Capza1 (capping protein (actin filament) muscle Z-line, alpha 1) - Rat Genome Database

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Gene: Capza1 (capping protein (actin filament) muscle Z-line, alpha 1) Mus musculus
Analyze
Symbol: Capza1
Name: capping protein (actin filament) muscle Z-line, alpha 1
RGD ID: 1314787
MGI Page MGI
Description: Contributes to actin filament binding activity. Involved in barbed-end actin filament capping. Localizes to several cellular components, including brush border; cell-cell junction; and cytoskeleton. Is expressed in early conceptus; head mesenchyme; and lung. Orthologous to human CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1); PARTICIPATES IN mitochondria transport pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ca; Cappa1; capping protein alpha 1; CAPZ; capZ alpha-1; CAZ1; F-actin capping protein alpha-1 subunit; F-actin-capping protein subunit alpha-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: 4933400A11Rik   Capza1-ps1   Capza1-ps2   Gm19104   Gm4757   Gm5920  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393104,730,097 - 104,771,821 (-)NCBIGRCm39mm39
GRCm39 Ensembl3104,730,095 - 104,771,821 (-)Ensembl
GRCm383104,822,781 - 104,864,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3104,822,779 - 104,864,505 (-)EnsemblGRCm38mm10GRCm38
MGSCv373104,625,703 - 104,667,423 (-)NCBIGRCm37mm9NCBIm37
MGSCv363104,950,989 - 104,992,450 (-)NCBImm8
Celera3107,016,204 - 107,060,141 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.88NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9119363   PMID:9331217   PMID:10349636   PMID:10493740   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11604420   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334  
PMID:16054028   PMID:16141072   PMID:16141073   PMID:16870209   PMID:16895918   PMID:16944949   PMID:16987810   PMID:16998848   PMID:17656356   PMID:17967808   PMID:18364747   PMID:18723693  
PMID:18799693   PMID:20360068   PMID:20884878   PMID:21267068   PMID:21589869   PMID:21873635   PMID:22114352   PMID:22882973   PMID:22918941   PMID:23793062   PMID:24457600   PMID:24614889  
PMID:24778263   PMID:26370502   PMID:27185186   PMID:28378742   PMID:28803871   PMID:29518331   PMID:30351272   PMID:31162944   PMID:32133840   PMID:32325033   PMID:32581705  


Genomics

Comparative Map Data
Capza1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393104,730,097 - 104,771,821 (-)NCBIGRCm39mm39
GRCm39 Ensembl3104,730,095 - 104,771,821 (-)Ensembl
GRCm383104,822,781 - 104,864,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3104,822,779 - 104,864,505 (-)EnsemblGRCm38mm10GRCm38
MGSCv373104,625,703 - 104,667,423 (-)NCBIGRCm37mm9NCBIm37
MGSCv363104,950,989 - 104,992,450 (-)NCBImm8
Celera3107,016,204 - 107,060,141 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.88NCBI
CAPZA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1112,619,805 - 112,671,616 (+)EnsemblGRCh38hg38GRCh38
GRCh381112,619,775 - 112,671,616 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371113,162,454 - 113,214,238 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361112,963,598 - 113,015,764 (+)NCBINCBI36hg18NCBI36
Build 341112,874,508 - 112,926,276NCBI
Celera1111,392,601 - 111,444,712 (+)NCBI
Cytogenetic Map1p13.2NCBI
HuRef1111,020,785 - 111,072,609 (+)NCBIHuRef
CHM1_11113,276,956 - 113,329,490 (+)NCBICHM1_1
Capza1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22192,319,696 - 192,364,755 (-)NCBI
Rnor_6.0 Ensembl2207,305,752 - 207,350,812 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02207,305,748 - 207,350,812 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02226,722,331 - 226,767,300 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42200,080,802 - 200,125,881 (-)NCBIRGSC3.4rn4RGSC3.4
Celera2184,785,867 - 184,830,762 (-)NCBICelera
Cytogenetic Map2q34NCBI
Capza1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543516,048,213 - 16,087,814 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543516,048,213 - 16,087,814 (+)NCBIChiLan1.0ChiLan1.0
CAPZA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11125,028,519 - 125,078,892 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1125,028,519 - 125,078,892 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01115,273,497 - 115,324,353 (+)NCBIMhudiblu_PPA_v0panPan3
CAPZA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11762,900,062 - 62,948,164 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1762,901,422 - 62,948,084 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1762,413,590 - 62,462,117 (-)NCBI
ROS_Cfam_1.01764,073,256 - 64,122,047 (-)NCBI
UMICH_Zoey_3.11762,807,805 - 62,856,662 (-)NCBI
UNSW_CanFamBas_1.01762,866,060 - 62,914,731 (-)NCBI
UU_Cfam_GSD_1.01763,625,654 - 63,674,438 (-)NCBI
Capza1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505816,254,005 - 16,293,011 (-)NCBI
SpeTri2.0NW_0049366901,184,644 - 1,223,732 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAPZA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4107,768,080 - 107,821,819 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14107,769,570 - 107,821,806 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24117,802,093 - 117,816,637 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CAPZA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12020,968,348 - 21,017,256 (-)NCBI
ChlSab1.1 Ensembl2020,969,828 - 20,991,971 (-)Ensembl
Vero_WHO_p1.0NW_02366603823,785,324 - 23,834,427 (-)NCBI
Capza1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247728,407,883 - 8,455,734 (+)NCBI

Position Markers
U16740  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F2.2UniSTS
Whitehead_YAC9 UniSTS
Capza1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F2.2UniSTS
cM Map355.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)341000000116000000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)368000000128600000Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372232660106232787Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372232660106232787Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375555995109556242Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379641414113641521Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381177336115177481Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382239727116239868Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383556675117556821Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383556675117556821Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383556675117556821Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383556675117556821Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383556675117556821Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383556675117556821Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383556675117556821Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383975596117975728Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384981602118981751Mouse
14746984Manh54_mmandible shape 54 (mouse)385381836119381836Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387301597125522587Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387320699121320699Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389232660137747247Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390469620124469756Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390470701124470701Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391092789125101432Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392344217126344334Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396700000148100000Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398830392132830548Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398841635132841734Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398841635132841734Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined399130456133130601Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100465596147339967Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100700000137500000Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101400000150100000Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103689010137689134Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:901
Count of miRNA genes:525
Interacting mature miRNAs:616
Transcripts:ENSMUST00000094028, ENSMUST00000155476
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001355044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC171110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY442029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U16740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000094028   ⟹   ENSMUSP00000102381
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3104,822,779 - 104,864,505 (-)Ensembl
RefSeq Acc Id: ENSMUST00000155476
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3104,842,322 - 104,864,373 (-)Ensembl
RefSeq Acc Id: ENSMUST00000195912   ⟹   ENSMUSP00000142606
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3104,834,138 - 104,864,400 (-)Ensembl
RefSeq Acc Id: ENSMUST00000196924
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3104,839,888 - 104,842,961 (-)Ensembl
RefSeq Acc Id: NM_001355044   ⟹   NP_001341973
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393104,730,097 - 104,771,821 (-)NCBI
GRCm383104,822,781 - 104,864,505 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009797   ⟹   NP_033927
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393104,730,097 - 104,771,821 (-)NCBI
GRCm383104,822,781 - 104,864,505 (-)NCBI
MGSCv373104,625,703 - 104,667,423 (-)RGD
Celera3107,016,204 - 107,060,141 (-)RGD
cM Map3 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033927   ⟸   NM_009797
- Peptide Label: isoform 1
- UniProtKB: Q5RKN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001341973   ⟸   NM_001355044
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000102381   ⟸   ENSMUST00000094028
RefSeq Acc Id: ENSMUSP00000142606   ⟸   ENSMUST00000195912

Promoters
RGD ID:6833528
Promoter ID:MM_KWN:35638
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   Spleen
Transcripts:OTTMUST00000052870,   OTTMUST00000052871
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363104,667,104 - 104,667,604 (-)MPROMDB
RGD ID:6881914
Promoter ID:EPDNEW_M4408
Type:initiation region
Name:Capza1_1
Description:Mus musculus capping protein muscle Z-line, alpha 1 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4410  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383104,864,390 - 104,864,450EPDNEW
RGD ID:6881918
Promoter ID:EPDNEW_M4410
Type:single initiation site
Name:Capza1_2
Description:Mus musculus capping protein muscle Z-line, alpha 1 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4408  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383104,864,496 - 104,864,556EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106227 AgrOrtholog
Ensembl Genes ENSMUSG00000070372 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000102381 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000142606 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000094028 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000195912 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1290.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.160.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CapZ_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CapZ_alpha/beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CapZ_alpha/beta_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CapZ_alpha_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F-actin_cap_asu_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:106227 ENTREZGENE
NCBI Gene 12340 ENTREZGENE
PANTHER PTHR10653 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam F-actin_cap_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Capza1 PhenoGen
PRINTS FACTINCAPA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE F_ACTIN_CAPPING_A_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F_ACTIN_CAPPING_A_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF90096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JE27_MOUSE UniProtKB/TrEMBL
  CAZA1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TLJ0_MOUSE UniProtKB/TrEMBL
  Q3UAS2_MOUSE UniProtKB/TrEMBL
  Q3UJV2_MOUSE UniProtKB/TrEMBL
  Q5RKN9 ENTREZGENE, UniProtKB/TrEMBL
  Q99L12_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q91YN7 UniProtKB/Swiss-Prot