Klhl2 (kelch-like 2, Mayven) - Rat Genome Database
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Gene: Klhl2 (kelch-like 2, Mayven) Mus musculus
Analyze
Symbol: Klhl2
Name: kelch-like 2, Mayven
RGD ID: 1314976
MGI Page MGI
Description: Predicted to have actin binding activity and protein homodimerization activity. Involved in protein ubiquitination. Localizes to Cul3-RING ubiquitin ligase complex and cytoplasm. Is expressed in white fat. Orthologous to human KLHL2 (kelch like family member 2); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6030411N21Rik; 8530402H02Rik; ABP-KE; ABP-KELCH; AU020744; hypothetical protein LOC78235; kelch-like protein 2; KIAA4249; M; Mav; mKIAA4249; RIKEN cDNA 8530402H02 gene; uncharacterized protein LOC78235
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39865,192,707 - 65,302,821 (-)NCBIGRCm39mm39
GRCm38864,739,673 - 64,850,169 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl864,739,675 - 64,850,017 (-)EnsemblGRCm38mm10GRCm38
MGSCv37867,335,578 - 67,373,716 (-)NCBIGRCm37mm9NCBIm37
MGSCv36867,631,868 - 67,672,057 (-)NCBImm8
Celera867,303,934 - 67,417,078 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10397770   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12652657   PMID:14610273   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:18799693   PMID:21549840   PMID:25556166   PMID:26607111   PMID:28190767   PMID:28414128  


Genomics

Comparative Map Data
Klhl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39865,192,707 - 65,302,821 (-)NCBIGRCm39mm39
GRCm38864,739,673 - 64,850,169 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl864,739,675 - 64,850,017 (-)EnsemblGRCm38mm10GRCm38
MGSCv37867,335,578 - 67,373,716 (-)NCBIGRCm37mm9NCBIm37
MGSCv36867,631,868 - 67,672,057 (-)NCBImm8
Celera867,303,934 - 67,417,078 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
KLHL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4165,207,561 - 165,323,156 (+)EnsemblGRCh38hg38GRCh38
GRCh384165,207,561 - 165,323,156 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374166,128,770 - 166,244,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364166,348,238 - 166,463,749 (+)NCBINCBI36hg18NCBI36
Build 344166,486,395 - 166,601,903NCBI
Celera4163,459,950 - 163,579,735 (+)NCBI
Cytogenetic Map4q32.3NCBI
HuRef4161,880,568 - 161,996,120 (+)NCBIHuRef
CHM1_14166,105,246 - 166,220,767 (+)NCBICHM1_1
Klhl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01626,755,246 - 26,852,134 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1626,739,389 - 26,852,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01626,622,472 - 26,731,058 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41626,634,400 - 26,690,756 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11626,648,722 - 26,691,115 (+)NCBI
Celera1624,962,535 - 25,057,740 (+)NCBICelera
Cytogenetic Map16p13NCBI
Klhl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540340,012,453 - 40,094,853 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540340,013,840 - 40,094,853 (-)NCBIChiLan1.0ChiLan1.0
KLHL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14169,572,832 - 169,602,304 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v04157,402,905 - 157,518,639 (+)NCBIMhudiblu_PPA_v0panPan3
KLHL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1561,204,363 - 61,298,581 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11561,204,371 - 61,289,020 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Klhl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936555684,300 - 765,934 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl843,749,425 - 43,870,997 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1843,749,423 - 43,871,011 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2845,677,143 - 45,798,587 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17111,569,027 - 111,684,065 (+)NCBI
ChlSab1.1 Ensembl7111,569,125 - 111,684,879 (+)Ensembl
Klhl2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475811,649,603 - 11,765,636 (-)NCBI

Position Markers
RH136561  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38864,740,262 - 64,740,499UniSTSGRCm38
MGSCv37867,219,059 - 67,219,296UniSTSGRCm37
Celera867,304,334 - 67,304,571UniSTS
Cytogenetic Map8B3.1UniSTS
D00570  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38864,807,651 - 64,807,813UniSTSGRCm38
MGSCv37867,331,551 - 67,331,713UniSTSGRCm37
Celera867,370,938 - 67,371,100UniSTS
Cytogenetic Map8B3.1UniSTS
Whitehead_YAC8 UniSTS
UniSTS:235903  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38864,740,475 - 64,740,557UniSTSGRCm38
MGSCv37867,219,272 - 67,219,354UniSTSGRCm37
Celera867,304,547 - 67,304,629UniSTS
Cytogenetic Map8B3.1UniSTS
D8Mit7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38864,793,915 - 64,794,093UniSTSGRCm38
MGSCv37867,272,712 - 67,272,890UniSTSGRCm37
Celera867,357,923 - 67,358,101UniSTS
Cytogenetic Map8B3.1UniSTS
cM Map832.0UniSTS
Whitehead Genetic833.9UniSTS
Whitehead_YAC8 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83383736267837502Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:257
Count of miRNA genes:216
Interacting mature miRNAs:225
Transcripts:ENSMUST00000034017
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_178633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC140351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC152168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC242529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK020050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK020239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG954275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034017   ⟹   ENSMUSP00000034017
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl864,739,675 - 64,850,017 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209458
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl864,759,760 - 64,799,664 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209544
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl864,811,767 - 64,842,197 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209919
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl864,751,158 - 64,754,971 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210166   ⟹   ENSMUSP00000147262
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl864,739,848 - 64,849,924 (-)Ensembl
RefSeq Acc Id: NM_178633   ⟹   NP_848748
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39865,192,709 - 65,302,576 (-)NCBI
GRCm38864,739,675 - 64,849,924 (-)NCBI
MGSCv37867,335,578 - 67,373,716 (-)RGD
Celera867,303,747 - 67,417,078 (-)NCBI
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017313011   ⟹   XP_017168500
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39865,192,707 - 65,302,681 (-)NCBI
GRCm38864,739,673 - 64,850,029 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017313012   ⟹   XP_017168501
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39865,194,025 - 65,302,821 (-)NCBI
GRCm38864,740,989 - 64,850,169 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036154378   ⟹   XP_036010271
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39865,192,707 - 65,290,816 (-)NCBI
RefSeq Acc Id: XM_036154379   ⟹   XP_036010272
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39865,192,880 - 65,290,999 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_848748   ⟸   NM_178633
- UniProtKB: Q8JZP3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017168500   ⟸   XM_017313011
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017168501   ⟸   XM_017313012
- Peptide Label: isoform X2
- UniProtKB: A0A1B0GQV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034017   ⟸   ENSMUST00000034017
RefSeq Acc Id: ENSMUSP00000147262   ⟸   ENSMUST00000210166
RefSeq Acc Id: XP_036010271   ⟸   XM_036154378
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036010272   ⟸   XM_036154379
- Peptide Label: isoform X4
Protein Domains
BTB

Promoters
RGD ID:8667171
Promoter ID:EPDNEW_M11617
Type:multiple initiation site
Name:Klhl2_1
Description:Mus musculus kelch-like 2, Mayven , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38864,849,954 - 64,850,014EPDNEW
RGD ID:6843370
Promoter ID:MM_KWN:54536
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4
Transcripts:NM_178633,   UC009LUZ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36867,373,806 - 67,374,306 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1924363 AgrOrtholog
Ensembl Genes ENSMUSG00000031605 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034017 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000147262 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034017 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000210166 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KLHL2_BTB/POZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:77113 UniProtKB/Swiss-Prot
MGD MGI:1924363 ENTREZGENE
NCBI Gene 77113 ENTREZGENE
Pfam BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klhl2 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.350347 ENTREZGENE
UniProt A0A1B0GQV2 ENTREZGENE, UniProtKB/TrEMBL
  KLHL2_MOUSE UniProtKB/Swiss-Prot
  Q5DTF0_MOUSE UniProtKB/TrEMBL
  Q8JZP3 ENTREZGENE
UniProt Secondary Q8CCU0 UniProtKB/Swiss-Prot
  Q8R3U4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-02-20 Klhl2  kelch-like 2, Mayven  8530402H02Rik  RIKEN cDNA 8530402H02 gene  Data Merged 737654 PROVISIONAL
2013-01-22 Klhl2  kelch-like 2, Mayven    kelch-like 2, Mayven (Drosophila)  Symbol and/or name change 5135510 APPROVED