Hsh2d (hematopoietic SH2 domain containing) - Rat Genome Database
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Gene: Hsh2d (hematopoietic SH2 domain containing) Mus musculus
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Symbol: Hsh2d
Name: hematopoietic SH2 domain containing
RGD ID: 1313877
MGI Page MGI
Description: Exhibits protein-macromolecule adaptor activity. Involved in T cell activation; negative regulation of B cell apoptotic process; and negative regulation of mitochondrial depolarization. Localizes to cytosol and mitochondrion. Is expressed in spleen and thymus. Orthologous to human HSH2D (hematopoietic SH2 domain containing); INTERACTS WITH 1,2-dimethylhydrazine; buta-1,3-diene; carbon nanotube.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: A; adaptor in lymphocytes of unknown function X; adaptor protein ALx2; ALX; hematopoietic SH2 domain-containing protein; hematopoietic SH2 protein; Hsh; Hsh2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,943,512 - 72,954,802 (+)NCBIGRCm39mm39
GRCm38872,189,668 - 72,200,958 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,189,638 - 72,201,527 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,713,567 - 74,724,857 (+)NCBIGRCm37mm9NCBIm37
MGSCv36875,118,657 - 75,129,947 (+)NCBImm8
Celera876,545,344 - 76,556,622 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IDA)
mitochondrion  (IDA)

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12960172   PMID:15489334   PMID:15569688   PMID:16141072   PMID:16141073   PMID:16547253  
PMID:16602821   PMID:16880512   PMID:17641043   PMID:21677750   PMID:21873522   PMID:21873635  


Genomics

Comparative Map Data
Hsh2d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,943,512 - 72,954,802 (+)NCBIGRCm39mm39
GRCm38872,189,668 - 72,200,958 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,189,638 - 72,201,527 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,713,567 - 74,724,857 (+)NCBIGRCm37mm9NCBIm37
MGSCv36875,118,657 - 75,129,947 (+)NCBImm8
Celera876,545,344 - 76,556,622 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
HSH2D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1916,134,028 - 16,158,575 (+)EnsemblGRCh38hg38GRCh38
GRCh381916,134,028 - 16,158,575 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371916,244,838 - 16,269,381 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361916,105,838 - 16,130,381 (+)NCBINCBI36hg18NCBI36
Build 341916,105,837 - 16,130,375NCBI
Celera1916,146,791 - 16,171,332 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1915,815,784 - 15,840,224 (+)NCBIHuRef
CHM1_11916,244,333 - 16,268,885 (+)NCBICHM1_1
Hsh2d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01619,336,400 - 19,349,868 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,336,271 - 19,349,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,194,746 - 19,207,770 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,060,515 - 18,072,470 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11618,060,512 - 18,068,141 (-)NCBI
Celera1617,849,742 - 17,862,624 (-)NCBICelera
Cytogenetic Map16p14NCBI
Hsh2d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555241,392,805 - 1,399,662 (-)NCBIChiLan1.0ChiLan1.0
HSH2D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11916,611,480 - 16,624,500 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1916,611,500 - 16,624,500 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01915,629,688 - 15,643,636 (+)NCBIMhudiblu_PPA_v0panPan3
HSH2D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2046,319,315 - 46,326,600 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12046,319,410 - 46,329,997 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Hsh2d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365964,371,480 - 4,376,985 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSH2D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl261,418,055 - 61,450,336 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1261,418,042 - 61,430,795 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2261,050,327 - 61,056,981 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSH2D
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl614,649,814 - 14,660,089 (+)Ensembl
ChlSab1.1614,644,424 - 14,660,859 (+)NCBI
Hsh2d
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,108,552 - 1,116,615 (-)NCBI

Position Markers
D8Mit359  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38872,193,080 - 72,193,226UniSTSGRCm38
MGSCv37874,716,979 - 74,717,125UniSTSGRCm37
Celera876,548,756 - 76,548,898UniSTS
Cytogenetic Map8B3.3UniSTS
cM Map834.0UniSTS
Whitehead Genetic836.1UniSTS
Whitehead/MRC_RH8774.95UniSTS
Whitehead_YAC8 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:283
Count of miRNA genes:153
Interacting mature miRNAs:157
Transcripts:ENSMUST00000072097, ENSMUST00000165324
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000072097   ⟹   ENSMUSP00000071970
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,189,638 - 72,201,527 (+)Ensembl
RefSeq Acc Id: ENSMUST00000165324   ⟹   ENSMUSP00000127575
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,193,443 - 72,200,995 (+)Ensembl
RefSeq Acc Id: NM_197944   ⟹   NP_922935
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,943,512 - 72,954,802 (+)NCBI
GRCm38872,189,668 - 72,200,958 (+)ENTREZGENE
MGSCv37874,713,567 - 74,724,857 (+)RGD
Celera876,545,344 - 76,556,622 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_922935 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH94291 (Get FASTA)   NCBI Sequence Viewer  
  AAQ81286 (Get FASTA)   NCBI Sequence Viewer  
  BAE33927 (Get FASTA)   NCBI Sequence Viewer  
  EDL10788 (Get FASTA)   NCBI Sequence Viewer  
  Q6VYH9 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_922935   ⟸   NM_197944
- UniProtKB: Q6VYH9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000071970   ⟸   ENSMUST00000072097
RefSeq Acc Id: ENSMUSP00000127575   ⟸   ENSMUST00000165324
Protein Domains
SH2

Promoters
RGD ID:8667457
Promoter ID:EPDNEW_M11760
Type:initiation region
Name:Hsh2d_1
Description:Mus musculus hematopoietic SH2 domain containing , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38872,189,638 - 72,189,698EPDNEW
RGD ID:6843306
Promoter ID:MM_KWN:54856
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:ENSMUST00000072097
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,713,329 - 74,713,829 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2676364 AgrOrtholog
Ensembl Genes ENSMUSG00000062007 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000071970 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000127575 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000072097 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000165324 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
InterPro HSH2D UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:209488 UniProtKB/Swiss-Prot
MGD MGI:2676364 ENTREZGENE
NCBI Gene 209488 ENTREZGENE
PANTHER PTHR14388:SF3 UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot
PhenoGen Hsh2d PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot
SMART SH2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55550 UniProtKB/Swiss-Prot
UniGene Mm.157431 ENTREZGENE
UniProt HSH2D_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q52KL3 UniProtKB/Swiss-Prot