Gene: Olig3 (oligodendrocyte transcription factor 3) Mus musculus
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Symbol:
Olig3
Name:
oligodendrocyte transcription factor 3
Description:
Exhibits transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II; spinal cord motor neuron cell fate specification; and spinal cord motor neuron migration. Predicted to localize to the nucleus. Is expressed in several structures, including central nervous system; future hindbrain; genitourinary system; inner ear; and skeletal muscle. Orthologous to human OLIG3 (oligodendrocyte transcription factor 3); INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; cadmium dichloride.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
basic helix-loop-helix domain-containing class B protein 7; Bhlhb7; bHLHe20; class B basic helix-loop-helix protein 7; oligo3; oligodendrocyte-specific bHLH transcription factor 3
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
OLIG3 (oligodendrocyte transcription factor 3) HGNC
Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Olig3 (oligodendrocyte transcription factor 3) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Olig3 (oligodendrocyte transcription factor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
OLIG3 (oligodendrocyte transcription factor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
OLIG3 (oligodendrocyte transcription factor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Olig3 (oligodendrocyte transcription factor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
OLIG3 (oligodendrocyte transcription factor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
OLIG2 (oligodendrocyte transcription factor 2) HGNC
OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Olig3 (oligodendrocyte transcription factor 3)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
OLIG3 (oligodendrocyte transcription factor 3)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
olig3 (oligodendrocyte transcription factor 3)
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PhylomeDB, Roundup, TreeFam, ZFIN)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 10 19,356,539 - 19,358,604 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 10 19,076,345 - 19,078,410 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 10 19,045,953 - 19,048,020 (+) NCBI mm8 Celera 10 19,255,439 - 19,257,539 (+) NCBI Celera Cytogenetic Map 10 A3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 aflatoxin B1 decreases methylation ISO RGD:1314358 6480464 Aflatoxin B1 results in decreased methylation of OLIG3 gene CTD PMID:27153756 arsenite(3-) increases methylation ISO RGD:1314358 6480464 arsenite results in increased methylation of OLIG3 promoter CTD PMID:23974009 benzo[a]pyrene decreases expression ISO RGD:1314358 6480464 Benzo(a)pyrene results in decreased expression of OLIG3 mRNA CTD PMID:22316170 benzo[a]pyrene increases expression ISO RGD:1314358 6480464 Benzo(a)pyrene results in increased expression of OLIG3 mRNA CTD PMID:30453624 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:1314358 6480464 Diethylhexyl Phthalate results in decreased expression of OLIG3 mRNA CTD PMID:31163220 bisphenol A decreases expression ISO RGD:1305997 6480464 bisphenol A results in decreased expression of OLIG3 mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:1305997 6480464 bisphenol A results in increased methylation of OLIG3 gene CTD PMID:28505145 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of OLIG3 mRNA CTD PMID:18974090 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of OLIG3 gene CTD PMID:20938992 dorsomorphin multiple interactions ISO RGD:1314358 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 entinostat multiple interactions ISO RGD:1314358 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OLIG3 mRNA CTD PMID:27188386 ethanol increases expression ISO RGD:1314358 6480464 Ethanol results in increased expression of OLIG3 mRNA CTD PMID:23378141 ethanol decreases expression ISO RGD:1314358 6480464 Ethanol results in decreased expression of OLIG3 mRNA CTD PMID:28986285 ethanol multiple interactions ISO RGD:1314358 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of OLIG3 mRNA CTD PMID:23378141 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of OLIG3 gene CTD PMID:20938992 folic acid multiple interactions ISO RGD:1314358 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of OLIG3 mRNA CTD PMID:23378141 fonofos increases methylation ISO RGD:1314358 6480464 Fonofos results in increased methylation of OLIG3 promoter CTD PMID:22847954 glyphosate increases methylation ISO RGD:1305997 6480464 glyphosate results in increased methylation of OLIG3 gene CTD PMID:31011160 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of OLIG3 gene CTD PMID:20938992 panobinostat multiple interactions ISO RGD:1314358 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OLIG3 mRNA CTD PMID:27188386 parathion increases methylation ISO RGD:1314358 6480464 Parathion results in increased methylation of OLIG3 promoter CTD PMID:22847954 perfluorooctanoic acid increases expression ISO RGD:1314358 6480464 perfluorooctanoic acid results in increased expression of OLIG3 protein CTD PMID:22609092 SB 431542 decreases expression ISO RGD:1314358 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of OLIG3 mRNA CTD PMID:25670856 SB 431542 multiple interactions ISO RGD:1314358 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide increases expression ISO RGD:1314358 6480464 Silicon Dioxide analog results in increased expression of OLIG3 mRNA CTD PMID:23806026 terbufos increases methylation ISO RGD:1314358 6480464 terbufos results in increased methylation of OLIG3 promoter CTD PMID:22847954 trichostatin A increases expression ISO RGD:1314358 6480464 trichostatin A results in increased expression of OLIG3 mRNA CTD PMID:24935251 valproic acid affects expression ISO RGD:1314358 6480464 Valproic Acid affects the expression of OLIG3 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:1314358 6480464 Valproic Acid results in increased expression of OLIG3 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:1314358 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OLIG3 mRNA CTD PMID:27188386
Gene Ontology Annotations
Biological Process negative regulation of transcription by RNA polymerase II IDA 2290270 (MGI:MGI:3531376, PMID:15769945) MGI MGI:MGI:3531376 , PMID:15769945 regulation of gene expression IMP MGI:MGI:3573868 2290270 (MGI:MGI:3531376, PMID:15769945) MGI MGI:MGI:3531376 , PMID:15769945 regulation of transcription, DNA-templated IEA InterPro:IPR032659 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 spinal cord motor neuron cell fate specification IMP MGI:MGI:3573868 2290270 (MGI:MGI:3531376, PMID:15769945) MGI MGI:MGI:3531376 , PMID:15769945 spinal cord motor neuron differentiation IGI MGI:MGI:104867 2290270 (MGI:MGI:3530702, PMID:15674731) MGI MGI:MGI:3530702 , PMID:15674731 spinal cord motor neuron differentiation IMP MGI:MGI:3573868 2290270 (MGI:MGI:3531376, PMID:15769945) MGI MGI:MGI:3531376 , PMID:15769945 spinal cord motor neuron migration IMP MGI:MGI:3573868 2290270 (MGI:MGI:3531376, PMID:15769945) MGI MGI:MGI:3531376 , PMID:15769945 
Gene Ontology Annotations
