Hs6st3 (heparan sulfate 6-O-sulfotransferase 3) - Rat Genome Database

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Gene: Hs6st3 (heparan sulfate 6-O-sulfotransferase 3) Mus musculus
Analyze
Symbol: Hs6st3
Name: heparan sulfate 6-O-sulfotransferase 3
RGD ID: 1314190
MGI Page MGI
Description: Enables heparan sulfate 6-O-sulfotransferase activity. Acts upstream of or within heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; genitourinary system; hindlimb ridge; limb bud; and sensory organ. Orthologous to human HS6ST3 (heparan sulfate 6-O-sulfotransferase 3); PARTICIPATES IN heparan sulfate biosynthetic pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6OS; 6OST3; heparan-sulfate 6-O-sulfotransferase 3; HS6ST-3; MGC144859; MGC144860; mHS6ST-3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914119,374,902 - 120,226,864 (+)NCBIGRCm39mm39
GRCm39 Ensembl14119,375,753 - 120,107,227 (+)Ensembl
GRCm3814119,137,516 - 119,869,815 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14119,138,341 - 119,869,815 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714119,537,487 - 120,269,037 (+)NCBIGRCm37mm9NCBIm37
MGSCv3614118,273,483 - 119,004,997 (+)NCBImm8
Celera14117,692,032 - 118,432,138 (+)NCBICelera
Cytogenetic Map14E4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:10644753   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12460940   PMID:12466851   PMID:12477932   PMID:12611590   PMID:14681479   PMID:15499561  
PMID:15944372   PMID:16141072   PMID:16141073   PMID:16326709   PMID:17405882   PMID:20410206   PMID:21267068   PMID:21357686   PMID:21873635   PMID:21951307   PMID:23223449   PMID:27655933  
PMID:28942923  


Genomics

Comparative Map Data
Hs6st3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914119,374,902 - 120,226,864 (+)NCBIGRCm39mm39
GRCm39 Ensembl14119,375,753 - 120,107,227 (+)Ensembl
GRCm3814119,137,516 - 119,869,815 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14119,138,341 - 119,869,815 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714119,537,487 - 120,269,037 (+)NCBIGRCm37mm9NCBIm37
MGSCv3614118,273,483 - 119,004,997 (+)NCBImm8
Celera14117,692,032 - 118,432,138 (+)NCBICelera
Cytogenetic Map14E4NCBI
HS6ST3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1396,090,107 - 96,839,562 (+)EnsemblGRCh38hg38GRCh38
GRCh381396,090,107 - 96,839,562 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371396,742,361 - 97,491,816 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361395,541,094 - 96,289,813 (+)NCBINCBI36hg18NCBI36
Build 341395,541,093 - 96,289,812NCBI
Celera1377,590,616 - 78,339,250 (+)NCBI
Cytogenetic Map13q32.1NCBI
HuRef1377,340,282 - 78,088,949 (+)NCBIHuRef
CHM1_11396,713,494 - 97,462,214 (+)NCBICHM1_1
Hs6st3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21596,281,502 - 97,000,804 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl15104,448,600 - 105,254,214 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.015104,448,479 - 105,254,540 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.015107,871,035 - 107,871,884 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.015108,635,603 - 108,663,069 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415104,157,904 - 104,914,126NCBIRGSC3.4rn4RGSC3.4
Celera1595,121,926 - 95,826,748 (+)NCBICelera
Cytogenetic Map15q24NCBI
Hs6st3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540413,468,128 - 14,128,707 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540413,461,906 - 14,129,089 (-)NCBIChiLan1.0ChiLan1.0
HS6ST3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11396,414,415 - 97,150,741 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1396,414,409 - 97,148,398 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01377,256,399 - 77,998,022 (+)NCBIMhudiblu_PPA_v0panPan3
HS6ST3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12247,257,641 - 47,265,143 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2247,117,757 - 47,259,351 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2246,415,114 - 47,045,651 (+)NCBI
ROS_Cfam_1.02247,059,742 - 47,690,994 (+)NCBI
UMICH_Zoey_3.12246,722,627 - 47,354,975 (+)NCBI
UNSW_CanFamBas_1.02246,755,655 - 47,387,212 (+)NCBI
UU_Cfam_GSD_1.02246,792,123 - 47,424,056 (+)NCBI
Hs6st3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945182,140,408 - 182,794,486 (+)NCBI
SpeTri2.0NW_00493647213,157,669 - 13,811,747 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HS6ST3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1165,516,296 - 66,186,846 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11165,516,180 - 66,193,410 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21173,192,012 - 73,199,496 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HS6ST3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1374,840,589 - 75,576,397 (+)NCBI
Vero_WHO_p1.0NW_02366604631,277,947 - 32,026,474 (+)NCBI
Hs6st3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248792,678,403 - 3,408,630 (+)NCBI

Position Markers
AW045863  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814119,784,768 - 119,784,893UniSTSGRCm38
GRCm38195,482,975 - 5,483,190UniSTSGRCm38
MGSCv37195,482,975 - 5,483,190UniSTSGRCm37
MGSCv3714120,183,990 - 120,184,115UniSTSGRCm37
Celera195,354,675 - 5,354,890UniSTS
Celera14118,346,963 - 118,347,088UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map14E4UniSTS
Whitehead/MRC_RH1958.76UniSTS
AI182501  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814119,784,875 - 119,784,997UniSTSGRCm38
GRCm38195,483,172 - 5,483,557UniSTSGRCm38
MGSCv37195,483,172 - 5,483,557UniSTSGRCm37
MGSCv3714120,184,097 - 120,184,219UniSTSGRCm37
Celera195,354,872 - 5,355,257UniSTS
Celera14118,347,070 - 118,347,192UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map14E4UniSTS
Whitehead/MRC_RH1964.42UniSTS
Hs6st3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv3714120,268,383 - 120,268,969UniSTSGRCm37
Celera14118,431,484 - 118,432,070UniSTS
Cytogenetic Map14E4UniSTS
cM Map14 UniSTS
PMC123054P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814119,643,979 - 119,644,165UniSTSGRCm38
MGSCv3714120,043,201 - 120,043,387UniSTSGRCm37
Celera14118,205,941 - 118,206,127UniSTS
Cytogenetic Map14E4UniSTS
Cytogenetic Map10B2UniSTS
cM Map1026.0UniSTS
UniSTS:224640  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814119,439,882 - 119,440,032UniSTSGRCm38
MGSCv3714119,839,104 - 119,839,254UniSTSGRCm37
Celera14117,996,725 - 117,996,875UniSTS
Cytogenetic Map14E4UniSTS
Hs6st3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814119,869,387 - 119,869,576UniSTSGRCm38
Celera14118,431,710 - 118,431,899UniSTS
Cytogenetic Map14E4UniSTS
Hs6st3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14E4UniSTS
Hs6st3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814119,869,161 - 119,869,747UniSTSGRCm38
MGSCv3714120,268,383 - 120,268,969UniSTSGRCm37
Celera14118,431,484 - 118,432,070UniSTS
Cytogenetic Map14E4UniSTS
cM Map14 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420837405121032392Mouse
10755523Hgb2_mhemoglobin 2 (mouse)14105647242124902244Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:163
Interacting mature miRNAs:174
Transcripts:ENSMUST00000065904
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000065904   ⟹   ENSMUSP00000070394
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl14119,138,341 - 119,869,815 (+)Ensembl
RefSeq Acc Id: NM_015820   ⟹   NP_056635
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914119,375,677 - 120,107,227 (+)NCBI
GRCm3814119,138,265 - 119,869,815 (+)NCBI
MGSCv3714119,537,487 - 120,269,037 (+)RGD
Celera14117,692,032 - 118,432,138 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006519238   ⟹   XP_006519301
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914119,374,902 - 119,781,153 (+)NCBI
GRCm3814119,137,516 - 119,543,741 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011245113   ⟹   XP_011243415
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914119,375,111 - 119,957,930 (+)NCBI
GRCm3814119,137,516 - 119,720,521 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036158750   ⟹   XP_036014643
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914119,375,111 - 120,226,864 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_056635   ⟸   NM_015820
- Peptide Label: precursor
- UniProtKB: Q9QYK4 (UniProtKB/Swiss-Prot),   Q149R8 (UniProtKB/TrEMBL),   Q3UTM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006519301   ⟸   XM_006519238
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011243415   ⟸   XM_011245113
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000070394   ⟸   ENSMUST00000065904
RefSeq Acc Id: XP_036014643   ⟸   XM_036158750
- Peptide Label: isoform X1

Promoters
RGD ID:6825064
Promoter ID:MM_KWN:17816
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Kidney
Transcripts:ENSMUST00000110724,   NM_015820
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3614119,536,816 - 119,537,677 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1354960 AgrOrtholog
Ensembl Genes ENSMUSG00000053465 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000070394 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000065904 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Heparan_SO4-6-sulfoTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot
  Sulfotransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:50787 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1354960 ENTREZGENE
NCBI Gene 50787 ENTREZGENE
PANTHER PTHR12812 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sulfotransfer_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hs6st3 PhenoGen
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt H6ST3_MOUSE UniProtKB/Swiss-Prot
  Q149R8 ENTREZGENE, UniProtKB/TrEMBL
  Q3UTM4 ENTREZGENE, UniProtKB/TrEMBL
  Q9QYK4 ENTREZGENE
UniProt Secondary Q148Q1 UniProtKB/Swiss-Prot