Tcf7 (transcription factor 7, T cell specific) - Rat Genome Database

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Gene: Tcf7 (transcription factor 7, T cell specific) Mus musculus
Analyze
Symbol: Tcf7
Name: transcription factor 7, T cell specific
RGD ID: 1314198
MGI Page MGI
Description: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including canonical Wnt signaling pathway involved in negative regulation of apoptotic process; gamma-delta T cell differentiation; and regulation of gamma-delta T cell differentiation. Acts upstream of or within several processes, including T cell differentiation; embryonic morphogenesis; and neural tube development. Located in euchromatin and nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to human TCF7 (transcription factor 7).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AI465550; T cell factor-1; T-cell factor 1; T-cell-specific transcription factor 1; TCF-1; TCF-7; Tcf1; transcription factor 7; transcription factor 7, T-cell specific
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,137,347 - 52,174,211 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1152,143,198 - 52,174,158 (-)EnsemblGRCm39 Ensembl
GRCm381152,246,527 - 52,283,383 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,252,371 - 52,283,331 (-)EnsemblGRCm38mm10GRCm38
MGSCv371152,066,106 - 52,096,073 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361152,096,027 - 52,125,994 (-)NCBIMGSCv36mm8
Celera1156,821,774 - 56,852,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
acetaldehyde  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AH23848  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (ISO)
amiodarone  (ISO)
amphetamine  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
Azoxymethane  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
casticin  (EXP)
celastrol  (EXP)
CGP 52608  (ISO)
choline  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (EXP)
DDE  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
disodium selenite  (ISO)
endosulfan  (ISO)
flavonoids  (ISO)
flusilazole  (EXP)
folic acid  (EXP)
FR900359  (ISO)
gentamycin  (ISO)
indometacin  (ISO)
inulin  (EXP)
iron dichloride  (ISO)
isoorientin  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (EXP,ISO)
nitrofen  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
poly(I:C)  (ISO)
propanal  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenic acid  (EXP)
sodium arsenite  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
tibolone  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. TCF transcription factors: molecular switches in carcinogenesis. Roose J and Clevers H, Biochim Biophys Acta. 1999 Oct 29;1424(2-3):M23-37.
9. TCF7 is suppressed by the androgen receptor via microRNA-1-mediated downregulation and is involved in the development of resistance to androgen deprivation in prostate cancer. Siu MK, etal., Prostate Cancer Prostatic Dis. 2017 Jun;20(2):172-178. doi: 10.1038/pcan.2017.2. Epub 2017 Feb 21.
Additional References at PubMed
PMID:1569101   PMID:1673925   PMID:1827138   PMID:1922061   PMID:7626895   PMID:7870176   PMID:8211130   PMID:8223271   PMID:8617303   PMID:8622675   PMID:9070927   PMID:9090377  
PMID:9462507   PMID:9780167   PMID:10087922   PMID:10090727   PMID:10349636   PMID:10489374   PMID:10549625   PMID:10631168   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851  
PMID:11265645   PMID:11404013   PMID:11447280   PMID:11477404   PMID:11731265   PMID:12226748   PMID:12235125   PMID:12433684   PMID:12477932   PMID:12490567   PMID:12520002   PMID:12731066  
PMID:12847244   PMID:14512296   PMID:14610273   PMID:14681479   PMID:15057272   PMID:15186480   PMID:15226261   PMID:15342465   PMID:15576404   PMID:15765534   PMID:15781225   PMID:15782199  
PMID:15866163   PMID:15866165   PMID:15899904   PMID:16141072   PMID:16141073   PMID:16292344   PMID:16495310   PMID:16585583   PMID:16678101   PMID:16678815   PMID:16782087   PMID:16813524  
PMID:16829211   PMID:16936075   PMID:17008323   PMID:17043652   PMID:17065530   PMID:17198697   PMID:17199045   PMID:17218525   PMID:17335794   PMID:17638895   PMID:17681174   PMID:17919533  
PMID:18247340   PMID:18287559   PMID:18579517   PMID:18635608   PMID:18799693   PMID:19303461   PMID:19515997   PMID:19536331   PMID:19557172   PMID:19563800   PMID:19648923   PMID:19717519  
PMID:19766620   PMID:19806668   PMID:19906864   PMID:19933277   PMID:20028982   PMID:20059953   PMID:20142358   PMID:20412781   PMID:20457902   PMID:20532162   PMID:20620996   PMID:20630950  
PMID:20727791   PMID:20805501   PMID:20883686   PMID:21267068   PMID:21339363   PMID:21571217   PMID:21600200   PMID:21677750   PMID:21685894   PMID:21747169   PMID:21814277   PMID:21873635  
PMID:21911092   PMID:21935461   PMID:21937690   PMID:22039299   PMID:22109558   PMID:22166339   PMID:22173065   PMID:22342532   PMID:22393260   PMID:22412390   PMID:22421361   PMID:22492686  
PMID:22550000   PMID:22564414   PMID:22573616   PMID:22723415   PMID:22859735   PMID:22875805   PMID:22988430   PMID:23026747   PMID:23071096   PMID:23103132   PMID:23152144   PMID:23185135  
PMID:23212152   PMID:23260145   PMID:23562159   PMID:23601684   PMID:23660861   PMID:23824573   PMID:23932570   PMID:23954131   PMID:24038093   PMID:24146773   PMID:24748645   PMID:24836425  
PMID:24952961   PMID:25043184   PMID:25215520   PMID:25355919   PMID:25533952   PMID:25536344   PMID:25715394   PMID:25753732   PMID:25758227   PMID:25810530   PMID:25978037   PMID:26006243  
PMID:26193896   PMID:26214740   PMID:26214741   PMID:26280998   PMID:26324778   PMID:26365183   PMID:26410627   PMID:26459597   PMID:26490636   PMID:26642437   PMID:26856890   PMID:26883626  
PMID:26934381   PMID:26969725   PMID:27044748   PMID:27090637   PMID:27111144   PMID:27376470   PMID:27433921   PMID:27487330   PMID:27501248   PMID:27533016   PMID:27582468   PMID:27705792  
PMID:27713059   PMID:27806296   PMID:27923906   PMID:27941786   PMID:28018990   PMID:28346462   PMID:28348272   PMID:28349581   PMID:28404635   PMID:28556921   PMID:28577307   PMID:28589954  
PMID:28604718   PMID:28621459   PMID:28652395   PMID:28705898   PMID:28723565   PMID:28844837   PMID:28930662   PMID:28973925   PMID:29183988   PMID:29184203   PMID:29337183   PMID:29358218  
PMID:29466737   PMID:29466756   PMID:29632143   PMID:29768177   PMID:30185805   PMID:30413363   PMID:30420627   PMID:30635236   PMID:30635237   PMID:30778251   PMID:30814995   PMID:30837262  
PMID:30991025   PMID:31142588   PMID:31175159   PMID:31202927   PMID:31216480   PMID:31227606   PMID:31358996   PMID:31606264   PMID:31816636   PMID:31970666   PMID:32186512   PMID:32265924  
PMID:32268106   PMID:32290615   PMID:32341523   PMID:32369449   PMID:32385253   PMID:32392347   PMID:32396847   PMID:32414917   PMID:32547546   PMID:32579593   PMID:32640236   PMID:32820720  
PMID:32868912   PMID:33104170   PMID:33128876   PMID:33176163   PMID:33195246   PMID:33535043   PMID:33664480   PMID:33741532   PMID:33857289   PMID:34032268   PMID:34172578   PMID:34376651  
PMID:34385712   PMID:34516781   PMID:34526724   PMID:34615872   PMID:34917097   PMID:35132438   PMID:35302059   PMID:35726060   PMID:35792753   PMID:35831952   PMID:35921443   PMID:36045674  
PMID:36208623   PMID:36239683   PMID:36401086   PMID:36449606   PMID:36562825   PMID:36658158   PMID:36802434   PMID:36806938   PMID:36901757   PMID:37074193   PMID:37122720   PMID:37516968  
PMID:37540600   PMID:37741305   PMID:37801516   PMID:37950867   PMID:38149929   PMID:38157853   PMID:38168955   PMID:38169425   PMID:38518774   PMID:38898157   PMID:39245681   PMID:39250420  
PMID:39447575  


Genomics

Comparative Map Data
Tcf7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,137,347 - 52,174,211 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1152,143,198 - 52,174,158 (-)EnsemblGRCm39 Ensembl
GRCm381152,246,527 - 52,283,383 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,252,371 - 52,283,331 (-)EnsemblGRCm38mm10GRCm38
MGSCv371152,066,106 - 52,096,073 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361152,096,027 - 52,125,994 (-)NCBIMGSCv36mm8
Celera1156,821,774 - 56,852,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.86NCBI
TCF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385134,108,218 - 134,148,210 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5134,114,681 - 134,151,865 (+)EnsemblGRCh38hg38GRCh38
GRCh375133,450,372 - 133,483,901 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365133,478,301 - 133,511,819 (+)NCBINCBI36Build 36hg18NCBI36
Celera5129,574,095 - 129,607,613 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5128,635,317 - 128,668,890 (+)NCBIHuRef
CHM1_15132,882,980 - 132,916,497 (+)NCBICHM1_1
T2T-CHM13v2.05134,630,059 - 134,671,840 (+)NCBIT2T-CHM13v2.0
Tcf7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,924,363 - 36,954,279 (-)NCBIGRCr8
mRatBN7.21036,423,443 - 36,454,350 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,423,445 - 36,453,535 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01037,616,033 - 37,646,027 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,617,279 - 37,645,802 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01037,389,506 - 37,419,457 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,686,862 - 37,716,831 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11037,693,621 - 37,723,030 (-)NCBI
Celera1035,778,033 - 35,807,975 (-)NCBICelera
Cytogenetic Map10q22NCBI
Tcf7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554085,362,084 - 5,388,527 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554085,362,423 - 5,388,684 (+)NCBIChiLan1.0ChiLan1.0
TCF7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24129,407,016 - 129,446,603 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15127,546,618 - 127,586,165 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05129,518,134 - 129,549,972 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15135,671,630 - 135,704,417 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5135,671,095 - 135,702,734 (+)Ensemblpanpan1.1panPan2
TCF7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11122,313,113 - 22,346,221 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1122,313,105 - 22,344,004 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1121,059,022 - 21,092,131 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01123,113,932 - 23,147,114 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11121,814,042 - 21,847,134 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01121,679,173 - 21,712,308 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01122,321,753 - 22,354,875 (+)NCBIUU_Cfam_GSD_1.0
Tcf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213114,092,704 - 114,122,991 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366471,097,019 - 1,125,729 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366471,096,726 - 1,125,753 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCF7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2136,422,940 - 136,457,910 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12136,422,740 - 136,456,323 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22142,042,088 - 142,051,487 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TCF7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12336,919,648 - 36,953,088 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2336,919,745 - 36,951,192 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603440,979,669 - 41,016,821 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tcf7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473338,076,410 - 38,104,173 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473338,076,800 - 38,104,265 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tcf7
988 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:790
Count of miRNA genes:407
Interacting mature miRNAs:439
Transcripts:ENSMUST00000086844, ENSMUST00000109071
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
4141770Tcpm1_mT-cell phenotype modifier 1 (mouse)Not determined5145247953615930Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse

Markers in Region
AI465550  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381152,252,425 - 52,252,510UniSTSGRCm38
MGSCv371152,065,927 - 52,066,012UniSTSGRCm37
Celera1156,821,595 - 56,821,680UniSTS
Cytogenetic Map11B1.3UniSTS
Whitehead/MRC_RH11718.84UniSTS
X61385  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381152,253,661 - 52,253,820UniSTSGRCm38
MGSCv371152,067,163 - 52,067,322UniSTSGRCm37
Celera1156,822,831 - 56,822,990UniSTS
Cytogenetic Map11B1.3UniSTS
Whitehead_YAC11 UniSTS
Tcf7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381152,252,966 - 52,253,654UniSTSGRCm38
MGSCv371152,066,468 - 52,067,156UniSTSGRCm37
Celera1156,822,136 - 56,822,824UniSTS
Cytogenetic Map11B1.3UniSTS
cM Map1128.0UniSTS
PMC316557P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381152,256,741 - 52,257,016UniSTSGRCm38
MGSCv371152,070,243 - 52,070,518UniSTSGRCm37
Celera1156,825,911 - 56,826,186UniSTS
Cytogenetic Map11B1.3UniSTS
PMC126018P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381152,256,759 - 52,257,803UniSTSGRCm38
MGSCv371152,070,261 - 52,071,305UniSTSGRCm37
Celera1156,825,929 - 56,826,973UniSTS
Cytogenetic Map11B1.3UniSTS
Tcf7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
cM Map1128.0UniSTS
Tcf7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381152,253,276 - 52,253,948UniSTSGRCm38
MGSCv371152,066,778 - 52,067,450UniSTSGRCm37
Celera1156,822,446 - 56,823,118UniSTS
Cytogenetic Map11B1.3UniSTS
Tcf7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381152,256,760 - 52,256,826UniSTSGRCm38
MGSCv371152,070,262 - 52,070,328UniSTSGRCm37
Celera1156,825,930 - 56,825,996UniSTS
Cytogenetic Map11B1.3UniSTS
Tcf7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001313981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001427422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001427423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001427424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001427425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001427426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK037616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK038140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL645862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW545274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC056630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY095426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X61385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000086844   ⟹   ENSMUSP00000084055
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1152,143,198 - 52,173,398 (-)Ensembl
GRCm38.p6 Ensembl1152,252,371 - 52,282,571 (-)Ensembl
Ensembl Acc Id: ENSMUST00000109071   ⟹   ENSMUSP00000104699
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1152,144,063 - 52,174,158 (-)Ensembl
GRCm38.p6 Ensembl1152,253,236 - 52,283,331 (-)Ensembl
Ensembl Acc Id: ENSMUST00000238914   ⟹   ENSMUSP00000158937
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1152,145,983 - 52,165,704 (-)Ensembl
GRCm38.p6 Ensembl1152,255,156 - 52,274,877 (-)Ensembl
RefSeq Acc Id: NM_001313981   ⟹   NP_001300910
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391152,143,113 - 52,174,197 (-)NCBI
GRCm381152,252,283 - 52,283,014 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001427422   ⟹   NP_001414351
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391152,143,113 - 52,174,197 (-)NCBI
RefSeq Acc Id: NM_001427423   ⟹   NP_001414352
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391152,143,113 - 52,174,197 (-)NCBI
RefSeq Acc Id: NM_001427424   ⟹   NP_001414353
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391152,143,113 - 52,174,197 (-)NCBI
RefSeq Acc Id: NM_001427425   ⟹   NP_001414354
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391152,143,113 - 52,174,197 (-)NCBI
RefSeq Acc Id: NM_001427426   ⟹   NP_001414355
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391152,143,113 - 52,173,154 (-)NCBI
RefSeq Acc Id: NM_009331   ⟹   NP_033357
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391152,143,113 - 52,173,398 (-)NCBI
GRCm381152,252,283 - 52,282,595 (-)NCBI
MGSCv371152,066,106 - 52,096,073 (-)RGD
Celera1156,821,774 - 56,852,195 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030245766   ⟹   XP_030101626
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391152,137,347 - 52,174,211 (-)NCBI
GRCm381152,246,527 - 52,283,383 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245769   ⟹   XP_030101629
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391152,137,347 - 52,174,211 (-)NCBI
GRCm381152,246,527 - 52,283,383 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245773   ⟹   XP_030101633
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391152,137,347 - 52,169,374 (-)NCBI
GRCm381152,246,527 - 52,276,766 (-)NCBI
Sequence:
RefSeq Acc Id: NP_033357   ⟸   NM_009331
- Peptide Label: isoform 2
- UniProtKB: Q80UF1 (UniProtKB/TrEMBL),   B7ZNN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300910   ⟸   NM_001313981
- Peptide Label: isoform 1
- UniProtKB: Q00417 (UniProtKB/Swiss-Prot),   A0A5K1VVQ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030101626   ⟸   XM_030245766
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030101629   ⟸   XM_030245769
- Peptide Label: isoform X3
- UniProtKB: Q00417 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_030101633   ⟸   XM_030245773
- Peptide Label: isoform X7
Ensembl Acc Id: ENSMUSP00000084055   ⟸   ENSMUST00000086844
Ensembl Acc Id: ENSMUSP00000158937   ⟸   ENSMUST00000238914
Ensembl Acc Id: ENSMUSP00000104699   ⟸   ENSMUST00000109071
RefSeq Acc Id: NP_001414353   ⟸   NM_001427424
- Peptide Label: isoform 5
- UniProtKB: Q00417 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001414354   ⟸   NM_001427425
- Peptide Label: isoform 6
- UniProtKB: Q00417 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001414351   ⟸   NM_001427422
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001414352   ⟸   NM_001427423
- Peptide Label: isoform 4
- UniProtKB: Q00417 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001414355   ⟸   NM_001427426
- Peptide Label: isoform 7
Protein Domains
HMG box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00417-F1-model_v2 AlphaFold Q00417 1-419 view protein structure

Promoters
RGD ID:6822297
Promoter ID:MM_KWN:7343
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung,   Spleen
Transcripts:UC007IVL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361152,073,841 - 52,075,067 (-)MPROMDB
RGD ID:8674582
Promoter ID:EPDNEW_M15321
Type:initiation region
Name:Tcf7_1
Description:Mus musculus transcription factor 7, T cell specific , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381152,282,571 - 52,282,631EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98507 AgrOrtholog
Ensembl Genes ENSMUSG00000000782 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000086844 ENTREZGENE
  ENSMUST00000086844.10 UniProtKB/Swiss-Prot
  ENSMUST00000109071 ENTREZGENE
  ENSMUST00000109071.3 UniProtKB/TrEMBL
  ENSMUST00000238914.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Catenin_binding_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTNNB1-bd_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCF/LEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21414 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98507 ENTREZGENE
NCBI Gene 21414 ENTREZGENE
PANTHER PTHR10373 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10373:SF33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CTNNB1_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tcf7 PhenoGen
PROSITE HMG_BOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HMG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5F8MPS9_MOUSE UniProtKB/TrEMBL
  A0A5K1VVQ7 ENTREZGENE, UniProtKB/TrEMBL
  B7ZNN3 ENTREZGENE, UniProtKB/TrEMBL
  Q00417 ENTREZGENE
  Q80UF1 ENTREZGENE, UniProtKB/TrEMBL
  Q8CAQ6_MOUSE UniProtKB/TrEMBL
  TCF7_MOUSE UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Tcf7  transcription factor 7, T cell specific  Tcf7  transcription factor 7, T-cell specific  Symbol and/or name change 5135510 APPROVED