LY6D (lymphocyte antigen 6 family member D) - Rat Genome Database

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Gene: LY6D (lymphocyte antigen 6 family member D) Homo sapiens
Analyze
Symbol: LY6D
Name: lymphocyte antigen 6 family member D
RGD ID: 1314571
HGNC Page HGNC
Description: Predicted to be involved in lymphocyte differentiation. Predicted to localize to cell surface; INTERACTS WITH aflatoxin B1; all-trans-retinoic acid; arsane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E48; e48 antigen; Ly-6D; lymphocyte antigen 6 complex, locus D; lymphocyte antigen 6D
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8142,784,882 - 142,786,539 (-)EnsemblGRCh38hg38GRCh38
GRCh388142,784,882 - 142,786,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378143,866,298 - 143,867,955 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368143,863,300 - 143,865,010 (-)NCBINCBI36hg18NCBI36
Build 348143,863,299 - 143,865,010NCBI
Celera8140,176,029 - 140,177,739 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8139,118,457 - 139,120,167 (-)NCBIHuRef
CHM1_18143,906,449 - 143,908,159 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:7790363   PMID:8889548   PMID:9366413   PMID:9551972   PMID:12477932   PMID:15340161   PMID:15489334   PMID:17207965   PMID:17474147   PMID:18187620   PMID:21873635   PMID:21988832  
PMID:23075424   PMID:23672314   PMID:26223706   PMID:30137688   PMID:30566873   PMID:30890647   PMID:32296183  


Genomics

Comparative Map Data
LY6D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8142,784,882 - 142,786,539 (-)EnsemblGRCh38hg38GRCh38
GRCh388142,784,882 - 142,786,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378143,866,298 - 143,867,955 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368143,863,300 - 143,865,010 (-)NCBINCBI36hg18NCBI36
Build 348143,863,299 - 143,865,010NCBI
Celera8140,176,029 - 140,177,739 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8139,118,457 - 139,120,167 (-)NCBIHuRef
CHM1_18143,906,449 - 143,908,159 (-)NCBICHM1_1
Ly6d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391574,633,905 - 74,635,416 (-)NCBIGRCm39mm39
GRCm39 Ensembl1574,633,905 - 74,635,469 (-)Ensembl
GRCm381574,762,056 - 74,763,567 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1574,762,056 - 74,763,620 (-)EnsemblGRCm38mm10GRCm38
MGSCv371574,592,486 - 74,593,997 (-)NCBIGRCm37mm9NCBIm37
MGSCv361574,589,311 - 74,590,822 (-)NCBImm8
Celera1576,267,012 - 76,268,523 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1534.27NCBI
Ly6d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27106,643,225 - 106,644,733 (-)NCBI
Rnor_6.0 Ensembl7115,993,301 - 115,994,783 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07115,993,304 - 115,994,812 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07115,898,693 - 115,900,201 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47112,872,991 - 112,874,499 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17112,907,219 - 112,908,700 (-)NCBI
Celera7103,044,373 - 103,045,881 (-)NCBICelera
Cytogenetic Map7q34NCBI
Ly6d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554541,473,191 - 1,475,038 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554541,473,405 - 1,474,950 (-)NCBIChiLan1.0ChiLan1.0
LY6D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18142,534,009 - 142,542,207 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8142,540,251 - 142,542,207 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08139,497,413 - 139,499,182 (-)NCBIMhudiblu_PPA_v0panPan3
LY6D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1336,697,717 - 36,705,631 (-)NCBI
ROS_Cfam_1.01337,225,183 - 37,233,099 (-)NCBI
UMICH_Zoey_3.11336,943,849 - 36,951,762 (-)NCBI
UNSW_CanFamBas_1.01337,033,467 - 37,041,380 (-)NCBI
UU_Cfam_GSD_1.01337,455,627 - 37,463,542 (-)NCBI
LOC101968671
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053031,673,330 - 1,675,006 (+)NCBI
SpeTri2.0NW_0049364709,099,502 - 9,101,105 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LY6D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl41,444,114 - 1,445,712 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.141,444,029 - 1,445,714 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LY6D
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18137,033,609 - 137,038,589 (-)NCBI
Ly6d
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473513,871,505 - 13,873,045 (+)NCBI

Position Markers
RH18136  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378143,866,467 - 143,866,592UniSTSGRCh37
Build 368143,863,469 - 143,863,594RGDNCBI36
Celera8140,176,198 - 140,176,323RGD
Cytogenetic Map8q24UniSTS
HuRef8139,118,626 - 139,118,751UniSTS
GeneMap99-GB4 RH Map8559.03UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1397
Count of miRNA genes:626
Interacting mature miRNAs:706
Transcripts:ENST00000301263, ENST00000518434, ENST00000518469, ENST00000518884
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 15 690 5 54 2 17 383
Medium 54 12 261 43 5 8 875 41 249 32 182 46 42 9 567 1
Low 1126 1069 518 166 398 84 1320 796 1372 38 673 656 89 1 568 940 5 1
Below cutoff 1091 1649 630 192 801 165 1091 1198 1603 126 417 670 26 571 809 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000301263   ⟹   ENSP00000301263
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8142,784,882 - 142,786,539 (-)Ensembl
RefSeq Acc Id: ENST00000518434
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8142,784,882 - 142,786,529 (-)Ensembl
RefSeq Acc Id: ENST00000518469
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8142,784,882 - 142,786,304 (-)Ensembl
RefSeq Acc Id: ENST00000518884
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8142,785,295 - 142,785,932 (-)Ensembl
RefSeq Acc Id: NM_003695   ⟹   NP_003686
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388142,784,882 - 142,786,539 (-)NCBI
GRCh378143,866,298 - 143,868,008 (-)RGD
GRCh378143,866,298 - 143,868,008 (-)NCBI
Build 368143,863,300 - 143,865,010 (-)NCBI Archive
Celera8140,176,029 - 140,177,739 (-)RGD
HuRef8139,118,457 - 139,120,167 (-)ENTREZGENE
CHM1_18143,906,449 - 143,908,159 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003686   ⟸   NM_003695
- Peptide Label: precursor
- UniProtKB: Q14210 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000301263   ⟸   ENST00000301263
Protein Domains
UPAR/Ly6

Promoters
RGD ID:7214311
Promoter ID:EPDNEW_H12902
Type:multiple initiation site
Name:LY6D_1
Description:lymphocyte antigen 6 family member D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12903  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388142,786,539 - 142,786,599EPDNEW
RGD ID:7214313
Promoter ID:EPDNEW_H12903
Type:multiple initiation site
Name:LY6D_2
Description:lymphocyte antigen 6 family member D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12902  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388142,788,598 - 142,788,658EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q24.21-24.3(chr8:128220912-145049449)x3 copy number gain See cases [RCV000050830] Chr8:128220912..145049449 [GRCh38]
Chr8:129233158..146274835 [GRCh37]
Chr8:129302340..146245639 [NCBI36]
Chr8:8q24.21-24.3
pathogenic
GRCh38/hg38 8q23.3-24.3(chr8:113580402-145054634)x3 copy number gain See cases [RCV000050638] Chr8:113580402..145054634 [GRCh38]
Chr8:114592631..146280020 [GRCh37]
Chr8:114661807..146250824 [NCBI36]
Chr8:8q23.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000053678] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:139447227-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|See cases [RCV000053701] Chr8:139447227..145054775 [GRCh38]
Chr8:140459470..146280161 [GRCh37]
Chr8:140528652..146250965 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
NM_003695.2(LY6D):c.228G>A (p.Gln76=) single nucleotide variant Malignant melanoma [RCV000068189] Chr8:142785380 [GRCh38]
Chr8:143866796 [GRCh37]
Chr8:143863798 [NCBI36]
Chr8:8q24.3
not provided
NM_003695.2(LY6D):c.154G>A (p.Glu52Lys) single nucleotide variant Malignant melanoma [RCV000068190] Chr8:142785454 [GRCh38]
Chr8:143866870 [GRCh37]
Chr8:143863872 [NCBI36]
Chr8:8q24.3
not provided
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:142201468-144002730)x1 copy number loss See cases [RCV000135981] Chr8:142201468..144002730 [GRCh38]
Chr8:143282829..145076898 [GRCh37]
Chr8:143280736..145148886 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8q24.22-24.3(chr8:130639182-145068712)x3 copy number gain See cases [RCV000137644] Chr8:130639182..145068712 [GRCh38]
Chr8:131651428..146294098 [GRCh37]
Chr8:131720610..146264902 [NCBI36]
Chr8:8q24.22-24.3
pathogenic|conflicting data from submitters
GRCh38/hg38 8q24.3(chr8:139236824-145068712)x3 copy number gain See cases [RCV000137466] Chr8:139236824..145068712 [GRCh38]
Chr8:140249067..146294098 [GRCh37]
Chr8:140318249..146264902 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.3(chr8:139004218-145049449)x3 copy number gain See cases [RCV000137340] Chr8:139004218..145049449 [GRCh38]
Chr8:140016461..146274835 [GRCh37]
Chr8:140085643..146245639 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124498498-145068712)x3 copy number gain See cases [RCV000137346] Chr8:124498498..145068712 [GRCh38]
Chr8:125510739..146294098 [GRCh37]
Chr8:125579920..146264902 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:141738068-144140607)x1 copy number loss See cases [RCV000140913] Chr8:141738068..144140607 [GRCh38]
Chr8:142764538..145195510 [GRCh37]
Chr8:142823655..145267498 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:142763122-142880038)x3 copy number gain See cases [RCV000140669] Chr8:142763122..142880038 [GRCh38]
Chr8:143844540..143961454 [GRCh37]
Chr8:143841542..143958456 [NCBI36]
Chr8:8q24.3
likely benign
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000148117] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:143762893-143867731)x3 copy number gain See cases [RCV000239918] Chr8:143762893..143867731 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:134825277-146280828)x3 copy number gain See cases [RCV000448348] Chr8:134825277..146280828 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:136378789-146295771)x3 copy number gain See cases [RCV000512003] Chr8:136378789..146295771 [GRCh37]
Chr8:8q24.22-24.3
likely pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:142840194-146280020) copy number gain Intellectual disability [RCV000626547] Chr8:142840194..146280020 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q23.3-24.3(chr8:114853126-146295771)x3 copy number gain See cases [RCV000512401] Chr8:114853126..146295771 [GRCh37]
Chr8:8q23.3-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121694649-146295771)x3 copy number gain not provided [RCV000683044] Chr8:121694649..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:143815037-146295771)x3 copy number gain not provided [RCV000683020] Chr8:143815037..146295771 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:143570920-144459613)x1 copy number loss not provided [RCV001006151] Chr8:143570920..144459613 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.23-24.3(chr8:139188797-146295771)x3 copy number gain not provided [RCV000846814] Chr8:139188797..146295771 [GRCh37]
Chr8:8q24.23-24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:122193546-146295771)x3 copy number gain not provided [RCV000849762] Chr8:122193546..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:142132678-145569441)x1 copy number loss not provided [RCV001006150] Chr8:142132678..145569441 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:143786100-143964656)x3 copy number gain not provided [RCV000849655] Chr8:143786100..143964656 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8q24.22-24.3(chr8:136059859-146295771)x3 copy number gain not provided [RCV000847171] Chr8:136059859..146295771 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:142988974-144218537)x3 copy number gain not provided [RCV000846118] Chr8:142988974..144218537 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8q24.13-24.3(chr8:125496223-146295771)x3 copy number gain not provided [RCV000845705] Chr8:125496223..146295771 [GRCh37]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:143728492-144093928)x3 copy number gain not provided [RCV001006153] Chr8:143728492..144093928 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8q24.12-24.3(chr8:121042467-146295771)x3 copy number gain not provided [RCV001006140] Chr8:121042467..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:143616831-144930611)x1 copy number loss not provided [RCV001006152] Chr8:143616831..144930611 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q24.21-24.3(chr8:128877995-146295771)x3 copy number gain not provided [RCV001006146] Chr8:128877995..146295771 [GRCh37]
Chr8:8q24.21-24.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:13348 AgrOrtholog
COSMIC LY6D COSMIC
Ensembl Genes ENSG00000167656 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000301263 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000301263 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000167656 GTEx
HGNC ID HGNC:13348 ENTREZGENE
Human Proteome Map LY6D Human Proteome Map
InterPro CD59_antigen_CS UniProtKB/Swiss-Prot
  LY6_UPA_recep-like UniProtKB/Swiss-Prot
  Ly6D UniProtKB/Swiss-Prot
KEGG Report hsa:8581 UniProtKB/Swiss-Prot
NCBI Gene 8581 ENTREZGENE
OMIM 606204 OMIM
PANTHER PTHR16982 UniProtKB/Swiss-Prot
Pfam UPAR_LY6 UniProtKB/Swiss-Prot
PharmGKB PA134928593 PharmGKB
PROSITE LY6_UPAR UniProtKB/Swiss-Prot
SMART SM00134 UniProtKB/Swiss-Prot
UniProt LY6D_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2R5F1 UniProtKB/Swiss-Prot
  D3DWJ0 UniProtKB/Swiss-Prot
  O43783 UniProtKB/Swiss-Prot
  Q6GTV9 UniProtKB/Swiss-Prot
  Q8TBD4 UniProtKB/Swiss-Prot
  Q92933 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-31 LY6D  lymphocyte antigen 6 family member D    lymphocyte antigen 6 complex, locus D  Symbol and/or name change 5135510 APPROVED