PLCL2 (phospholipase C like 2) - Rat Genome Database

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Gene: PLCL2 (phospholipase C like 2) Homo sapiens
Analyze
Symbol: PLCL2
Name: phospholipase C like 2
RGD ID: 1314267
HGNC Page HGNC:9064
Description: Enables GABA receptor binding activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway; negative regulation of cold-induced thermogenesis; and regulation of GABAergic synaptic transmission. Predicted to act upstream of or within B cell proliferation involved in immune response; B-1a B cell differentiation; and negative regulation of B cell receptor signaling pathway. Predicted to be located in cytoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FLJ13484; inactive phospholipase C-like protein 2; KIAA1092; phospholipase C, epsilon 2; phospholipase C-epsilon-2; phospholipase C-L2; phospholipase C-like 2; PLC-epsilon-2; PLC-L(2); PLC-L2; PLCE2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38316,884,955 - 17,090,606 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl316,802,651 - 17,090,604 (+)EnsemblGRCh38hg38GRCh38
GRCh37316,926,448 - 17,132,098 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36316,949,586 - 17,107,089 (+)NCBINCBI36Build 36hg18NCBI36
Build 34316,949,585 - 17,107,089NCBI
Celera316,865,522 - 17,071,160 (+)NCBICelera
Cytogenetic Map3p24.3NCBI
HuRef316,860,717 - 17,066,984 (+)NCBIHuRef
CHM1_1316,877,832 - 17,083,991 (+)NCBICHM1_1
T2T-CHM13v2.0316,803,899 - 17,092,796 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889549   PMID:10470851   PMID:10581172   PMID:12421765   PMID:12477932   PMID:14702039   PMID:15231748   PMID:16754670   PMID:19898481   PMID:21399635   PMID:21822266   PMID:21833088  
PMID:21873635   PMID:22658674   PMID:24390342   PMID:24916648   PMID:25880423   PMID:26186194   PMID:26706316   PMID:27173435   PMID:27609421   PMID:27880917   PMID:28514442   PMID:29507755  
PMID:31970634   PMID:32392189   PMID:32814053   PMID:33961781   PMID:34079125  


Genomics

Comparative Map Data
PLCL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38316,884,955 - 17,090,606 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl316,802,651 - 17,090,604 (+)EnsemblGRCh38hg38GRCh38
GRCh37316,926,448 - 17,132,098 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36316,949,586 - 17,107,089 (+)NCBINCBI36Build 36hg18NCBI36
Build 34316,949,585 - 17,107,089NCBI
Celera316,865,522 - 17,071,160 (+)NCBICelera
Cytogenetic Map3p24.3NCBI
HuRef316,860,717 - 17,066,984 (+)NCBIHuRef
CHM1_1316,877,832 - 17,083,991 (+)NCBICHM1_1
T2T-CHM13v2.0316,803,899 - 17,092,796 (+)NCBIT2T-CHM13v2.0
Plcl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391750,815,893 - 50,995,522 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1750,816,431 - 50,995,512 (+)EnsemblGRCm39 Ensembl
GRCm381750,508,865 - 50,688,494 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1750,509,403 - 50,688,484 (+)EnsemblGRCm38mm10GRCm38
MGSCv371750,648,872 - 50,827,819 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361749,974,984 - 50,154,037 (+)NCBIMGSCv36mm8
Celera1753,955,768 - 54,144,820 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1725.86NCBI
Plcl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr893,529,117 - 3,713,712 (+)NCBIGRCr8
mRatBN7.293,292,564 - 3,477,009 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl93,292,695 - 3,477,009 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx94,459,203 - 4,644,048 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.099,631,258 - 9,816,096 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.098,764,438 - 8,949,289 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.091,782,536 - 1,984,654 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl91,782,536 - 1,984,654 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.091,813,654 - 1,937,548 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.091,740,384 - 1,773,917 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.494,687,320 - 4,873,780 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.194,687,896 - 4,877,255 (-)NCBI
Celera9198,050 - 381,326 (+)NCBICelera
Cytogenetic Map9q11NCBI
Plcl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554309,157,074 - 9,348,563 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554309,157,074 - 9,347,366 (+)NCBIChiLan1.0ChiLan1.0
PLCL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2216,795,633 - 17,074,904 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1316,800,391 - 17,079,668 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0316,736,430 - 17,015,531 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1317,154,506 - 17,351,287 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl317,154,500 - 17,351,287 (+)Ensemblpanpan1.1panPan2
PLCL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12325,814,392 - 25,999,666 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2325,814,862 - 25,999,749 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2325,789,455 - 25,974,932 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02326,315,064 - 26,500,436 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2326,315,091 - 26,556,082 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12326,016,655 - 26,201,771 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02326,077,652 - 26,263,001 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02326,326,490 - 26,512,317 (-)NCBIUU_Cfam_GSD_1.0
Plcl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118176,490,039 - 176,663,140 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364739,627,811 - 9,802,132 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364739,628,612 - 9,801,713 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl133,992,835 - 4,201,569 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1133,992,230 - 4,201,574 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2134,457,260 - 4,510,455 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLCL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11561,745,338 - 61,940,176 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1561,745,163 - 61,942,655 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604134,728,205 - 34,928,173 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plcl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248212,131,851 - 2,315,934 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248212,132,075 - 2,316,624 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLCL2
38 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p26.3-22.2(chr3:52266-37148076)x3 copy number gain See cases [RCV000051097] Chr3:52266..37148076 [GRCh38]
Chr3:93949..37189567 [GRCh37]
Chr3:68949..37164571 [NCBI36]
Chr3:3p26.3-22.2		 pathogenic
GRCh38/hg38 3p26.3-24.3(chr3:52066-20280127)x3 copy number gain See cases [RCV000051690] Chr3:52066..20280127 [GRCh38]
Chr3:93749..20321619 [GRCh37]
Chr3:68749..20296623 [NCBI36]
Chr3:3p26.3-24.3		 pathogenic
GRCh38/hg38 3p26.3-24.1(chr3:52266-29248782)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051718]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051718]|See cases [RCV000051718] Chr3:52266..29248782 [GRCh38]
Chr3:93949..29290273 [GRCh37]
Chr3:68949..29265277 [NCBI36]
Chr3:3p26.3-24.1		 pathogenic
GRCh38/hg38 3p26.3-24.3(chr3:63843-19510600)x3 copy number gain See cases [RCV000051719] Chr3:63843..19510600 [GRCh38]
Chr3:105526..19552092 [GRCh37]
Chr3:80526..19527096 [NCBI36]
Chr3:3p26.3-24.3		 pathogenic
GRCh38/hg38 3p25.3-22.2(chr3:11463328-38919543)x3 copy number gain See cases [RCV000051720] Chr3:11463328..38919543 [GRCh38]
Chr3:11504802..38961034 [GRCh37]
Chr3:11479802..38936038 [NCBI36]
Chr3:3p25.3-22.2		 pathogenic
NM_015184.5(PLCL2):c.1835C>T (p.Ser612Phe) single nucleotide variant Malignant melanoma [RCV000065915] Chr3:17011559 [GRCh38]
Chr3:17053051 [GRCh37]
Chr3:17028055 [NCBI36]
Chr3:3p24.3		 not provided
NM_015184.5(PLCL2):c.2106C>T (p.Arg702=) single nucleotide variant Malignant melanoma [RCV000065916] Chr3:17011830 [GRCh38]
Chr3:17053322 [GRCh37]
Chr3:17028326 [NCBI36]
Chr3:3p24.3		 not provided
NM_015184.5(PLCL2):c.212G>A (p.Gly71Glu) single nucleotide variant Malignant melanoma [RCV000060761] Chr3:17009936 [GRCh38]
Chr3:17051428 [GRCh37]
Chr3:17026432 [NCBI36]
Chr3:3p24.3		 not provided
NM_015184.5(PLCL2):c.2074C>A (p.Gln692Lys) single nucleotide variant Malignant melanoma [RCV000060762] Chr3:17011798 [GRCh38]
Chr3:17053290 [GRCh37]
Chr3:17028294 [NCBI36]
Chr3:3p24.3		 not provided
GRCh38/hg38 3p26.3-24.1(chr3:32241-30064208)x3 copy number gain See cases [RCV000138004] Chr3:32241..30064208 [GRCh38]
Chr3:73914..30105699 [GRCh37]
Chr3:48914..30080703 [NCBI36]
Chr3:3p26.3-24.1		 pathogenic
GRCh38/hg38 3p26.3-24.3(chr3:32241-20334387)x3 copy number gain See cases [RCV000137941] Chr3:32241..20334387 [GRCh38]
Chr3:73914..20375879 [GRCh37]
Chr3:48914..20350883 [NCBI36]
Chr3:3p26.3-24.3		 pathogenic
GRCh38/hg38 3p26.3-22.1(chr3:53308-41381521)x3 copy number gain See cases [RCV000141810] Chr3:53308..41381521 [GRCh38]
Chr3:94991..41423012 [GRCh37]
Chr3:69991..41398016 [NCBI36]
Chr3:3p26.3-22.1		 pathogenic
GRCh38/hg38 3p25.1-24.3(chr3:14360747-21656134)x4 copy number gain See cases [RCV000143767] Chr3:14360747..21656134 [GRCh38]
Chr3:14402247..21697626 [GRCh37]
Chr3:14377251..21672630 [NCBI36]
Chr3:3p25.1-24.3		 pathogenic
GRCh37/hg19 3p26.3-24.2(chr3:61891-24432821)x3 copy number gain See cases [RCV000447247] Chr3:61891..24432821 [GRCh37]
Chr3:3p26.3-24.2		 pathogenic
GRCh37/hg19 3p26.3-22.2(chr3:61891-36710181)x3 copy number gain See cases [RCV000448528] Chr3:61891..36710181 [GRCh37]
Chr3:3p26.3-22.2		 pathogenic
GRCh37/hg19 3p26.3-22.3(chr3:61891-33958201)x3 copy number gain See cases [RCV000510429] Chr3:61891..33958201 [GRCh37]
Chr3:3p26.3-22.3		 pathogenic
GRCh37/hg19 3p26.3-22.2(chr3:61891-37459464)x3 copy number gain See cases [RCV000511463] Chr3:61891..37459464 [GRCh37]
Chr3:3p26.3-22.2		 pathogenic
GRCh37/hg19 3p25.1-24.3(chr3:13720222-17808236)x1 copy number loss See cases [RCV000511037] Chr3:13720222..17808236 [GRCh37]
Chr3:3p25.1-24.3		 likely pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-24.3(chr3:1897972-19519085)x3 copy number gain not provided [RCV000682215] Chr3:1897972..19519085 [GRCh37]
Chr3:3p26.3-24.3		 pathogenic
GRCh37/hg19 3p24.3-21.31(chr3:16923595-45249923)x2,3 copy number gain not provided [RCV000682249] Chr3:16923595..45249923 [GRCh37]
Chr3:3p24.3-21.31		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p25.2-24.2(chr3:13276005-24295240)x3 copy number gain not provided [RCV000742260] Chr3:13276005..24295240 [GRCh37]
Chr3:3p25.2-24.2		 pathogenic
NM_001144382.2(PLCL2):c.3382T>G (p.Ter1128Gly) single nucleotide variant not provided [RCV000946716] Chr3:17089910 [GRCh38]
Chr3:17131402 [GRCh37]
Chr3:3p24.3		 benign
NM_001144382.2(PLCL2):c.2893C>T (p.Pro965Ser) single nucleotide variant not provided [RCV000956075] Chr3:17014786 [GRCh38]
Chr3:17056278 [GRCh37]
Chr3:3p24.3		 benign
NM_001144382.2(PLCL2):c.1362C>T (p.Ser454=) single nucleotide variant not provided [RCV001539878] Chr3:17010708 [GRCh38]
Chr3:17052200 [GRCh37]
Chr3:3p24.3		 benign
Single allele deletion 3p- syndrome [RCV002280352] Chr3:13371737..20095506 [GRCh38]
Chr3:3p25.1-24.3		 pathogenic
GRCh37/hg19 3p26.3-22.2(chr3:61891-36710181) copy number gain not specified [RCV002053300] Chr3:61891..36710181 [GRCh37]
Chr3:3p26.3-22.2		 pathogenic
GRCh37/hg19 3p26.3-24.2(chr3:61891-24432821) copy number gain not specified [RCV002053299] Chr3:61891..24432821 [GRCh37]
Chr3:3p26.3-24.2		 pathogenic
NC_000003.11:g.(?_16710965)_(41275270_?)del deletion not provided [RCV001958625] Chr3:16710965..41275270 [GRCh37]
Chr3:3p24.3-22.1		 pathogenic
GRCh37/hg19 3p25.1-24.2(chr3:13836340-25357427)x3 copy number gain See cases [RCV002287839] Chr3:13836340..25357427 [GRCh37]
Chr3:3p25.1-24.2		 pathogenic
NM_001144382.2(PLCL2):c.1065A>G (p.Lys355=) single nucleotide variant Inborn genetic diseases [RCV003364230] Chr3:17010411 [GRCh38]
Chr3:17051903 [GRCh37]
Chr3:3p24.3		 likely benign
GRCh37/hg19 3p26.3-24.1(chr3:310747-28297447)x3 copy number gain not provided [RCV003484107] Chr3:310747..28297447 [GRCh37]
Chr3:3p26.3-24.1		 pathogenic
GRCh37/hg19 3p26.3-22.3(chr3:61891-33946644)x3 copy number gain not specified [RCV003986437] Chr3:61891..33946644 [GRCh37]
Chr3:3p26.3-22.3		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:948
Count of miRNA genes:522
Interacting mature miRNAs:567
Transcripts:ENST00000396755, ENST00000418129, ENST00000419842, ENST00000432376, ENST00000460467
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH103238  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37317,131,803 - 17,131,924UniSTSGRCh37
Build 36317,106,807 - 17,106,928RGDNCBI36
Celera317,070,865 - 17,070,986RGD
Cytogenetic Map3p24.3UniSTS
HuRef317,066,689 - 17,066,810UniSTS
GeneMap99-GB4 RH Map369.58UniSTS
RH120067  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37317,045,028 - 17,045,348UniSTSGRCh37
Build 36317,020,032 - 17,020,352RGDNCBI36
Celera316,984,089 - 16,984,409RGD
Cytogenetic Map3p24.3UniSTS
HuRef316,979,732 - 16,980,052UniSTS
TNG Radiation Hybrid Map310611.0UniSTS
SHGC-146542  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37317,016,570 - 17,016,844UniSTSGRCh37
Build 36316,991,574 - 16,991,848RGDNCBI36
Celera316,955,632 - 16,955,906RGD
Cytogenetic Map3p24.3UniSTS
HuRef316,950,518 - 16,950,792UniSTS
TNG Radiation Hybrid Map310597.0UniSTS
PLCL2_9323  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37317,131,239 - 17,132,106UniSTSGRCh37
Build 36317,106,243 - 17,107,110RGDNCBI36
Celera317,070,301 - 17,071,168RGD
HuRef317,066,125 - 17,066,992UniSTS
RH70075  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37317,067,093 - 17,067,237UniSTSGRCh37
Build 36317,042,097 - 17,042,241RGDNCBI36
Celera317,006,155 - 17,006,299RGD
Cytogenetic Map3p24.3UniSTS
HuRef317,001,800 - 17,001,944UniSTS
GeneMap99-GB4 RH Map369.03UniSTS
D3S3397  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37316,977,537 - 16,977,637UniSTSGRCh37
Build 36316,952,541 - 16,952,641RGDNCBI36
Celera316,916,599 - 16,916,699RGD
Cytogenetic Map3p24.3UniSTS
HuRef316,911,483 - 16,911,583UniSTS
Whitehead-RH Map373.2UniSTS
Whitehead-YAC Contig Map3 UniSTS
NCBI RH Map3196.0UniSTS
SHGC-17248  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37317,129,806 - 17,129,939UniSTSGRCh37
Build 36317,104,810 - 17,104,943RGDNCBI36
Celera317,068,868 - 17,069,001RGD
Cytogenetic Map3p24.3UniSTS
HuRef317,064,692 - 17,064,825UniSTS
GeneMap99-G3 RH Map37995.0UniSTS
UniSTS:488216  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37316,944,323 - 16,944,377UniSTSGRCh37
Build 36316,919,327 - 16,919,381RGDNCBI36
Celera316,883,389 - 16,883,443RGD
HuRef10119,004,565 - 119,005,050UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 161 1009 346 32 1526 31 1667 910 1257 161 407 190 2 500 1084 3
Low 2227 1971 1362 579 416 421 2670 1266 2435 241 1014 1386 166 704 1700 2
Below cutoff 23 4 8 6 5 7 14 14 13 7 17 20 1 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001144382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006713073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047447799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054332058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054332059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054332060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054345853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054345854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054345855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB029015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC090943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKP01168581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK023546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL117515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ760209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF457605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  N93050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000419842   ⟹   ENSP00000404433
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl317,010,494 - 17,081,546 (+)Ensembl
RefSeq Acc Id: ENST00000432376   ⟹   ENSP00000412836
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl316,933,090 - 17,090,593 (+)Ensembl
RefSeq Acc Id: ENST00000460467
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl316,802,651 - 17,011,084 (+)Ensembl
RefSeq Acc Id: ENST00000615277   ⟹   ENSP00000478458
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl316,884,955 - 17,090,604 (+)Ensembl
RefSeq Acc Id: NM_001144382   ⟹   NP_001137854
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38316,884,955 - 17,090,604 (+)NCBI
GRCh37316,974,582 - 17,132,098 (+)NCBI
Celera316,865,522 - 17,071,160 (+)RGD
HuRef316,860,717 - 17,066,984 (+)ENTREZGENE
CHM1_1316,877,832 - 17,083,991 (+)NCBI
T2T-CHM13v2.0316,886,213 - 17,092,794 (+)NCBI
Sequence:
RefSeq Acc Id: NM_015184   ⟹   NP_055999
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38316,933,090 - 17,090,606 (+)NCBI
GRCh37316,974,582 - 17,132,098 (+)NCBI
Build 36316,949,586 - 17,107,089 (+)NCBI Archive
Celera316,865,522 - 17,071,160 (+)RGD
HuRef316,860,717 - 17,066,984 (+)ENTREZGENE
CHM1_1316,925,954 - 17,083,991 (+)NCBI
T2T-CHM13v2.0316,934,333 - 17,092,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006713073   ⟹   XP_006713136
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38316,898,988 - 17,090,606 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017006025   ⟹   XP_016861514
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38316,898,988 - 17,090,606 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047447799   ⟹   XP_047303755
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38316,898,988 - 17,090,606 (+)NCBI
RefSeq Acc Id: XM_054345853   ⟹   XP_054201828
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0316,803,899 - 17,092,796 (+)NCBI
RefSeq Acc Id: XM_054345854   ⟹   XP_054201829
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0316,938,795 - 17,092,796 (+)NCBI
RefSeq Acc Id: XM_054345855   ⟹   XP_054201830
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0316,900,173 - 17,092,796 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001137854   ⟸   NM_001144382
- Peptide Label: isoform 1
- UniProtKB: Q9H8L0 (UniProtKB/Swiss-Prot),   Q8N498 (UniProtKB/Swiss-Prot),   A8K5V4 (UniProtKB/Swiss-Prot),   Q9UFP9 (UniProtKB/Swiss-Prot),   Q9UPR0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_055999   ⟸   NM_015184
- Peptide Label: isoform 2
- UniProtKB: Q9UPR0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006713136   ⟸   XM_006713073
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016861514   ⟸   XM_017006025
- Peptide Label: isoform X3
- UniProtKB: Q9UPR0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000478458   ⟸   ENST00000615277
RefSeq Acc Id: ENSP00000404433   ⟸   ENST00000419842
RefSeq Acc Id: ENSP00000412836   ⟸   ENST00000432376
RefSeq Acc Id: XP_047303755   ⟸   XM_047447799
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054201828   ⟸   XM_054345853
- Peptide Label: isoform X4
- UniProtKB: Q9UPR0 (UniProtKB/Swiss-Prot),   Q9H8L0 (UniProtKB/Swiss-Prot),   Q8N498 (UniProtKB/Swiss-Prot),   A8K5V4 (UniProtKB/Swiss-Prot),   Q9UFP9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054201830   ⟸   XM_054345855
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054201829   ⟸   XM_054345854
- Peptide Label: isoform X3
Protein Domains
C2   PH   PI-PLC X-box   PI-PLC Y-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UPR0-F1-model_v2 AlphaFold Q9UPR0 1-1127 view protein structure

Promoters
RGD ID:6863736
Promoter ID:EPDNEW_H5033
Type:initiation region
Name:PLCL2_1
Description:phospholipase C like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5032  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38316,885,002 - 16,885,062EPDNEW
RGD ID:6801421
Promoter ID:HG_KWN:43976
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:NM_015184
Position:
Human AssemblyChrPosition (strand)Source
Build 36316,949,464 - 16,949,964 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9064 AgrOrtholog
COSMIC PLCL2 COSMIC
Ensembl Genes ENSG00000154822 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000284017 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000419842.1 UniProtKB/TrEMBL
  ENST00000432376 ENTREZGENE
  ENST00000432376.5 UniProtKB/Swiss-Prot
  ENST00000615277 ENTREZGENE
  ENST00000615277.5 UniProtKB/Swiss-Prot
  ENST00000638327.1 UniProtKB/Swiss-Prot
  ENST00000638466.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000154822 GTEx
  ENSG00000284017 GTEx
HGNC ID HGNC:9064 ENTREZGENE
Human Proteome Map PLCL2 Human Proteome Map
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  PI-PLC_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC_EF-hand-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLCL2 UniProtKB/Swiss-Prot
  PLipase_C_PInositol-sp_X_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:23228 UniProtKB/Swiss-Prot
NCBI Gene 23228 ENTREZGENE
OMIM 614276 OMIM
PANTHER PTHR10336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10336:SF84 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_12 UniProtKB/Swiss-Prot
  PI-PLC-X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33395 PharmGKB
PRINTS PHPHLIPASEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot
  PIPLC_X_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIPLC_Y_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PLCXc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLCYc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K5V4 ENTREZGENE
  H7C276_HUMAN UniProtKB/TrEMBL
  PLCL2_HUMAN UniProtKB/Swiss-Prot
  Q8N498 ENTREZGENE
  Q9H8L0 ENTREZGENE
  Q9UFP9 ENTREZGENE
  Q9UPR0 ENTREZGENE
UniProt Secondary A8K5V4 UniProtKB/Swiss-Prot
  Q8N498 UniProtKB/Swiss-Prot
  Q9H8L0 UniProtKB/Swiss-Prot
  Q9UFP9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 PLCL2  phospholipase C like 2    phospholipase C-like 2  Symbol and/or name change 5135510 APPROVED