GPR45 (G protein-coupled receptor 45) - Rat Genome Database
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Gene: GPR45 (G protein-coupled receptor 45) Homo sapiens
Analyze
Symbol: GPR45
Name: G protein-coupled receptor 45
RGD ID: 1314767
HGNC Page HGNC
Description: Predicted to have G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to localize to plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: high-affinity lysophosphatidic acid receptor; probable G-protein coupled receptor 45; PSP24; PSP24(ALPHA); PSP24-1; PSP24-alpha; PSP24A
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2105,241,743 - 105,243,467 (+)EnsemblGRCh38hg38GRCh38
GRCh382105,241,743 - 105,243,467 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372105,839,595 - 105,860,085 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362105,224,632 - 105,226,356 (+)NCBINCBI36hg18NCBI36
Build 342105,316,717 - 105,318,442NCBI
Celera2100,058,695 - 100,060,419 (+)NCBI
Cytogenetic Map2q12.1NCBI
HuRef299,627,102 - 99,628,826 (+)NCBIHuRef
CHM1_12105,862,513 - 105,864,237 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10036181   PMID:11027574   PMID:11027575   PMID:12477932   PMID:15489334   PMID:15815621   PMID:17474147   PMID:21873635   PMID:25231870   PMID:32296183  


Genomics

Comparative Map Data
GPR45
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2105,241,743 - 105,243,467 (+)EnsemblGRCh38hg38GRCh38
GRCh382105,241,743 - 105,243,467 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372105,839,595 - 105,860,085 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362105,224,632 - 105,226,356 (+)NCBINCBI36hg18NCBI36
Build 342105,316,717 - 105,318,442NCBI
Celera2100,058,695 - 100,060,419 (+)NCBI
Cytogenetic Map2q12.1NCBI
HuRef299,627,102 - 99,628,826 (+)NCBIHuRef
CHM1_12105,862,513 - 105,864,237 (+)NCBICHM1_1
Gpr45
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39142,992,032 - 43,074,611 (+)NCBIGRCm39mm39
GRCm38142,952,872 - 43,035,451 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl142,952,872 - 43,035,456 (+)EnsemblGRCm38mm10GRCm38
MGSCv37143,009,717 - 43,092,294 (+)NCBIGRCm37mm9NCBIm37
MGSCv36142,897,509 - 42,979,995 (+)NCBImm8
Celera143,291,673 - 43,373,768 (+)NCBICelera
Cytogenetic Map1BNCBI
Gpr45
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0949,837,868 - 49,841,337 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl949,837,868 - 49,841,337 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0949,424,620 - 49,511,913 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4942,236,809 - 42,240,278 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1942,238,371 - 42,239,587 (+)NCBI
Celera943,024,208 - 43,027,677 (+)NCBICelera
Cytogenetic Map9q22NCBI
Gpr45
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547010,166,182 - 10,167,300 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547010,166,164 - 10,169,031 (+)NCBIChiLan1.0ChiLan1.0
GPR45
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A106,330,296 - 106,333,824 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A106,330,536 - 106,331,654 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A96,582,250 - 96,681,444 (-)NCBIMhudiblu_PPA_v0panPan3
GPR45
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1038,173,418 - 38,174,539 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11038,170,264 - 38,175,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gpr45
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936764760,981 - 762,548 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR45
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl349,533,018 - 49,595,576 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1349,531,595 - 49,536,036 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2351,783,792 - 51,785,485 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPR45
(Chlorocebus sabaeus - African green monkey)
No map positions available.
Gpr45
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247499,319,475 - 9,373,631 (+)NCBI

Position Markers
GPR45_2561  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372105,859,252 - 105,859,890UniSTSGRCh37
Build 362105,225,684 - 105,226,322RGDNCBI36
Celera2100,059,747 - 100,060,385RGD
HuRef299,628,154 - 99,628,792UniSTS
UniSTS:481842  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372105,858,217 - 105,859,507UniSTSGRCh37
Celera2100,058,712 - 100,060,002UniSTS
HuRef299,627,119 - 99,628,409UniSTS
UniSTS:481936  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372105,858,284 - 105,859,468UniSTSGRCh37
Celera2100,058,779 - 100,059,963UniSTS
HuRef299,627,186 - 99,628,370UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:308
Count of miRNA genes:270
Interacting mature miRNAs:288
Transcripts:ENST00000258456
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1 1
Low 51 8 155 12 102 10 53 15 1393 61 409 181 2 9 20
Below cutoff 1832 1361 1233 403 857 280 2282 1179 2039 244 725 1062 131 824 1408 4

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000258456   ⟹   ENSP00000258456
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2105,241,743 - 105,243,467 (+)Ensembl
RefSeq Acc Id: NM_007227   ⟹   NP_009158
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382105,241,743 - 105,243,467 (+)NCBI
GRCh372105,839,595 - 105,860,085 (+)NCBI
Build 362105,224,632 - 105,226,356 (+)NCBI Archive
Celera2100,058,695 - 100,060,419 (+)RGD
HuRef299,627,102 - 99,628,826 (+)ENTREZGENE
CHM1_12105,862,513 - 105,864,237 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_009158   ⟸   NM_007227
- UniProtKB: Q9Y5Y3 (UniProtKB/Swiss-Prot),   B5B0C1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000258456   ⟸   ENST00000258456
Protein Domains
G_PROTEIN_RECEP_F1_2


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q11.2-12.3(chr2:100378510-108472871)x3 copy number gain See cases [RCV000050836] Chr2:100378510..108472871 [GRCh38]
Chr2:100994972..109089327 [GRCh37]
Chr2:100361404..108455759 [NCBI36]
Chr2:2q11.2-12.3
pathogenic
GRCh38/hg38 2q12.1-12.2(chr2:103739593-105485794)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052690]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052690]|See cases [RCV000052690] Chr2:103739593..105485794 [GRCh38]
Chr2:104356051..106102251 [GRCh37]
Chr2:103722483..105468683 [NCBI36]
Chr2:2q12.1-12.2
uncertain significance
GRCh38/hg38 2q11.2-13(chr2:97672522-110211318)x3 copy number gain See cases [RCV000052947] Chr2:97672522..110211318 [GRCh38]
Chr2:98288985..110968895 [GRCh37]
Chr2:97655417..110326184 [NCBI36]
Chr2:2q11.2-13
pathogenic
GRCh38/hg38 2q12.1-12.2(chr2:104700043-105547876)x1 copy number loss See cases [RCV000053807] Chr2:104700043..105547876 [GRCh38]
Chr2:105316501..106164333 [GRCh37]
Chr2:104682933..105530765 [NCBI36]
Chr2:2q12.1-12.2
uncertain significance
NM_007227.3(GPR45):c.615C>T (p.Phe205=) single nucleotide variant Malignant melanoma [RCV000065004] Chr2:105242473 [GRCh38]
Chr2:105858930 [GRCh37]
Chr2:105225362 [NCBI36]
Chr2:2q12.1
not provided
NM_007227.3(GPR45):c.1099G>A (p.Glu367Lys) single nucleotide variant Malignant melanoma [RCV000065005] Chr2:105242957 [GRCh38]
Chr2:105859414 [GRCh37]
Chr2:105225846 [NCBI36]
Chr2:2q12.1
not provided
GRCh38/hg38 2q11.2-12.2(chr2:102084275-106085903)x1 copy number loss See cases [RCV000134974] Chr2:102084275..106085903 [GRCh38]
Chr2:102700735..106702359 [GRCh37]
Chr2:102067167..106068791 [NCBI36]
Chr2:2q11.2-12.2
likely pathogenic
GRCh38/hg38 2q12.1-12.3(chr2:104381722-107312459)x1 copy number loss See cases [RCV000135282] Chr2:104381722..107312459 [GRCh38]
Chr2:104998180..107928915 [GRCh37]
Chr2:104364612..107295347 [NCBI36]
Chr2:2q12.1-12.3
likely pathogenic
GRCh38/hg38 2q12.1-12.2(chr2:105239034-106152100)x3 copy number gain See cases [RCV000135475] Chr2:105239034..106152100 [GRCh38]
Chr2:105855491..106768556 [GRCh37]
Chr2:105221923..106134988 [NCBI36]
Chr2:2q12.1-12.2
benign
GRCh38/hg38 2q11.2-13(chr2:101710825-110791418)x3 copy number gain See cases [RCV000138645] Chr2:101710825..110791418 [GRCh38]
Chr2:102327287..111548995 [GRCh37]
Chr2:101693719..111265466 [NCBI36]
Chr2:2q11.2-13
pathogenic
GRCh38/hg38 2q12.1-12.2(chr2:104871270-105354003)x1 copy number loss See cases [RCV000140132] Chr2:104871270..105354003 [GRCh38]
Chr2:105487728..105970460 [GRCh37]
Chr2:104854160..105336892 [NCBI36]
Chr2:2q12.1-12.2
uncertain significance
GRCh38/hg38 2q11.1-13(chr2:94678532-110602409)x3 copy number gain See cases [RCV000141075] Chr2:94678532..110602409 [GRCh38]
Chr2:95344257..111359986 [GRCh37]
Chr2:94707984..111076455 [NCBI36]
Chr2:2q11.1-13
pathogenic
GRCh38/hg38 2q11.2-12.2(chr2:100478285-106498909)x3 copy number gain See cases [RCV000141445] Chr2:100478285..106498909 [GRCh38]
Chr2:101094747..107115365 [GRCh37]
Chr2:100461179..106481797 [NCBI36]
Chr2:2q11.2-12.2
uncertain significance
GRCh38/hg38 2q11.2-12.2(chr2:101234070-105679157)x1 copy number loss See cases [RCV000142969] Chr2:101234070..105679157 [GRCh38]
Chr2:101850532..106295614 [GRCh37]
Chr2:101216964..105662046 [NCBI36]
Chr2:2q11.2-12.2
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q11.1-12.3(chr2:95529039-108518266) copy number gain See cases [RCV000449270] Chr2:95529039..108518266 [GRCh37]
Chr2:2q11.1-12.3
pathogenic
GRCh37/hg19 2q11.1-13(chr2:95327499-111370025)x4 copy number gain See cases [RCV000446842] Chr2:95327499..111370025 [GRCh37]
Chr2:2q11.1-13
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q12.1(chr2:105239993-105899739)x3 copy number gain See cases [RCV000511153] Chr2:105239993..105899739 [GRCh37]
Chr2:2q12.1
likely benign
Single allele inversion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
GRCh37/hg19 2q11.1-12.2(chr2:95518497-107186127) copy number gain See cases [RCV000511158] Chr2:95518497..107186127 [GRCh37]
Chr2:2q11.1-12.2
uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q12.1-24.3(chr2:104172062-168223828)x1 copy number loss PARP Inhibitor response [RCV000626436] Chr2:104172062..168223828 [GRCh37]
Chr2:2q12.1-24.3
drug response
GRCh37/hg19 2q12.1-12.2(chr2:104327052-106123901)x3 copy number gain not provided [RCV000682140] Chr2:104327052..106123901 [GRCh37]
Chr2:2q12.1-12.2
uncertain significance
GRCh37/hg19 2q12.1-12.2(chr2:104995799-106679055)x1 copy number loss not provided [RCV000682137] Chr2:104995799..106679055 [GRCh37]
Chr2:2q12.1-12.2
likely pathogenic
GRCh37/hg19 2q11.1-13(chr2:96353030-114045463)x3 copy number gain not provided [RCV000682168] Chr2:96353030..114045463 [GRCh37]
Chr2:2q11.1-13
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q12.1-12.2(chr2:102917327-106755564)x1 copy number loss not provided [RCV000848959] Chr2:102917327..106755564 [GRCh37]
Chr2:2q12.1-12.2
uncertain significance
GRCh37/hg19 2q12.1-12.2(chr2:104816400-106617614)x3 copy number gain not provided [RCV000848461] Chr2:104816400..106617614 [GRCh37]
Chr2:2q12.1-12.2
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4503 AgrOrtholog
COSMIC GPR45 COSMIC
Ensembl Genes ENSG00000135973 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000258456 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000258456 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000135973 GTEx
HGNC ID HGNC:4503 ENTREZGENE
Human Proteome Map GPR45 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:11250 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 11250 ENTREZGENE
OMIM 604838 OMIM
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28892 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.590903 ENTREZGENE
UniProt B5B0C1 ENTREZGENE, UniProtKB/TrEMBL
  GPR45_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6NWS4 UniProtKB/Swiss-Prot
  Q6NXU6 UniProtKB/Swiss-Prot