CMTM7 (CKLF like MARVEL transmembrane domain containing 7)

Gene: CMTM7 (CKLF like MARVEL transmembrane domain containing 7) Homo sapiens

Analyze

Symbol:

CMTM7

Name:

CKLF like MARVEL transmembrane domain containing 7

RGD ID:

1313855

HGNC Page

HGNC:19178

Description:

Predicted to enable cytokine activity. Predicted to be involved in chemotaxis and signal transduction. Predicted to act upstream of or within B-1a B cell differentiation. Located in membrane.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

chemokine-like factor super family 7; chemokine-like factor super family member 7 variant 2; chemokine-like factor superfamily 7; chemokine-like factor superfamily member 7; CKLF-like MARVEL transmembrane domain containing 7; CKLF-like MARVEL transmembrane domain-containing protein 7; CKLFSF7; FLJ30992

RGD Orthologs

Alliance Genes

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	32,391,853 - 32,455,528 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	32,391,698 - 32,483,067 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	32,433,345 - 32,497,020 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	32,408,167 - 32,471,337 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	32,408,166 - 32,471,337	NCBI
Celera	3	32,370,594 - 32,433,419 (+)	NCBI		Celera
Cytogenetic Map	3	p22.3	NCBI
HuRef	3	32,368,696 - 32,431,820 (+)	NCBI		HuRef
CHM1_1	3	32,383,146 - 32,446,330 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	32,388,830 - 32,452,466 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP)

2-butoxyethanol (ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (ISO)

all-trans-retinoic acid (EXP,ISO)

amiodarone (EXP)

antirheumatic drug (EXP)

arsane (EXP)

arsenic atom (EXP)

atrazine (EXP)

avobenzone (EXP)

benzo[a]pyrene (EXP,ISO)

bisphenol A (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (EXP)

cobalt dichloride (EXP)

copper atom (EXP)

copper(0) (EXP)

crotonaldehyde (EXP)

Cuprizon (ISO)

diuron (ISO)

dorsomorphin (EXP)

doxorubicin (EXP)

endosulfan (ISO)

folic acid (ISO)

fulvestrant (EXP)

genistein (EXP)

ketoconazole (EXP)

L-methionine (ISO)

lead(0) (EXP)

methyl methanesulfonate (EXP)

nickel atom (EXP)

Octicizer (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (EXP)

quercetin (EXP)

SB 431542 (EXP)

sodium arsenate (EXP,ISO)

sodium arsenite (ISO)

Soman (ISO)

temozolomide (EXP)

tetrachloromethane (ISO)

thioacetamide (ISO)

trichostatin A (EXP)

tunicamycin (EXP)

valproic acid (EXP)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B-1a B cell differentiation (IEA,ISO)

chemotaxis (IEA)

signal transduction (IEA)

Cellular Component

extracellular space (IEA)

membrane (HDA,IEA)

Molecular Function

cytokine activity (IEA)

protein binding (IPI)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:12782130	PMID:14702039	PMID:15489334	PMID:19946888	PMID:20400778	PMID:21873635	PMID:22363743	PMID:23893243	PMID:23981602	PMID:24623722	PMID:26528697
PMID:30392914	PMID:30903681	PMID:32111069	PMID:32296183	PMID:32568178	PMID:34281589	PMID:34294040	PMID:36829181	PMID:37616343

Genomics

Comparative Map Data

CMTM7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	32,391,853 - 32,455,528 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	32,391,698 - 32,483,067 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	32,433,345 - 32,497,020 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	32,408,167 - 32,471,337 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	32,408,166 - 32,471,337	NCBI
Celera	3	32,370,594 - 32,433,419 (+)	NCBI		Celera
Cytogenetic Map	3	p22.3	NCBI
HuRef	3	32,368,696 - 32,431,820 (+)	NCBI		HuRef
CHM1_1	3	32,383,146 - 32,446,330 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	32,388,830 - 32,452,466 (+)	NCBI		T2T-CHM13v2.0

Cmtm7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	114,585,904 - 114,611,061 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	114,585,904 - 114,610,924 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	114,756,836 - 114,781,993 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	114,756,836 - 114,781,856 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	114,665,954 - 114,690,947 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	114,605,534 - 114,630,527 (-)	NCBI		MGSCv36	mm8
Celera	9	115,232,130 - 115,257,424 (-)	NCBI		Celera
Cytogenetic Map	9	F3	NCBI
cM Map	9	65.13	NCBI

Cmtm7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	123,326,233 - 123,353,148 (-)	NCBI		GRCr8
mRatBN7.2	8	114,448,037 - 114,474,958 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	114,448,042 - 114,474,621 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	120,065,256 - 120,092,224 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	118,264,493 - 118,291,459 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	116,107,340 - 116,134,310 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	122,814,563 - 122,841,479 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	122,812,459 - 122,841,477 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	122,126,648 - 122,153,564 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	119,175,165 - 119,202,081 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	113,694,951 - 113,721,844 (-)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

Cmtm7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	23,752,919 - 23,807,141 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955430	23,752,910 - 23,803,754 (+)	NCBI	ChiLan1.0	ChiLan1.0

CMTM7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	32,366,245 - 32,432,252 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	32,373,547 - 32,437,019 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	32,308,975 - 32,372,711 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	32,624,258 - 32,687,245 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

CMTM7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	12,317,636 - 12,382,836 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	12,328,303 - 12,382,837 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	12,292,218 - 12,357,621 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	12,608,527 - 12,674,013 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	12,619,421 - 12,674,012 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	12,409,876 - 12,475,201 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	12,551,996 - 12,617,616 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	12,557,185 - 12,630,035 (-)	NCBI		UU_Cfam_GSD_1.0

Cmtm7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	189,798,491 - 189,808,681 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	22,937,056 - 22,947,381 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936473	22,932,965 - 22,947,309 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CMTM7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	18,412,215 - 18,424,122 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	18,371,327 - 18,424,132 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	20,399,737 - 20,411,233 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CMTM7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	76,896,216 - 76,960,117 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666041	50,250,298 - 50,314,312 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cmtm7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624788	10,477,355 - 10,523,596 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624788	10,477,476 - 10,523,506 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CMTM7
9 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 3p22.3-22.2(chr3:32322382-36775606)x1	copy number loss	See cases [RCV000051509]	Chr3:32322382..36775606 [GRCh38] Chr3:32363874..36817097 [GRCh37] Chr3:32338878..36792101 [NCBI36] Chr3:3p22.3-22.2	pathogenic
GRCh38/hg38 3p26.3-22.2(chr3:52266-37148076)x3	copy number gain	See cases [RCV000051097]	Chr3:52266..37148076 [GRCh38] Chr3:93949..37189567 [GRCh37] Chr3:68949..37164571 [NCBI36] Chr3:3p26.3-22.2	pathogenic
GRCh38/hg38 3p25.3-22.2(chr3:11463328-38919543)x3	copy number gain	See cases [RCV000051720]	Chr3:11463328..38919543 [GRCh38] Chr3:11504802..38961034 [GRCh37] Chr3:11479802..38936038 [NCBI36] Chr3:3p25.3-22.2	pathogenic
GRCh38/hg38 3p26.3-22.1(chr3:53308-41381521)x3	copy number gain	See cases [RCV000141810]	Chr3:53308..41381521 [GRCh38] Chr3:94991..41423012 [GRCh37] Chr3:69991..41398016 [NCBI36] Chr3:3p26.3-22.1	pathogenic
GRCh37/hg19 3p24.1-22.3(chr3:29689082-34233218)x1	copy number loss	See cases [RCV000240426]	Chr3:29689082..34233218 [GRCh37] Chr3:3p24.1-22.3	pathogenic
GRCh37/hg19 3p24.2-22.3(chr3:25045365-32691140)x1	copy number loss	See cases [RCV000447472]	Chr3:25045365..32691140 [GRCh37] Chr3:3p24.2-22.3	likely pathogenic
GRCh37/hg19 3p26.3-22.2(chr3:61891-36710181)x3	copy number gain	See cases [RCV000448528]	Chr3:61891..36710181 [GRCh37] Chr3:3p26.3-22.2	pathogenic
GRCh37/hg19 3p26.3-22.3(chr3:61891-33958201)x3	copy number gain	See cases [RCV000510429]	Chr3:61891..33958201 [GRCh37] Chr3:3p26.3-22.3	pathogenic
GRCh37/hg19 3p26.3-22.2(chr3:61891-37459464)x3	copy number gain	See cases [RCV000511463]	Chr3:61891..37459464 [GRCh37] Chr3:3p26.3-22.2	pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)	copy number gain	See cases [RCV000512358]	Chr3:61892..197851986 [GRCh37] Chr3:3p26.3-q29	pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3	copy number gain	See cases [RCV000511055]	Chr3:61892..197851986 [GRCh37] Chr3:3p26.3-q29	pathogenic
GRCh37/hg19 3p24.3-21.31(chr3:16923595-45249923)x2,3	copy number gain	not provided [RCV000682249]	Chr3:16923595..45249923 [GRCh37] Chr3:3p24.3-21.31	pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3	copy number gain	not provided [RCV000742133]	Chr3:60174..197948027 [GRCh37] Chr3:3p26.3-q29	pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3	copy number gain	not provided [RCV000742138]	Chr3:61495..197838262 [GRCh37] Chr3:3p26.3-q29	pathogenic
GRCh37/hg19 3p22.3(chr3:32249166-32510263)x3	copy number gain	not provided [RCV001259691]	Chr3:32249166..32510263 [GRCh37] Chr3:3p22.3	likely benign
NM_138410.4(CMTM7):c.304G>C (p.Val102Leu)	single nucleotide variant	Inborn genetic diseases [RCV003253989]	Chr3:32441984 [GRCh38] Chr3:32483476 [GRCh37] Chr3:3p22.3	uncertain significance
GRCh37/hg19 3p26.3-22.2(chr3:61891-36710181)	copy number gain	not specified [RCV002053300]	Chr3:61891..36710181 [GRCh37] Chr3:3p26.3-22.2	pathogenic
GRCh37/hg19 3p24.2-22.3(chr3:25045365-32691140)	copy number loss	not specified [RCV002053334]	Chr3:25045365..32691140 [GRCh37] Chr3:3p24.2-22.3	likely pathogenic
GRCh37/hg19 3p23-22.3(chr3:31859973-33127072)	copy number gain	not specified [RCV002053337]	Chr3:31859973..33127072 [GRCh37] Chr3:3p23-22.3	uncertain significance
NC_000003.11:g.(?_16710965)_(41275270_?)del	deletion	not provided [RCV001958625]	Chr3:16710965..41275270 [GRCh37] Chr3:3p24.3-22.1	pathogenic
NM_138410.4(CMTM7):c.29C>T (p.Thr10Ile)	single nucleotide variant	Inborn genetic diseases [RCV002818458]	Chr3:32391935 [GRCh38] Chr3:32433427 [GRCh37] Chr3:3p22.3	uncertain significance
NM_138410.4(CMTM7):c.55G>C (p.Gly19Arg)	single nucleotide variant	Inborn genetic diseases [RCV002688357]	Chr3:32391961 [GRCh38] Chr3:32433453 [GRCh37] Chr3:3p22.3	uncertain significance
NM_138410.4(CMTM7):c.242C>A (p.Thr81Asn)	single nucleotide variant	Inborn genetic diseases [RCV002912078]	Chr3:32441922 [GRCh38] Chr3:32483414 [GRCh37] Chr3:3p22.3	uncertain significance
NM_138410.4(CMTM7):c.304G>A (p.Val102Met)	single nucleotide variant	Inborn genetic diseases [RCV002835535]	Chr3:32441984 [GRCh38] Chr3:32483476 [GRCh37] Chr3:3p22.3	uncertain significance
NM_138410.4(CMTM7):c.217G>A (p.Ala73Thr)	single nucleotide variant	Inborn genetic diseases [RCV003351915]	Chr3:32441897 [GRCh38] Chr3:32483389 [GRCh37] Chr3:3p22.3	uncertain significance
NM_138410.4(CMTM7):c.349T>G (p.Leu117Val)	single nucleotide variant	Inborn genetic diseases [RCV003350362]	Chr3:32449469 [GRCh38] Chr3:32490961 [GRCh37] Chr3:3p22.3	uncertain significance
GRCh37/hg19 3p22.3(chr3:32324460-33982773)x3	copy number gain	not provided [RCV003484125]	Chr3:32324460..33982773 [GRCh37] Chr3:3p22.3	uncertain significance
GRCh37/hg19 3p26.3-22.3(chr3:61891-33946644)x3	copy number gain	not specified [RCV003986437]	Chr3:61891..33946644 [GRCh37] Chr3:3p26.3-22.3	pathogenic

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1943
Count of miRNA genes:	740
Interacting mature miRNAs:	823
Transcripts:	ENST00000334983, ENST00000349718, ENST00000454304, ENST00000464689, ENST00000465248, ENST00000487007
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

SHGC-76805

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	3	32,452,558 - 32,452,708	UniSTS	GRCh37
Build 36	3	32,427,562 - 32,427,712	RGD	NCBI36
Celera	3	32,389,975 - 32,390,125	RGD
Cytogenetic Map	3	p22.3	UniSTS
HuRef	3	32,388,076 - 32,388,226	UniSTS
TNG Radiation Hybrid Map	3	19689.0	UniSTS
GeneMap99-GB4 RH Map	3	117.78	UniSTS
Whitehead-RH Map	3	121.1	UniSTS
Whitehead-YAC Contig Map	3		UniSTS
NCBI RH Map	3	329.8	UniSTS

SHGC-173738

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	3	32,492,296 - 32,492,592	UniSTS	GRCh37
Build 36	3	32,467,300 - 32,467,596	RGD	NCBI36
Celera	3	32,429,386 - 32,429,682	RGD
Cytogenetic Map	3	p22.3	UniSTS
HuRef	3	32,427,787 - 32,428,083	UniSTS
TNG Radiation Hybrid Map	3	19709.0	UniSTS

WI-17396

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	3	32,491,755 - 32,491,879	UniSTS	GRCh37
Build 36	3	32,466,759 - 32,466,883	RGD	NCBI36
Celera	3	32,428,845 - 32,428,969	RGD
Cytogenetic Map	3	p22.3	UniSTS
HuRef	3	32,427,246 - 32,427,370	UniSTS
GeneMap99-GB4 RH Map	3	117.5	UniSTS
Whitehead-RH Map	3	124.2	UniSTS

STS-R72760

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	3	32,496,166 - 32,496,291	UniSTS	GRCh37
Build 36	3	32,471,170 - 32,471,295	RGD	NCBI36
Celera	3	32,433,252 - 32,433,377	RGD
Cytogenetic Map	3	p22.3	UniSTS
HuRef	3	32,431,653 - 32,431,778	UniSTS
TNG Radiation Hybrid Map	3	19724.0	UniSTS
GeneMap99-GB4 RH Map	3	111.36	UniSTS
NCBI RH Map	3	273.2	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

entire extraembryonic component

pharyngeal arch

High

Medium

533

1068

822

147

1333

1956

113

843

199

750

1474

1119

893

Low

1904

1921

903

477

528

402

2338

2005

2678

220

703

122

1837

Below cutoff

205

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_138410	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_181472	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017005646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054345104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC098475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF479263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK055554	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK308878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL832450	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY174113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC010116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CD366110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ132881	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000334983 ⟹ ENSP00000335605

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	3	32,391,853 - 32,455,528 (+)	Ensembl

RefSeq Acc Id:

ENST00000349718 ⟹ ENSP00000283621

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	3	32,391,698 - 32,454,830 (+)	Ensembl

RefSeq Acc Id:

ENST00000454304 ⟹ ENSP00000414480

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	3	32,391,889 - 32,454,358 (+)	Ensembl

RefSeq Acc Id:

ENST00000464689

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	3	32,451,003 - 32,454,835 (+)	Ensembl

RefSeq Acc Id:

ENST00000465248 ⟹ ENSP00000440333

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	3	32,392,039 - 32,454,819 (+)	Ensembl

RefSeq Acc Id:

ENST00000487007 ⟹ ENSP00000445027

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	3	32,449,515 - 32,483,067 (+)	Ensembl

RefSeq Acc Id:

NM_138410 ⟹ NP_612419

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	3	32,391,853 - 32,455,528 (+)	NCBI
GRCh37	3	32,433,163 - 32,496,333 (+)	RGD
Build 36	3	32,408,167 - 32,471,337 (+)	NCBI Archive
Celera	3	32,370,594 - 32,433,419 (+)	RGD
HuRef	3	32,368,696 - 32,431,820 (+)	ENTREZGENE
CHM1_1	3	32,383,146 - 32,446,333 (+)	NCBI
T2T-CHM13v2.0	3	32,388,830 - 32,452,466 (+)	NCBI

Sequence:

show sequence

ATCTGGCCCCTGGGCAGCTGCCCGGGGAGGCGGCCAGCGAGCTGGGGCCGCGCAATGTCGCACG
GAGCCGGGCTCGTCCGCACCACGTGCAGCAGCGGCAGCGCGCTCGGACCCGGGGCCGGCGCGGC
CCAGCCCAGCGCGAGCCCCTTGGAGGGGCTGCTGGACCTCAGCTACCCCCGCACCCACGCGGCC
CTGCTGAAAGTGGCGCAAATGGTCACCCTGCTGATTGCCTTCATCTGTGTGCGGAGCTCCCTGT
GGACCAACTACAGCGCCTACAGCTACTTTGAAGTGGTCACCATTTGCGACTTGATAATGATCCT
CGCCTTTTACCTGGTCCACCTCTTCCGCTTCTACCGCGTGCTCACCTGTATCAGCTGGCCCCTG
TCGGAACTTCTGCACTATTTAATCGGTACCCTGCTCCTCCTCATCGCCTCCATTGTGGCAGCTT
CCAAGAGTTACAACCAGAGCGGACTGGTAGCCGGAGCGATCTTTGGTTTCATGGCCACCTTCCT
CTGCATGGCAAGCATATGGCTGTCCTATAAGATCTCGTGTGTAACCCAGTCCACAGATGCAGCC
GTCTGATGAGGCCACAACCCCTAGGCCCCTCAGGAGCTTTGCAGAGAGGAGGACGTGTACTCCA
GGCGAGGCCTCTGGACCTGTGTTCCTGTGCCAAAGTCCTGTCAGGCTGGTGGGCACCAGGAAAG
GCCTGCACCCTCTTCCTGCTCTCCCAGGAAGCCAGCTCCCTGAGCTCCTGAGCCAGCCGGAAAC
TCTTCCTCCAGCCTTCCGGGGAGAACATCCCTCCCATTCTGGGAAAGGAAAGCAGCCTCCAGGG
AAATGTTTTCTGCCTTCCTGCTTCTAGAACCACCTCAGGTACTGATGAACCCCACTTAGCACAG
CTGAAGGGGTTTGTGAATACTCCCGCCTAAATCCCTTCTACTTCACTCCTCAGGGGAGTGAAGT
GCCTTAAGAAACAAAGCCCTGTCCTAATTTATCTAGCTTGTCAGTCCGGTCTTAGAGATACCCT
CTTTCCTGAAGTGAGGCGTGCCTGTAGAAACACTATGTGGTCAGCCTGTCCCCAAGGAGATCTT
GTGTCTCCTCTCCATCTCTGCCTTTGTTACCAGTGTGCATGTGTTTGTGTGTTTTTTAATAAAA
TATTGACTCGGCCAGTTGCACAAGGATTTCTTATTGAACCAGATGAAGGCTGTAAAACCTGGCC
TGAAACAGTTTCCATTCGAGCTTGTGTCTGGCCCATGGCCCTCCACCCGTGCTCTGTGTGTGCC
CCTTGCTGAACTGCTGGACTTCAGGTTTTCTCTCCATCTTGGGGGATAGTATAGCAGGGCAGAG
TTTTAGGTAAACATGTGCAGGTTCTCAATTATATTCACGTCCTCCTTCTCCTGCAATACCAATC
TTCTCATTTTGGAAAGAGCTTTAGAGCAAGCTAAGGGTTGTGTTTACACTATGATGATTAATGA
TCTCGGCCTAAATGTGCTGTTTCGCTGATCTTGAGCTGCTCAGTTGGCTAGAAAAAGGAGGGAT
GGAACAATGTTTGAGCAACCCCGTGTGCAAGGACCTACATTCACAACCACATCTAATAGCGATG
GTAGTGACTGCAAGGGGGCAGGTTATAGGACCACATTTTTAGAAATGAAATCGGGGCTCCATCC
CCAGGCACAGGGCAAGCCAGTGAGGAGCTGGGCTCAGGATCTAGGTCTGCCTGACTCCCAGCCC
CATCCTTGCCTCTGCTGAGTGTTGCCGGAAATGGAAGCAGCCCCTGTGGGCTTTGAGCTGGAGC
TCTGGGGCTACTCTTGTGGCTGCTGGCCAGCTCGGGGCATCGGGTTCTGTCTGGGATGATCTAA

hide sequence

RefSeq Acc Id:

NM_181472 ⟹ NP_852137

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	3	32,391,853 - 32,455,528 (+)	NCBI
GRCh37	3	32,433,163 - 32,496,333 (+)	RGD
Build 36	3	32,408,167 - 32,471,337 (+)	NCBI Archive
Celera	3	32,370,594 - 32,433,419 (+)	RGD
HuRef	3	32,368,696 - 32,431,820 (+)	ENTREZGENE
CHM1_1	3	32,383,146 - 32,447,017 (+)	NCBI
T2T-CHM13v2.0	3	32,388,830 - 32,452,466 (+)	NCBI

Sequence:

show sequence

ATCTGGCCCCTGGGCAGCTGCCCGGGGAGGCGGCCAGCGAGCTGGGGCCGCGCAATGTCGCACG
GAGCCGGGCTCGTCCGCACCACGTGCAGCAGCGGCAGCGCGCTCGGACCCGGGGCCGGCGCGGC
CCAGCCCAGCGCGAGCCCCTTGGAGGGGCTGCTGGACCTCAGCTACCCCCGCACCCACGCGGCC
CTGCTGAAAGTGGCGCAAATGGTCACCCTGCTGATTGCCTTCATCTGTGTGCGGAGCTCCCTGT
GGACCAACTACAGCGCCTACAGCTACTTTGAAGTGGTCACCATTTGCGACTTGATAATGATCCT
CGCCTTTTACCTGGTCCACCTCTTCCGCTTCTACCGCGTGCTCACCTGTATCAGCTGGCCCCTG
TCGATCTTTGGTTTCATGGCCACCTTCCTCTGCATGGCAAGCATATGGCTGTCCTATAAGATCT
CGTGTGTAACCCAGTCCACAGATGCAGCCGTCTGATGAGGCCACAACCCCTAGGCCCCTCAGGA
GCTTTGCAGAGAGGAGGACGTGTACTCCAGGCGAGGCCTCTGGACCTGTGTTCCTGTGCCAAAG
TCCTGTCAGGCTGGTGGGCACCAGGAAAGGCCTGCACCCTCTTCCTGCTCTCCCAGGAAGCCAG
CTCCCTGAGCTCCTGAGCCAGCCGGAAACTCTTCCTCCAGCCTTCCGGGGAGAACATCCCTCCC
ATTCTGGGAAAGGAAAGCAGCCTCCAGGGAAATGTTTTCTGCCTTCCTGCTTCTAGAACCACCT
CAGGTACTGATGAACCCCACTTAGCACAGCTGAAGGGGTTTGTGAATACTCCCGCCTAAATCCC
TTCTACTTCACTCCTCAGGGGAGTGAAGTGCCTTAAGAAACAAAGCCCTGTCCTAATTTATCTA
GCTTGTCAGTCCGGTCTTAGAGATACCCTCTTTCCTGAAGTGAGGCGTGCCTGTAGAAACACTA
TGTGGTCAGCCTGTCCCCAAGGAGATCTTGTGTCTCCTCTCCATCTCTGCCTTTGTTACCAGTG
TGCATGTGTTTGTGTGTTTTTTAATAAAATATTGACTCGGCCAGTTGCACAAGGATTTCTTATT
GAACCAGATGAAGGCTGTAAAACCTGGCCTGAAACAGTTTCCATTCGAGCTTGTGTCTGGCCCA
TGGCCCTCCACCCGTGCTCTGTGTGTGCCCCTTGCTGAACTGCTGGACTTCAGGTTTTCTCTCC
ATCTTGGGGGATAGTATAGCAGGGCAGAGTTTTAGGTAAACATGTGCAGGTTCTCAATTATATT
CACGTCCTCCTTCTCCTGCAATACCAATCTTCTCATTTTGGAAAGAGCTTTAGAGCAAGCTAAG
GGTTGTGTTTACACTATGATGATTAATGATCTCGGCCTAAATGTGCTGTTTCGCTGATCTTGAG
CTGCTCAGTTGGCTAGAAAAAGGAGGGATGGAACAATGTTTGAGCAACCCCGTGTGCAAGGACC
TACATTCACAACCACATCTAATAGCGATGGTAGTGACTGCAAGGGGGCAGGTTATAGGACCACA
TTTTTAGAAATGAAATCGGGGCTCCATCCCCAGGCACAGGGCAAGCCAGTGAGGAGCTGGGCTC
AGGATCTAGGTCTGCCTGACTCCCAGCCCCATCCTTGCCTCTGCTGAGTGTTGCCGGAAATGGA
AGCAGCCCCTGTGGGCTTTGAGCTGGAGCTCTGGGGCTACTCTTGTGGCTGCTGGCCAGCTCGG
GGCATCGGGTTCTGTCTGGGATGATCTAA

hide sequence

RefSeq Acc Id:

XM_054345104 ⟹ XP_054201079

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	3	32,388,830 - 32,449,415 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_612419	(Get FASTA)	NCBI Sequence Viewer
	NP_852137	(Get FASTA)	NCBI Sequence Viewer
	XP_054201079	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH10116	(Get FASTA)	NCBI Sequence Viewer
	AAN73041	(Get FASTA)	NCBI Sequence Viewer
	AAO44955	(Get FASTA)	NCBI Sequence Viewer
	AAZ57435	(Get FASTA)	NCBI Sequence Viewer
	CAD38626	(Get FASTA)	NCBI Sequence Viewer
	EAW64424	(Get FASTA)	NCBI Sequence Viewer
	EAW64425	(Get FASTA)	NCBI Sequence Viewer
	EAW64426	(Get FASTA)	NCBI Sequence Viewer
	EAW64427	(Get FASTA)	NCBI Sequence Viewer
	EAW64428	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000283621
	ENSP00000283621.5
	ENSP00000335605
	ENSP00000335605.5
	ENSP00000414480.2
	ENSP00000440333.1
	ENSP00000445027.1
GenBank Protein	Q96FZ5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_612419 ⟸ NM_138410
- Peptide Label:	isoform a
- UniProtKB:	Q5VLK1 (UniProtKB/Swiss-Prot), Q96FZ5 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MSHGAGLVRTTCSSGSALGPGAGAAQPSASPLEGLLDLSYPRTHAALLKVAQMVTLLIAFICVR SSLWTNYSAYSYFEVVTICDLIMILAFYLVHLFRFYRVLTCISWPLSELLHYLIGTLLLLIASI VAASKSYNQSGLVAGAIFGFMATFLCMASIWLSYKISCVTQSTDAAV hide sequence

RefSeq Acc Id:	NP_852137 ⟸ NM_181472
- Peptide Label:	isoform b
- UniProtKB:	Q96FZ5 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MSHGAGLVRTTCSSGSALGPGAGAAQPSASPLEGLLDLSYPRTHAALLKVAQMVTLLIAFICVR SSLWTNYSAYSYFEVVTICDLIMILAFYLVHLFRFYRVLTCISWPLSIFGFMATFLCMASIWLS YKISCVTQSTDAAV hide sequence

RefSeq Acc Id:

ENSP00000440333 ⟸ ENST00000465248

RefSeq Acc Id:

ENSP00000335605 ⟸ ENST00000334983

RefSeq Acc Id:

ENSP00000283621 ⟸ ENST00000349718

RefSeq Acc Id:

ENSP00000414480 ⟸ ENST00000454304

RefSeq Acc Id:

ENSP00000445027 ⟸ ENST00000487007

RefSeq Acc Id:	XP_054201079 ⟸ XM_054345104
- Peptide Label:	isoform X1
- UniProtKB:	F8WDZ3 (UniProtKB/TrEMBL)

Protein Domains

MARVEL

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q96FZ5-F1-model_v2	AlphaFold	Q96FZ5	1-175	view protein structure

Promoters

RGD ID:

6863892

Promoter ID:

EPDNEW_H5111

Type:

initiation region

Name:

CMTM7_2

Description:

CKLF like MARVEL transmembrane domain containing 7

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H5112

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	3	32,391,671 - 32,391,731	EPDNEW

RGD ID:

6863894

Promoter ID:

EPDNEW_H5112

Type:

initiation region

Name:

CMTM7_1

Description:

CKLF like MARVEL transmembrane domain containing 7

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H5111

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	3	32,391,879 - 32,391,939	EPDNEW

RGD ID:

6800778

Promoter ID:

HG_KWN:44234

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, HeLa_S3, Lymphoblastoid, NB4

Transcripts:

ENST00000396546, NM_181472, OTTHUMT00000342084, OTTHUMT00000342087, OTTHUMT00000342088

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	3	32,408,084 - 32,408,584 (+)	MPROMDB

RGD ID:

6852974

Promoter ID:

EP74307

Type:

initiation region

Name:

HS_CKLFSF7

Description:

Chemokine-like factor super family 7.

SO ACC ID:

SO:0000170

Source:

EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Mammalian gene collection (MGC) full-length cDNA cloning

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	3	32,408,385 - 32,408,445	EPD

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:19178	AgrOrtholog
COSMIC	CMTM7	COSMIC
Ensembl Genes	ENSG00000153551	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENST00000334983	ENTREZGENE
	ENST00000334983.10	UniProtKB/Swiss-Prot
	ENST00000349718	ENTREZGENE
	ENST00000349718.8	UniProtKB/Swiss-Prot
	ENST00000454304.6	UniProtKB/TrEMBL
	ENST00000465248.1	UniProtKB/TrEMBL
	ENST00000487007.1	UniProtKB/TrEMBL
GTEx	ENSG00000153551	GTEx
HGNC ID	HGNC:19178	ENTREZGENE
Human Proteome Map	CMTM7	Human Proteome Map
InterPro	Marvel	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:112616	UniProtKB/Swiss-Prot
NCBI Gene	112616	ENTREZGENE
OMIM	607890	OMIM
PANTHER	CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	MARVEL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA38817	PharmGKB
PROSITE	MARVEL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	CKLF7_HUMAN	UniProtKB/Swiss-Prot
	F8WDZ3	ENTREZGENE, UniProtKB/TrEMBL
	H0YFU6_HUMAN	UniProtKB/TrEMBL
	H0YGW1_HUMAN	UniProtKB/TrEMBL
	Q5VLK1	ENTREZGENE
	Q96FZ5	ENTREZGENE
UniProt Secondary	Q5VLK1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-02	CMTM7	CKLF like MARVEL transmembrane domain containing 7	CMTM7	CKLF-like MARVEL transmembrane domain containing 7	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar