SLAMF8 (SLAM family member 8) - Rat Genome Database

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Gene: SLAMF8 (SLAM family member 8) Homo sapiens
Analyze
Symbol: SLAMF8
Name: SLAM family member 8
RGD ID: 1314782
HGNC Page HGNC:21391
Description: Predicted to enable identical protein binding activity and signaling receptor activity. Predicted to be involved in B-1 B cell lineage commitment; leukocyte chemotaxis involved in inflammatory response; and regulation of B cell differentiation. Predicted to act upstream of or within several processes, including negative regulation of leukocyte migration; negative regulation of respiratory burst involved in inflammatory response; and phagosome acidification. Predicted to be located in membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: B lymphocyte activator macrophage expressed; B-lymphocyte activator macrophage expressed; BCM-like membrane protein; BLAME; CD353; FLJ20442; MGC129578; SBBI42
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,826,873 - 159,837,492 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,826,811 - 159,837,492 (+)EnsemblGRCh38hg38GRCh38
GRCh371159,796,663 - 159,807,282 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,063,103 - 158,073,906 (+)NCBINCBI36Build 36hg18NCBI36
Build 341156,609,673 - 156,620,354NCBI
Celera1132,864,904 - 132,875,709 (+)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,152,909 - 131,163,714 (+)NCBIHuRef
CHM1_11161,191,825 - 161,202,629 (+)NCBICHM1_1
T2T-CHM13v2.01158,963,866 - 158,974,492 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (NAS)
membrane  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11313408   PMID:12477932   PMID:12928397   PMID:14702039   PMID:15340161   PMID:15489334   PMID:16303743   PMID:16344560   PMID:16710414   PMID:20237496   PMID:21873635   PMID:28514442  
PMID:28700943   PMID:29498772   PMID:32054954   PMID:32296183   PMID:33961781   PMID:35259711   PMID:35432371   PMID:35506438   PMID:38158136  


Genomics

Comparative Map Data
SLAMF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,826,873 - 159,837,492 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,826,811 - 159,837,492 (+)EnsemblGRCh38hg38GRCh38
GRCh371159,796,663 - 159,807,282 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,063,103 - 158,073,906 (+)NCBINCBI36Build 36hg18NCBI36
Build 341156,609,673 - 156,620,354NCBI
Celera1132,864,904 - 132,875,709 (+)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,152,909 - 131,163,714 (+)NCBIHuRef
CHM1_11161,191,825 - 161,202,629 (+)NCBICHM1_1
T2T-CHM13v2.01158,963,866 - 158,974,492 (+)NCBIT2T-CHM13v2.0
Slamf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,408,944 - 172,418,482 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,409,325 - 172,418,135 (-)EnsemblGRCm39 Ensembl
GRCm381172,581,377 - 172,590,873 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,581,758 - 172,590,568 (-)EnsemblGRCm38mm10GRCm38
MGSCv371174,511,508 - 174,520,699 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361174,418,433 - 174,427,163 (-)NCBIMGSCv36mm8
Celera1175,435,779 - 175,444,985 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.99NCBI
Slamf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,580,081 - 87,589,941 (-)NCBIGRCr8
mRatBN7.21385,047,729 - 85,057,571 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,047,727 - 85,057,211 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1387,551,280 - 87,560,366 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01388,951,551 - 88,960,639 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01386,136,289 - 86,145,381 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01390,967,862 - 90,978,752 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,967,739 - 90,977,734 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,487,053 - 95,497,327 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,586,512 - 88,596,072 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11388,764,354 - 88,785,176 (-)NCBI
Celera1384,657,034 - 84,666,075 (-)NCBICelera
Cytogenetic Map13q24NCBI
Slamf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546811,623,197 - 11,632,573 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546811,623,092 - 11,632,566 (+)NCBIChiLan1.0ChiLan1.0
SLAMF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2190,017,255 - 90,027,775 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,757,279 - 89,767,800 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,178,241 - 135,189,005 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11139,098,929 - 139,109,725 (+)NCBIpanpan1.1PanPan1.1panPan2
SLAMF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13822,299,455 - 22,307,090 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3822,300,128 - 22,307,096 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3822,376,851 - 22,384,998 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03822,422,349 - 22,430,469 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3822,422,105 - 22,430,377 (-)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.03822,721,713 - 22,729,848 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03823,132,591 - 23,140,763 (-)NCBIUU_Cfam_GSD_1.0
Slamf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050585,968,095 - 5,978,925 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936740776,455 - 786,357 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936740776,557 - 786,182 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLAMF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl490,661,985 - 90,672,572 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1490,661,984 - 90,673,044 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2498,822,988 - 98,834,116 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103223747
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1204,114,403 - 4,127,122 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl204,116,630 - 4,124,988 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660383,218,491 - 3,230,109 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slamf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247941,418,228 - 1,429,561 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247941,418,727 - 1,428,836 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLAMF8
22 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q23.2-24.1(chr1:159479887-166895086)x1 copy number loss See cases [RCV000051172] Chr1:159479887..166895086 [GRCh38]
Chr1:159449677..166864323 [GRCh37]
Chr1:157716301..165130947 [NCBI36]
Chr1:1q23.2-24.1		 pathogenic
GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3 copy number gain See cases [RCV000051854] Chr1:157747246..176021247 [GRCh38]
Chr1:157717036..175990383 [GRCh37]
Chr1:155983660..174257006 [NCBI36]
Chr1:1q23.1-25.1		 pathogenic
GRCh38/hg38 1q23.1-23.3(chr1:156664483-160727411)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051851]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051851]|See cases [RCV000051851] Chr1:156664483..160727411 [GRCh38]
Chr1:156634275..160697201 [GRCh37]
Chr1:154900899..158963825 [NCBI36]
Chr1:1q23.1-23.3		 pathogenic
NM_020125.2(SLAMF8):c.494G>A (p.Arg165Gln) single nucleotide variant Malignant melanoma [RCV000064249] Chr1:159833002 [GRCh38]
Chr1:159802792 [GRCh37]
Chr1:158069416 [NCBI36]
Chr1:1q23.2		 not provided
NM_001134233.1(C1orf204):c.*804C>T single nucleotide variant Malignant melanoma [RCV000064250] Chr1:159835353 [GRCh38]
Chr1:159805143 [GRCh37]
Chr1:158071767 [NCBI36]
Chr1:1q23.2		 not provided
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_020125.3(SLAMF8):c.119C>G (p.Pro40Arg) single nucleotide variant Inborn genetic diseases [RCV003255701] Chr1:159829944 [GRCh38]
Chr1:159799734 [GRCh37]
Chr1:1q23.2		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_020125.3(SLAMF8):c.235C>G (p.Arg79Gly) single nucleotide variant Inborn genetic diseases [RCV003290930] Chr1:159830060 [GRCh38]
Chr1:159799850 [GRCh37]
Chr1:1q23.2		 uncertain significance
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
NM_020125.3(SLAMF8):c.710T>A (p.Val237Glu) single nucleotide variant Inborn genetic diseases [RCV003304497] Chr1:159833298 [GRCh38]
Chr1:159803088 [GRCh37]
Chr1:1q23.2		 uncertain significance
GRCh37/hg19 1q23.2-23.3(chr1:159778364-160770515)x3 copy number gain not provided [RCV002474924] Chr1:159778364..160770515 [GRCh37]
Chr1:1q23.2-23.3		 uncertain significance
NM_020125.3(SLAMF8):c.650G>T (p.Trp217Leu) single nucleotide variant Inborn genetic diseases [RCV002841805] Chr1:159833158 [GRCh38]
Chr1:159802948 [GRCh37]
Chr1:1q23.2		 uncertain significance
NM_020125.3(SLAMF8):c.56C>T (p.Thr19Ile) single nucleotide variant Inborn genetic diseases [RCV002734342] Chr1:159829881 [GRCh38]
Chr1:159799671 [GRCh37]
Chr1:1q23.2		 uncertain significance
NM_020125.3(SLAMF8):c.23G>A (p.Ser8Asn) single nucleotide variant Inborn genetic diseases [RCV002703871] Chr1:159826921 [GRCh38]
Chr1:159796711 [GRCh37]
Chr1:1q23.2		 uncertain significance
NM_020125.3(SLAMF8):c.271G>A (p.Gly91Arg) single nucleotide variant Inborn genetic diseases [RCV002710010] Chr1:159830096 [GRCh38]
Chr1:159799886 [GRCh37]
Chr1:1q23.2		 likely benign
NM_020125.3(SLAMF8):c.413G>A (p.Arg138Lys) single nucleotide variant Inborn genetic diseases [RCV002698528] Chr1:159832921 [GRCh38]
Chr1:159802711 [GRCh37]
Chr1:1q23.2		 uncertain significance
NM_020125.3(SLAMF8):c.497G>T (p.Arg166Leu) single nucleotide variant Inborn genetic diseases [RCV002718600] Chr1:159833005 [GRCh38]
Chr1:159802795 [GRCh37]
Chr1:1q23.2		 uncertain significance
NM_020125.3(SLAMF8):c.513C>G (p.Asp171Glu) single nucleotide variant Inborn genetic diseases [RCV002792965] Chr1:159833021 [GRCh38]
Chr1:159802811 [GRCh37]
Chr1:1q23.2		 uncertain significance
NM_020125.3(SLAMF8):c.91G>A (p.Gly31Ser) single nucleotide variant Inborn genetic diseases [RCV002717762] Chr1:159829916 [GRCh38]
Chr1:159799706 [GRCh37]
Chr1:1q23.2		 uncertain significance
NM_020125.3(SLAMF8):c.128T>C (p.Phe43Ser) single nucleotide variant Inborn genetic diseases [RCV003217517] Chr1:159829953 [GRCh38]
Chr1:159799743 [GRCh37]
Chr1:1q23.2		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_020125.3(SLAMF8):c.92G>A (p.Gly31Asp) single nucleotide variant Inborn genetic diseases [RCV003244463] Chr1:159829917 [GRCh38]
Chr1:159799707 [GRCh37]
Chr1:1q23.2		 likely benign
GRCh37/hg19 1q23.1-24.2(chr1:157321299-167391423)x1 copy number loss not provided [RCV000848773] Chr1:157321299..167391423 [GRCh37]
Chr1:1q23.1-24.2		 pathogenic
NC_000001.10:g.(?_158581054)_(162750036_?)dup duplication Autoimmune interstitial lung disease-arthritis syndrome [RCV001918952]|not provided [RCV001918953] Chr1:158581054..162750036 [GRCh37]
Chr1:1q23.1-23.3		 uncertain significance|no classifications from unflagged records
NM_020125.3(SLAMF8):c.667G>A (p.Glu223Lys) single nucleotide variant Inborn genetic diseases [RCV003196407] Chr1:159833175 [GRCh38]
Chr1:159802965 [GRCh37]
Chr1:1q23.2		 uncertain significance
NM_020125.3(SLAMF8):c.496C>T (p.Arg166Trp) single nucleotide variant Inborn genetic diseases [RCV003204274] Chr1:159833004 [GRCh38]
Chr1:159802794 [GRCh37]
Chr1:1q23.2		 uncertain significance
NM_020125.3(SLAMF8):c.298A>C (p.Asn100His) single nucleotide variant Inborn genetic diseases [RCV003205851] Chr1:159830123 [GRCh38]
Chr1:159799913 [GRCh37]
Chr1:1q23.2		 uncertain significance
NM_020125.3(SLAMF8):c.707T>C (p.Leu236Pro) single nucleotide variant Inborn genetic diseases [RCV003386066] Chr1:159833295 [GRCh38]
Chr1:159803085 [GRCh37]
Chr1:1q23.2		 uncertain significance
NM_020125.3(SLAMF8):c.406G>A (p.Val136Ile) single nucleotide variant Inborn genetic diseases [RCV003366666] Chr1:159832914 [GRCh38]
Chr1:159802704 [GRCh37]
Chr1:1q23.2		 uncertain significance
GRCh37/hg19 1q23.1-23.3(chr1:158001058-162858285)x1 copy number loss not provided [RCV003483944] Chr1:158001058..162858285 [GRCh37]
Chr1:1q23.1-23.3		 likely pathogenic
NM_020125.3(SLAMF8):c.725C>T (p.Ser242Leu) single nucleotide variant Inborn genetic diseases [RCV003354331] Chr1:159833313 [GRCh38]
Chr1:159803103 [GRCh37]
Chr1:1q23.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1385
Count of miRNA genes:690
Interacting mature miRNAs:766
Transcripts:ENST00000289707, ENST00000368104, ENST00000471286, ENST00000497141
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SLAMF8_2285  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,806,626 - 159,807,373UniSTSGRCh37
Build 361158,073,250 - 158,073,997RGDNCBI36
Celera1132,875,053 - 132,875,800RGD
HuRef1131,163,058 - 131,163,805UniSTS
WI-11725  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,806,890 - 159,807,039UniSTSGRCh37
Build 361158,073,514 - 158,073,663RGDNCBI36
Celera1132,875,317 - 132,875,466RGD
Cytogenetic Map1q23.2UniSTS
HuRef1131,163,322 - 131,163,471UniSTS
GeneMap99-GB4 RH Map1587.43UniSTS
GeneMap99-GB4 RH Map1590.02UniSTS
Whitehead-RH Map1709.9UniSTS
NCBI RH Map11436.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 188 265 166 48 434 29 225 22 298 75 120 537 20 206 77
Low 2126 2568 1372 403 910 261 3552 1711 2853 280 1201 888 144 996 2379 2
Below cutoff 62 140 152 145 252 144 396 427 512 42 70 106 7 2 331 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001330741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005245345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011509775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011509776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011509777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011509778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011509779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF144235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF146761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL590560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC109194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ782632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA578369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000289707   ⟹   ENSP00000289707
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1159,826,873 - 159,837,492 (+)Ensembl
RefSeq Acc Id: ENST00000368104   ⟹   ENSP00000357084
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1159,826,811 - 159,835,679 (+)Ensembl
RefSeq Acc Id: ENST00000471286
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1159,830,008 - 159,837,249 (+)Ensembl
RefSeq Acc Id: ENST00000497141
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1159,833,005 - 159,837,249 (+)Ensembl
RefSeq Acc Id: NM_001330741   ⟹   NP_001317670
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,826,873 - 159,837,492 (+)NCBI
T2T-CHM13v2.01158,963,866 - 158,974,487 (+)NCBI
Sequence:
RefSeq Acc Id: NM_020125   ⟹   NP_064510
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,826,873 - 159,837,492 (+)NCBI
GRCh371159,796,440 - 159,807,282 (+)NCBI
Build 361158,063,103 - 158,073,906 (+)NCBI Archive
Celera1132,864,904 - 132,875,709 (+)RGD
HuRef1131,152,909 - 131,163,714 (+)ENTREZGENE
CHM1_11161,191,825 - 161,202,629 (+)NCBI
T2T-CHM13v2.01158,963,866 - 158,974,487 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005245345   ⟹   XP_005245402
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,826,873 - 159,837,492 (+)NCBI
GRCh371159,796,440 - 159,807,282 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011509775   ⟹   XP_011508077
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,826,873 - 159,837,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011509776   ⟹   XP_011508078
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,826,873 - 159,837,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011509777   ⟹   XP_011508079
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,826,873 - 159,837,249 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011509778   ⟹   XP_011508080
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,826,873 - 159,837,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011509779   ⟹   XP_011508081
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,826,873 - 159,837,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017001844   ⟹   XP_016857333
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,826,873 - 159,837,249 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017001845   ⟹   XP_016857334
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,826,873 - 159,837,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017001846   ⟹   XP_016857335
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,826,873 - 159,837,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054337742   ⟹   XP_054193717
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01158,963,866 - 158,974,492 (+)NCBI
RefSeq Acc Id: XM_054337743   ⟹   XP_054193718
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01158,963,866 - 158,974,492 (+)NCBI
RefSeq Acc Id: XM_054337744   ⟹   XP_054193719
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01158,963,866 - 158,974,492 (+)NCBI
RefSeq Acc Id: XM_054337745   ⟹   XP_054193720
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01158,963,866 - 158,974,244 (+)NCBI
RefSeq Acc Id: XM_054337746   ⟹   XP_054193721
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01158,963,866 - 158,974,244 (+)NCBI
RefSeq Acc Id: XM_054337747   ⟹   XP_054193722
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01158,963,866 - 158,974,492 (+)NCBI
RefSeq Acc Id: XM_054337748   ⟹   XP_054193723
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01158,963,866 - 158,974,487 (+)NCBI
RefSeq Acc Id: XM_054337749   ⟹   XP_054193724
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01158,963,866 - 158,974,487 (+)NCBI
RefSeq Acc Id: XM_054337750   ⟹   XP_054193725
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01158,963,866 - 158,974,492 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001317670 (Get FASTA)   NCBI Sequence Viewer  
  NP_064510 (Get FASTA)   NCBI Sequence Viewer  
  XP_005245402 (Get FASTA)   NCBI Sequence Viewer  
  XP_011508077 (Get FASTA)   NCBI Sequence Viewer  
  XP_011508078 (Get FASTA)   NCBI Sequence Viewer  
  XP_011508079 (Get FASTA)   NCBI Sequence Viewer  
  XP_011508080 (Get FASTA)   NCBI Sequence Viewer  
  XP_011508081 (Get FASTA)   NCBI Sequence Viewer  
  XP_016857333 (Get FASTA)   NCBI Sequence Viewer  
  XP_016857334 (Get FASTA)   NCBI Sequence Viewer  
  XP_016857335 (Get FASTA)   NCBI Sequence Viewer  
  XP_054193717 (Get FASTA)   NCBI Sequence Viewer  
  XP_054193718 (Get FASTA)   NCBI Sequence Viewer  
  XP_054193719 (Get FASTA)   NCBI Sequence Viewer  
  XP_054193720 (Get FASTA)   NCBI Sequence Viewer  
  XP_054193721 (Get FASTA)   NCBI Sequence Viewer  
  XP_054193722 (Get FASTA)   NCBI Sequence Viewer  
  XP_054193723 (Get FASTA)   NCBI Sequence Viewer  
  XP_054193724 (Get FASTA)   NCBI Sequence Viewer  
  XP_054193725 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD33923 (Get FASTA)   NCBI Sequence Viewer  
  AAF67470 (Get FASTA)   NCBI Sequence Viewer  
  AAI09195 (Get FASTA)   NCBI Sequence Viewer  
  BAC11123 (Get FASTA)   NCBI Sequence Viewer  
  CAF85891 (Get FASTA)   NCBI Sequence Viewer  
  EAW52774 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000289707
  ENSP00000289707.5
  ENSP00000357084
  ENSP00000357084.4
GenBank Protein Q9P0V8 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_064510   ⟸   NM_020125
- Peptide Label: isoform 1 precursor
- UniProtKB: Q32MC6 (UniProtKB/Swiss-Prot),   Q5VU15 (UniProtKB/Swiss-Prot),   Q9P0V8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005245402   ⟸   XM_005245345
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011508077   ⟸   XM_011509775
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011508079   ⟸   XM_011509777
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011508078   ⟸   XM_011509776
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011508080   ⟸   XM_011509778
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011508081   ⟸   XM_011509779
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_016857333   ⟸   XM_017001844
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016857334   ⟸   XM_017001845
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_016857335   ⟸   XM_017001846
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: NP_001317670   ⟸   NM_001330741
- Peptide Label: isoform 2
- UniProtKB: Q9P0V8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000289707   ⟸   ENST00000289707
RefSeq Acc Id: ENSP00000357084   ⟸   ENST00000368104
RefSeq Acc Id: XP_054193717   ⟸   XM_054337742
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054193719   ⟸   XM_054337744
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054193718   ⟸   XM_054337743
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054193722   ⟸   XM_054337747
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054193725   ⟸   XM_054337750
- Peptide Label: isoform X8
RefSeq Acc Id: XP_054193723   ⟸   XM_054337748
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054193724   ⟸   XM_054337749
- Peptide Label: isoform X7
RefSeq Acc Id: XP_054193720   ⟸   XM_054337745
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054193721   ⟸   XM_054337746
- Peptide Label: isoform X4
Protein Domains
Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9P0V8-F1-model_v2 AlphaFold Q9P0V8 1-285 view protein structure

Promoters
RGD ID:6786863
Promoter ID:HG_KWN:5706
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   Lymphoblastoid
Transcripts:ENST00000368104,   NM_020125
Position:
Human AssemblyChrPosition (strand)Source
Build 361158,062,761 - 158,063,261 (+)MPROMDB
RGD ID:6857730
Promoter ID:EPDNEW_H2030
Type:initiation region
Name:SLAMF8_2
Description:SLAM family member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2031  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,826,650 - 159,826,710EPDNEW
RGD ID:6857732
Promoter ID:EPDNEW_H2031
Type:initiation region
Name:SLAMF8_1
Description:SLAM family member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2030  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,826,873 - 159,826,933EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:21391 AgrOrtholog
COSMIC SLAMF8 COSMIC
Ensembl Genes ENSG00000158714 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000289707 ENTREZGENE
  ENST00000289707.10 UniProtKB/Swiss-Prot
  ENST00000368104 ENTREZGENE
  ENST00000368104.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
GTEx ENSG00000158714 GTEx
HGNC ID HGNC:21391 ENTREZGENE
Human Proteome Map SLAMF8 Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
KEGG Report hsa:56833 UniProtKB/Swiss-Prot
NCBI Gene 56833 ENTREZGENE
OMIM 606620 OMIM
PANTHER SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE UniProtKB/Swiss-Prot
  SLAM FAMILY MEMBER 8 UniProtKB/Swiss-Prot
PharmGKB PA134983606 PharmGKB
PROSITE IG_LIKE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt Q32MC6 ENTREZGENE
  Q5VU15 ENTREZGENE
  Q9P0V8 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q32MC6 UniProtKB/Swiss-Prot
  Q5VU15 UniProtKB/Swiss-Prot