Pikfyve (phosphoinositide kinase, FYVE type zinc finger containing) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Pikfyve (phosphoinositide kinase, FYVE type zinc finger containing) Mus musculus
Analyze
Symbol: Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
RGD ID: 1313819
MGI Page MGI
Description: Exhibits phosphotransferase activity, alcohol group as acceptor and zinc ion binding activity. Involved in several processes, including neutrophil chemotaxis; phosphatidylinositol metabolic process; and vesicle organization. Localizes to several cellular components, including cell-cell junction; perinuclear region of cytoplasm; and vesicle membrane. Is expressed in brain; genitourinary system; integumental system; limb; and skeleton. Used to study Crohn's disease. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKFYVE (phosphoinositide kinase, FYVE-type zinc finger containing); PARTICIPATES IN inositol metabolic pathway; phosphoinositide metabolic pathway; inositol phosphate metabolic pathway; INTERACTS WITH 3,4-methylenedioxymethamphetamine; 4-hydroxyphenyl retinamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1-phosphatidylinositol 3-phosphate 5-kinase; 1-phosphatidylinositol-3-phosphate 5-kinase; 5230400C17Rik; FYVE finger-containing phosphoinositide kinase; P; p235; phosphatidylinositol 3-phosphate 5-kinase; phosphatidylinositol 3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphatidylinositol-4-phosphate 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; Pip; Pip5k; Pip5k3; Pipk5k3; PipkIII; PIPkin-III; PtdIns(4)P-5-kinase; serine-protein kinase PIKFYVE; type III PIP kinase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,225,796 - 65,317,855 (+)NCBIGRCm39mm39
GRCm39 Ensembl165,225,842 - 65,317,854 (+)Ensembl
GRCm38165,186,640 - 65,278,696 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,186,683 - 65,278,695 (+)EnsemblGRCm38mm10GRCm38
MGSCv37165,233,259 - 65,325,270 (+)NCBIGRCm37mm9NCBIm37
MGSCv36165,120,978 - 65,208,034 (+)NCBImm8
Celera165,677,339 - 65,769,254 (+)NCBICelera
Cytogenetic Map1C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alveolar macrophage morphology  (IAGP)
abnormal alveolar macrophage physiology  (IAGP)
abnormal atrium myocardium morphology  (IAGP)
abnormal blastocoele morphology  (IAGP)
abnormal blastocyst morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brainstem morphology  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cerebellum deep nucleus morphology  (IAGP)
abnormal circulating enzyme level  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal DNA replication  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal embryonic/fetal subventricular zone morphology  (IAGP)
abnormal endosome to melanosome transport  (IAGP)
abnormal enterocyte morphology  (IAGP)
abnormal hair follicle melanocyte morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal inner cell mass morphology  (IAGP)
abnormal lipid level  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal melanosome maturation  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal pons morphology  (IAGP)
abnormal pulmonary alveolar system morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal small intestinal microvillus morphology  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal superior vena cava morphology  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal trophectoderm morphology  (IAGP)
abnormal ventricle myocardium morphology  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
abnormal visceral endoderm physiology  (IAGP)
absent blastocoele  (IAGP)
brain vacuoles  (IAGP)
decreased alveolar macrophage number  (IAGP)
decreased birth body size  (IAGP)
decreased body weight  (IAGP)
decreased brain weight  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating serum albumin level  (IAGP)
decreased circulating total protein level  (IAGP)
decreased embryo size  (IAGP)
decreased heart weight  (IAGP)
decreased muscle cell glucose uptake  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased small intestinal microvillus size  (IAGP)
diarrhea  (IAGP)
dilated heart right ventricle  (IAGP)
diluted coat color  (IAGP)
disheveled coat  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
embryonic lethality before implantation, incomplete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
enlarged heart right atrium  (IAGP)
hunched posture  (IAGP)
impaired glucose tolerance  (IAGP)
increased adipocyte glucose uptake  (IAGP)
increased body weight  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased eosinophil cell number  (IAGP)
increased fat cell size  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased interleukin-13 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased renal fat pad weight  (IAGP)
increased susceptibility to age related obesity  (IAGP)
increased susceptibility to type I hypersensitivity reaction  (IAGP)
increased total body fat amount  (IAGP)
insulin resistance  (IAGP)
intestinal fibrosis  (IAGP)
intestinal inflammation  (IAGP)
kidney degeneration  (IAGP)
lethality, incomplete penetrance  (IAGP)
lethargy  (IAGP)
melena  (IAGP)
no abnormal phenotype detected  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
pulmonary vascular congestion  (IAGP)
reduced hair shaft melanin granule number  (IAGP)
small heart  (IAGP)
spleen hypoplasia  (IAGP)
thymus hypoplasia  (IAGP)
References

Additional References at PubMed
PMID:9858586   PMID:10349636   PMID:10419465   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11112776   PMID:11123925   PMID:11285266   PMID:11706043   PMID:12270933   PMID:12904583  
PMID:14530284   PMID:14610273   PMID:14681479   PMID:15018809   PMID:15368895   PMID:15546921   PMID:16141072   PMID:16141073   PMID:16512683   PMID:17475247   PMID:17556371   PMID:17967808  
PMID:18287559   PMID:18799693   PMID:18950639   PMID:19056739   PMID:19840946   PMID:19841139   PMID:19951917   PMID:20513353   PMID:20841379   PMID:21267068   PMID:21349843   PMID:21737449  
PMID:22028665   PMID:22621786   PMID:22696681   PMID:22988430   PMID:23047693   PMID:23068606   PMID:23297396   PMID:23322734   PMID:23673157   PMID:23680464   PMID:23793062   PMID:24600036  
PMID:25178411   PMID:25619930   PMID:25754822   PMID:25925170   PMID:26232680   PMID:26825532   PMID:26934981   PMID:27008179   PMID:27273882   PMID:27623384   PMID:28396567   PMID:28533230  
PMID:28779020   PMID:29584722   PMID:29661845   PMID:30295876   PMID:31427458   PMID:31692073   PMID:32325033  


Genomics

Comparative Map Data
Pikfyve
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,225,796 - 65,317,855 (+)NCBIGRCm39mm39
GRCm39 Ensembl165,225,842 - 65,317,854 (+)Ensembl
GRCm38165,186,640 - 65,278,696 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,186,683 - 65,278,695 (+)EnsemblGRCm38mm10GRCm38
MGSCv37165,233,259 - 65,325,270 (+)NCBIGRCm37mm9NCBIm37
MGSCv36165,120,978 - 65,208,034 (+)NCBImm8
Celera165,677,339 - 65,769,254 (+)NCBICelera
Cytogenetic Map1C3NCBI
PIKFYVE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2208,266,255 - 208,358,746 (+)EnsemblGRCh38hg38GRCh38
GRCh382208,266,178 - 208,358,747 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372209,130,979 - 209,223,470 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,839,236 - 208,931,720 (+)NCBINCBI36hg18NCBI36
Celera2202,898,915 - 202,991,410 (+)NCBI
Cytogenetic Map2q34NCBI
HuRef2200,978,970 - 201,070,591 (+)NCBIHuRef
CHM1_12209,136,843 - 209,229,320 (+)NCBICHM1_1
Pikfyve
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2966,563,747 - 66,657,873 (+)NCBI
Rnor_6.0 Ensembl971,915,421 - 72,005,838 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0971,911,744 - 72,005,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0970,566,016 - 70,660,374 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,798,743 - 63,890,905 (+)NCBIRGSC3.4rn4RGSC3.4
Celera963,959,029 - 64,052,994 (+)NCBICelera
Cytogenetic Map9q32NCBI
Pikfyve
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554576,748,534 - 6,842,489 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554576,749,226 - 6,841,855 (-)NCBIChiLan1.0ChiLan1.0
PIKFYVE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B213,628,997 - 213,721,299 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B213,628,997 - 213,721,299 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B95,505,376 - 95,597,792 (+)NCBIMhudiblu_PPA_v0panPan3
PIKFYVE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13716,537,095 - 16,620,427 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3716,541,562 - 16,619,554 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3717,419,766 - 17,503,074 (+)NCBI
ROS_Cfam_1.03716,472,780 - 16,556,108 (+)NCBI
UMICH_Zoey_3.13716,416,782 - 16,500,119 (+)NCBI
UNSW_CanFamBas_1.03716,390,154 - 16,473,467 (+)NCBI
UU_Cfam_GSD_1.03716,399,401 - 16,482,715 (+)NCBI
Pikfyve
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303164,903,831 - 164,987,854 (+)NCBI
SpeTri2.0NW_004936950242,071 - 323,204 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIKFYVE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15111,372,173 - 111,467,919 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115111,372,148 - 111,468,720 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215122,893,751 - 122,991,762 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIKFYVE
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11094,051,096 - 94,144,968 (+)NCBI
ChlSab1.1 Ensembl1094,056,923 - 94,145,268 (+)Ensembl
Vero_WHO_p1.0NW_023666040105,226,813 - 105,319,971 (-)NCBI
Pikfyve
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247657,684,770 - 7,806,381 (-)NCBI

Position Markers
D1Mit327  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38165,265,339 - 65,265,478UniSTSGRCm38
MGSCv37165,311,913 - 65,312,052UniSTSGRCm37
Celera165,755,906 - 65,756,045UniSTS
Cytogenetic Map1C2UniSTS
cM Map132.8UniSTS
Whitehead Genetic132.8UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12307051073937756Mouse
1357822Lvrq3_mliver weight QTL 3 (mouse)Not determined13472105773937756Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13472105773937756Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13472105773937756Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13472105773937756Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13472105773937756Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13472105773937756Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13472105773937756Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13909372774477206Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139093727126517573Mouse
12910780Pwgrq11_mpost-weaning growth rate QTL 11 (mouse)14082884867231097Mouse
12910786Pwgrq10_mpost-weaning growth rate QTL 10 (mouse)14082884867231097Mouse
12910788Pwgrq9_mpost-weaning growth rate QTL 9 (mouse)14082884867231097Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14123396575234112Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14123624075236240Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4222050876220508Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14289887276899008Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14537861372935898Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14590759679907723Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14681553180815680Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14681553180815680Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14731073581310854Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14884984782850051Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14884984782850051Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14885318682853326Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15085105784851057Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5138244685382446Mouse
4142307Shali1_msurvival time to hyperoxic acute lung injury 1 (mouse)Not determined5192486670367430Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15593578989935898Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15622705590227201Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15622705590227201Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15668776390687918Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15668776390687918Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15790219291902192Mouse
14747009Manh49_mmandible shape 49 (mouse)15790219291902192Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15795281891952921Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15795281891952921Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15795281891952921Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15857254792572799Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15857254792572799Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162907596120601949Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163815531189571420Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163880843153681816Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:78
Interacting mature miRNAs:83
Transcripts:ENSMUST00000081154, ENSMUST00000097707
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001310624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011238454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC164079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF102777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK173077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY271210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000081154   ⟹   ENSMUSP00000079926
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl165,186,702 - 65,278,695 (+)Ensembl
RefSeq Acc Id: ENSMUST00000097707   ⟹   ENSMUSP00000095314
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl165,186,750 - 65,274,012 (+)Ensembl
RefSeq Acc Id: ENSMUST00000185263   ⟹   ENSMUSP00000140932
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl165,186,713 - 65,192,187 (+)Ensembl
RefSeq Acc Id: ENSMUST00000185317
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl165,186,683 - 65,205,706 (+)Ensembl
RefSeq Acc Id: ENSMUST00000186404
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl165,186,704 - 65,233,284 (+)Ensembl
RefSeq Acc Id: ENSMUST00000187579
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl165,186,694 - 65,192,483 (+)Ensembl
RefSeq Acc Id: ENSMUST00000188799
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl165,186,693 - 65,226,117 (+)Ensembl
RefSeq Acc Id: ENSMUST00000189925
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl165,186,696 - 65,206,174 (+)Ensembl
RefSeq Acc Id: ENSMUST00000190058   ⟹   ENSMUSP00000140204
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl165,186,689 - 65,246,898 (+)Ensembl
RefSeq Acc Id: ENSMUST00000190847
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl165,196,760 - 65,216,262 (+)Ensembl
RefSeq Acc Id: ENSMUST00000213081
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl165,186,704 - 65,209,399 (+)Ensembl
RefSeq Acc Id: NM_001310624   ⟹   NP_001297553
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,844 - 65,317,855 (+)NCBI
GRCm38165,186,685 - 65,278,696 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011086   ⟹   NP_035216
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,844 - 65,317,855 (+)NCBI
GRCm38165,186,685 - 65,278,696 (+)NCBI
MGSCv37165,233,259 - 65,325,270 (+)RGD
Celera165,677,339 - 65,769,254 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006495776   ⟹   XP_006495839
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
GRCm38165,186,640 - 65,278,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006495777   ⟹   XP_006495840
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
GRCm38165,186,640 - 65,278,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006495779   ⟹   XP_006495842
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
GRCm38165,186,640 - 65,278,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006495781   ⟹   XP_006495844
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
GRCm38165,186,640 - 65,278,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006495782   ⟹   XP_006495845
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
GRCm38165,186,640 - 65,278,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011238454   ⟹   XP_011236756
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,796 - 65,294,287 (+)NCBI
GRCm38165,186,640 - 65,255,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030252267   ⟹   XP_030108127
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
GRCm38165,186,640 - 65,278,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030252271   ⟹   XP_030108131
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
GRCm38165,186,640 - 65,278,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162776   ⟹   XP_036018669
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
RefSeq Acc Id: XM_036162778   ⟹   XP_036018671
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
RefSeq Acc Id: XM_036162779   ⟹   XP_036018672
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_035216   ⟸   NM_011086
- Peptide Label: isoform 2
- UniProtKB: Q9Z1T6 (UniProtKB/Swiss-Prot),   D3Z5N5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006495839   ⟸   XM_006495776
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006495845   ⟸   XM_006495782
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006495842   ⟸   XM_006495779
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006495840   ⟸   XM_006495777
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006495844   ⟸   XM_006495781
- Peptide Label: isoform X3
- UniProtKB: Q9Z1T6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011236756   ⟸   XM_011238454
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: NP_001297553   ⟸   NM_001310624
- Peptide Label: isoform 1
- UniProtKB: Q9Z1T6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030108131   ⟸   XM_030252271
- Peptide Label: isoform X7
RefSeq Acc Id: XP_030108127   ⟸   XM_030252267
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000140932   ⟸   ENSMUST00000185263
RefSeq Acc Id: ENSMUSP00000140204   ⟸   ENSMUST00000190058
RefSeq Acc Id: ENSMUSP00000079926   ⟸   ENSMUST00000081154
RefSeq Acc Id: ENSMUSP00000095314   ⟸   ENSMUST00000097707
RefSeq Acc Id: XP_036018669   ⟸   XM_036162776
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036018671   ⟸   XM_036162778
- Peptide Label: isoform X5
RefSeq Acc Id: XP_036018672   ⟸   XM_036162779
- Peptide Label: isoform X7
Protein Domains
DEP   FYVE-type   PIPK

Promoters
RGD ID:6873964
Promoter ID:EPDNEW_M433
Type:initiation region
Name:Pikfyve_1
Description:Mus musculus phosphoinositide kinase, FYVE type zinc finger containing, transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38165,186,692 - 65,186,752EPDNEW
RGD ID:6817968
Promoter ID:MM_KWN:1016
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001111320,   NM_011086,   UC007BHO.1,   UC007BHP.1,   UC007BHQ.1,   UC007BHR.1,   UC007BHT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36165,232,246 - 65,233,412 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1335106 AgrOrtholog
Ensembl Genes ENSMUSG00000025949 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000079926 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000095314 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000140204 UniProtKB/TrEMBL
  ENSMUSP00000140932 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000081154 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000097707 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000185263 UniProtKB/TrEMBL
  ENSMUST00000190058 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.800.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.7.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cpn60/TCP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GroEL-like_apical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIKfyve UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIKfyve_DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PInositol-4-P-5-kinase_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PInositol-4-P-5-kinase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCP-1-like_intermed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18711 UniProtKB/Swiss-Prot
MGD MGI:1335106 ENTREZGENE
NCBI Gene 18711 ENTREZGENE
PANTHER PTHR46715 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cpn60_TCP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIP5K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pikfyve PhenoGen
PROSITE DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIPK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIPKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52029 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54849 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57903 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WQI1_MOUSE UniProtKB/TrEMBL
  A0A087WS78_MOUSE UniProtKB/TrEMBL
  D3Z5N5 ENTREZGENE, UniProtKB/TrEMBL
  FYV1_MOUSE UniProtKB/Swiss-Prot
  Q3TR41_MOUSE UniProtKB/TrEMBL
  Q9Z1T6 ENTREZGENE
UniProt Secondary E9QL40 UniProtKB/Swiss-Prot
  Q3TNE4 UniProtKB/Swiss-Prot
  Q3UTT6 UniProtKB/Swiss-Prot
  Q69ZU1 UniProtKB/Swiss-Prot
  Q9CU94 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-09 Pikfyve  phosphoinositide kinase, FYVE type zinc finger containing    phosphoinositide kinase, FYVE finger containing  Symbol and/or name change 5135510 APPROVED