POP7 (POP7 homolog, ribonuclease P/MRP subunit) - Rat Genome Database

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Gene: POP7 (POP7 homolog, ribonuclease P/MRP subunit) Homo sapiens
Analyze
Symbol: POP7
Name: POP7 homolog, ribonuclease P/MRP subunit
RGD ID: 1315010
HGNC Page HGNC:19949
Description: Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in nucleolus. Part of multimeric ribonuclease P complex and ribonuclease MRP complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 0610037N12Rik; hPOP7; POP7 (processing of precursor, S. cerevisiae) homolog; processing of precursor 7, ribonuclease P subunit; processing of precursor 7, ribonuclease p subunit (s. cerevisiae); processing of precursor 7, ribonuclease P/MRP subunit; ribonuclease P protein subunit p20; ribonucleases P/MRP protein subunit POP7 homolog; RNaseP protein p20; RPP2; RPP20
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,706,121 - 100,707,486 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,706,121 - 100,707,486 (+)EnsemblGRCh38hg38GRCh38
GRCh377100,303,744 - 100,305,109 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,141,612 - 100,143,059 (+)NCBINCBI36Build 36hg18NCBI36
Build 34799,948,419 - 99,949,768NCBI
Celera795,034,260 - 95,035,707 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,934,483 - 94,935,930 (+)NCBIHuRef
CHM1_17100,233,954 - 100,235,401 (+)NCBICHM1_1
T2T-CHM13v2.07101,946,186 - 101,947,551 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,663,281 - 99,664,728 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects. Lai LB, etal., FEBS Lett. 2010 Jan 21;584(2):287-96. doi: 10.1016/j.febslet.2009.11.048. Epub .
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9618478   PMID:9630247   PMID:11158571   PMID:12477932   PMID:12690205   PMID:14715275   PMID:15096576   PMID:15489334   PMID:15635413   PMID:16723659   PMID:20215441   PMID:21145461  
PMID:21832049   PMID:21873635   PMID:22681889   PMID:22810586   PMID:22863883   PMID:22939629   PMID:24778252   PMID:25416956   PMID:26186194   PMID:26472760   PMID:26496610   PMID:26949251  
PMID:27025967   PMID:28186131   PMID:28514442   PMID:29298432   PMID:29395067   PMID:29509190   PMID:29625199   PMID:29845934   PMID:30454648   PMID:31091453   PMID:31462741   PMID:31515488  
PMID:31527615   PMID:31980649   PMID:32296183   PMID:32807901   PMID:33226137   PMID:33306668   PMID:33961781   PMID:34373451   PMID:34917906   PMID:34941261   PMID:35271311   PMID:35579257  
PMID:35944360   PMID:36244648   PMID:37536630  


Genomics

Comparative Map Data
POP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,706,121 - 100,707,486 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,706,121 - 100,707,486 (+)EnsemblGRCh38hg38GRCh38
GRCh377100,303,744 - 100,305,109 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,141,612 - 100,143,059 (+)NCBINCBI36Build 36hg18NCBI36
Build 34799,948,419 - 99,949,768NCBI
Celera795,034,260 - 95,035,707 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,934,483 - 94,935,930 (+)NCBIHuRef
CHM1_17100,233,954 - 100,235,401 (+)NCBICHM1_1
T2T-CHM13v2.07101,946,186 - 101,947,551 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,663,281 - 99,664,728 (+)NCBI
Pop7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,499,701 - 137,500,682 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,499,700 - 137,500,780 (-)EnsemblGRCm39 Ensembl
GRCm385137,501,439 - 137,502,429 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,501,438 - 137,502,518 (-)EnsemblGRCm38mm10GRCm38
MGSCv375137,942,667 - 137,943,657 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,731,227 - 137,732,219 (-)NCBIMGSCv36mm8
Celera5134,485,124 - 134,486,114 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.51NCBI
Pop7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,826,161 - 24,827,202 (+)NCBIGRCr8
mRatBN7.21219,189,384 - 19,190,425 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,189,138 - 19,190,674 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,345,656 - 20,346,697 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,958,580 - 20,959,621 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,022,926 - 20,023,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,259,713 - 22,260,754 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,259,713 - 22,260,754 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,276,481 - 24,277,522 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,570,020 - 19,571,061NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1220,994,229 - 20,995,270 (+)NCBICelera
Cytogenetic Map12q12NCBI
Pop7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573215,932 - 218,976 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955573217,809 - 218,915 (-)NCBIChiLan1.0ChiLan1.0
POP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26118,606,480 - 118,619,578 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,871,238 - 166,884,200 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0792,722,839 - 92,734,708 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,124,018 - 106,135,430 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,134,766 - 106,135,188 (+)Ensemblpanpan1.1panPan2
POP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,005,622 - 9,017,245 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,005,892 - 9,006,314 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,710,085 - 10,721,664 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.068,940,039 - 8,951,401 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,940,058 - 8,941,513 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,792,579 - 8,803,948 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,770,761 - 8,782,031 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.068,952,482 - 8,963,842 (-)NCBIUU_Cfam_GSD_1.0
Pop7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,303,817 - 133,310,686 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543725,268 - 736,748 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936543725,338 - 732,707 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,605,018 - 8,610,218 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,607,531 - 8,609,391 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.238,001,655 - 8,003,744 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,501,363 - 12,502,766 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,501,457 - 12,502,737 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,800,051 - 3,802,184 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pop7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,398,272 - 16,399,417 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,398,272 - 16,399,364 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in POP7
7 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q21.3-22.1(chr7:98288474-101259804)x3 copy number gain See cases [RCV000053573] Chr7:98288474..101259804 [GRCh38]
Chr7:97917786..100903085 [GRCh37]
Chr7:97755722..100689805 [NCBI36]
Chr7:7q21.3-22.1		 pathogenic
GRCh38/hg38 7q22.1(chr7:99219420-100902269)x1 copy number loss See cases [RCV000054154] Chr7:99219420..100902269 [GRCh38]
Chr7:98817043..100499889 [GRCh37]
Chr7:98654979..100337825 [NCBI36]
Chr7:7q22.1		 pathogenic
GRCh38/hg38 7q22.1(chr7:100419914-102482826)x1 copy number loss See cases [RCV000054155] Chr7:100419914..102482826 [GRCh38]
Chr7:100017537..102123273 [GRCh37]
Chr7:99855473..101910278 [NCBI36]
Chr7:7q22.1		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q22.1(chr7:99195836-102258175)x1 copy number loss See cases [RCV000135782] Chr7:99195836..102258175 [GRCh38]
Chr7:98793459..101718950 [GRCh37]
Chr7:98631395..101688175 [NCBI36]
Chr7:7q22.1		 pathogenic|uncertain significance
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3		 pathogenic
GRCh38/hg38 7q22.1(chr7:99932610-102473188)x3 copy number gain See cases [RCV000138109] Chr7:99932610..102473188 [GRCh38]
Chr7:99530233..102113635 [GRCh37]
Chr7:99368169..101900640 [NCBI36]
Chr7:7q22.1		 uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
GRCh37/hg19 7q22.1(chr7:98847725-102472176)x1 copy number loss not provided [RCV000682904] Chr7:98847725..102472176 [GRCh37]
Chr7:7q22.1		 pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1(chr7:100141861-100552714)x1 copy number loss not provided [RCV000746918] Chr7:100141861..100552714 [GRCh37]
Chr7:7q22.1		 likely benign
GRCh37/hg19 7q22.1(chr7:100214015-100304735)x3 copy number gain not provided [RCV000746919] Chr7:100214015..100304735 [GRCh37]
Chr7:7q22.1		 benign
GRCh37/hg19 7q22.1(chr7:100256228-100304735)x3 copy number gain not provided [RCV000746921] Chr7:100256228..100304735 [GRCh37]
Chr7:7q22.1		 benign
GRCh37/hg19 7q22.1(chr7:100271521-100304735)x3 copy number gain not provided [RCV000746923] Chr7:100271521..100304735 [GRCh37]
Chr7:7q22.1		 benign
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1(chr7:99593346-102470275)x1 copy number loss See cases [RCV001195072] Chr7:99593346..102470275 [GRCh37]
Chr7:7q22.1		 likely pathogenic
GRCh37/hg19 7q21.12-22.1(chr7:87477185-100333327) copy number gain Isolated Pierre-Robin syndrome [RCV001352649] Chr7:87477185..100333327 [GRCh37]
Chr7:7q21.12-22.1		 pathogenic
GRCh37/hg19 7q22.1-31.1(chr7:99417471-111586308) copy number loss not specified [RCV002053711] Chr7:99417471..111586308 [GRCh37]
Chr7:7q22.1-31.1		 pathogenic
NC_000007.13:g.(?_98983338)_(100860555_?)del deletion not provided [RCV001877526] Chr7:98983338..100860555 [GRCh37]
Chr7:7q22.1		 pathogenic|uncertain significance
NC_000007.13:g.(?_98507659)_(100860555_?)dup duplication not provided [RCV003113282] Chr7:98507659..100860555 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
NM_005837.3(POP7):c.302A>G (p.Asn101Ser) single nucleotide variant Inborn genetic diseases [RCV002728994] Chr7:100707132 [GRCh38]
Chr7:100304755 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_005837.3(POP7):c.85C>T (p.Arg29Cys) single nucleotide variant Inborn genetic diseases [RCV002689183] Chr7:100706915 [GRCh38]
Chr7:100304538 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_005837.3(POP7):c.326A>C (p.Asp109Ala) single nucleotide variant Inborn genetic diseases [RCV002902263] Chr7:100707156 [GRCh38]
Chr7:100304779 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_005837.3(POP7):c.68G>T (p.Arg23Met) single nucleotide variant Inborn genetic diseases [RCV002660288] Chr7:100706898 [GRCh38]
Chr7:100304521 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_005837.3(POP7):c.298G>A (p.Ala100Thr) single nucleotide variant Inborn genetic diseases [RCV002691304] Chr7:100707128 [GRCh38]
Chr7:100304751 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh38/hg38 7q22.1(chr7:98454022-100723798)x1 copy number loss Multiple congenital anomalies/dysmorphic syndrome [RCV003327701] Chr7:98454022..100723798 [GRCh38]
Chr7:7q22.1		 pathogenic
NM_005837.3(POP7):c.251T>C (p.Ile84Thr) single nucleotide variant Inborn genetic diseases [RCV003370588] Chr7:100707081 [GRCh38]
Chr7:100304704 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_005837.3(POP7):c.170A>T (p.Asp57Val) single nucleotide variant Inborn genetic diseases [RCV003363626] Chr7:100707000 [GRCh38]
Chr7:100304623 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh37/hg19 7q22.1(chr7:99114000-101878272)x1 copy number loss not provided [RCV003482971] Chr7:99114000..101878272 [GRCh37]
Chr7:7q22.1		 pathogenic
GRCh37/hg19 7q22.1(chr7:98396469-102108193)x1 copy number loss not specified [RCV003986701] Chr7:98396469..102108193 [GRCh37]
Chr7:7q22.1		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:387
Count of miRNA genes:276
Interacting mature miRNAs:286
Transcripts:ENST00000303151, ENST00000457480
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
STS-T99819  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377100,304,844 - 100,305,059UniSTSGRCh37
Build 367100,142,780 - 100,142,995RGDNCBI36
Celera795,035,428 - 95,035,643RGD
Cytogenetic Map7q22UniSTS
HuRef794,935,651 - 94,935,866UniSTS
CRA_TCAGchr7v2799,664,449 - 99,664,664UniSTS
GeneMap99-GB4 RH Map7510.4UniSTS
RH48437  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q22UniSTS
GeneMap99-GB4 RH Map7517.07UniSTS
NCBI RH Map71062.2UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2436 2590 1714 619 1654 460 4356 2100 3559 408 1450 1602 174 1203 2788 6 2
Low 3 401 12 5 297 5 1 97 175 11 10 11 1 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000303151   ⟹   ENSP00000304353
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7100,706,121 - 100,707,486 (+)Ensembl
RefSeq Acc Id: ENST00000457480   ⟹   ENSP00000387814
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7100,706,336 - 100,707,242 (+)Ensembl
RefSeq Acc Id: NM_005837   ⟹   NP_005828
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,706,121 - 100,707,486 (+)NCBI
GRCh377100,303,676 - 100,305,123 (+)RGD
Build 367100,141,612 - 100,143,059 (+)NCBI Archive
Celera795,034,260 - 95,035,707 (+)RGD
HuRef794,934,483 - 94,935,930 (+)ENTREZGENE
CHM1_17100,233,954 - 100,235,401 (+)NCBI
T2T-CHM13v2.07101,946,186 - 101,947,551 (+)NCBI
CRA_TCAGchr7v2799,663,281 - 99,664,728 (+)ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_005828 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC24113 (Get FASTA)   NCBI Sequence Viewer  
  AAH01430 (Get FASTA)   NCBI Sequence Viewer  
  EAL23821 (Get FASTA)   NCBI Sequence Viewer  
  EAW76495 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000304353
  ENSP00000304353.4
  ENSP00000387814.1
GenBank Protein O75817 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_005828   ⟸   NM_005837
- UniProtKB: A4D2E0 (UniProtKB/Swiss-Prot),   Q9BV74 (UniProtKB/Swiss-Prot),   O75817 (UniProtKB/Swiss-Prot),   C9JYM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000387814   ⟸   ENST00000457480
RefSeq Acc Id: ENSP00000304353   ⟸   ENST00000303151

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O75817-F1-model_v2 AlphaFold O75817 1-140 view protein structure

Promoters
RGD ID:6806043
Promoter ID:HG_KWN:58967
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_005837,   OTTHUMT00000347233,   UC010LHG.1
Position:
Human AssemblyChrPosition (strand)Source
Build 367100,140,971 - 100,141,727 (+)MPROMDB
RGD ID:7211407
Promoter ID:EPDNEW_H11450
Type:initiation region
Name:POP7_1
Description:POP7 homolog, ribonuclease P/MRP subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11449  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,706,121 - 100,706,181EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19949 AgrOrtholog
COSMIC POP7 COSMIC
Ensembl Genes ENSG00000172336 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000303151 ENTREZGENE
  ENST00000303151.5 UniProtKB/Swiss-Prot
  ENST00000457480.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.110.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000172336 GTEx
HGNC ID HGNC:19949 ENTREZGENE
Human Proteome Map POP7 Human Proteome Map
InterPro Alba-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pop7/Rpp20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10248 UniProtKB/Swiss-Prot
NCBI Gene 10248 ENTREZGENE
OMIM 606113 OMIM
PANTHER PTHR15314 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBONUCLEASE P PROTEIN SUBUNIT P20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Rpp20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134887425 PharmGKB
PIRSF RPP20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF82704 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A4D2E0 ENTREZGENE
  C9JYM0 ENTREZGENE, UniProtKB/TrEMBL
  O75817 ENTREZGENE, UniProtKB/Swiss-Prot
  Q9BV74 ENTREZGENE
UniProt Secondary A4D2E0 UniProtKB/Swiss-Prot
  Q9BV74 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-14 POP7  POP7 homolog, ribonuclease P/MRP subunit    processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED