Wnt8a (wingless-type MMTV integration site family, member 8A) - Rat Genome Database

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Gene: Wnt8a (wingless-type MMTV integration site family, member 8A) Mus musculus
Analyze
Symbol: Wnt8a
Name: wingless-type MMTV integration site family, member 8A
RGD ID: 1314862
MGI Page MGI
Description: Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within several processes, including axis specification; endoderm development; and regulation of protein localization. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human WNT8A (Wnt family member 8A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: stimulated by retinoic acid gene 11 protein; Str; Stra11; wingless-related MMTV integration site 8A; wingless-related MMTV integration site 8D; wnt-8; Wnt-8A; Wnt-8D; Wnt8d
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,675,380 - 34,681,114 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,675,366 - 34,681,326 (+)EnsemblGRCm39 Ensembl
GRCm381834,542,327 - 34,548,061 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,542,313 - 34,548,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv371834,701,982 - 34,707,715 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,667,114 - 34,673,074 (+)NCBIMGSCv36mm8
Celera1834,995,948 - 35,001,675 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
8. Alternative wnt signaling is initiated by distinct receptors. van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
Additional References at PubMed
PMID:7649373   PMID:8887323   PMID:8967950   PMID:10640709   PMID:10654602   PMID:10727869   PMID:11429295   PMID:11520664   PMID:11914369   PMID:12477932   PMID:12490556   PMID:12702652  
PMID:12719544   PMID:12812787   PMID:14681479   PMID:15053977   PMID:15226823   PMID:15342465   PMID:15857914   PMID:15880404   PMID:16116452   PMID:16256739   PMID:16352730   PMID:16378759  
PMID:16452098   PMID:16602821   PMID:16678101   PMID:16943279   PMID:17055474   PMID:17127040   PMID:17576928   PMID:17804636   PMID:17943183   PMID:18364260   PMID:18403408   PMID:18635608  
PMID:18799693   PMID:18800919   PMID:18973680   PMID:19168680   PMID:19185060   PMID:19282366   PMID:19285468   PMID:19515997   PMID:19539783   PMID:19562671   PMID:20171206   PMID:20940229  
PMID:21041481   PMID:21267068   PMID:21320481   PMID:21331042   PMID:21362415   PMID:21873635   PMID:21936019   PMID:22166339   PMID:22956684   PMID:23041177   PMID:23190887   PMID:23376422  
PMID:23884445   PMID:24394376   PMID:24586192   PMID:25053429   PMID:25809880   PMID:26443994   PMID:27362799   PMID:28069946   PMID:28813421   PMID:28834739   PMID:30347193   PMID:30940800  
PMID:32325033   PMID:33141892   PMID:33687475   PMID:34861058   PMID:35831952   PMID:36305473  


Genomics

Comparative Map Data
Wnt8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,675,380 - 34,681,114 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,675,366 - 34,681,326 (+)EnsemblGRCm39 Ensembl
GRCm381834,542,327 - 34,548,061 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,542,313 - 34,548,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv371834,701,982 - 34,707,715 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,667,114 - 34,673,074 (+)NCBIMGSCv36mm8
Celera1834,995,948 - 35,001,675 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.69NCBI
WNT8A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,077,367 - 138,092,365 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,083,990 - 138,092,365 (+)EnsemblGRCh38hg38GRCh38
GRCh375137,419,722 - 137,428,054 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,447,673 - 137,455,098 (+)NCBINCBI36Build 36hg18NCBI36
Build 345137,447,577 - 137,455,953NCBI
Celera5133,541,722 - 133,549,145 (+)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,610,733 - 132,618,179 (+)NCBIHuRef
CHM1_15136,852,364 - 136,859,793 (+)NCBICHM1_1
T2T-CHM13v2.05138,603,716 - 138,618,708 (+)NCBIT2T-CHM13v2.0
Wnt8a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,411,833 - 26,417,426 (+)NCBIGRCr8
mRatBN7.21826,137,690 - 26,143,283 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,137,690 - 26,143,283 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,265,080 - 26,270,673 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01827,028,812 - 27,034,426 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,363,713 - 26,369,327 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,331,236 - 27,336,829 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,331,236 - 27,336,829 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,044,608 - 27,050,201 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,007,156 - 27,012,749 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,029,469 - 27,038,824 (+)NCBI
Celera1825,876,225 - 25,881,818 (+)NCBICelera
Cytogenetic Map18p12NCBI
Wnt8a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554182,332,636 - 2,338,085 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554182,332,636 - 2,338,099 (-)NCBIChiLan1.0ChiLan1.0
WNT8A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24133,354,550 - 133,367,296 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,494,107 - 131,506,856 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,419,324 - 133,471,094 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15139,598,229 - 139,605,926 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,598,229 - 139,605,926 (+)Ensemblpanpan1.1panPan2
WNT8A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11125,707,058 - 25,752,724 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1125,744,780 - 25,749,748 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,470,773 - 24,519,397 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,556,926 - 26,605,507 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,558,406 - 26,603,592 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,264,436 - 25,313,063 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,088,231 - 25,136,559 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01125,751,347 - 25,800,034 (+)NCBIUU_Cfam_GSD_1.0
Wnt8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213154,332,315 - 154,337,724 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,273,882 - 7,278,959 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365317,273,681 - 7,279,394 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT8A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,103,830 - 140,109,862 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,103,322 - 140,113,682 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22145,777,794 - 145,784,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WNT8A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12340,750,907 - 40,759,421 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2340,751,780 - 40,758,790 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603437,130,575 - 37,139,750 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt8a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474330,890,359 - 30,895,682 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474330,852,463 - 30,896,443 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wnt8a
213 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:232
Count of miRNA genes:186
Interacting mature miRNAs:205
Transcripts:ENSMUST00000012426
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
1301950Otx2m1_morthodenticle homolog 2 (Drosophila) modifier 1 (mouse)Not determined182156868236187740Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse

Markers in Region
Wnt8a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381834,547,531 - 34,548,126UniSTSGRCm38
MGSCv371834,707,185 - 34,707,780UniSTSGRCm37
Celera1835,001,145 - 35,001,740UniSTS
Cytogenetic Map18B3UniSTS
cM Map18 UniSTS
Z68889  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381834,547,745 - 34,547,908UniSTSGRCm38
MGSCv371834,707,399 - 34,707,562UniSTSGRCm37
Celera1835,001,359 - 35,001,522UniSTS
Cytogenetic Map18B3UniSTS
Whitehead_YAC18 UniSTS
UniSTS:237770  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381834,547,889 - 34,547,973UniSTSGRCm38
MGSCv371834,707,543 - 34,707,627UniSTSGRCm37
Celera1835,001,503 - 35,001,587UniSTS
Cytogenetic Map18B3UniSTS
Wnt8a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18B3UniSTS
Wnt8a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381834,547,350 - 34,547,550UniSTSGRCm38
MGSCv371834,707,004 - 34,707,204UniSTSGRCm37
Celera1835,000,964 - 35,001,164UniSTS
Cytogenetic Map18B3UniSTS
cM Map18 UniSTS
Wnt8a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18B3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000012426   ⟹   ENSMUSP00000012426
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1834,675,366 - 34,681,326 (+)Ensembl
GRCm38.p6 Ensembl1834,542,313 - 34,548,273 (+)Ensembl
RefSeq Acc Id: NM_009290   ⟹   NP_033316
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391834,675,380 - 34,681,114 (+)NCBI
GRCm381834,542,327 - 34,548,061 (+)NCBI
MGSCv371834,701,982 - 34,707,715 (+)RGD
Celera1834,995,948 - 35,001,675 (+)RGD
cM Map18 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_033316 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI19213 (Get FASTA)   NCBI Sequence Viewer  
  AAI20518 (Get FASTA)   NCBI Sequence Viewer  
  CAA93117 (Get FASTA)   NCBI Sequence Viewer  
  CAI38669 (Get FASTA)   NCBI Sequence Viewer  
  EDK97092 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000012426
  ENSMUSP00000012426.3
GenBank Protein Q64527 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_033316   ⟸   NM_009290
- Peptide Label: precursor
- UniProtKB: Q64527 (UniProtKB/Swiss-Prot),   E9QL90 (UniProtKB/Swiss-Prot),   Q0VBT1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000012426   ⟸   ENSMUST00000012426

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64527-F1-model_v2 AlphaFold Q64527 1-354 view protein structure

Promoters
RGD ID:13677366
Promoter ID:EPDNEW_M22832
Type:single initiation site
Name:Wnt8a_1
Description:Mus musculus wingless-type MMTV integration site family, member8A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381834,542,327 - 34,542,387EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107924 AgrOrtholog
Ensembl Genes ENSMUSG00000012282 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000012426 ENTREZGENE
  ENSMUST00000012426.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.2460.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Wnt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20890 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107924 ENTREZGENE
NCBI Gene 20890 ENTREZGENE
PANTHER PTHR12027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12027:SF92 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam wnt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wnt8a PhenoGen
PRINTS WNT8PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WNT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9QL90 ENTREZGENE
  Q0VBT1 ENTREZGENE, UniProtKB/TrEMBL
  Q64527 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary E9QL90 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-01 Wnt8a  wingless-type MMTV integration site family, member 8A    wingless-related MMTV integration site 8A  Symbol and/or name change 5135510 APPROVED