Tvp23b (trans-golgi network vesicle protein 23B) - Rat Genome Database

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Gene: Tvp23b (trans-golgi network vesicle protein 23B) Mus musculus
Analyze
Symbol: Tvp23b
Name: trans-golgi network vesicle protein 23B
RGD ID: 1314910
MGI Page MGI
Description: Predicted to be involved in protein secretion and vesicle-mediated transport. Predicted to be located in membrane. Is expressed in lung. Orthologous to several human genes including TVP23B (trans-golgi network vesicle protein 23 homolog B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1810036I24Rik; Fam18; Fam18b; Fam18b1; family with sequence similarity 18, member B; Golgi apparatus membrane protein TVP23 homolog B; hypothetical protein LOC67510; ortholog of human family with sequence similarity 18 member B FAM18B; RP23-428I5.3
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,770,281 - 62,786,012 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,770,281 - 62,807,606 (+)EnsemblGRCm39 Ensembl
GRCm381162,879,455 - 62,895,186 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,879,455 - 62,916,780 (+)EnsemblGRCm38mm10GRCm38
MGSCv371162,692,992 - 62,708,686 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361162,695,685 - 62,711,379 (+)NCBIMGSCv36mm8
Celera1169,804,590 - 69,823,714 (+)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1138.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Golgi membrane  (IBA)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15747579   PMID:16141072   PMID:16141073   PMID:17720922  
PMID:18799693   PMID:21267068   PMID:21873635   PMID:32325033   PMID:32554809   PMID:37339972  


Genomics

Comparative Map Data
Tvp23b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,770,281 - 62,786,012 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,770,281 - 62,807,606 (+)EnsemblGRCm39 Ensembl
GRCm381162,879,455 - 62,895,186 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,879,455 - 62,916,780 (+)EnsemblGRCm38mm10GRCm38
MGSCv371162,692,992 - 62,708,686 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361162,695,685 - 62,711,379 (+)NCBIMGSCv36mm8
Celera1169,804,590 - 69,823,714 (+)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1138.81NCBI
TVP23B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381718,781,183 - 18,806,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1718,781,111 - 18,806,714 (+)EnsemblGRCh38hg38GRCh38
GRCh371718,684,496 - 18,710,027 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361718,625,307 - 18,650,751 (+)NCBINCBI36Build 36hg18NCBI36
Build 341718,625,306 - 18,650,751NCBI
Celera1719,300,281 - 19,303,861 (+)NCBICelera
Cytogenetic Map17p11.2NCBI
CHM1_11718,694,070 - 18,719,517 (+)NCBICHM1_1
T2T-CHM13v2.01718,727,332 - 18,752,867 (+)NCBIT2T-CHM13v2.0
Tvp23b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81048,053,005 - 48,067,326 (+)NCBIGRCr8
mRatBN7.21047,553,789 - 47,565,203 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1047,553,831 - 47,565,203 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1052,256,751 - 52,268,046 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01051,747,288 - 51,758,583 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01047,250,711 - 47,262,006 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01049,299,125 - 49,312,814 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1049,299,125 - 49,310,400 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01049,077,748 - 49,089,025 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41049,060,663 - 49,072,663 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1046,797,871 - 46,809,178 (+)NCBICelera
Cytogenetic Map10q23NCBI
TVP23B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21953,844,344 - 53,870,832 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11758,466,440 - 58,493,029 (+)NCBINHGRI_mPanPan1
TVP23B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1539,079,975 - 39,099,309 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl539,080,078 - 39,099,309 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha539,224,771 - 39,244,126 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0539,188,063 - 39,207,499 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl539,187,294 - 39,207,458 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1539,161,028 - 39,180,389 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0539,106,370 - 39,125,719 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0539,294,665 - 39,314,022 (-)NCBIUU_Cfam_GSD_1.0
TVP23B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1258,816,344 - 58,923,072 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11258,879,198 - 58,894,040 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21261,895,965 - 61,907,741 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103247579
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_0236660596,360,015 - 6,386,338 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tvp23b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248773,516,159 - 3,631,561 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248773,536,540 - 3,631,960 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tvp23b
684 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:619
Count of miRNA genes:449
Interacting mature miRNAs:510
Transcripts:ENSMUST00000014321, ENSMUST00000128698, ENSMUST00000140377, ENSMUST00000154176
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115406567067078411Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115408094165103841Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5406567063319522Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115925661769482699Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000014321   ⟹   ENSMUSP00000014321
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1162,770,281 - 62,786,011 (+)Ensembl
GRCm38.p6 Ensembl1162,879,455 - 62,895,185 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128698
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1162,770,316 - 62,782,878 (+)Ensembl
GRCm38.p6 Ensembl1162,879,490 - 62,892,052 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140377
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1162,774,488 - 62,807,606 (+)Ensembl
GRCm38.p6 Ensembl1162,883,662 - 62,916,780 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154176
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1162,770,440 - 62,776,172 (+)Ensembl
GRCm38.p6 Ensembl1162,879,614 - 62,885,346 (+)Ensembl
RefSeq Acc Id: NM_001356520   ⟹   NP_001343449
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391162,770,281 - 62,786,012 (+)NCBI
GRCm381162,879,455 - 62,895,186 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001356521   ⟹   NP_001343450
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391162,770,281 - 62,786,012 (+)NCBI
GRCm381162,879,455 - 62,895,186 (+)NCBI
Sequence:
RefSeq Acc Id: NM_026210   ⟹   NP_080486
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391162,770,281 - 62,786,012 (+)NCBI
GRCm381162,879,455 - 62,895,186 (+)NCBI
MGSCv371162,692,992 - 62,708,686 (+)RGD
Celera1169,804,590 - 69,823,714 (+)ENTREZGENE
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_080486   ⟸   NM_026210
- Peptide Label: isoform 1
- UniProtKB: Q3UBJ3 (UniProtKB/Swiss-Prot),   Q9D8T4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001343450   ⟸   NM_001356521
- Peptide Label: isoform 3 precursor
RefSeq Acc Id: NP_001343449   ⟸   NM_001356520
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000014321   ⟸   ENSMUST00000014321

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D8T4-F1-model_v2 AlphaFold Q9D8T4 1-205 view protein structure

Promoters
RGD ID:6820855
Promoter ID:MM_KWN:7854
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000013091,   OTTMUST00000013092,   OTTMUST00000013093
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361162,692,701 - 62,693,352 (+)MPROMDB
RGD ID:8675012
Promoter ID:EPDNEW_M15537
Type:initiation region
Name:Tvp23b_1
Description:Mus musculus trans-golgi network vesicle protein 23B , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381162,879,513 - 62,879,573EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914760 AgrOrtholog
Ensembl Genes ENSMUSG00000014177 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000014321 ENTREZGENE
  ENSMUST00000014321.5 UniProtKB/Swiss-Prot
InterPro TVP23-like UniProtKB/Swiss-Prot
KEGG Report mmu:67510 UniProtKB/Swiss-Prot
MGD MGI:1914760 ENTREZGENE
NCBI Gene 67510 ENTREZGENE
PANTHER GOLGI APPARATUS MEMBRANE PROTEIN TVP23 HOMOLOG B UniProtKB/Swiss-Prot
  PTHR13019 UniProtKB/Swiss-Prot
Pfam DUF846 UniProtKB/Swiss-Prot
PhenoGen Tvp23b PhenoGen
UniProt Q3UBJ3 ENTREZGENE
  Q9D8T4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3UBJ3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-25 Tvp23b  trans-golgi network vesicle protein 23B  Fam18b  family with sequence similarity 18, member B  Symbol and/or name change 5135510 APPROVED