ETF1 (eukaryotic translation termination factor 1) - Rat Genome Database

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Gene: ETF1 (eukaryotic translation termination factor 1) Homo sapiens
Analyze
Symbol: ETF1
Name: eukaryotic translation termination factor 1
RGD ID: 1313906
HGNC Page HGNC:3477
Description: Enables aminoacyl-tRNA hydrolase activity; sequence-specific mRNA binding activity; and translation release factor activity. Involved in regulation of translational termination. Acts upstream of or within translational termination. Located in cytoplasm. Part of translation release factor complex. Is active in cytosolic ribosome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: D5S1995; ERF; ERF1; eukaryotic peptide chain release factor subunit 1; eukaryotic release factor 1; MGC111066; polypeptide chain release factor 1; protein Cl1; RF1; sup45 (yeast omnipotent suppressor 45) homolog-like 1; SUP45L1; TB3-1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: ETF1P1   ETF1P2   ETF1P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,506,095 - 138,543,236 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,506,095 - 138,543,236 (-)EnsemblGRCh38hg38GRCh38
GRCh375137,841,784 - 137,878,925 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,869,687 - 137,906,802 (-)NCBINCBI36Build 36hg18NCBI36
Build 345137,869,686 - 137,906,802NCBI
Celera5133,963,667 - 134,000,818 (-)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5133,032,353 - 133,069,485 (-)NCBIHuRef
CHM1_15137,274,606 - 137,311,379 (-)NCBICHM1_1
T2T-CHM13v2.05139,032,342 - 139,069,467 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (ISO)
2-methoxyethanol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
Benoxacor  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
copper(II) sulfate  (EXP)
cyclosporin A  (EXP)
deguelin  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
estriol  (ISO)
flutamide  (ISO)
folic acid  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
isoprenaline  (ISO)
ivermectin  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
methidathion  (ISO)
methimazole  (ISO)
methyl methanesulfonate  (EXP)
nefazodone  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (EXP)
sodium dichromate  (ISO)
Soman  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
sunitinib  (EXP)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA,NAS,TAS)
cytosol  (IBA,IEA,TAS)
cytosolic ribosome  (IDA)
nucleus  (IDA)
translation release factor complex  (IBA,IDA,IEA,IPI)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The elongation, termination, and recycling phases of translation in eukaryotes. Dever TE and Green R, Cold Spring Harb Perspect Biol. 2012 Jul 1;4(7):a013706. doi: 10.1101/cshperspect.a013706.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1537561   PMID:1546371   PMID:7759135   PMID:7990965   PMID:9003791   PMID:9620853   PMID:9712840   PMID:9928949   PMID:10413110   PMID:10445876   PMID:10676813   PMID:10702684  
PMID:10773672   PMID:11358506   PMID:11779511   PMID:11790298   PMID:12356746   PMID:12426392   PMID:12477932   PMID:12665801   PMID:12867083   PMID:12909007   PMID:15174051   PMID:15326224  
PMID:15489334   PMID:15635413   PMID:15716307   PMID:16189514   PMID:16282590   PMID:16341674   PMID:16344560   PMID:16452507   PMID:16777602   PMID:16797113   PMID:18056425   PMID:18187620  
PMID:18256688   PMID:18447585   PMID:18539146   PMID:19140327   PMID:19265422   PMID:19417105   PMID:19615732   PMID:20418372   PMID:20688868   PMID:21602268   PMID:21873635   PMID:22383581  
PMID:22517631   PMID:22658674   PMID:22863883   PMID:22990118   PMID:23091004   PMID:23435318   PMID:24163370   PMID:24335085   PMID:24486019   PMID:24797263   PMID:25056061   PMID:25416956  
PMID:25437307   PMID:25659154   PMID:25735746   PMID:26186194   PMID:26245381   PMID:26344197   PMID:26496610   PMID:26655225   PMID:26673895   PMID:26725946   PMID:26777405   PMID:27371349  
PMID:27565346   PMID:27684187   PMID:27863242   PMID:28514442   PMID:28515276   PMID:28700943   PMID:29127299   PMID:29128334   PMID:29395067   PMID:29509190   PMID:29511261   PMID:30021884  
PMID:30463901   PMID:30575818   PMID:30658672   PMID:30682371   PMID:30948266   PMID:31091453   PMID:31116665   PMID:31452512   PMID:31871319   PMID:31950832   PMID:31980649   PMID:32059759  
PMID:32129710   PMID:32296183   PMID:32416067   PMID:32529326   PMID:32614325   PMID:32687490   PMID:32941674   PMID:32994395   PMID:33226137   PMID:33239621   PMID:33916271   PMID:33961781  
PMID:34272367   PMID:34315543   PMID:34373451   PMID:34591612   PMID:34709727   PMID:35008187   PMID:35256949   PMID:35271311   PMID:35384245   PMID:35439318   PMID:35509820   PMID:35763353  
PMID:35831314   PMID:35944360   PMID:36215168   PMID:36217030   PMID:36398858   PMID:36424410   PMID:36526897   PMID:36597993   PMID:36638793   PMID:37827155  


Genomics

Comparative Map Data
ETF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,506,095 - 138,543,236 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,506,095 - 138,543,236 (-)EnsemblGRCh38hg38GRCh38
GRCh375137,841,784 - 137,878,925 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,869,687 - 137,906,802 (-)NCBINCBI36Build 36hg18NCBI36
Build 345137,869,686 - 137,906,802NCBI
Celera5133,963,667 - 134,000,818 (-)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5133,032,353 - 133,069,485 (-)NCBIHuRef
CHM1_15137,274,606 - 137,311,379 (-)NCBICHM1_1
T2T-CHM13v2.05139,032,342 - 139,069,467 (-)NCBIT2T-CHM13v2.0
Etf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391835,035,838 - 35,065,060 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1835,035,838 - 35,065,060 (-)EnsemblGRCm39 Ensembl
GRCm381834,902,785 - 34,932,008 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,902,785 - 34,932,007 (-)EnsemblGRCm38mm10GRCm38
MGSCv371835,062,439 - 35,091,657 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361835,029,893 - 35,057,927 (-)NCBIMGSCv36mm8
Celera1835,357,083 - 35,386,323 (-)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.78NCBI
Etf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,776,518 - 26,804,857 (-)NCBIGRCr8
mRatBN7.21826,502,413 - 26,530,753 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,504,080 - 26,530,810 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,631,118 - 26,658,118 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01827,394,786 - 27,421,871 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,729,671 - 26,756,759 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,698,693 - 27,725,694 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,698,695 - 27,725,694 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,409,448 - 27,436,622 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,386,539 - 27,413,545 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,413,186 - 27,440,191 (-)NCBI
Celera1826,240,446 - 26,267,428 (-)NCBICelera
Cytogenetic Map18p12NCBI
Etf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554181,943,233 - 1,974,241 (+)NCBIChiLan1.0ChiLan1.0
ETF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24133,781,540 - 133,818,141 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,921,094 - 131,957,688 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,886,074 - 133,922,682 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15140,015,518 - 140,052,063 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5140,015,518 - 140,051,974 (-)Ensemblpanpan1.1panPan2
ETF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11126,078,611 - 26,110,805 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,080,478 - 26,110,894 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,849,760 - 24,879,852 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,934,917 - 26,967,373 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,934,919 - 26,967,344 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,643,833 - 25,674,484 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,466,681 - 25,497,013 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01126,130,745 - 26,160,981 (-)NCBIUU_Cfam_GSD_1.0
Etf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213153,917,982 - 153,947,623 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,663,882 - 7,693,549 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365317,665,246 - 7,693,563 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ETF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,469,306 - 140,504,287 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,471,931 - 140,504,381 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22146,186,588 - 146,219,180 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ETF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12341,180,547 - 41,219,125 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603436,667,090 - 36,706,807 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Etf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474331,280,547 - 31,313,086 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ETF1
4 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
GRCh38/hg38 5q31.1-31.3(chr5:135297294-140106003)x3 copy number gain See cases [RCV000133750] Chr5:135297294..140106003 [GRCh38]
Chr5:134632984..139485588 [GRCh37]
Chr5:134660883..139465772 [NCBI36]
Chr5:5q31.1-31.3
pathogenic
GRCh38/hg38 5q31.2-31.3(chr5:137836682-140696361)x3 copy number gain See cases [RCV000134725] Chr5:137836682..140696361 [GRCh38]
Chr5:137172371..140075946 [GRCh37]
Chr5:137200270..140056130 [NCBI36]
Chr5:5q31.2-31.3
pathogenic
GRCh38/hg38 5q31.2(chr5:138179894-139039890)x3 copy number gain See cases [RCV000135679] Chr5:138179894..139039890 [GRCh38]
Chr5:137515583..138375579 [GRCh37]
Chr5:137543482..138403478 [NCBI36]
Chr5:5q31.2
uncertain significance
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV002231249]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
GRCh37/hg19 5q31.2(chr5:137865800-139097368)x1 copy number loss not provided [RCV000846144] Chr5:137865800..139097368 [GRCh37]
Chr5:5q31.2
pathogenic
GRCh37/hg19 5q31.2(chr5:137754277-138994590)x1 copy number loss not provided [RCV001270645] Chr5:137754277..138994590 [GRCh37]
Chr5:5q31.2
likely pathogenic
NC_000005.9:g.(?_136633338)_(140998481_?)dup duplication PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome [RCV001339088] Chr5:136633338..140998481 [GRCh37]
Chr5:5q31.2-31.3
uncertain significance
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910) copy number gain not specified [RCV002053526] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
NC_000005.9:g.(?_136957787)_(140078137_?)dup duplication PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome [RCV003116437] Chr5:136957787..140078137 [GRCh37]
Chr5:5q31.2-31.3
uncertain significance
NC_000005.9:g.(?_136957787)_(138861289_?)del deletion STING-associated vasculopathy with onset in infancy [RCV003113978] Chr5:136957787..138861289 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_004730.4(ETF1):c.722T>C (p.Met241Thr) single nucleotide variant Inborn genetic diseases [RCV003200206] Chr5:138512774 [GRCh38]
Chr5:137848463 [GRCh37]
Chr5:5q31.2
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3319
Count of miRNA genes:1023
Interacting mature miRNAs:1259
Transcripts:ENST00000360541, ENST00000499810, ENST00000503014, ENST00000503183, ENST00000506345, ENST00000507939, ENST00000512198, ENST00000514005, ENST00000572514
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D5S500  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,846,950 - 137,847,161UniSTSGRCh37
GRCh375137,846,893 - 137,847,160UniSTSGRCh37
Build 365137,874,849 - 137,875,060RGDNCBI36
Celera5133,968,773 - 133,969,040UniSTS
Celera5133,968,830 - 133,969,041RGD
Cytogenetic Map5q31.1UniSTS
HuRef5133,037,459 - 133,037,726UniSTS
HuRef5133,037,516 - 133,037,727UniSTS
Marshfield Genetic Map5140.72RGD
Genethon Genetic Map5141.4UniSTS
deCODE Assembly Map5138.96UniSTS
Stanford-G3 RH Map55189.0UniSTS
GeneMap99-GB4 RH Map5522.43UniSTS
Whitehead-RH Map5433.8UniSTS
Whitehead-YAC Contig Map5 UniSTS
GeneMap99-G3 RH Map55277.0UniSTS
RH79934  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,000,779 - 30,000,969UniSTSGRCh37
GRCh375137,843,805 - 137,843,995UniSTSGRCh37
Build 365137,871,704 - 137,871,894RGDNCBI36
Celera631,599,004 - 31,599,194UniSTS
Celera5133,965,688 - 133,965,878RGD
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map6p22.1UniSTS
HuRef629,798,930 - 29,799,120UniSTS
HuRef5133,034,376 - 133,034,566UniSTS
RH41003  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,001,341 - 30,001,539UniSTSGRCh37
GRCh375137,843,230 - 137,843,428UniSTSGRCh37
Build 365137,871,129 - 137,871,327RGDNCBI36
Celera631,599,566 - 31,599,764UniSTS
Celera5133,965,113 - 133,965,311RGD
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map6p22.1UniSTS
HuRef629,799,492 - 29,799,690UniSTS
HuRef5133,033,801 - 133,033,999UniSTS
RH80626  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q31.1UniSTS
D5S500  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q31.1UniSTS
Marshfield Genetic Map5140.72UniSTS
Genethon Genetic Map5141.4UniSTS
deCODE Assembly Map5138.96UniSTS
GeneMap99-GB4 RH Map5522.43UniSTS
Whitehead-RH Map5433.8UniSTS
Whitehead-YAC Contig Map5 UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2434 2840 1698 599 1885 440 4355 2115 3582 414 1455 1609 173 1204 2788 6 2
Low 5 151 28 25 66 25 1 82 152 5 5 4 2 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001256302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001364160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_157090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047416930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047416931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047416932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC011385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC113403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF095901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL553004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW131045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI460904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM819293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB060174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC297662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M75715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U90176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X80916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X81625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000360541   ⟹   ENSP00000353741
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,506,095 - 138,543,236 (-)Ensembl
RefSeq Acc Id: ENST00000499810   ⟹   ENSP00000421288
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,506,095 - 138,543,229 (-)Ensembl
RefSeq Acc Id: ENST00000503014   ⟹   ENSP00000422203
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,507,990 - 138,541,711 (-)Ensembl
RefSeq Acc Id: ENST00000503183
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,512,699 - 138,517,641 (-)Ensembl
RefSeq Acc Id: ENST00000506345
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,511,104 - 138,517,662 (-)Ensembl
RefSeq Acc Id: ENST00000507939   ⟹   ENSP00000425689
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,513,651 - 138,543,209 (-)Ensembl
RefSeq Acc Id: ENST00000512198   ⟹   ENSP00000422272
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,511,525 - 138,543,151 (-)Ensembl
RefSeq Acc Id: ENST00000514005
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,517,561 - 138,541,686 (-)Ensembl
RefSeq Acc Id: ENST00000572514   ⟹   ENSP00000461082
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,512,772 - 138,543,216 (-)Ensembl
RefSeq Acc Id: NM_001256302   ⟹   NP_001243231
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,506,095 - 138,543,236 (-)NCBI
HuRef5133,032,353 - 133,069,485 (-)NCBI
CHM1_15137,274,606 - 137,311,379 (-)NCBI
T2T-CHM13v2.05139,032,342 - 139,069,467 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001282185   ⟹   NP_001269114
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,506,095 - 138,541,711 (-)NCBI
HuRef5133,032,353 - 133,069,485 (-)NCBI
CHM1_15137,274,606 - 137,309,790 (-)NCBI
T2T-CHM13v2.05139,032,342 - 139,067,944 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001291974   ⟹   NP_001278903
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,506,095 - 138,541,711 (-)NCBI
CHM1_15137,274,606 - 137,309,790 (-)NCBI
T2T-CHM13v2.05139,032,342 - 139,067,944 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001291975   ⟹   NP_001278904
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,506,095 - 138,543,236 (-)NCBI
CHM1_15137,274,606 - 137,311,379 (-)NCBI
T2T-CHM13v2.05139,032,342 - 139,069,467 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001364160   ⟹   NP_001351089
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,506,095 - 138,543,236 (-)NCBI
T2T-CHM13v2.05139,032,342 - 139,069,467 (-)NCBI
Sequence:
RefSeq Acc Id: NM_004730   ⟹   NP_004721
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,506,095 - 138,543,236 (-)NCBI
GRCh375137,841,782 - 137,878,989 (-)NCBI
Build 365137,869,687 - 137,906,802 (-)NCBI Archive
HuRef5133,032,353 - 133,069,485 (-)NCBI
CHM1_15137,274,606 - 137,311,379 (-)NCBI
T2T-CHM13v2.05139,032,342 - 139,069,467 (-)NCBI
Sequence:
RefSeq Acc Id: NR_157090
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,506,095 - 138,543,236 (-)NCBI
T2T-CHM13v2.05139,032,342 - 139,069,467 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047416930   ⟹   XP_047272886
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,506,095 - 138,542,943 (-)NCBI
RefSeq Acc Id: XM_047416931   ⟹   XP_047272887
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,506,095 - 138,542,943 (-)NCBI
RefSeq Acc Id: XM_047416932   ⟹   XP_047272888
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,506,095 - 138,542,943 (-)NCBI
RefSeq Acc Id: XM_054352046   ⟹   XP_054208021
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05139,032,342 - 139,069,167 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001243231 (Get FASTA)   NCBI Sequence Viewer  
  NP_001269114 (Get FASTA)   NCBI Sequence Viewer  
  NP_001278903 (Get FASTA)   NCBI Sequence Viewer  
  NP_001278904 (Get FASTA)   NCBI Sequence Viewer  
  NP_001351089 (Get FASTA)   NCBI Sequence Viewer  
  NP_004721 (Get FASTA)   NCBI Sequence Viewer  
  XP_047272886 (Get FASTA)   NCBI Sequence Viewer  
  XP_047272887 (Get FASTA)   NCBI Sequence Viewer  
  XP_047272888 (Get FASTA)   NCBI Sequence Viewer  
  XP_054208021 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA36665 (Get FASTA)   NCBI Sequence Viewer  
  AAB49726 (Get FASTA)   NCBI Sequence Viewer  
  AAD43966 (Get FASTA)   NCBI Sequence Viewer  
  AAH14269 (Get FASTA)   NCBI Sequence Viewer  
  AAH88358 (Get FASTA)   NCBI Sequence Viewer  
  AAP36038 (Get FASTA)   NCBI Sequence Viewer  
  BAG35411 (Get FASTA)   NCBI Sequence Viewer  
  BAH13684 (Get FASTA)   NCBI Sequence Viewer  
  CAA57281 (Get FASTA)   NCBI Sequence Viewer  
  EAW62130 (Get FASTA)   NCBI Sequence Viewer  
  EAW62131 (Get FASTA)   NCBI Sequence Viewer  
  EAW62132 (Get FASTA)   NCBI Sequence Viewer  
  EAW62133 (Get FASTA)   NCBI Sequence Viewer  
  EAW62134 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000353741
  ENSP00000353741.5
  ENSP00000421288
  ENSP00000421288.1
  ENSP00000422203
  ENSP00000422203.1
  ENSP00000422272.1
  ENSP00000425689.1
  ENSP00000461082.1
GenBank Protein P62495 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_004721   ⟸   NM_004730
- Peptide Label: isoform 1
- UniProtKB: Q5M7Z7 (UniProtKB/Swiss-Prot),   P46055 (UniProtKB/Swiss-Prot),   D3DQC1 (UniProtKB/Swiss-Prot),   B2R6B4 (UniProtKB/Swiss-Prot),   Q96CG1 (UniProtKB/Swiss-Prot),   P62495 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001243231   ⟸   NM_001256302
- Peptide Label: isoform 2
- UniProtKB: P62495 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001269114   ⟸   NM_001282185
- Peptide Label: isoform 3
- UniProtKB: B7Z7P8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278904   ⟸   NM_001291975
- Peptide Label: isoform 2
- UniProtKB: P62495 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001278903   ⟸   NM_001291974
- Peptide Label: isoform 2
- UniProtKB: P62495 (UniProtKB/Swiss-Prot),   B7Z7P8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001351089   ⟸   NM_001364160
- Peptide Label: isoform 2
RefSeq Acc Id: ENSP00000422203   ⟸   ENST00000503014
RefSeq Acc Id: ENSP00000353741   ⟸   ENST00000360541
RefSeq Acc Id: ENSP00000425689   ⟸   ENST00000507939
RefSeq Acc Id: ENSP00000461082   ⟸   ENST00000572514
RefSeq Acc Id: ENSP00000421288   ⟸   ENST00000499810
RefSeq Acc Id: ENSP00000422272   ⟸   ENST00000512198
RefSeq Acc Id: XP_047272888   ⟸   XM_047416932
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047272886   ⟸   XM_047416930
- Peptide Label: isoform X1
- UniProtKB: Q5M7Z7 (UniProtKB/Swiss-Prot),   P62495 (UniProtKB/Swiss-Prot),   P46055 (UniProtKB/Swiss-Prot),   D3DQC1 (UniProtKB/Swiss-Prot),   B2R6B4 (UniProtKB/Swiss-Prot),   Q96CG1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047272887   ⟸   XM_047416931
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054208021   ⟸   XM_054352046
- Peptide Label: isoform X3
Protein Domains
eRF1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62495-F1-model_v2 AlphaFold P62495 1-437 view protein structure

Promoters
RGD ID:6812705
Promoter ID:HG_ACW:65460
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:ETF1.CAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 365137,905,419 - 137,905,919 (-)MPROMDB
RGD ID:6803176
Promoter ID:HG_KWN:51211
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_004730,   UC003LDD.2,   UC010JEX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 365137,906,666 - 137,907,267 (-)MPROMDB
RGD ID:6870710
Promoter ID:EPDNEW_H8520
Type:initiation region
Name:ETF1_1
Description:eukaryotic translation termination factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,543,165 - 138,543,225EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3477 AgrOrtholog
COSMIC ETF1 COSMIC
Ensembl Genes ENSG00000120705 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000360541 ENTREZGENE
  ENST00000360541.10 UniProtKB/Swiss-Prot
  ENST00000499810 ENTREZGENE
  ENST00000499810.6 UniProtKB/Swiss-Prot
  ENST00000503014 ENTREZGENE
  ENST00000503014.5 UniProtKB/TrEMBL
  ENST00000507939.5 UniProtKB/TrEMBL
  ENST00000512198.1 UniProtKB/TrEMBL
  ENST00000572514.5 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1330.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.960.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000120705 GTEx
HGNC ID HGNC:3477 ENTREZGENE
Human Proteome Map ETF1 Human Proteome Map
InterPro eFR1_2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  eRF1_1_Pelota UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  eRF1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  eRF1_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L30e-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptide_chain-rel_eRF1/aRF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Release_factor_eRF1/aRF1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2107 UniProtKB/Swiss-Prot
NCBI Gene 2107 ENTREZGENE
OMIM 600285 OMIM
PANTHER EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1 UniProtKB/Swiss-Prot
  EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1 UniProtKB/TrEMBL
  EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1 UniProtKB/TrEMBL
  PTHR10113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam eRF1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  eRF1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  eRF1_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27893 PharmGKB
SMART eRF1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55315 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55481 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Translational machinery components UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2R6B4 ENTREZGENE
  B7Z7P8 ENTREZGENE, UniProtKB/TrEMBL
  D3DQC1 ENTREZGENE
  D6RCB3_HUMAN UniProtKB/TrEMBL
  D6RJE8_HUMAN UniProtKB/TrEMBL
  ERF1_HUMAN UniProtKB/Swiss-Prot
  I3L492_HUMAN UniProtKB/TrEMBL
  P46055 ENTREZGENE
  P62495 ENTREZGENE
  Q5M7Z7 ENTREZGENE
  Q96CG1 ENTREZGENE
UniProt Secondary B2R6B4 UniProtKB/Swiss-Prot
  D3DQC1 UniProtKB/Swiss-Prot
  P46055 UniProtKB/Swiss-Prot
  Q5M7Z7 UniProtKB/Swiss-Prot
  Q96CG1 UniProtKB/Swiss-Prot