DUSP2 (dual specificity phosphatase 2) - Rat Genome Database

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Gene: DUSP2 (dual specificity phosphatase 2) Homo sapiens
Analyze
Symbol: DUSP2
Name: dual specificity phosphatase 2
RGD ID: 1314060
HGNC Page HGNC:3068
Description: Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in endoderm formation and negative regulation of MAPK cascade. Located in nuclear membrane and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: dual specificity protein phosphatase 2; dual specificity protein phosphatase PAC-1; dual-specificity phosphatase 2; PAC-1; PAC1; serine/threonine specific protein phosphatase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38296,143,169 - 96,145,440 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl296,143,169 - 96,145,440 (-)EnsemblGRCh38hg38GRCh38
GRCh37296,808,908 - 96,811,179 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36296,172,638 - 96,174,906 (-)NCBINCBI36Build 36hg18NCBI36
Build 34296,230,790 - 96,233,053NCBI
Celera291,249,715 - 91,251,986 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef290,770,185 - 90,772,456 (-)NCBIHuRef
CHM1_1296,813,182 - 96,815,453 (-)NCBICHM1_1
T2T-CHM13v2.0296,649,773 - 96,656,541 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (EXP)
amitrole  (ISO)
aristolochic acid A  (EXP)
arsenous acid  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
cyclophosphamide  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dieldrin  (EXP)
dimethylarsinic acid  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
disulfiram  (EXP)
dorsomorphin  (EXP)
endosulfan  (ISO)
etoposide  (EXP)
ferroheme b  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
genistein  (EXP)
gentamycin  (ISO)
glucose  (ISO)
glyphosate  (EXP)
heme b  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP)
irinotecan  (EXP)
L-methionine  (ISO)
Licochalcone B  (EXP)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (ISO)
melphalan  (EXP)
menadione  (EXP)
mercury dibromide  (EXP)
methimazole  (ISO)
methotrexate  (EXP)
methylarsonic acid  (ISO)
methylisothiazolinone  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (EXP)
omega-6 fatty acid  (EXP)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
potassium bromate  (ISO)
potassium chromate  (EXP)
raloxifene  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
sulfadimethoxine  (ISO)
tamoxifen  (EXP)
tebuconazole  (EXP)
tetraphene  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (EXP)
vincristine  (EXP)
zearalenone  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
nuclear membrane  (IDA)
nucleoplasm  (IDA)
nucleus  (IBA,IEA,TAS)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing. Wen W, etal., Cell Discov. 2020 May 4;6:31. doi: 10.1038/s41421-020-0168-9. eCollection 2020.
Additional References at PubMed
PMID:7535770   PMID:7590752   PMID:7681221   PMID:7806236   PMID:8107850   PMID:12270932   PMID:12477932   PMID:12575935   PMID:12673251   PMID:12826159   PMID:14680939   PMID:15489334  
PMID:16288922   PMID:17471234   PMID:17827388   PMID:18178562   PMID:18600034   PMID:19913121   PMID:20628086   PMID:20723301   PMID:21490398   PMID:21784977   PMID:21873635   PMID:21984126  
PMID:25596742   PMID:26207425   PMID:26658840   PMID:26833217   PMID:27432908   PMID:27880917   PMID:28026024   PMID:28252035   PMID:28440564   PMID:28652251   PMID:28675297   PMID:29852174  
PMID:30458195   PMID:31889045   PMID:31932812   PMID:32513696   PMID:33961781   PMID:34857952   PMID:36243803  


Genomics

Comparative Map Data
DUSP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38296,143,169 - 96,145,440 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl296,143,169 - 96,145,440 (-)EnsemblGRCh38hg38GRCh38
GRCh37296,808,908 - 96,811,179 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36296,172,638 - 96,174,906 (-)NCBINCBI36Build 36hg18NCBI36
Build 34296,230,790 - 96,233,053NCBI
Celera291,249,715 - 91,251,986 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef290,770,185 - 90,772,456 (-)NCBIHuRef
CHM1_1296,813,182 - 96,815,453 (-)NCBICHM1_1
T2T-CHM13v2.0296,649,773 - 96,656,541 (-)NCBIT2T-CHM13v2.0
Dusp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,178,079 - 127,180,297 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,178,079 - 127,180,296 (+)EnsemblGRCm39 Ensembl
GRCm382127,336,159 - 127,338,377 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,336,159 - 127,338,376 (+)EnsemblGRCm38mm10GRCm38
MGSCv372127,161,895 - 127,164,113 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362128,316,151 - 128,318,369 (+)NCBIMGSCv36mm8
MGSCv362127,027,600 - 127,029,818 (+)NCBIMGSCv36mm8
Cytogenetic Map2F1NCBI
cM Map261.93NCBI
Dusp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,009,636 - 135,011,821 (+)NCBIGRCr8
mRatBN7.23114,556,325 - 114,558,510 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,556,325 - 114,558,499 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,445,557 - 118,447,742 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,041,118 - 127,043,303 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,701,487 - 124,703,672 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,776,925 - 119,779,110 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,776,925 - 119,779,099 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,303,199 - 126,305,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,838,605 - 114,840,790 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13114,744,177 - 114,746,352 (+)NCBI
Celera3113,395,499 - 113,397,684 (+)NCBICelera
Cytogenetic Map3q36NCBI
Dusp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554703,735,871 - 3,737,568 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554703,735,224 - 3,737,667 (-)NCBIChiLan1.0ChiLan1.0
DUSP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21232,163,053 - 32,165,336 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A32,165,812 - 32,168,095 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A103,169,874 - 103,172,158 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A97,068,210 - 97,070,505 (-)NCBIpanpan1.1PanPan1.1panPan2
DUSP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11734,586,635 - 34,589,076 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1734,586,716 - 34,588,453 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1734,356,392 - 34,358,603 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01735,357,957 - 35,360,188 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1735,357,957 - 35,360,187 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11734,487,278 - 34,489,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01734,555,607 - 34,557,809 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01734,762,735 - 34,764,961 (+)NCBIUU_Cfam_GSD_1.0
Dusp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629283,018,673 - 83,020,329 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936744271,469 - 273,326 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936744271,619 - 273,272 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl347,052,458 - 47,054,810 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1347,052,443 - 47,054,816 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2349,187,416 - 49,194,997 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114580,686 - 582,939 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14580,694 - 582,910 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041168,001,720 - 168,004,581 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247492,258,356 - 2,260,455 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247492,258,317 - 2,260,542 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DUSP2
18 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q11.1-11.2(chr2:95879602-97029672)x3 copy number gain Global developmental delay [RCV000050366]|See cases [RCV000050366] Chr2:95879602..97029672 [GRCh38]
Chr2:96545350..97695409 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95879602-97285797)x1 copy number loss See cases [RCV000051260] Chr2:95879602..97285797 [GRCh38]
Chr2:96545350..98013866 [GRCh37]
Chr2:95909077..97380005 [NCBI36]
Chr2:2q11.1-11.2		 pathogenic
GRCh38/hg38 2q11.2(chr2:96100812-97285797)x1 copy number loss See cases [RCV000051137] Chr2:96100812..97285797 [GRCh38]
Chr2:96766560..98013866 [GRCh37]
Chr2:96130287..97380005 [NCBI36]
Chr2:2q11.2		 pathogenic
GRCh38/hg38 2q11.1-11.2(chr2:95806265-97285797)x3 copy number gain See cases [RCV000053136] Chr2:95806265..97285797 [GRCh38]
Chr2:96472013..98013866 [GRCh37]
Chr2:95835740..97380005 [NCBI36]
Chr2:2q11.1-11.2		 uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95810453-97024341)x3 copy number gain See cases [RCV000053137] Chr2:95810453..97024341 [GRCh38]
Chr2:96476201..97690078 [GRCh37]
Chr2:95839928..97053805 [NCBI36]
Chr2:2q11.1-11.2		 uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95880668-97131646)x3 copy number gain See cases [RCV000053138] Chr2:95880668..97131646 [GRCh38]
Chr2:96546416..97797383 [GRCh37]
Chr2:95910143..97161110 [NCBI36]
Chr2:2q11.1-11.2		 uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95916534-97024341)x3 copy number gain See cases [RCV000053139] Chr2:95916534..97024341 [GRCh38]
Chr2:96582282..97690078 [GRCh37]
Chr2:95946009..97053805 [NCBI36]
Chr2:2q11.1-11.2		 uncertain significance
GRCh38/hg38 2q11.2(chr2:96100612-97285797)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053140]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053140]|See cases [RCV000053140] Chr2:96100612..97285797 [GRCh38]
Chr2:96766360..98014007 [GRCh37]
Chr2:96130087..97380146 [NCBI36]
Chr2:2q11.2		 uncertain significance
GRCh38/hg38 2q11.1-12.1(chr2:94817406-103252396)x3 copy number gain See cases [RCV000052946] Chr2:94817406..103252396 [GRCh38]
Chr2:95618109..103868854 [GRCh37]
Chr2:94846878..103235286 [NCBI36]
Chr2:2q11.1-12.1		 pathogenic
GRCh38/hg38 2p11.2-q11.2(chr2:91443218-102334856)x3 copy number gain See cases [RCV000052945] Chr2:91443218..102334856 [GRCh38]
Chr2:91617683..102951316 [GRCh37]
Chr2:90981410..102317748 [NCBI36]
Chr2:2p11.2-q11.2		 pathogenic
GRCh38/hg38 2q11.1-11.2(chr2:95493468-96977610)x3 copy number gain See cases [RCV000133839] Chr2:95493468..96977610 [GRCh38]
Chr2:96159216..97643347 [GRCh37]
Chr2:95522943..97007074 [NCBI36]
Chr2:2q11.1-11.2		 uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95879602-97029672)x3 copy number gain See cases [RCV000050366] Chr2:95879602..97029672 [GRCh38]
Chr2:96545350..97695409 [GRCh37]
Chr2:95909077..97059136 [NCBI36]
Chr2:2q11.1-11.2		 uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95879602-97029672)x1 copy number loss See cases [RCV000134141] Chr2:95879602..97029672 [GRCh38]
Chr2:96545350..97695409 [GRCh37]
Chr2:95909077..97059136 [NCBI36]
Chr2:2q11.1-11.2		 pathogenic
GRCh38/hg38 2q11.2(chr2:96073560-97062710)x1 copy number loss See cases [RCV000135343] Chr2:96073560..97062710 [GRCh38]
Chr2:96739308..97728447 [GRCh37]
Chr2:96103035..97092174 [NCBI36]
Chr2:2q11.2		 pathogenic
GRCh38/hg38 2q11.2(chr2:96100812-97154835)x1 copy number loss See cases [RCV000137012] Chr2:96100812..97154835 [GRCh38]
Chr2:96766560..97820572 [GRCh37]
Chr2:96130287..97184299 [NCBI36]
Chr2:2q11.2		 uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95337458-99072953)x3 copy number gain See cases [RCV000138012] Chr2:95337458..99072953 [GRCh38]
Chr2:96003206..99689416 [GRCh37]
Chr2:95366933..99055848 [NCBI36]
Chr2:2q11.1-11.2		 uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95766541-97589743)x3 copy number gain See cases [RCV000137817] Chr2:95766541..97589743 [GRCh38]
Chr2:96432289..98206206 [GRCh37]
Chr2:95796016..97572638 [NCBI36]
Chr2:2q11.1-11.2		 uncertain significance
GRCh38/hg38 2q11.1-13(chr2:94678532-110602409)x3 copy number gain See cases [RCV000141075] Chr2:94678532..110602409 [GRCh38]
Chr2:95344257..111359986 [GRCh37]
Chr2:94707984..111076455 [NCBI36]
Chr2:2q11.1-13		 pathogenic
GRCh38/hg38 2q11.2(chr2:96066771-97285797)x3 copy number gain See cases [RCV000142146] Chr2:96066771..97285797 [GRCh38]
Chr2:96732519..98079569 [GRCh37]
Chr2:96096246..97432433 [NCBI36]
Chr2:2q11.2		 uncertain significance
GRCh38/hg38 2q11.2(chr2:96100816-97285797)x3 copy number gain See cases [RCV000142814] Chr2:96100816..97285797 [GRCh38]
Chr2:96766564..98013954 [GRCh37]
Chr2:96130291..97380093 [NCBI36]
Chr2:2q11.2		 uncertain significance
GRCh38/hg38 2q11.2(chr2:96073560-97513144)x1 copy number loss See cases [RCV000142800] Chr2:96073560..97513144 [GRCh38]
Chr2:96739308..98066294 [GRCh37]
Chr2:96103035..97496039 [NCBI36]
Chr2:2q11.2		 pathogenic
GRCh38/hg38 2q11.2(chr2:96073560-97589743)x3 copy number gain See cases [RCV000143142] Chr2:96073560..97589743 [GRCh38]
Chr2:96739308..98206206 [GRCh37]
Chr2:96103035..97572638 [NCBI36]
Chr2:2q11.2		 likely benign
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2q11.1-12.3(chr2:95529039-108518266) copy number gain See cases [RCV000449270] Chr2:95529039..108518266 [GRCh37]
Chr2:2q11.1-12.3		 pathogenic
GRCh37/hg19 2q11.1-13(chr2:95327499-111370025)x4 copy number gain See cases [RCV000446842] Chr2:95327499..111370025 [GRCh37]
Chr2:2q11.1-13		 pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96544602-98118115)x1 copy number loss See cases [RCV000446002] Chr2:96544602..98118115 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96698012-97757442)x3 copy number gain See cases [RCV000445685] Chr2:96698012..97757442 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:95691600-100587394) copy number gain See cases [RCV000447723] Chr2:95691600..100587394 [GRCh37]
Chr2:2q11.1-11.2		 pathogenic
NC_000002.11:g.(?_96738407)_(97742073_?)del deletion Schizophrenia [RCV000416822] Chr2:96738407..97742073 [GRCh37]
Chr2:96102134..97105800 [NCBI36]
Chr2:2q11.1-11.2		 likely pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96778661-97757978)x3 copy number gain See cases [RCV000448583] Chr2:96778661..97757978 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96468158-97871906)x3 copy number gain See cases [RCV000511375] Chr2:96468158..97871906 [GRCh37]
Chr2:2q11.1-11.2		 likely pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96097383-97679933)x1 copy number loss See cases [RCV000511715] Chr2:96097383..97679933 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96732519-98225552)x3 copy number gain See cases [RCV000511635] Chr2:96732519..98225552 [GRCh37]
Chr2:2q11.1-11.2		 likely benign
GRCh37/hg19 2q11.1-11.2(chr2:96712139-98249638)x1 copy number loss See cases [RCV000511596] Chr2:96712139..98249638 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2q11.1-12.2(chr2:95518497-107186127) copy number gain See cases [RCV000511158] Chr2:95518497..107186127 [GRCh37]
Chr2:2q11.1-12.2		 uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NM_004418.4(DUSP2):c.265G>A (p.Val89Met) single nucleotide variant Inborn genetic diseases [RCV003276506] Chr2:96145090 [GRCh38]
Chr2:96810829 [GRCh37]
Chr2:2q11.2		 uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96735977-98258828)x1 copy number loss not provided [RCV000682130] Chr2:96735977..98258828 [GRCh37]
Chr2:2q11.1-11.2		 likely pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96544602-98138405)x1 copy number loss not provided [RCV000682132] Chr2:96544602..98138405 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2q11.1-13(chr2:96353030-114045463)x3 copy number gain not provided [RCV000682168] Chr2:96353030..114045463 [GRCh37]
Chr2:2q11.1-13		 pathogenic
Single allele deletion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3		 likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NC_000002.12:g.(?_96063558)_(97079140_?)del deletion Schizophrenia [RCV000754268] Chr2:96063558..97079140 [GRCh38]
Chr2:2q11.2		 likely pathogenic
NC_000002.11:g.(?_96780545)_(96971175_?)dup duplication not provided [RCV001031839] Chr2:96780545..96971175 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
NC_000002.11:g.(?_96780545)_(96994037_?)dup duplication not provided [RCV001031880] Chr2:96780545..96994037 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
NM_004418.4(DUSP2):c.483C>T (p.Ser161=) single nucleotide variant not provided [RCV000971265] Chr2:96144788 [GRCh38]
Chr2:96810527 [GRCh37]
Chr2:2q11.2		 benign
GRCh37/hg19 2q11.1-11.2(chr2:96747466-98193473)x1 copy number loss See cases [RCV000790587] Chr2:96747466..98193473 [GRCh37]
Chr2:2q11.1-11.2		 likely pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96737083-98261802)x1 copy number loss See cases [RCV001194515] Chr2:96737083..98261802 [GRCh37]
Chr2:2q11.1-11.2		 likely pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96552903-98118115)x1 copy number loss not provided [RCV000848564] Chr2:96552903..98118115 [GRCh37]
Chr2:2q11.1-11.2		 pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96732519-98118115)x3 copy number gain not provided [RCV001005296] Chr2:96732519..98118115 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96515883-98025634)x3 copy number gain not provided [RCV000845755] Chr2:96515883..98025634 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96628608-96981369)x3 copy number gain not provided [RCV002472784] Chr2:96628608..96981369 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96712139-98254657)x1 copy number loss not provided [RCV001005295] Chr2:96712139..98254657 [GRCh37]
Chr2:2q11.1-11.2		 likely pathogenic|uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96737083-98193473)x3 copy number gain See cases [RCV001194576] Chr2:96737083..98193473 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96515883-98162176)x3 copy number gain not provided [RCV001259641] Chr2:96515883..98162176 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96421161-97765561)x1 copy number loss not provided [RCV001259642] Chr2:96421161..97765561 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96544602-97706860)x3 copy number gain not provided [RCV001259643] Chr2:96544602..97706860 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96630256-96836549)x3 copy number gain not provided [RCV001259640] Chr2:96630256..96836549 [GRCh37]
Chr2:2q11.1-11.2		 likely benign
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96755045-98021592) copy number loss Fetal growth restriction [RCV001352673] Chr2:96755045..98021592 [GRCh37]
Chr2:2q11.1-11.2		 pathogenic
Single allele deletion Intellectual disability [RCV001293378] Chr2:96737083..98193473 [GRCh37]
Chr2:2q11.1-11.2		 pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96544603-98025634)x3 copy number gain not provided [RCV001832989] Chr2:96544603..98025634 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
NC_000002.11:g.(?_96780545)_(97475254_?)dup duplication not provided [RCV001981292] Chr2:96780545..97475254 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2p25.1-q13(chr2:11504318-111365996)x1 copy number loss See cases [RCV002287563] Chr2:11504318..111365996 [GRCh37]
Chr2:2p25.1-q13		 pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:95341388-100340514)x3 copy number gain not provided [RCV002473932] Chr2:95341388..100340514 [GRCh37]
Chr2:2q11.1-11.2		 likely pathogenic
NM_004418.4(DUSP2):c.743A>C (p.Asn248Thr) single nucleotide variant Inborn genetic diseases [RCV002992604] Chr2:96144025 [GRCh38]
Chr2:96809764 [GRCh37]
Chr2:2q11.2		 uncertain significance
NM_004418.4(DUSP2):c.126C>G (p.His42Gln) single nucleotide variant Inborn genetic diseases [RCV002946369] Chr2:96145229 [GRCh38]
Chr2:96810968 [GRCh37]
Chr2:2q11.2		 uncertain significance
NM_004418.4(DUSP2):c.92A>C (p.Asp31Ala) single nucleotide variant Inborn genetic diseases [RCV002905916] Chr2:96145263 [GRCh38]
Chr2:96811002 [GRCh37]
Chr2:2q11.2		 uncertain significance
NM_004418.4(DUSP2):c.364C>T (p.Pro122Ser) single nucleotide variant Inborn genetic diseases [RCV002879936] Chr2:96144991 [GRCh38]
Chr2:96810730 [GRCh37]
Chr2:2q11.2		 uncertain significance
NM_004418.4(DUSP2):c.877G>T (p.Val293Phe) single nucleotide variant Inborn genetic diseases [RCV002732700] Chr2:96143891 [GRCh38]
Chr2:96809630 [GRCh37]
Chr2:2q11.2		 uncertain significance
NM_004418.4(DUSP2):c.322C>G (p.His108Asp) single nucleotide variant Inborn genetic diseases [RCV002737960] Chr2:96145033 [GRCh38]
Chr2:96810772 [GRCh37]
Chr2:2q11.2		 uncertain significance
NM_004418.4(DUSP2):c.259C>T (p.Arg87Trp) single nucleotide variant Inborn genetic diseases [RCV002704737] Chr2:96145096 [GRCh38]
Chr2:96810835 [GRCh37]
Chr2:2q11.2		 uncertain significance
NM_004418.4(DUSP2):c.217G>C (p.Asp73His) single nucleotide variant Inborn genetic diseases [RCV002872956] Chr2:96145138 [GRCh38]
Chr2:96810877 [GRCh37]
Chr2:2q11.2		 uncertain significance
NM_004418.4(DUSP2):c.28G>C (p.Glu10Gln) single nucleotide variant Inborn genetic diseases [RCV002696488] Chr2:96145327 [GRCh38]
Chr2:96811066 [GRCh37]
Chr2:2q11.2		 uncertain significance
NM_004418.4(DUSP2):c.794C>T (p.Ala265Val) single nucleotide variant Inborn genetic diseases [RCV002748301] Chr2:96143974 [GRCh38]
Chr2:96809713 [GRCh37]
Chr2:2q11.2		 uncertain significance
NM_004418.4(DUSP2):c.563C>T (p.Ser188Leu) single nucleotide variant Inborn genetic diseases [RCV002808502] Chr2:96144321 [GRCh38]
Chr2:96810060 [GRCh37]
Chr2:2q11.2		 uncertain significance
NM_004418.4(DUSP2):c.392G>T (p.Gly131Val) single nucleotide variant Inborn genetic diseases [RCV002855572] Chr2:96144879 [GRCh38]
Chr2:96810618 [GRCh37]
Chr2:2q11.2		 uncertain significance
NM_004418.4(DUSP2):c.826C>T (p.Arg276Cys) single nucleotide variant Inborn genetic diseases [RCV002673816] Chr2:96143942 [GRCh38]
Chr2:96809681 [GRCh37]
Chr2:2q11.2		 uncertain significance
NM_004418.4(DUSP2):c.691G>A (p.Glu231Lys) single nucleotide variant Inborn genetic diseases [RCV003200179] Chr2:96144193 [GRCh38]
Chr2:96809932 [GRCh37]
Chr2:2q11.2		 uncertain significance
NM_004418.4(DUSP2):c.742A>G (p.Asn248Asp) single nucleotide variant Inborn genetic diseases [RCV003177945] Chr2:96144026 [GRCh38]
Chr2:96809765 [GRCh37]
Chr2:2q11.2		 uncertain significance
Single allele deletion not provided [RCV003448678] Chr2:96555654..97769352 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:95773428-102550061)x3 copy number gain not provided [RCV003484069] Chr2:95773428..102550061 [GRCh37]
Chr2:2q11.1-11.2		 likely pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96732520-97671333)x3 copy number gain not provided [RCV003484070] Chr2:96732520..97671333 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96732520-99142320)x3 copy number gain not provided [RCV003484071] Chr2:96732520..99142320 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
NM_004418.4(DUSP2):c.927C>T (p.Thr309=) single nucleotide variant not provided [RCV003427132] Chr2:96143841 [GRCh38]
Chr2:96809580 [GRCh37]
Chr2:2q11.2		 likely benign
GRCh37/hg19 2q11.1-11.2(chr2:96735977-98212850)x3 copy number gain not specified [RCV003986352] Chr2:96735977..98212850 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
Single allele deletion Pheochromocytoma [RCV003986083] Chr2:96693904..96930791 [GRCh37]
Chr2:2q11.1-11.2		 uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96780545-98098961)x1 copy number loss not provided [RCV003885488] Chr2:96780545..98098961 [GRCh37]
Chr2:2q11.1-11.2		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1057
Count of miRNA genes:542
Interacting mature miRNAs:619
Transcripts:ENST00000288943, ENST00000488952
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH75846  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37296,809,278 - 96,809,523UniSTSGRCh37
Build 36296,173,005 - 96,173,250RGDNCBI36
Celera291,250,085 - 91,250,330RGD
Cytogenetic Map2q11UniSTS
HuRef290,770,555 - 90,770,800UniSTS
PMC343947P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37296,809,581 - 96,810,094UniSTSGRCh37
Build 36296,173,308 - 96,173,821RGDNCBI36
Celera291,250,388 - 91,250,901RGD
Cytogenetic Map2q11UniSTS
HuRef290,770,858 - 90,771,371UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 6 17 1 1
Medium 440 1068 649 117 1484 95 1893 116 1152 141 628 886 25 664 1021
Low 1916 1832 1042 488 435 349 2349 1962 2512 262 806 699 148 1 539 1662 3 2
Below cutoff 77 83 27 14 9 16 109 114 63 12 18 19 1 1 104 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000288943   ⟹   ENSP00000288943
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl296,143,169 - 96,145,440 (-)Ensembl
RefSeq Acc Id: ENST00000488952
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl296,143,729 - 96,144,617 (-)Ensembl
RefSeq Acc Id: NM_004418   ⟹   NP_004409
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38296,143,169 - 96,145,440 (-)NCBI
GRCh37296,808,908 - 96,811,206 (-)NCBI
Build 36296,172,638 - 96,174,906 (-)NCBI Archive
HuRef290,770,185 - 90,772,456 (-)ENTREZGENE
CHM1_1296,813,182 - 96,815,453 (-)NCBI
T2T-CHM13v2.0296,649,773 - 96,652,044 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017003546   ⟹   XP_016859035
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38296,143,169 - 96,145,440 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054340916   ⟹   XP_054196891
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0296,649,773 - 96,656,541 (-)NCBI
RefSeq Acc Id: XM_054340917   ⟹   XP_054196892
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0296,649,773 - 96,653,677 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_004409   ⟸   NM_004418
- UniProtKB: Q53T45 (UniProtKB/Swiss-Prot),   Q05923 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016859035   ⟸   XM_017003546
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000288943   ⟸   ENST00000288943
RefSeq Acc Id: XP_054196891   ⟸   XM_054340916
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054196892   ⟸   XM_054340917
- Peptide Label: isoform X3
Protein Domains
Rhodanese   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05923-F1-model_v2 AlphaFold Q05923 1-314 view protein structure

Promoters
RGD ID:6861036
Promoter ID:EPDNEW_H3683
Type:multiple initiation site
Name:DUSP2_1
Description:dual specificity phosphatase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38296,145,440 - 96,145,500EPDNEW
RGD ID:6797117
Promoter ID:HG_KWN:33917
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000252847,   OTTHUMT00000338806
Position:
Human AssemblyChrPosition (strand)Source
Build 36296,173,681 - 96,175,892 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3068 AgrOrtholog
COSMIC DUSP2 COSMIC
Ensembl Genes ENSG00000158050 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000288943 ENTREZGENE
  ENST00000288943.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot
  3.90.190.10 UniProtKB/Swiss-Prot
GTEx ENSG00000158050 GTEx
HGNC ID HGNC:3068 ENTREZGENE
Human Proteome Map DUSP2 Human Proteome Map
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot
  MKP UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  Rhodanese-like_dom UniProtKB/Swiss-Prot
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot
  Tyr_Pase_AS UniProtKB/Swiss-Prot
  Tyr_Pase_cat UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot
KEGG Report hsa:1844 UniProtKB/Swiss-Prot
NCBI Gene 1844 ENTREZGENE
OMIM 603068 OMIM
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 2 UniProtKB/Swiss-Prot
Pfam DSPc UniProtKB/Swiss-Prot
  Rhodanese UniProtKB/Swiss-Prot
PharmGKB PA27525 PharmGKB
PIRSF MAPK_Ptase UniProtKB/Swiss-Prot
PRINTS MAPKPHPHTASE UniProtKB/Swiss-Prot
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot
SMART DSPc UniProtKB/Swiss-Prot
  PTPc_motif UniProtKB/Swiss-Prot
  RHOD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot
  SSF52821 UniProtKB/Swiss-Prot
UniProt DUS2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q53T45 ENTREZGENE
UniProt Secondary Q53T45 UniProtKB/Swiss-Prot