Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-alpha-phellandrene | increases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | alpha phellandrene results in increased expression of HELZ2 mRNA | CTD | PMID:25075043 | (1->4)-beta-D-glucan | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of HELZ2 mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | increases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of HELZ2 mRNA | CTD | PMID:27840820 | 17beta-estradiol | decreases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of HELZ2 mRNA | CTD | PMID:19167446 | 17beta-estradiol | multiple interactions | ISO | Helz2 (Rattus norvegicus) | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of HELZ2 mRNA | CTD | PMID:32741896 | 17beta-estradiol | multiple interactions | ISO | HELZ2 (Homo sapiens) | 6480464 | Estradiol affects the reaction [ESR1 protein binds to HELZ2 protein] and Estradiol promotes the reaction [ESR1 protein binds to HELZ2 protein] | CTD | PMID:29389661 and PMID:32088792 | 17beta-estradiol 3-benzoate | increases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | estradiol 3-benzoate results in increased expression of HELZ2 mRNA | CTD | PMID:32741896 | 17beta-estradiol 3-benzoate | multiple interactions | ISO | Helz2 (Rattus norvegicus) | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of HELZ2 mRNA | CTD | PMID:32741896 | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | multiple interactions | ISO | HELZ2 (Homo sapiens) | 6480464 | [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to HELZ2 protein modified form] | CTD | PMID:28751236 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | decreases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:36804509 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HELZ2 mRNA | CTD | PMID:21215274 and PMID:33387578 | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | 3 more ... | CTD | PMID:32119087 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | HELZ2 (Homo sapiens) | 6480464 | bisphenol S inhibits the reaction [ESR1 protein binds to HELZ2 protein] | CTD | PMID:29389661 | 5-aza-2'-deoxycytidine | affects expression | ISO | HELZ2 (Homo sapiens) | 6480464 | Decitabine affects the expression of HELZ2 mRNA | CTD | PMID:23300844 | acetamide | increases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | acetamide results in increased expression of HELZ2 mRNA | CTD | PMID:31881176 | acrylamide | decreases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of HELZ2 mRNA | CTD | PMID:32763439 | all-trans-retinoic acid | increases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of HELZ2 mRNA | CTD | PMID:33167477 | alpha-phellandrene | increases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | alpha phellandrene results in increased expression of HELZ2 mRNA | CTD | PMID:25075043 | aristolochic acid A | increases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of HELZ2 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | HELZ2 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to HELZ2 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | increases methylation | ISO | HELZ2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of HELZ2 5' UTR | CTD | PMID:27901495 | benzo[e]pyrene | decreases methylation | ISO | HELZ2 (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of HELZ2 promoter | CTD | PMID:30157460 | bisphenol A | affects expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of HELZ2 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of HELZ2 mRNA | CTD | PMID:32145629 | bisphenol A | multiple interactions | ISO | HELZ2 (Homo sapiens) | 6480464 | [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to HELZ2 protein modified form] and bisphenol A inhibits the reaction [ESR1 protein binds to HELZ2 protein] | CTD | PMID:28751236 and PMID:29389661 | C60 fullerene | increases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | fullerene C60 results in increased expression of HELZ2 mRNA | CTD | PMID:19167457 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of HELZ2 mRNA | CTD | PMID:37019170 | chromium(6+) | affects expression | EXP | | 6480464 | chromium hexavalent ion affects the expression of HELZ2 mRNA | CTD | PMID:28472532 | cisplatin | affects expression | ISO | HELZ2 (Homo sapiens) | 6480464 | Cisplatin affects the expression of HELZ2 mRNA | CTD | PMID:23300844 | coumestrol | decreases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of HELZ2 mRNA | CTD | PMID:19167446 | coumestrol | multiple interactions | ISO | HELZ2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of HELZ2 mRNA | CTD | PMID:19167446 | cyproterone acetate | multiple interactions | ISO | HELZ2 (Homo sapiens) | 6480464 | [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to HELZ2 protein modified form] | CTD | PMID:28751236 | dioxygen | multiple interactions | ISO | Helz2 (Rattus norvegicus) | 6480464 | [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of HELZ2 mRNA | CTD | PMID:33729688 | doxorubicin | decreases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of HELZ2 mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | Endosulfan results in decreased expression of HELZ2 mRNA | CTD | PMID:29391264 | Enterolactone | multiple interactions | ISO | HELZ2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of HELZ2 mRNA | CTD | PMID:19167446 | fenthion | decreases expression | EXP | | 6480464 | Fenthion results in decreased expression of HELZ2 mRNA | CTD | PMID:34813904 | finasteride | decreases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | Finasteride results in decreased expression of HELZ2 mRNA | CTD | PMID:24136188 | flutamide | decreases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | Flutamide results in decreased expression of HELZ2 mRNA | CTD | PMID:24136188 | FR900359 | decreases phosphorylation | ISO | HELZ2 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of HELZ2 protein | CTD | PMID:37730182 | furan | decreases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | furan results in decreased expression of HELZ2 mRNA | CTD | PMID:26194646 | gentamycin | increases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of HELZ2 mRNA | CTD | PMID:33387578 | indole-3-methanol | affects expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | indole-3-carbinol affects the expression of HELZ2 mRNA | CTD | PMID:21396975 | inulin | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of HELZ2 mRNA | CTD | PMID:36331819 | ivermectin | decreases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of HELZ2 protein | CTD | PMID:32959892 | lipopolysaccharide | multiple interactions | EXP | | 6480464 | (+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of HELZ2 mRNA] | CTD | PMID:25890327 | lipopolysaccharide | multiple interactions | ISO | HELZ2 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of HELZ2 mRNA | CTD | PMID:35811015 | lipopolysaccharide | increases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | Lipopolysaccharides results in increased expression of HELZ2 mRNA and Lipopolysaccharides results in increased expression of HELZ2 protein | CTD | PMID:30501627 and PMID:35811015 | lipopolysaccharide | increases expression | EXP | | 6480464 | Lipopolysaccharides results in increased expression of HELZ2 mRNA | CTD | PMID:25890327 | methapyrilene | decreases methylation | ISO | HELZ2 (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of HELZ2 promoter | CTD | PMID:30157460 | nefazodone | decreases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | nefazodone results in decreased expression of HELZ2 mRNA | CTD | PMID:24136188 | nickel atom | increases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | Nickel results in increased expression of HELZ2 mRNA | CTD | PMID:24768652 and PMID:25583101 | niclosamide | increases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | Niclosamide results in increased expression of HELZ2 mRNA | CTD | PMID:36318118 | oxaliplatin | multiple interactions | ISO | Helz2 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of HELZ2 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of HELZ2 mRNA | CTD | PMID:34911549 | ozone | decreases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | Ozone results in decreased expression of HELZ2 mRNA | CTD | PMID:35737395 | paracetamol | increases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of HELZ2 mRNA | CTD | PMID:22230336 | paracetamol | increases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of HELZ2 mRNA | CTD | PMID:33387578 | PCB138 | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | pentachlorophenol | increases expression | EXP | | 6480464 | Pentachlorophenol results in increased expression of HELZ2 mRNA | CTD | PMID:23892564 | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of HELZ2 mRNA more ... | CTD | PMID:36331819 | perfluorooctanoic acid | decreases expression | EXP | | 6480464 | perfluorooctanoic acid results in decreased expression of HELZ2 protein | CTD | PMID:36214631 | rotenone | decreases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | Rotenone results in decreased expression of HELZ2 mRNA | CTD | PMID:28374803 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | HELZ2 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of HELZ2 mRNA | CTD | PMID:35811015 | silver atom | decreases expression | EXP | | 6480464 | Silver results in decreased expression of HELZ2 mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | EXP | | 6480464 | Silver results in decreased expression of HELZ2 mRNA | CTD | PMID:27131904 | sodium arsenite | increases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of HELZ2 mRNA | CTD | PMID:34032870 | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of HELZ2 mRNA | CTD | PMID:36209798 | sulindac | decreases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | Sulindac results in decreased expression of HELZ2 mRNA | CTD | PMID:24136188 | temozolomide | increases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of HELZ2 mRNA | CTD | PMID:31758290 | testosterone | multiple interactions | ISO | Helz2 (Rattus norvegicus) | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of HELZ2 mRNA | CTD | PMID:32741896 | tetraphene | decreases expression | EXP | | 6480464 | benz(a)anthracene results in decreased expression of HELZ2 mRNA | CTD | PMID:26377693 | thioacetamide | increases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of HELZ2 mRNA | CTD | PMID:34492290 | topotecan | increases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | Topotecan results in increased expression of HELZ2 mRNA | CTD | PMID:25729387 | topotecan | multiple interactions | ISO | Helz2 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of HELZ2 mRNA | CTD | PMID:25729387 | trichostatin A | affects expression | ISO | HELZ2 (Homo sapiens) | 6480464 | trichostatin A affects the expression of HELZ2 mRNA | CTD | PMID:28542535 | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of HELZ2 mRNA | CTD | PMID:30912803 | urethane | increases expression | ISO | HELZ2 (Homo sapiens) | 6480464 | Urethane results in increased expression of HELZ2 mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | HELZ2 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of HELZ2 gene | CTD | PMID:29154799 | vinclozolin | decreases expression | ISO | Helz2 (Rattus norvegicus) | 6480464 | vinclozolin results in decreased expression of HELZ2 mRNA | CTD | PMID:23869203 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 2. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 3. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 4. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:10349636 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12466851 | PMID:12477932 | PMID:14610273 | PMID:14681479 | PMID:15368895 | PMID:16141072 | PMID:16141073 | PMID:21267068 |
| PMID:21873635 | PMID:23525231 | PMID:25004093 | PMID:28378742 | PMID:30196744 | PMID:30333137 | PMID:32325033 | PMID:34052659 |
Genomics
Comparative Map Data
| Helz2 (Mus musculus - house mouse) |
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| HELZ2 (Homo sapiens - human) |
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| Helz2 (Rattus norvegicus - Norway rat) |
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| Helz2 (Chinchilla lanigera - long-tailed chinchilla) |
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| HELZ2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| HELZ2 (Canis lupus familiaris - dog) |
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| Helz2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| HELZ2 (Sus scrofa - pig) |
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| HELZ2 (Chlorocebus sabaeus - green monkey) |
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| Helz2 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Helz2
397 total Variants 
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