Gene: Arih2 (ariadne RBR E3 ubiquitin protein ligase 2) Mus musculus
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Symbol:
Arih2
Name:
ariadne RBR E3 ubiquitin protein ligase 2
Description:
ENCODES a protein that exhibits ubiquitin conjugating enzyme binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN ubiquitin-dependent protein catabolic process; developmental cell growth (ortholog); hematopoietic stem cell proliferation (ortholog); ASSOCIATED WITH abnormal dendritic cell physiology; abnormal liver physiology; abnormal survival; FOUND IN Cul5-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4'-tetrachlorobiphenyl; 4,4'-diaminodiphenylmethane
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AI843547; ARI-2; ARI2; ariadne 2; ariadne homolog 2; E3 ubiquitin-protein ligase ARIH2; protein ariadne-2 homolog; RING-type E3 ubiquitin transferase ARIH2; TRIAD1; ubcM4-interacting protein 48; UIP48
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Arih2 (ariadne RBR E3 ubiquitin protein ligase 2) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Arih2 (ariadne RBR E3 ubiquitin protein ligase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Arih2 (ariadne RBR E3 ubiquitin protein ligase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Arih2 (ariadne RBR E3 ubiquitin protein ligase 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
arih2 (ariadne homolog 2 (Drosophila))
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
HEL1
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Caenorhabditis elegans (roundworm):
ari-2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
ari-2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Related Pseudogenes:
Gm12263
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 108,602,942 - 108,653,681 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 108,505,273 - 108,551,711 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 108,460,279 - 108,506,785 (-) NCBI mm8 Celera 9 108,214,330 - 108,260,897 (-) NCBI Celera Cytogenetic Map 9 F2 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions ISO RGD:1305839 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of ARIH2 mRNA CTD PMID:25729387 14-Deoxy-11,12-didehydroandrographolide decreases expression ISO RGD:1314113 6480464 14-deoxy-11, 12-didehydroandrographolide results in decreased expression of ARIH2 mRNA CTD PMID:22101062 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of ARIH2 mRNA CTD PMID:19770486 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ARIH2 mRNA CTD PMID:21570461 2,6-dinitrotoluene affects expression ISO RGD:1305839 6480464 2, 6-dinitrotoluene affects the expression of ARIH2 mRNA CTD PMID:21346803 3,3',4,4'-tetrachlorobiphenyl multiple interactions EXP 6480464 3 more ... CTD PMID:19467301 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1314113 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ARIH2 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ARIH2 mRNA CTD PMID:28628672 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in increased expression of ARIH2 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1314113 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ARIH2 mRNA CTD PMID:28628672 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of ARIH2 mRNA CTD PMID:28973697 4-tert-Octylphenol increases expression ISO RGD:1305839 6480464 4-tert-octylphenol results in increased expression of ARIH2 mRNA CTD PMID:17011747 acrylamide increases expression ISO RGD:1305839 6480464 Acrylamide results in increased expression of ARIH2 mRNA CTD PMID:28959563 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of ARIH2 mRNA CTD PMID:19770486 arsane affects expression ISO RGD:1314113 6480464 Arsenic affects the expression of ARIH2 mRNA CTD PMID:18414638 arsenic atom affects expression ISO RGD:1314113 6480464 Arsenic affects the expression of ARIH2 mRNA CTD PMID:18414638 arsenic(3+) affects expression ISO RGD:1314113 6480464 Arsenic affects the expression of ARIH2 mRNA CTD PMID:18414638 benzo[a]pyrene decreases expression ISO RGD:1314113 6480464 Benzo(a)pyrene results in decreased expression of ARIH2 mRNA CTD PMID:26238291 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of ARIH2 mRNA CTD PMID:21318169 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1305839 6480464 Diethylhexyl Phthalate results in increased expression of ARIH2 mRNA CTD PMID:21318169 bisphenol A affects expression ISO RGD:1305839 6480464 bisphenol A affects the expression of ARIH2 mRNA CTD PMID:25181051 bisphenol A multiple interactions ISO RGD:1314113 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ARIH2 mRNA CTD PMID:28628672 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of ARIH2 mRNA CTD PMID:20061341 carbamazepine affects expression ISO RGD:1314113 6480464 Carbamazepine affects the expression of ARIH2 mRNA CTD PMID:25979313 chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of ARIH2 mRNA CTD PMID:20350560 cisplatin increases expression ISO RGD:1314113 6480464 Cisplatin results in increased expression of ARIH2 mRNA CTD PMID:27392435 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of ARIH2 mRNA CTD PMID:17585979 cyclosporin A increases expression ISO RGD:1314113 6480464 Cyclosporine results in increased expression of ARIH2 mRNA CTD PMID:20106945 dexamethasone multiple interactions ISO RGD:1314113 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ARIH2 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ARIH2 mRNA CTD PMID:28628672 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of ARIH2 mRNA CTD PMID:21266533 dibutyl phthalate increases expression ISO RGD:1305839 6480464 Dibutyl Phthalate results in increased expression of ARIH2 mRNA CTD PMID:21266533 diethylstilbestrol increases expression ISO RGD:1305839 6480464 Diethylstilbestrol results in increased expression of ARIH2 mRNA CTD PMID:17011747 disodium selenite increases expression ISO RGD:1314113 6480464 Sodium Selenite results in increased expression of ARIH2 mRNA CTD PMID:18175754 ethanol affects splicing EXP 6480464 Ethanol affects the splicing of ARIH2 mRNA CTD PMID:30319688 flutamide increases expression ISO RGD:1305839 6480464 Flutamide results in increased expression of ARIH2 mRNA CTD PMID:24136188 hydralazine multiple interactions ISO RGD:1314113 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of ARIH2 mRNA CTD PMID:17183730 indometacin multiple interactions ISO RGD:1314113 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ARIH2 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ARIH2 mRNA CTD PMID:28628672 methyl methanesulfonate increases expression ISO RGD:1314113 6480464 Methyl Methanesulfonate results in increased expression of ARIH2 mRNA CTD PMID:23649840 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of ARIH2 mRNA CTD PMID:20061341 methylphenidate decreases expression EXP 6480464 Methylphenidate results in decreased expression of ARIH2 mRNA CTD PMID:22470460 oxaliplatin multiple interactions ISO RGD:1305839 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of ARIH2 mRNA CTD PMID:25729387 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of ARIH2 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:1314113 6480464 Acetaminophen results in increased expression of ARIH2 mRNA CTD PMID:29067470 paracetamol multiple interactions EXP 6480464 [CTH gene mutant form results in increased susceptibility to Acetaminophen] which affects the expression of ARIH2 protein CTD PMID:25499718 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of ARIH2 mRNA CTD PMID:15375163 silicon dioxide increases expression ISO RGD:1314113 6480464 Silicon Dioxide analog results in increased expression of ARIH2 mRNA CTD PMID:23806026 silicon dioxide decreases expression ISO RGD:1314113 6480464 Silicon Dioxide results in decreased expression of ARIH2 mRNA CTD PMID:25351596 Soman increases expression ISO RGD:1305839 6480464 Soman results in increased expression of ARIH2 mRNA CTD PMID:19281266 tetraphene increases expression EXP 6480464 benz(a)anthracene results in increased expression of ARIH2 mRNA CTD PMID:26377693 topotecan multiple interactions ISO RGD:1305839 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of ARIH2 mRNA CTD PMID:25729387 tunicamycin increases expression ISO RGD:1314113 6480464 Tunicamycin results in increased expression of ARIH2 mRNA CTD PMID:29453283 valproic acid multiple interactions ISO RGD:1314113 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of ARIH2 mRNA CTD PMID:17183730 valproic acid affects expression ISO RGD:1314113 6480464 Valproic Acid affects the expression of ARIH2 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:1314113 6480464 Valproic Acid results in increased expression of ARIH2 mRNA CTD PMID:23179753 more ...
Gene Ontology Annotations
Biological Process developmental cell growth ISO UniProtKB:O95376 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 hematopoietic stem cell proliferation ISO UniProtKB:O95376 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA MGI:MGI:1355296 , PANTHER:PTN000188395 2290270 (PMID:21873635) GO_Central PMID:21873635 protein K48-linked ubiquitination ISO UniProtKB:O95376 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein K63-linked ubiquitination ISO UniProtKB:O95376 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein polyubiquitination ISO UniProtKB:O95376 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein polyubiquitination IBA FB:FBgn0041100 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 protein ubiquitination ISO UniProtKB:O95376 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 ubiquitin-dependent protein catabolic process IPI UniProtKB:P68037 2290270 (MGI:MGI:1340728, PMID:10431818) MGI MGI:MGI:1340728 , PMID:10431818 ubiquitin-dependent protein catabolic process IBA FB:FBgn0017418 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 ubiquitin-dependent protein catabolic process ISO UniProtKB:O95376 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 
Gene Ontology Annotations
