Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | TRDMT1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TRDMT1 mRNA | CTD | PMID:22079256 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of TRDMT1 mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TRDMT1 mRNA | CTD | PMID:22574217 | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of TRDMT1 mRNA | CTD | PMID:28973697 | 5-aza-2'-deoxycytidine | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Decitabine results in decreased expression of TRDMT1 mRNA | CTD | PMID:18676679 | acrylamide | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of TRDMT1 mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases methylation | ISO | TRDMT1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of TRDMT1 gene | CTD | PMID:27153756 | aflatoxin B1 | increases expression | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | Aflatoxin B1 results in increased expression of TRDMT1 mRNA | CTD | PMID:33354967 | allethrin | multiple interactions | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of DNMT2 mRNA more ... | CTD | PMID:33051911 more ... | aristolochic acid A | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of TRDMT1 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | increases mutagenesis | ISO | TRDMT1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased mutagenesis of TRDMT1 gene | CTD | PMID:25435355 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of TRDMT1 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of TRDMT1 mRNA | CTD | PMID:20064835 | benzo[e]pyrene | decreases methylation | ISO | TRDMT1 (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of TRDMT1 intron | CTD | PMID:30157460 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of TRDMT1 mRNA | CTD | PMID:31163220 | bisphenol A | increases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of TRDMT1 mRNA | CTD | PMID:31715268 | bisphenol A | decreases methylation | ISO | TRDMT1 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of TRDMT1 gene | CTD | PMID:31601247 | bisphenol A | increases expression | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of TRDMT1 mRNA | CTD | PMID:27571134 and PMID:33296240 | CGP 52608 | multiple interactions | ISO | TRDMT1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to DNMT2 gene] | CTD | PMID:28238834 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of TRDMT1 mRNA | CTD | PMID:37019170 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRDMT1 mRNA | CTD | PMID:20938992 | chromium(6+) | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | chromium hexavalent ion results in decreased expression of TRDMT1 mRNA | CTD | PMID:27793765 | curcumin | increases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Curcumin results in increased expression of DNMT2 | CTD | PMID:25644192 | cyclosporin A | increases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of TRDMT1 mRNA | CTD | PMID:27989131 | cyhalothrin | multiple interactions | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of DNMT2 mRNA more ... | CTD | PMID:33051911 more ... | cypermethrin | multiple interactions | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of DNMT2 mRNA more ... | CTD | PMID:33051911 more ... | DDT | increases methylation | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | DDT results in increased methylation of TRDMT1 gene | CTD | PMID:30207508 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of TRDMT1 mRNA | CTD | PMID:17361019 and PMID:21266533 | diethyl maleate | decreases expression | EXP | | 6480464 | diethyl maleate results in decreased expression of TRDMT1 mRNA | CTD | PMID:25270620 | dorsomorphin | multiple interactions | ISO | TRDMT1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of TRDMT1 mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | Endosulfan results in decreased expression of TRDMT1 mRNA | CTD | PMID:29391264 | ethyl methanesulfonate | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of TRDMT1 mRNA | CTD | PMID:23649840 | fenarimol | decreases expression | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | fenarimol results in decreased expression of TRDMT1 mRNA | CTD | PMID:28970091 | fenvalerate | multiple interactions | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of DNMT2 mRNA more ... | CTD | PMID:33051911 more ... | flusilazole | decreases expression | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | flusilazole results in decreased expression of TRDMT1 mRNA | CTD | PMID:28263823 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRDMT1 mRNA | CTD | PMID:20938992 | irinotecan | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Irinotecan metabolite results in decreased expression of TRDMT1 mRNA and Irinotecan results in decreased expression of TRDMT1 mRNA | CTD | PMID:15956246 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRDMT1 mRNA | CTD | PMID:20938992 | levetiracetam | decreases expression | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | Levetiracetam results in decreased expression of TRDMT1 mRNA | CTD | PMID:20345932 | mercury dichloride | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Mercuric Chloride results in decreased expression of TRDMT1 mRNA | CTD | PMID:27188386 | methapyrilene | decreases methylation | ISO | TRDMT1 (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of TRDMT1 intron | CTD | PMID:30157460 | methoxychlor | affects methylation | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of TRDMT1 gene | CTD | PMID:35440735 | methyl methanesulfonate | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of TRDMT1 mRNA | CTD | PMID:23649840 | methylmercury chloride | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of TRDMT1 mRNA | CTD | PMID:28001369 | Monobutylphthalate | decreases expression | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | monobutyl phthalate results in decreased expression of TRDMT1 mRNA | CTD | PMID:29162477 | morphine | affects expression | EXP | | 6480464 | Morphine affects the expression of TRDMT1 mRNA | CTD | PMID:33891991 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of TRDMT1 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of TRDMT1 mRNA | CTD | PMID:33387578 | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of TRDMT1 mRNA | CTD | PMID:36331819 | phenylmercury acetate | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of TRDMT1 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | TRDMT1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRDMT1 mRNA | CTD | PMID:27188386 | potassium chromate | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of TRDMT1 mRNA | CTD | PMID:22079256 | potassium chromate | multiple interactions | ISO | TRDMT1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TRDMT1 mRNA | CTD | PMID:22079256 | propiconazole | increases expression | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | propiconazole results in increased expression of TRDMT1 mRNA | CTD | PMID:28970091 | pyrethrins | decreases expression | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | Pyrethrins results in decreased expression of DNMT2 mRNA | CTD | PMID:36053783 | pyrethrins | affects expression | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | Pyrethrins affects the expression of TRDMT1 mRNA | CTD | PMID:34896426 | SB 431542 | multiple interactions | ISO | TRDMT1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of TRDMT1 mRNA | CTD | PMID:25895662 | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of TRDMT1 mRNA | CTD | PMID:19822182 | tetrachloromethane | increases expression | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in increased expression of TRDMT1 mRNA | CTD | PMID:31150632 | thimerosal | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of TRDMT1 mRNA | CTD | PMID:27188386 | trichostatin A | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of TRDMT1 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | TRDMT1 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRDMT1 mRNA | CTD | PMID:27188386 | tungsten | increases expression | EXP | | 6480464 | Tungsten results in increased expression of TRDMT1 mRNA | CTD | PMID:30912803 | urethane | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Urethane results in decreased expression of TRDMT1 mRNA | CTD | PMID:28818685 | valproic acid | increases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of TRDMT1 mRNA | CTD | PMID:23179753 and PMID:29154799 | valproic acid | affects expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of TRDMT1 mRNA | CTD | PMID:25979313 | vinclozolin | decreases expression | ISO | Trdmt1 (Rattus norvegicus) | 6480464 | vinclozolin results in decreased expression of TRDMT1 mRNA | CTD | PMID:18042343 | vorinostat | decreases expression | ISO | TRDMT1 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of TRDMT1 mRNA | CTD | PMID:27188386 | zidovudine | multiple interactions | ISO | TRDMT1 (Homo sapiens) | 6480464 | [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TRDMT1 mRNA | CTD | PMID:20370541 | |