Ndufa8 (NADH:ubiquinone oxidoreductase subunit A8) - Rat Genome Database

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Gene: Ndufa8 (NADH:ubiquinone oxidoreductase subunit A8) Mus musculus
Analyze
Symbol: Ndufa8
Name: NADH:ubiquinone oxidoreductase subunit A8
RGD ID: 1314816
MGI Page MGI
Description: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Is expressed in alimentary system; axial skeleton; liver; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Orthologous to human NDUFA8 (NADH:ubiquinone oxidoreductase subunit A8).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 0610033L03Rik; AW261656; CI-19kD; CI-PGIV; complex I-19kD; complex I-PGIV; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; NADH-ubiquinone oxidoreductase 19 kDa subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39235,926,336 - 35,939,350 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl235,926,338 - 35,939,418 (-)EnsemblGRCm39 Ensembl
GRCm38236,036,324 - 36,049,338 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl236,036,326 - 36,049,406 (-)EnsemblGRCm38mm10GRCm38
MGSCv37235,891,854 - 35,904,812 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36235,858,343 - 35,871,301 (-)NCBIMGSCv36mm8
Celera235,740,041 - 35,752,999 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12865426   PMID:14610273   PMID:14681479   PMID:15489334   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:17500595   PMID:18614015   PMID:18614564   PMID:21267068   PMID:21556144   PMID:21873635   PMID:23209302   PMID:24457600   PMID:26764384   PMID:27626380   PMID:27899360  
PMID:28378742   PMID:29111377   PMID:30030361   PMID:30550785   PMID:32325033   PMID:32732898   PMID:36808153  


Genomics

Comparative Map Data
Ndufa8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39235,926,336 - 35,939,350 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl235,926,338 - 35,939,418 (-)EnsemblGRCm39 Ensembl
GRCm38236,036,324 - 36,049,338 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl236,036,326 - 36,049,406 (-)EnsemblGRCm38mm10GRCm38
MGSCv37235,891,854 - 35,904,812 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36235,858,343 - 35,871,301 (-)NCBIMGSCv36mm8
Celera235,740,041 - 35,752,999 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.13NCBI
NDUFA8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389122,132,466 - 122,159,779 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9122,144,058 - 122,159,779 (-)EnsemblGRCh38hg38GRCh38
GRCh379124,894,745 - 124,922,058 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369123,946,158 - 123,961,919 (-)NCBINCBI36Build 36hg18NCBI36
Build 349121,985,893 - 122,001,652NCBI
Celera995,554,625 - 95,570,387 (-)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef994,521,087 - 94,536,866 (-)NCBIHuRef
CHM1_19125,054,401 - 125,070,162 (-)NCBICHM1_1
T2T-CHM13v2.09134,329,934 - 134,357,249 (-)NCBIT2T-CHM13v2.0
Ndufa8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8339,783,479 - 39,799,507 (-)NCBIGRCr8
mRatBN7.2319,386,062 - 19,402,090 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl319,386,065 - 19,402,071 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx322,464,557 - 22,480,588 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0331,049,481 - 31,065,512 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0329,296,778 - 29,312,780 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0315,362,888 - 15,379,386 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl315,362,824 - 15,379,381 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0320,672,277 - 20,685,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4315,146,311 - 15,159,529 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1315,042,657 - 15,058,476 (-)NCBI
Celera314,098,638 - 14,111,855 (-)NCBICelera
Cytogenetic Map3p11NCBI
Ndufa8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554195,903,392 - 5,917,733 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554195,903,392 - 5,917,045 (+)NCBIChiLan1.0ChiLan1.0
NDUFA8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21117,187,324 - 17,203,091 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1917,189,673 - 17,205,504 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0993,268,929 - 93,284,704 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19121,598,510 - 121,625,688 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9121,610,091 - 121,625,688 (-)Ensemblpanpan1.1panPan2
NDUFA8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1960,404,486 - 60,418,234 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl960,404,379 - 60,418,236 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha959,599,651 - 59,613,176 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0961,319,355 - 61,333,635 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl961,319,374 - 61,333,632 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1960,093,716 - 60,107,991 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0960,410,179 - 60,424,517 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0960,498,595 - 60,513,193 (+)NCBIUU_Cfam_GSD_1.0
Ndufa8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947190,773,958 - 190,788,677 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648710,542,101 - 10,557,432 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648710,542,484 - 10,557,199 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFA8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1262,236,482 - 262,264,097 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11262,243,225 - 262,258,186 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21294,544,826 - 294,559,785 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NDUFA8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11217,434,527 - 17,450,068 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1217,434,524 - 17,450,352 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603525,599,159 - 25,614,703 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndufa8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476013,131,769 - 13,149,487 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476013,131,760 - 13,148,001 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ndufa8
528 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:63
Interacting mature miRNAs:64
Transcripts:ENSMUST00000070112
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22702264256396228Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
14746979Manh51_mmandible shape 51 (mouse)22896112962961129Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22896112962961129Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
12904008Cfq6_mconditioned fear QTL 6 (mouse)23120303544508204Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
13464253Ifvrq1_minfluenza virus resistance QTL 1 (mouse)23303449252034492Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3579732469797406Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3579732469797406Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3579732469797406Mouse

Markers in Region
AW261656  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38236,036,548 - 36,036,629UniSTSGRCm38
MGSCv37235,892,068 - 35,892,149UniSTSGRCm37
Celera235,740,255 - 35,740,336UniSTS
Cytogenetic Map2BUniSTS
Whitehead/MRC_RH2666.96UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000070112   ⟹   ENSMUSP00000065352
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl235,926,338 - 35,939,418 (-)Ensembl
GRCm38.p6 Ensembl236,036,326 - 36,049,406 (-)Ensembl
RefSeq Acc Id: NM_026703   ⟹   NP_080979
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39235,926,336 - 35,939,350 (-)NCBI
GRCm38236,036,324 - 36,049,338 (-)NCBI
MGSCv37235,891,854 - 35,904,812 (-)RGD
Celera235,740,041 - 35,752,999 (-)RGD
cM Map2 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_080979 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH12416 (Get FASTA)   NCBI Sequence Viewer  
  AAH24673 (Get FASTA)   NCBI Sequence Viewer  
  AQS27611 (Get FASTA)   NCBI Sequence Viewer  
  BAB22322 (Get FASTA)   NCBI Sequence Viewer  
  EDL08665 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000065352
  ENSMUSP00000065352.6
GenBank Protein Q9DCJ5 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_080979   ⟸   NM_026703
- UniProtKB: A2AL45 (UniProtKB/Swiss-Prot),   Q9DCJ5 (UniProtKB/Swiss-Prot),   A0A1S6GWI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000065352   ⟸   ENSMUST00000070112
Protein Domains
CHCH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9DCJ5-F1-model_v2 AlphaFold Q9DCJ5 1-172 view protein structure

Promoters
RGD ID:6831845
Promoter ID:MM_KWN:28913
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000028784,   OTTMUST00000028796
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36235,903,911 - 35,904,912 (+)MPROMDB
RGD ID:6877154
Promoter ID:EPDNEW_M2028
Type:initiation region
Name:Ndufa8_1
Description:Mus musculus NADH dehydrogenase 1 alpha subcomplex, 8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38236,049,324 - 36,049,384EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915625 AgrOrtholog
Ensembl Genes ENSMUSG00000026895 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000070112 ENTREZGENE
  ENSMUST00000070112.6 UniProtKB/Swiss-Prot
InterPro CHCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NDUFA8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:68375 UniProtKB/Swiss-Prot
MGD MGI:1915625 ENTREZGENE
NCBI Gene 68375 ENTREZGENE
PANTHER NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13344 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CHCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ndufa8 PhenoGen
PIRSF NDUA8 UniProtKB/Swiss-Prot
PROSITE CHCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1S6GWI0 ENTREZGENE, UniProtKB/TrEMBL
  A2AL45 ENTREZGENE
  NDUA8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2AL45 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-22 Ndufa8  NADH:ubiquinone oxidoreductase subunit A8    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8  Symbol and/or name change 5135510 APPROVED