Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | ISO | Spire2 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SPIRE2 mRNA] | CTD | PMID:31150632 | (1->4)-beta-D-glucan | multiple interactions | ISO | Spire2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SPIRE2 mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | increases expression | ISO | Spire2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of SPIRE2 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Estradiol binds to ESR2 protein] which results in increased expression of SPIRE2 mRNA | CTD | PMID:20404318 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of SPIRE2 mRNA | CTD | PMID:31614463 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Spire2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SPIRE2 mRNA | CTD | PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Spire2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SPIRE2 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Spire2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SPIRE2 mRNA | CTD | PMID:21570461 and PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Spire2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SPIRE2 mRNA | CTD | PMID:22298810 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Spire2 (Rattus norvegicus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of SPIRE2 mRNA | CTD | PMID:30071829 | 4,4'-diaminodiphenylmethane | increases expression | ISO | Spire2 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of SPIRE2 mRNA | CTD | PMID:18648102 | acetamide | increases expression | ISO | Spire2 (Rattus norvegicus) | 6480464 | acetamide results in increased expression of SPIRE2 mRNA | CTD | PMID:31881176 | aflatoxin B1 | increases methylation | EXP | | 6480464 | Aflatoxin B1 results in increased methylation of SPIRE2 gene and Aflatoxin B1 results in increased methylation of SPIRE2 intron | CTD | PMID:27153756 and PMID:30157460 | Aflatoxin B2 alpha | affects methylation | EXP | | 6480464 | aflatoxin B2 affects the methylation of SPIRE2 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | Spire2 (Rattus norvegicus) | 6480464 | Tretinoin results in increased expression of SPIRE2 mRNA | CTD | PMID:20488242 | aristolochic acid A | increases expression | EXP | | 6480464 | aristolochic acid I results in increased expression of SPIRE2 mRNA | CTD | PMID:33212167 | arsane | affects methylation | EXP | | 6480464 | Arsenic affects the methylation of SPIRE2 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | EXP | | 6480464 | Arsenic affects the methylation of SPIRE2 gene | CTD | PMID:25304211 | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of SPIRE2 intron and Benzo(a)pyrene affects the methylation of SPIRE2 promoter | CTD | PMID:27901495 and PMID:30157460 | benzo[e]pyrene | decreases methylation | EXP | | 6480464 | benzo(e)pyrene results in decreased methylation of SPIRE2 intron | CTD | PMID:30157460 | bisphenol A | decreases expression | ISO | Spire2 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of SPIRE2 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | Spire2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SPIRE2 mRNA | CTD | PMID:32156529 | caffeine | affects phosphorylation | EXP | | 6480464 | Caffeine affects the phosphorylation of SPIRE2 protein | CTD | PMID:35688186 | chlorpyrifos | increases expression | ISO | Spire2 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of SPIRE2 mRNA | CTD | PMID:37019170 | choline | multiple interactions | ISO | Spire2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPIRE2 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SPIRE2 gene | CTD | PMID:20938992 | clothianidin | decreases expression | EXP | | 6480464 | clothianidin results in decreased expression of SPIRE2 mRNA | CTD | PMID:29044138 | copper atom | multiple interactions | ISO | Spire2 (Rattus norvegicus) | 6480464 | [Copper co-treated with Dietary Sucrose] results in increased expression of SPIRE2 mRNA | CTD | PMID:26033743 | copper atom | increases expression | ISO | Spire2 (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of SPIRE2 mRNA | CTD | PMID:26033743 | copper(0) | increases expression | ISO | Spire2 (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of SPIRE2 mRNA | CTD | PMID:26033743 | copper(0) | multiple interactions | ISO | Spire2 (Rattus norvegicus) | 6480464 | [Copper co-treated with Dietary Sucrose] results in increased expression of SPIRE2 mRNA | CTD | PMID:26033743 | coumestrol | decreases expression | EXP | | 6480464 | Coumestrol results in decreased expression of SPIRE2 mRNA | CTD | PMID:19167446 | crocidolite asbestos | increases expression | ISO | Spire2 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in increased expression of SPIRE2 mRNA | CTD | PMID:29279043 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of SPIRE2 mRNA | CTD | PMID:25562108 | cyclosporin A | increases methylation | EXP | | 6480464 | Cyclosporine results in increased methylation of SPIRE2 promoter | CTD | PMID:27989131 | endosulfan | increases expression | ISO | Spire2 (Rattus norvegicus) | 6480464 | Endosulfan results in increased expression of SPIRE2 mRNA | CTD | PMID:29391264 | folic acid | multiple interactions | ISO | Spire2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPIRE2 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SPIRE2 gene | CTD | PMID:20938992 | folic acid | decreases expression | ISO | Spire2 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of SPIRE2 mRNA | CTD | PMID:25629700 | FR900359 | decreases phosphorylation | EXP | | 6480464 | FR900359 results in decreased phosphorylation of SPIRE2 protein | CTD | PMID:37730182 | inulin | multiple interactions | ISO | Spire2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of SPIRE2 mRNA | CTD | PMID:36331819 | L-methionine | multiple interactions | ISO | Spire2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPIRE2 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SPIRE2 gene | CTD | PMID:20938992 | methapyrilene | decreases methylation | EXP | | 6480464 | Methapyrilene results in decreased methylation of SPIRE2 intron | CTD | PMID:30157460 | nitrofen | decreases expression | ISO | Spire2 (Rattus norvegicus) | 6480464 | nitrofen results in decreased expression of SPIRE2 mRNA | CTD | PMID:26720608 | Nor-9-carboxy-delta9-THC | multiple interactions | EXP | | 6480464 | [Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which affects the methylation of SPIRE2 gene | CTD | PMID:30521419 | paracetamol | affects expression | ISO | Spire2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of SPIRE2 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | Spire2 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of SPIRE2 mRNA | CTD | PMID:33387578 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of SPIRE2 mRNA | CTD | PMID:29067470 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Spire2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SPIRE2 mRNA more ... | CTD | PMID:36331819 | quercetin | increases phosphorylation | EXP | | 6480464 | Quercetin results in increased phosphorylation of SPIRE2 protein | CTD | PMID:35688186 | resveratrol | multiple interactions | EXP | | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of SPIRE2 mRNA | CTD | PMID:23557933 | silicon dioxide | increases expression | ISO | Spire2 (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of SPIRE2 mRNA | CTD | PMID:29203145 | sunitinib | decreases expression | EXP | | 6480464 | Sunitinib results in decreased expression of SPIRE2 mRNA | CTD | PMID:31533062 | tetrachloromethane | increases expression | ISO | Spire2 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in increased expression of SPIRE2 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | ISO | Spire2 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SPIRE2 mRNA] | CTD | PMID:31150632 | thioacetamide | increases expression | ISO | Spire2 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of SPIRE2 mRNA | CTD | PMID:23411599 and PMID:34492290 | titanium dioxide | increases expression | ISO | Spire2 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of SPIRE2 mRNA | CTD | PMID:29264374 | trichloroethene | increases expression | ISO | Spire2 (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of SPIRE2 mRNA | CTD | PMID:33387578 | valproic acid | increases methylation | EXP | | 6480464 | Valproic Acid results in increased methylation of SPIRE2 gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | Spire2 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of SPIRE2 mRNA | CTD | PMID:21427059 | |