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Gene: PPAN (peter pan homolog) Homo sapiens
Symbol: PPAN
Name: peter pan homolog
Description: The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: brix domain-containing protein 3; BXDC3; homolog of S. cerevisiae SSF1; MGC14226; MGC45852; peter pan homolog (Drosophila); second-step splicing factor 1; SSF; SSF-1; SSF1; SSF2; suppressor of sterile four 1; suppressor of SWI4 1 homolog
Mus musculus (house mouse) : Ppan (peter pan homolog)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ppan (peter pan homolog)  Alliance
Canis lupus familiaris (dog) : PPAN (peter pan homolog)
Sus scrofa (pig) : PPAN (peter pan homolog)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381910,106,223 - 10,112,012 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,216,899 - 10,221,975 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,077,965 - 10,082,975 (+)NCBINCBI36hg18NCBI36
Build 341910,077,964 - 10,082,975NCBI
Celera1910,112,456 - 10,117,466 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef199,797,545 - 9,802,621 (+)NCBIHuRef
CHM1_11910,217,181 - 10,222,257 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PPAN
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1314882
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.