Tmem14c (transmembrane protein 14C) - Rat Genome Database

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Gene: Tmem14c (transmembrane protein 14C) Mus musculus
Analyze
Symbol: Tmem14c
Name: transmembrane protein 14C
RGD ID: 1313921
MGI Page MGI
Description: Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including erythrocyte differentiation; mitochondrial transport; and regulation of heme biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including central nervous system; hemolymphoid system; salivary gland primordium; sensory organ; and skeletal muscle. Orthologous to several human genes including TMEM14C (transmembrane protein 14C).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110021D01Rik; AU020193; HSPC1; HSPC194
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391341,169,726 - 41,176,058 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1341,169,768 - 41,176,062 (+)EnsemblGRCm39 Ensembl
GRCm381341,016,250 - 41,022,582 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1341,016,292 - 41,022,586 (+)EnsemblGRCm38mm10GRCm38
MGSCv371341,111,619 - 41,117,951 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361341,027,266 - 41,033,552 (+)NCBIMGSCv36mm8
Celera1342,098,081 - 42,104,427 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1320.25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12819125   PMID:14610273   PMID:14651853   PMID:15489334   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:18614015   PMID:19656490   PMID:21267068   PMID:21873635   PMID:24457600   PMID:25157825   PMID:26287972  


Genomics

Comparative Map Data
Tmem14c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391341,169,726 - 41,176,058 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1341,169,768 - 41,176,062 (+)EnsemblGRCm39 Ensembl
GRCm381341,016,250 - 41,022,582 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1341,016,292 - 41,022,586 (+)EnsemblGRCm38mm10GRCm38
MGSCv371341,111,619 - 41,117,951 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361341,027,266 - 41,033,552 (+)NCBIMGSCv36mm8
Celera1342,098,081 - 42,104,427 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1320.25NCBI
TMEM14C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38610,723,070 - 10,731,127 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl610,722,915 - 10,731,129 (+)EnsemblGRCh38hg38GRCh38
GRCh37610,723,303 - 10,731,360 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36610,831,324 - 10,839,348 (+)NCBINCBI36Build 36hg18NCBI36
Build 34610,831,323 - 10,839,347NCBI
Celera611,951,641 - 11,959,855 (+)NCBICelera
Cytogenetic Map6p24.2NCBI
HuRef610,598,765 - 10,606,980 (+)NCBIHuRef
CHM1_1610,725,261 - 10,733,475 (+)NCBICHM1_1
T2T-CHM13v2.0610,590,767 - 10,598,824 (+)NCBIT2T-CHM13v2.0
Tmem14c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81723,939,501 - 23,945,622 (-)NCBIGRCr8
mRatBN7.21723,733,769 - 23,739,906 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1723,733,894 - 23,753,320 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1723,603,484 - 23,609,583 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01725,206,952 - 25,213,051 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01723,544,453 - 23,550,552 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01721,571,510 - 21,577,651 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1721,571,518 - 21,577,631 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01723,554,045 - 23,560,180 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41729,701,923 - 29,708,044 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11729,706,089 - 29,710,339 (-)NCBI
Celera1723,403,979 - 23,410,100 (-)NCBICelera
Cytogenetic Map17p12NCBI
Tmem14c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554653,621,652 - 3,628,355 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554653,621,652 - 3,628,355 (-)NCBIChiLan1.0ChiLan1.0
TMEM14C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2525,372,617 - 25,380,768 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1621,362,090 - 21,370,454 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0610,564,011 - 10,572,177 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1610,843,062 - 10,851,278 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl610,843,062 - 10,851,278 (+)Ensemblpanpan1.1panPan2
LOC478720
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13510,454,501 - 10,462,296 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3510,403,361 - 10,411,166 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03510,558,831 - 10,566,639 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13510,387,855 - 10,395,670 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03510,435,099 - 10,442,904 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03511,755,626 - 11,763,442 (+)NCBIUU_Cfam_GSD_1.0
Tmem14c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494613,964,481 - 13,971,237 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365342,233,467 - 2,240,223 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100517166
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.177,462,187 - 7,530,881 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.277,774,429 - 7,781,646 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103222178
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11761,416,703 - 61,424,884 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236691521,292 - 5,427 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem14c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475615,179,801 - 15,187,475 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem14c
213 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:136
Interacting mature miRNAs:139
Transcripts:ENSMUST00000021790
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse

Markers in Region
RH136375  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381736,194,353 - 36,194,558UniSTSGRCm38
GRCm381341,022,195 - 41,022,397UniSTSGRCm38
MGSCv371341,117,564 - 41,117,766UniSTSGRCm37
MGSCv371736,331,298 - 36,331,503UniSTSGRCm37
Celera1342,104,040 - 42,104,242UniSTS
Cytogenetic Map13A3.3UniSTS
Cytogenetic Map17B1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001360770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_025387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006516938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC133496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK019395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY785978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO039120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000021790   ⟹   ENSMUSP00000021790
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1341,169,768 - 41,176,062 (+)Ensembl
GRCm38.p6 Ensembl1341,016,292 - 41,022,586 (+)Ensembl
RefSeq Acc Id: NM_001360770   ⟹   NP_001347699
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391341,169,726 - 41,176,058 (+)NCBI
GRCm381341,016,250 - 41,022,582 (+)NCBI
Sequence:
RefSeq Acc Id: NM_025387   ⟹   NP_079663
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391341,169,726 - 41,176,058 (+)NCBI
GRCm381341,016,250 - 41,022,582 (+)ENTREZGENE
MGSCv371341,111,619 - 41,117,951 (+)RGD
Celera1342,098,081 - 42,104,427 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516938   ⟹   XP_006517001
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391341,169,732 - 41,176,058 (+)NCBI
GRCm381341,016,256 - 41,022,582 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_079663   ⟸   NM_025387
- Peptide Label: isoform 1
- UniProtKB: Q543H6 (UniProtKB/Swiss-Prot),   Q9D849 (UniProtKB/Swiss-Prot),   Q9CQN6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006517001   ⟸   XM_006516938
- Peptide Label: isoform X1
- UniProtKB: Q8C297 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001347699   ⟸   NM_001360770
- Peptide Label: isoform 2
- UniProtKB: Q8C297 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000021790   ⟸   ENSMUST00000021790

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CQN6-F1-model_v2 AlphaFold Q9CQN6 1-114 view protein structure

Promoters
RGD ID:8680160
Promoter ID:EPDNEW_M18111
Type:initiation region
Name:Tmem14c_1
Description:Mus musculus transmembrane protein 14C , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381341,016,302 - 41,016,362EPDNEW
RGD ID:6824445
Promoter ID:MM_KWN:13888
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000021790,   UC007QEU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361341,110,826 - 41,112,127 (+)MPROMDB
RGD ID:6849020
Promoter ID:MM_XEF:1848
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   BoneMarrow_0Hour,   Liver,   Spleen
Transcripts:NM_001035437,   NM_001135545,   NM_001165258,   NM_016462,   NM_134395
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361341,112,176 - 41,112,676 (+)MPROMDB
RGD ID:6847088
Promoter ID:MM_ACW:12988
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:STONO.ASEP07-UNSPLICED,   TMEM14C.FSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361341,116,271 - 41,116,771 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913404 AgrOrtholog
Ensembl Genes ENSMUSG00000021361 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021790 ENTREZGENE
  ENSMUST00000021790.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.1740 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TMEM14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TMEM14_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66154 UniProtKB/Swiss-Prot
MGD MGI:1913404 ENTREZGENE
NCBI Gene 66154 ENTREZGENE
PANTHER PTHR12668 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 14C-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tmemb_14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmem14c PhenoGen
UniProt Q543H6 ENTREZGENE
  Q8C297 ENTREZGENE, UniProtKB/TrEMBL
  Q9CQN6 ENTREZGENE
  Q9D849 ENTREZGENE
  TM14C_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q543H6 UniProtKB/Swiss-Prot
  Q9D849 UniProtKB/Swiss-Prot