Stac (src homology three (SH3) and cysteine rich domain) - Rat Genome Database
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Gene: Stac (src homology three (SH3) and cysteine rich domain) Mus musculus
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Symbol: Stac
Name: src homology three (SH3) and cysteine rich domain
RGD ID: 1313961
MGI Page MGI
Description: Is expressed in lens. Orthologous to human STAC (SH3 and cysteine rich domain); INTERACTS WITH benzo[a]pyrene; bis(2-ethylhexyl) phthalate; ciguatoxin CTX1B.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC130287; MGC130288; SH3 and cysteine-rich domain-containing protein; SRC homology 3 and cysteine-rich domain-containing protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399111,386,476 - 111,519,673 (-)NCBIGRCm39mm39
GRCm39 Ensembl9111,390,505 - 111,519,416 (-)Ensembl
GRCm389111,561,437 - 111,690,588 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9111,561,437 - 111,690,348 (-)EnsemblGRCm38mm10GRCm38
MGSCv379111,463,938 - 111,592,720 (-)NCBIGRCm37mm9NCBIm37
MGSCv369111,406,250 - 111,535,105 (-)NCBImm8
Celera9111,283,101 - 111,415,949 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map961.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:8954993   PMID:9465308   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12140191   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:18755693   PMID:20736085   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23818578   PMID:27149520   PMID:29467163   PMID:31118233  


Genomics

Comparative Map Data
Stac
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399111,386,476 - 111,519,673 (-)NCBIGRCm39mm39
GRCm39 Ensembl9111,390,505 - 111,519,416 (-)Ensembl
GRCm389111,561,437 - 111,690,588 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9111,561,437 - 111,690,348 (-)EnsemblGRCm38mm10GRCm38
MGSCv379111,463,938 - 111,592,720 (-)NCBIGRCm37mm9NCBIm37
MGSCv369111,406,250 - 111,535,105 (-)NCBImm8
Celera9111,283,101 - 111,415,949 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map961.81NCBI
STAC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl336,380,503 - 36,548,007 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl336,380,344 - 36,548,007 (+)EnsemblGRCh38hg38GRCh38
GRCh38336,380,343 - 36,548,007 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37336,421,996 - 36,589,499 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36336,397,101 - 36,564,500 (+)NCBINCBI36hg18NCBI36
Build 34336,397,100 - 36,564,500NCBI
Celera336,365,008 - 36,532,250 (+)NCBI
Cytogenetic Map3p22.3-p22.2NCBI
HuRef336,362,945 - 36,530,233 (+)NCBIHuRef
CHM1_1336,371,725 - 36,539,726 (+)NCBICHM1_1
Stac
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28111,530,800 - 111,653,228 (-)NCBI
Rnor_6.0 Ensembl8119,821,901 - 119,889,661 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08119,820,664 - 119,941,867 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08119,168,403 - 119,287,773 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,961,972 - 116,076,186 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18115,981,426 - 116,112,914 (-)NCBI
Celera8110,812,081 - 110,932,713 (-)NCBICelera
Cytogenetic Map8q32NCBI
Stac
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554213,325,199 - 3,471,742 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554213,325,199 - 3,471,748 (+)NCBIChiLan1.0ChiLan1.0
STAC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1336,578,543 - 36,747,971 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl336,578,543 - 36,747,971 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0336,287,485 - 36,457,151 (+)NCBIMhudiblu_PPA_v0panPan3
STAC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl236,372,257 - 6,519,748 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1236,372,337 - 6,524,334 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Stac
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647326,055,630 - 26,194,296 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11321,429,570 - 21,548,784 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21323,304,681 - 23,428,311 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STAC
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11580,742,955 - 80,906,053 (+)NCBI
ChlSab1.1 Ensembl1580,801,748 - 80,906,044 (+)Ensembl
Stac
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478814,360,682 - 14,540,035 (+)NCBI

Position Markers
RH134192  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389111,561,479 - 111,561,667UniSTSGRCm38
MGSCv379111,463,983 - 111,464,171UniSTSGRCm37
Celera9111,283,146 - 111,283,334UniSTS
Cytogenetic Map9F3UniSTS
cM Map962.0UniSTS
D86639  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389111,561,987 - 111,562,135UniSTSGRCm38
MGSCv379111,464,491 - 111,464,639UniSTSGRCm37
Celera9111,283,654 - 111,283,802UniSTS
Cytogenetic Map9F3UniSTS
cM Map962.0UniSTS
Whitehead/MRC_RH91129.65UniSTS
Stac  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389111,561,571 - 111,561,921UniSTSGRCm38
MGSCv379111,464,075 - 111,464,425UniSTSGRCm37
Celera9111,283,238 - 111,283,588UniSTS
Cytogenetic Map9F3UniSTS
cM Map962.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
13515058Adip20d_madiposity 20d (mouse)9108915010118915010Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1290
Count of miRNA genes:541
Interacting mature miRNAs:643
Transcripts:ENSMUST00000035083, ENSMUST00000161995, ENSMUST00000162345
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035083   ⟹   ENSMUSP00000035083
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9111,561,437 - 111,690,348 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161995   ⟹   ENSMUSP00000125182
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9111,561,437 - 111,690,225 (-)Ensembl
RefSeq Acc Id: ENSMUST00000162345
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9111,634,968 - 111,690,329 (-)Ensembl
RefSeq Acc Id: NM_001324546   ⟹   NP_001311475
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399111,390,505 - 111,519,416 (-)NCBI
GRCm389111,561,437 - 111,690,348 (-)NCBI
Sequence:
RefSeq Acc Id: NM_016853   ⟹   NP_058549
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399111,390,505 - 111,519,416 (-)NCBI
GRCm389111,561,437 - 111,690,348 (-)NCBI
MGSCv379111,463,938 - 111,592,720 (-)RGD
Celera9111,283,101 - 111,415,949 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006512016   ⟹   XP_006512079
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399111,386,476 - 111,519,673 (-)NCBI
GRCm389111,561,437 - 111,690,588 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058549   ⟸   NM_016853
- Peptide Label: isoform 1
- UniProtKB: P97306 (UniProtKB/Swiss-Prot),   Q3UPL9 (UniProtKB/TrEMBL),   Q3UYD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512079   ⟸   XM_006512016
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001311475   ⟸   NM_001324546
- Peptide Label: isoform 2
- UniProtKB: Q3UYD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000035083   ⟸   ENSMUST00000035083
RefSeq Acc Id: ENSMUSP00000125182   ⟸   ENSMUST00000161995
Protein Domains
Phorbol-ester/DAG-type   SH3

Promoters
RGD ID:8671064
Promoter ID:EPDNEW_M13563
Type:multiple initiation site
Name:Stac_1
Description:Mus musculus src homology three and cysteine rich domain , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389111,690,329 - 111,690,389EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1201400 AgrOrtholog
Ensembl Genes ENSMUSG00000032502 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000035083 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000125182 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035083 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000161995 UniProtKB/TrEMBL
InterPro PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAC1/2/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20840 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1201400 ENTREZGENE
NCBI Gene 20840 ENTREZGENE
PANTHER PTHR15135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15135:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stac PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F2Z462_MOUSE UniProtKB/TrEMBL
  P97306 ENTREZGENE
  Q3UPL9 ENTREZGENE, UniProtKB/TrEMBL
  Q3UYD4 ENTREZGENE, UniProtKB/TrEMBL
  STAC_MOUSE UniProtKB/Swiss-Prot