CPSF1 (cleavage and polyadenylation specific factor 1) - Rat Genome Database

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Gene: CPSF1 (cleavage and polyadenylation specific factor 1) Homo sapiens
Analyze
Symbol: CPSF1
Name: cleavage and polyadenylation specific factor 1
RGD ID: 1315001
HGNC Page HGNC
Description: Exhibits enzyme binding activity and mRNA 3'-UTR AU-rich region binding activity. Involved in mRNA polyadenylation. Localizes to mRNA cleavage and polyadenylation specificity factor complex and nucleoplasm. Implicated in myopia.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cleavage and polyadenylation specific factor 1, 160kDa; cleavage and polyadenylation specificity factor 160 kDa subunit; cleavage and polyadenylation specificity factor subunit 1; CPSF 160 kDa subunit; CPSF160; HSU37012; MYP27; P/cl.18; polyadenylation specificity factor
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: CPSF1P1   CPSF1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8144,393,229 - 144,409,335 (-)EnsemblGRCh38hg38GRCh38
GRCh388144,393,231 - 144,409,400 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378145,618,446 - 145,634,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,589,254 - 145,605,541 (-)NCBINCBI36hg18NCBI36
Build 348145,589,253 - 145,605,541NCBI
Celera8141,792,905 - 141,809,167 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,731,448 - 140,747,966 (-)NCBIHuRef
CHM1_18145,656,550 - 145,673,024 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:1756731   PMID:7590244   PMID:7651824   PMID:8302877   PMID:8654386   PMID:9002523   PMID:9311784   PMID:10669729   PMID:11060040   PMID:11124521   PMID:11739730   PMID:11992410  
PMID:12226669   PMID:12392551   PMID:12477932   PMID:14667819   PMID:14749727   PMID:15302935   PMID:15489334   PMID:16055720   PMID:17289029   PMID:18173839   PMID:19136632   PMID:19224921  
PMID:20020773   PMID:20467437   PMID:21102410   PMID:21145461   PMID:21549307   PMID:21822216   PMID:21873635   PMID:22586326   PMID:22658674   PMID:22939629   PMID:23125841   PMID:23151878  
PMID:23602568   PMID:23752268   PMID:24332808   PMID:24457600   PMID:24550385   PMID:24639526   PMID:24711643   PMID:25201988   PMID:25319826   PMID:25416956   PMID:25798074   PMID:25921289  
PMID:26344197   PMID:26354767   PMID:26496610   PMID:27320910   PMID:27609421   PMID:27684187   PMID:27880917   PMID:28380382   PMID:28431233   PMID:28514442   PMID:28700943   PMID:29274231  
PMID:29298432   PMID:29358555   PMID:29358758   PMID:29395067   PMID:29467281   PMID:29467282   PMID:29509190   PMID:29511261   PMID:29564676   PMID:29676528   PMID:29802200   PMID:30021884  
PMID:30689892   PMID:30804502   PMID:30890647   PMID:30948266   PMID:31048545   PMID:31076518   PMID:31091453   PMID:31180492   PMID:31586073   PMID:32203420   PMID:32296183   PMID:32416067  
PMID:32694731   PMID:32780723   PMID:32877691   PMID:33469008  


Genomics

Comparative Map Data
CPSF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8144,393,229 - 144,409,335 (-)EnsemblGRCh38hg38GRCh38
GRCh388144,393,231 - 144,409,400 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378145,618,446 - 145,634,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,589,254 - 145,605,541 (-)NCBINCBI36hg18NCBI36
Build 348145,589,253 - 145,605,541NCBI
Celera8141,792,905 - 141,809,167 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,731,448 - 140,747,966 (-)NCBIHuRef
CHM1_18145,656,550 - 145,673,024 (-)NCBICHM1_1
Cpsf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,480,008 - 76,491,861 (-)NCBIGRCm39mm39
GRCm39 Ensembl1576,480,003 - 76,491,791 (-)Ensembl
GRCm381576,595,808 - 76,607,661 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,595,803 - 76,607,591 (-)EnsemblGRCm38mm10GRCm38
MGSCv371576,426,238 - 76,438,021 (-)NCBIGRCm37mm9NCBIm37
MGSCv361576,423,063 - 76,434,809 (-)NCBImm8
Celera1578,089,201 - 78,101,206 (-)NCBICelera
Cytogenetic Map15D3NCBI
Cpsf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27108,319,429 - 108,330,023 (-)NCBI
Rnor_6.0 Ensembl7117,661,661 - 117,672,373 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07117,661,779 - 117,672,373 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07117,649,863 - 117,660,456 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,647,975 - 114,658,568 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17114,682,284 - 114,692,737 (-)NCBI
Celera7104,669,635 - 104,680,226 (-)NCBICelera
Cytogenetic Map7q34NCBI
Cpsf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554543,024,406 - 3,039,425 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554543,024,324 - 3,039,004 (-)NCBIChiLan1.0ChiLan1.0
CPSF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18144,149,253 - 144,166,183 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8144,148,075 - 144,166,043 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08141,158,494 - 141,176,354 (-)NCBIMhudiblu_PPA_v0panPan3
CPSF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,817,440 - 37,827,868 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,817,442 - 37,825,212 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,780,111 - 37,793,256 (-)NCBI
ROS_Cfam_1.01338,293,061 - 38,306,204 (-)NCBI
UMICH_Zoey_3.11337,984,868 - 37,998,022 (-)NCBI
UNSW_CanFamBas_1.01338,093,511 - 38,106,668 (-)NCBI
UU_Cfam_GSD_1.01338,569,886 - 38,583,035 (-)NCBI
Cpsf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303419,543 - 431,194 (+)NCBI
SpeTri2.0NW_0049364707,848,846 - 7,857,291 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPSF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.14382,887 - 393,732 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24473,501 - 482,157 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPSF1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,602,549 - 138,618,802 (-)NCBI
ChlSab1.1 Ensembl8138,602,835 - 138,617,071 (-)Ensembl
Cpsf1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473512,444,371 - 12,457,864 (+)NCBI

Position Markers
RH104428  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378145,618,523 - 145,618,741UniSTSGRCh37
Build 368145,589,331 - 145,589,549RGDNCBI36
Celera8141,792,982 - 141,793,200RGD
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map8q24.23UniSTS
HuRef8140,731,525 - 140,731,743UniSTS
GeneMap99-GB4 RH Map2299.26UniSTS
ECD00501  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372232,665,400 - 32,666,302UniSTSGRCh37
Build 362230,995,400 - 30,996,302RGDNCBI36
Celera2216,467,619 - 16,468,521RGD
Cytogenetic Map22q12.3UniSTS
Cytogenetic Map8q24.23UniSTS
HuRef2215,623,032 - 15,623,934UniSTS
STS-R82814  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378145,625,404 - 145,625,641UniSTSGRCh37
Build 368145,596,212 - 145,596,449RGDNCBI36
Celera2216,467,870 - 16,468,023UniSTS
Celera8141,799,630 - 141,799,863RGD
Cytogenetic Map22q12.3UniSTS
Cytogenetic Map8q24.23UniSTS
HuRef2215,623,283 - 15,623,436UniSTS
HuRef8140,738,406 - 140,738,641UniSTS
GeneMap99-GB4 RH Map2294.76UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4427
Count of miRNA genes:1007
Interacting mature miRNAs:1263
Transcripts:ENST00000349769, ENST00000526271, ENST00000527827, ENST00000527916, ENST00000529288, ENST00000531042, ENST00000531480, ENST00000531683, ENST00000531727, ENST00000532560, ENST00000532725, ENST00000532935, ENST00000533492
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 2436 2773 1705 605 1853 446 4340 2078 3413 381 1457 1607 175 1 1204 2774 5 2
Low 3 218 21 19 98 19 17 119 321 38 2 6 14 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006716548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB046744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC233992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF205589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD299980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000526271
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8144,393,699 - 144,394,716 (-)Ensembl
RefSeq Acc Id: ENST00000527827
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8144,396,015 - 144,396,730 (-)Ensembl
RefSeq Acc Id: ENST00000527916
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8144,398,523 - 144,399,346 (-)Ensembl
RefSeq Acc Id: ENST00000529288
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8144,395,313 - 144,395,979 (-)Ensembl
RefSeq Acc Id: ENST00000531042   ⟹   ENSP00000435761
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8144,394,769 - 144,409,181 (-)Ensembl
RefSeq Acc Id: ENST00000531480
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8144,393,229 - 144,394,416 (-)Ensembl
RefSeq Acc Id: ENST00000531727   ⟹   ENSP00000483775
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8144,393,229 - 144,394,441 (-)Ensembl
RefSeq Acc Id: ENST00000532560
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8144,399,800 - 144,400,986 (-)Ensembl
RefSeq Acc Id: ENST00000532725
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8144,393,565 - 144,394,237 (-)Ensembl
RefSeq Acc Id: ENST00000532935   ⟹   ENSP00000478161
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8144,393,883 - 144,394,761 (-)Ensembl
RefSeq Acc Id: ENST00000533492
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8144,399,220 - 144,399,807 (-)Ensembl
RefSeq Acc Id: ENST00000616140   ⟹   ENSP00000484669
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8144,393,231 - 144,409,335 (-)Ensembl
RefSeq Acc Id: ENST00000620219   ⟹   ENSP00000478145
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8144,393,318 - 144,409,288 (-)Ensembl
RefSeq Acc Id: ENST00000622776
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8144,399,809 - 144,401,675 (-)Ensembl
RefSeq Acc Id: NM_013291   ⟹   NP_037423
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388144,393,231 - 144,409,335 (-)NCBI
GRCh378145,618,446 - 145,634,733 (-)ENTREZGENE
Build 368145,589,254 - 145,605,541 (-)NCBI Archive
HuRef8140,731,448 - 140,747,966 (-)ENTREZGENE
CHM1_18145,656,550 - 145,673,024 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006716548   ⟹   XP_006716611
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388144,393,231 - 144,409,400 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024447139   ⟹   XP_024302907
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388144,393,231 - 144,409,400 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024447140   ⟹   XP_024302908
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388144,393,231 - 144,409,103 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024447141   ⟹   XP_024302909
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388144,393,231 - 144,409,303 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024447142   ⟹   XP_024302910
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388144,393,231 - 144,409,103 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037423   ⟸   NM_013291
- UniProtKB: Q10570 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006716611   ⟸   XM_006716548
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_024302907   ⟸   XM_024447139
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024302909   ⟸   XM_024447141
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_024302910   ⟸   XM_024447142
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_024302908   ⟸   XM_024447140
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000478145   ⟸   ENST00000620219
RefSeq Acc Id: ENSP00000483775   ⟸   ENST00000531727
RefSeq Acc Id: ENSP00000435761   ⟸   ENST00000531042
RefSeq Acc Id: ENSP00000478161   ⟸   ENST00000532935
RefSeq Acc Id: ENSP00000484669   ⟸   ENST00000616140
Protein Domains
CPSF_A

Promoters
RGD ID:7214465
Promoter ID:EPDNEW_H12979
Type:initiation region
Name:CPSF1_1
Description:cleavage and polyadenylation specific factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388144,409,313 - 144,409,373EPDNEW
RGD ID:6813370
Promoter ID:HG_ACW:79425
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:CPSF1.EAPR07,   CPSF1.FAPR07,   CPSF1.GAPR07,   CPSF1.MAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 368145,591,091 - 145,591,591 (-)MPROMDB
RGD ID:6813369
Promoter ID:HG_ACW:79428
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid
Transcripts:CPSF1.HAPR07,   CPSF1.LAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 368145,595,956 - 145,596,456 (-)MPROMDB
RGD ID:6806576
Promoter ID:HG_KWN:62339
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_013291,   UC003ZCL.1
Position:
Human AssemblyChrPosition (strand)Source
Build 368145,605,291 - 145,605,791 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q24.21-24.3(chr8:128220912-145049449)x3 copy number gain See cases [RCV000050830] Chr8:128220912..145049449 [GRCh38]
Chr8:129233158..146274835 [GRCh37]
Chr8:129302340..146245639 [NCBI36]
Chr8:8q24.21-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:144002671-144796947)x3 copy number gain See cases [RCV000050640] Chr8:144002671..144796947 [GRCh38]
Chr8:145076839..146022332 [GRCh37]
Chr8:145148827..145993136 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8q23.3-24.3(chr8:113580402-145054634)x3 copy number gain See cases [RCV000050638] Chr8:113580402..145054634 [GRCh38]
Chr8:114592631..146280020 [GRCh37]
Chr8:114661807..146250824 [NCBI36]
Chr8:8q23.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:144287919-144723120)x3 copy number gain See cases [RCV000052187] Chr8:144287919..144723120 [GRCh38]
Chr8:145511620..145948505 [GRCh37]
Chr8:145482428..145919314 [NCBI36]
Chr8:8q24.3
uncertain significance
GRCh38/hg38 8q24.3(chr8:144375621-144605333)x3 copy number gain See cases [RCV000052188] Chr8:144375621..144605333 [GRCh38]
Chr8:145599310..145830717 [GRCh37]
Chr8:145570118..145801525 [NCBI36]
Chr8:8q24.3
uncertain significance
GRCh38/hg38 8q24.3(chr8:144392063-144458958)x3 copy number gain See cases [RCV000052189] Chr8:144392063..144458958 [GRCh38]
Chr8:145617263..145684341 [GRCh37]
Chr8:145588071..145655149 [NCBI36]
Chr8:8q24.3
uncertain significance
GRCh38/hg38 8q24.3(chr8:144002671-145054634)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053702]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053702]|See cases [RCV000053702] Chr8:144002671..145054634 [GRCh38]
Chr8:145076839..146280020 [GRCh37]
Chr8:145148827..146250824 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000053678] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:139447227-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|See cases [RCV000053701] Chr8:139447227..145054775 [GRCh38]
Chr8:140459470..146280161 [GRCh37]
Chr8:140528652..146250965 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:144002471-145054775)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054311]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054311]|See cases [RCV000054311] Chr8:144002471..145054775 [GRCh38]
Chr8:145076639..146280161 [GRCh37]
Chr8:145148627..146250965 [NCBI36]
Chr8:8q24.3
pathogenic
NM_013291.2(CPSF1):c.3767A>G (p.Tyr1256Cys) single nucleotide variant Malignant melanoma [RCV000061767] Chr8:144394278 [GRCh38]
Chr8:145619493 [GRCh37]
Chr8:145590301 [NCBI36]
Chr8:8q24.3
not provided
NM_130849.3(SLC39A4):c.1864C>T (p.Leu622=) single nucleotide variant Malignant melanoma [RCV000068211] Chr8:144412618 [GRCh38]
Chr8:145638002 [GRCh37]
Chr8:145608810 [NCBI36]
Chr8:8q24.3
not provided
GRCh38/hg38 8q24.3(chr8:144264907-144668170)x1 copy number loss See cases [RCV000134352] Chr8:144264907..144668170 [GRCh38]
Chr8:145319810..145893555 [GRCh37]
Chr8:145391798..145864363 [NCBI36]
Chr8:8q24.3
benign
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.22-24.3(chr8:130639182-145068712)x3 copy number gain See cases [RCV000137644] Chr8:130639182..145068712 [GRCh38]
Chr8:131651428..146294098 [GRCh37]
Chr8:131720610..146264902 [NCBI36]
Chr8:8q24.22-24.3
pathogenic|conflicting data from submitters
GRCh38/hg38 8q24.3(chr8:139236824-145068712)x3 copy number gain See cases [RCV000137466] Chr8:139236824..145068712 [GRCh38]
Chr8:140249067..146294098 [GRCh37]
Chr8:140318249..146264902 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.3(chr8:139004218-145049449)x3 copy number gain See cases [RCV000137340] Chr8:139004218..145049449 [GRCh38]
Chr8:140016461..146274835 [GRCh37]
Chr8:140085643..146245639 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124498498-145068712)x3 copy number gain See cases [RCV000137346] Chr8:124498498..145068712 [GRCh38]
Chr8:125510739..146294098 [GRCh37]
Chr8:125579920..146264902 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:144340449-144585787)x3 copy number gain See cases [RCV000140255] Chr8:144340449..144585787 [GRCh38]
Chr8:145564111..145811171 [GRCh37]
Chr8:145534919..145781979 [NCBI36]
Chr8:8q24.3
likely benign
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000148117] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:145600952-145834119)x3 copy number gain See cases [RCV000203425] Chr8:145600952..145834119 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8q24.3(chr8:145603153-145811230)x3 copy number gain See cases [RCV000239970] Chr8:145603153..145811230 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8q24.3(chr8:145033244-146297937)x3 copy number gain not provided [RCV001270667] Chr8:145033244..146297937 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:134825277-146280828)x3 copy number gain See cases [RCV000448348] Chr8:134825277..146280828 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:144779442-146113113)x3 copy number gain See cases [RCV000510396] Chr8:144779442..146113113 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:136378789-146295771)x3 copy number gain See cases [RCV000512003] Chr8:136378789..146295771 [GRCh37]
Chr8:8q24.22-24.3
likely pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:142840194-146280020) copy number gain Intellectual disability [RCV000626547] Chr8:142840194..146280020 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q23.3-24.3(chr8:114853126-146295771)x3 copy number gain See cases [RCV000512401] Chr8:114853126..146295771 [GRCh37]
Chr8:8q23.3-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121694649-146295771)x3 copy number gain not provided [RCV000683044] Chr8:121694649..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:143815037-146295771)x3 copy number gain not provided [RCV000683020] Chr8:143815037..146295771 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:145513753-145758661)x3 copy number gain not provided [RCV000748011] Chr8:145513753..145758661 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:145513753-145758635)x3 copy number gain not provided [RCV000748010] Chr8:145513753..145758635 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.3(chr8:145634413-145753161)x3 copy number gain not provided [RCV000748021] Chr8:145634413..145753161 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.3(chr8:145634556-145772939)x3 copy number gain not provided [RCV000748022] Chr8:145634556..145772939 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.3(chr8:145579325-145758635)x3 copy number gain not provided [RCV000748019] Chr8:145579325..145758635 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.3(chr8:145580535-145755918)x3 copy number gain not provided [RCV000748020] Chr8:145580535..145755918 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.3(chr8:145513753-145753161)x3 copy number gain not provided [RCV000748009] Chr8:145513753..145753161 [GRCh37]
Chr8:8q24.3
benign
NM_013291.3(CPSF1):c.1603_1604del (p.Met535fs) deletion not provided [RCV001038883] Chr8:144398813..144398814 [GRCh38]
Chr8:145624203..145624204 [GRCh37]
Chr8:8q24.3
pathogenic
NC_000008.10:g.(?_144990335)_(145701149_?)dup duplication Epidermolysis bullosa simplex with muscular dystrophy [RCV000823255] Chr8:144990335..145701149 [GRCh37]
Chr8:8q24.3
uncertain significance
NC_000008.10:g.(?_144990325)_(145700664_?)dup duplication Brown-Vialetto-Van Laere syndrome 2 [RCV000808636] Chr8:144990325..145700664 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8q24.12-24.3(chr8:122193546-146295771)x3 copy number gain not provided [RCV000849762] Chr8:122193546..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:145603133-145695493)x3 copy number gain not provided [RCV000846119] Chr8:145603133..145695493 [GRCh37]
Chr8:8q24.3
uncertain significance
NM_013291.3(CPSF1):c.2823_2824del (p.Val943fs) deletion Myopia 27 [RCV001029439] Chr8:144396600..144396601 [GRCh38]
Chr8:145621815..145621816 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q24.21-24.3(chr8:128877995-146295771)x3 copy number gain not provided [RCV001006146] Chr8:128877995..146295771 [GRCh37]
Chr8:8q24.21-24.3
pathogenic
GRCh37/hg19 8q24.23-24.3(chr8:139188797-146295771)x3 copy number gain not provided [RCV000846814] Chr8:139188797..146295771 [GRCh37]
Chr8:8q24.23-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:144190206-146295771)x3 copy number gain not provided [RCV000847854] Chr8:144190206..146295771 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:136059859-146295771)x3 copy number gain not provided [RCV000847171] Chr8:136059859..146295771 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:145287199-145705521)x3 copy number gain not provided [RCV001006156] Chr8:145287199..145705521 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.13-24.3(chr8:125496223-146295771)x3 copy number gain not provided [RCV000845705] Chr8:125496223..146295771 [GRCh37]
Chr8:8q24.13-24.3
pathogenic
NM_013291.3(CPSF1):c.1962C>T (p.Pro654=) single nucleotide variant not provided [RCV001171998] Chr8:144398065 [GRCh38]
Chr8:145623280 [GRCh37]
Chr8:8q24.3
likely benign
NM_013291.3(CPSF1):c.4146-2A>G single nucleotide variant Myopia 27 [RCV001029433] Chr8:144393592 [GRCh38]
Chr8:145618807 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121042467-146295771)x3 copy number gain not provided [RCV001006140] Chr8:121042467..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
NM_013291.3(CPSF1):c.3823G>T (p.Asp1275Tyr) single nucleotide variant Myopia 27 [RCV001029435] Chr8:144394149 [GRCh38]
Chr8:145619364 [GRCh37]
Chr8:8q24.3
pathogenic
NM_013291.3(CPSF1):c.1858C>T (p.Gln620Ter) single nucleotide variant Myopia 27 [RCV001029437] Chr8:144398338 [GRCh38]
Chr8:145623728 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:144262042-146295771)x3 copy number gain not provided [RCV001259034] Chr8:144262042..146295771 [GRCh37]
Chr8:8q24.3
likely pathogenic
GRCh37/hg19 8q24.3(chr8:145555125-145779806)x3 copy number gain not provided [RCV001259512] Chr8:145555125..145779806 [GRCh37]
Chr8:8q24.3
uncertain significance
NC_000008.10:g.(?_144990335)_(145701149_?)dup duplication Epidermolysis bullosa simplex with muscular dystrophy [RCV001327821] Chr8:144990335..145701149 [GRCh37]
Chr8:8q24.3
uncertain significance
NC_000008.10:g.(?_145047561)_(145701149_?)dup duplication Brown-Vialetto-Van Laere syndrome 2 [RCV001301200] Chr8:145047561..145701149 [GRCh37]
Chr8:8q24.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2324 AgrOrtholog
COSMIC CPSF1 COSMIC
Ensembl Genes ENSG00000071894 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000285049 UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000435761 UniProtKB/TrEMBL
  ENSP00000478145 UniProtKB/Swiss-Prot
  ENSP00000478161 UniProtKB/TrEMBL
  ENSP00000483775 UniProtKB/TrEMBL
  ENSP00000484669 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000495020 UniProtKB/Swiss-Prot
  ENSP00000495102 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000531042 UniProtKB/TrEMBL
  ENST00000531727 UniProtKB/TrEMBL
  ENST00000532935 UniProtKB/TrEMBL
  ENST00000616140 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000620219 UniProtKB/Swiss-Prot
  ENST00000643746 UniProtKB/Swiss-Prot
  ENST00000644539 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000071894 GTEx
  ENSG00000285049 GTEx
HGNC ID HGNC:2324 ENTREZGENE
Human Proteome Map CPSF1 Human Proteome Map
InterPro Cleavage/polyA-sp_fac_asu_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cleavage/polyA-sp_fac_asu_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:29894 UniProtKB/Swiss-Prot
NCBI Gene 29894 ENTREZGENE
OMIM 606027 OMIM
  618827 OMIM
Pfam CPSF_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MMS1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26841 PharmGKB
UniProt A0A087WTV4_HUMAN UniProtKB/TrEMBL
  A0A087X101_HUMAN UniProtKB/TrEMBL
  CPSF1_HUMAN UniProtKB/Swiss-Prot
  D3DWL9_HUMAN UniProtKB/TrEMBL
  E9PIM1_HUMAN UniProtKB/TrEMBL
  Q10570 ENTREZGENE
UniProt Secondary Q96AF0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 CPSF1  cleavage and polyadenylation specific factor 1    cleavage and polyadenylation specific factor 1, 160kDa  Symbol and/or name change 5135510 APPROVED
2011-08-17 CPSF1  cleavage and polyadenylation specific factor 1, 160kDa  CPSF1  cleavage and polyadenylation specific factor 1, 160kDa  Symbol and/or name change 5135510 APPROVED