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Gene: SP140 (SP140 nuclear body protein) Homo sapiens
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Symbol: SP140
Name: SP140 nuclear body protein
Description: This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: lymphoid-restricted homolog of Sp100; lymphoid-specific SP100 homolog; LYSP100; LYSP100-A; LYSP100-B; MGC126440; nuclear autoantigen Sp-140; nuclear body protein SP140; speckled 140 kDa
Orthologs:
Mus musculus (house mouse) : Sp140 (Sp140 nuclear body protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sp140 (SP140 nuclear body protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sp140 (SP140 nuclear body protein)
Pan paniscus (bonobo/pygmy chimpanzee) : SP140 (SP140 nuclear body protein)
Canis lupus familiaris (dog) : SP140 (SP140 nuclear body protein)
Sus scrofa (pig) : SP140 (SP140 nuclear body protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,202,743 - 230,316,571 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372231,090,445 - 231,177,930 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362230,798,690 - 230,886,174 (+)NCBINCBI36hg18NCBI36
Build 342230,915,950 - 231,003,435NCBI
Celera2224,866,569 - 224,954,088 (+)NCBI
Cytogenetic Map2q37.1NCBI
HuRef2222,930,492 - 223,018,082 (+)NCBIHuRef
CHM1_12231,096,298 - 231,183,775 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on SP140
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1314926
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.