,513 - 164,322,157 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2164,207,513 - 164,244,247 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2171,425,256 - 171,539,995 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02169,440,712 - 169,555,299 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02164,049,532 - 164,164,134 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02177,836,191 - 178,057,378 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2177,836,202 - 178,057,157 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02197,171,946 - 197,285,983 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42170,472,420 - 170,587,987 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12170,422,533 - 170,512,880 (-)NCBI
Celera2158,305,258 - 158,419,241 (-)NCBICelera
Cytogenetic Map2q33NCBI
Rapgef2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547112,670,764 - 12,815,430 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547112,670,837 - 12,838,910 (+)NCBIChiLan1.0ChiLan1.0
RAPGEF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23156,967,271 - 157,228,616 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14157,322,566 - 157,584,039 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04151,419,402 - 151,680,769 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14163,316,387 - 163,489,514 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4163,316,396 - 163,487,495 (+)Ensemblpanpan1.1panPan2
RAPGEF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11556,133,094 - 56,353,609 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1556,174,578 - 56,352,569 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1556,473,491 - 56,715,382 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01556,855,560 - 57,097,663 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1556,855,619 - 57,097,663 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11556,092,734 - 56,334,363 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01556,190,343 - 56,432,335 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01556,504,459 - 56,746,362 (+)NCBIUU_Cfam_GSD_1.0
Rapgef2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530133,800,312 - 33,963,070 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365765,583,805 - 5,746,671 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365765,583,847 - 5,746,583 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl848,021,604 - 48,277,454 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1848,183,518 - 48,277,476 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2850,390,322 - 50,684,115 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAPGEF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17105,672,583 - 105,883,544 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7105,624,608 - 105,884,366 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603785,337,825 - 85,597,514 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapgef2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248483,968,362 - 4,182,885 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248483,968,845 - 4,184,740 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rapgef2
13254 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1655
Count of miRNA genes:558
Interacting mature miRNAs:688
Transcripts:ENSMUST00000118100, ENSMUST00000118340, ENSMUST00000124647, ENSMUST00000136126, ENSMUST00000152275
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35262550986625745Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35292318386923183Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34949500583495118Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35262550986625745Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34949500583495118Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35262550986625745Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4935758183357581Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse

Markers in Region
RH125415  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38379,266,669 - 79,266,892UniSTSGRCm38
MGSCv37379,070,591 - 79,070,814UniSTSGRCm37
Celera379,299,518 - 79,299,741UniSTS
Cytogenetic Map3E3UniSTS
Rapgef2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3E3UniSTS
cM Map3 UniSTS
RH125973  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38379,116,016 - 79,116,225UniSTSGRCm38
MGSCv37378,919,938 - 78,920,147UniSTSGRCm37
Celera379,148,646 - 79,148,855UniSTS
Cytogenetic Map3E3UniSTS
Whitehead/MRC_RH3767.95UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001099624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001310536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006502250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006502252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011240276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011240277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB093228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC157941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC164560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP758717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF410089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000118100   ⟹   ENSMUSP00000114119
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl378,969,823 - 79,052,284 (-)Ensembl
GRCm38.p6 Ensembl379,062,516 - 79,144,977 (-)Ensembl
Ensembl Acc Id: ENSMUST00000118340   ⟹   ENSMUSP00000113778
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl378,969,835 - 79,053,182 (-)Ensembl
GRCm38.p6 Ensembl379,062,528 - 79,145,875 (-)Ensembl
Ensembl Acc Id: ENSMUST00000124647
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl379,019,488 - 79,080,607 (-)Ensembl
GRCm38.p6 Ensembl379,112,181 - 79,173,300 (-)Ensembl
Ensembl Acc Id: ENSMUST00000136126
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl379,076,756 - 79,088,647 (-)Ensembl
GRCm38.p6 Ensembl379,169,449 - 79,181,340 (-)Ensembl
Ensembl Acc Id: ENSMUST00000152275
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl379,016,373 - 79,080,505 (-)Ensembl
GRCm38.p6 Ensembl379,109,066 - 79,173,198 (-)Ensembl
Ensembl Acc Id: ENSMUST00000195708   ⟹   ENSMUSP00000141542
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl378,969,838 - 79,193,824 (-)Ensembl
GRCm38.p6 Ensembl379,062,531 - 79,286,517 (-)Ensembl
RefSeq Acc Id: NM_001099624   ⟹   NP_001093094
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39378,969,818 - 79,053,182 (-)NCBI
GRCm38379,062,511 - 79,145,875 (-)NCBI
MGSCv37378,866,450 - 78,949,797 (-)RGD
Celera379,094,490 - 79,178,178 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001310536   ⟹   NP_001297465
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39378,969,818 - 79,053,053 (-)NCBI
GRCm38379,062,511 - 79,145,746 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006502250   ⟹   XP_006502313
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39378,969,818 - 79,194,681 (-)NCBI
GRCm38379,062,511 - 79,286,545 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006502252   ⟹   XP_006502315
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39378,969,818 - 79,103,189 (-)NCBI
GRCm38379,062,511 - 79,195,725 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011240276   ⟹   XP_011238578
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39378,969,818 - 79,194,681 (-)NCBI
GRCm38379,062,511 - 79,286,545 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011240277   ⟹   XP_011238579
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39378,969,818 - 79,194,681 (-)NCBI
GRCm38379,062,511 - 79,286,545 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030252869   ⟹   XP_030108729
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39378,969,818 - 79,052,108 (-)NCBI
GRCm38379,062,511 - 79,144,809 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036163389   ⟹   XP_036019282
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39378,969,818 - 79,103,189 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001093094   ⟸   NM_001099624
- Peptide Label: isoform 1
- UniProtKB: Q6NXI4 (UniProtKB/TrEMBL),   E9QNQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006502313   ⟸   XM_006502250
- Peptide Label: isoform X2
- UniProtKB: A0A0A6YWG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006502315   ⟸   XM_006502252
- Peptide Label: isoform X4
- UniProtKB: Q6NXI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011238579   ⟸   XM_011240277
- Peptide Label: isoform X3
- UniProtKB: A0A0A6YWG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011238578   ⟸   XM_011240276
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001297465   ⟸   NM_001310536
- Peptide Label: isoform 2
- UniProtKB: Q8CHG7 (UniProtKB/Swiss-Prot),   E9QMD0 (UniProtKB/Swiss-Prot),   Q6NXI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030108729   ⟸   XM_030252869
- Peptide Label: isoform X6
- UniProtKB: Q6NXI4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000114119   ⟸   ENSMUST00000118100
Ensembl Acc Id: ENSMUSP00000113778   ⟸   ENSMUST00000118340
Ensembl Acc Id: ENSMUSP00000141542   ⟸   ENSMUST00000195708
RefSeq Acc Id: XP_036019282   ⟸   XM_036163389
- Peptide Label: isoform X5
- UniProtKB: Q6NXI4 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CHG7-F1-model_v2 AlphaFold Q8CHG7 1-1496 view protein structure

Promoters
RGD ID:6834343
Promoter ID:MM_KWN:34627
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung
Transcripts:ENSMUST00000118100
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36378,948,751 - 78,949,547 (-)MPROMDB
RGD ID:6834342
Promoter ID:MM_KWN:34628
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung
Transcripts:ENSMUST00000037943
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36378,949,951 - 78,950,737 (-)MPROMDB
RGD ID:6834341
Promoter ID:MM_KWN:34629
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver
Transcripts:ENSMUST00000099032,   OTTMUST00000079131,   OTTMUST00000079132
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36378,976,889 - 78,977,389 (-)MPROMDB
RGD ID:6834344
Promoter ID:MM_KWN:34630
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000079133
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36378,985,056 - 78,985,887 (-)MPROMDB
RGD ID:6880914
Promoter ID:EPDNEW_M3908
Type:initiation region
Name:Rapgef2_3
Description:Mus musculus Rap guanine nucleotide exchange factor 2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3909  EPDNEW_M3910  EPDNEW_M3911  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38379,138,471 - 79,138,531EPDNEW
RGD ID:6880916
Promoter ID:EPDNEW_M3909
Type:initiation region
Name:Rapgef2_4
Description:Mus musculus Rap guanine nucleotide exchange factor 2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3908  EPDNEW_M3910  EPDNEW_M3911  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38379,144,974 - 79,145,034EPDNEW
RGD ID:6880918
Promoter ID:EPDNEW_M3910
Type:initiation region
Name:Rapgef2_2
Description:Mus musculus Rap guanine nucleotide exchange factor 2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3908  EPDNEW_M3909  EPDNEW_M3911  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38379,145,924 - 79,145,984EPDNEW
RGD ID:6880920
Promoter ID:EPDNEW_M3911
Type:initiation region
Name:Rapgef2_1
Description:Mus musculus Rap guanine nucleotide exchange factor 2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3908  EPDNEW_M3909  EPDNEW_M3910  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38379,173,296 - 79,173,356EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2659071 AgrOrtholog
Ensembl Genes ENSMUSG00000062232 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000118100 ENTREZGENE
  ENSMUST00000118100.8 UniProtKB/Swiss-Prot
  ENSMUST00000118340 ENTREZGENE
  ENSMUST00000118340.7 UniProtKB/TrEMBL
  ENSMUST00000195708 ENTREZGENE
  ENSMUST00000195708.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RA_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Ras-like_Gua-exchang_fac_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras_GEF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGRF_CDC25 UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
KEGG Report mmu:76089 UniProtKB/TrEMBL
MGD MGI:2659071 ENTREZGENE
NCBI Gene 76089 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE RAS GEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOSKELETON-ASSOCIATED PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00788 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rapgef2 PhenoGen
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEFN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00314 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP cNMP_binding UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  Ras_GEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF51206 UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A6YWG7 ENTREZGENE, UniProtKB/TrEMBL
  E9QMD0 ENTREZGENE
  E9QNQ4 ENTREZGENE, UniProtKB/TrEMBL
  Q3TA27_MOUSE UniProtKB/TrEMBL
  Q6NXI4 ENTREZGENE, UniProtKB/TrEMBL
  Q8CHG7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary E9QMD0 UniProtKB/Swiss-Prot