Pikfyve (phosphoinositide kinase, FYVE type zinc finger containing) - Rat Genome Database

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Gene: Pikfyve (phosphoinositide kinase, FYVE type zinc finger containing) Mus musculus
Analyze
Symbol: Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
RGD ID: 1313819
MGI Page MGI
Description: Enables phosphatidylinositol kinase activity; protein serine/threonine kinase activity; and zinc ion binding activity. Involved in several processes, including neutrophil chemotaxis; phosphatidylinositol metabolic process; and vesicle organization. Acts upstream of or within myelin assembly. Located in several cellular components, including cell-cell junction; perinuclear region of cytoplasm; and vesicle membrane. Is expressed in several structures, including brain; genitourinary system; integumental system; limb; and skeleton. Used to study Crohn's disease. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKFYVE (phosphoinositide kinase, FYVE-type zinc finger containing).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1-phosphatidylinositol 3-phosphate 5-kinase; 1-phosphatidylinositol-3-phosphate 5-kinase; 5230400C17Rik; FYVE finger-containing phosphoinositide kinase; P; p235; phosphatidylinositol 3-phosphate 5-kinase; phosphatidylinositol 3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphatidylinositol-4-phosphate 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; Pip; Pip5k; Pip5k3; Pipk5k3; PipkIII; PIPkin-III; PtdIns(4)P-5-kinase; serine-protein kinase PIKFYVE; type III PIP kinase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,225,796 - 65,317,855 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,225,842 - 65,317,854 (+)EnsemblGRCm39 Ensembl
GRCm38165,186,640 - 65,278,696 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,186,683 - 65,278,695 (+)EnsemblGRCm38mm10GRCm38
MGSCv37165,233,259 - 65,325,270 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36165,120,978 - 65,208,034 (+)NCBIMGSCv36mm8
Celera165,677,339 - 65,769,254 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map132.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alveolar macrophage morphology  (IAGP)
abnormal alveolar macrophage physiology  (IAGP)
abnormal atrium myocardium morphology  (IAGP)
abnormal blastocoele morphology  (IAGP)
abnormal blastocyst morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brainstem morphology  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cerebellum deep nucleus morphology  (IAGP)
abnormal circulating enzyme level  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal embryonic/fetal subventricular zone morphology  (IAGP)
abnormal endosome to melanosome transport  (IAGP)
abnormal enterocyte morphology  (IAGP)
abnormal hair follicle melanocyte morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal inner cell mass morphology  (IAGP)
abnormal lipid level  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal melanosome maturation  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal pons morphology  (IAGP)
abnormal pulmonary alveolar system morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal small intestinal microvillus morphology  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal superior vena cava morphology  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal trophectoderm morphology  (IAGP)
abnormal ventricle myocardium morphology  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
abnormal visceral endoderm physiology  (IAGP)
absent blastocoele  (IAGP)
brain vacuoles  (IAGP)
decreased alveolar macrophage number  (IAGP)
decreased birth body size  (IAGP)
decreased body weight  (IAGP)
decreased brain weight  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating serum albumin level  (IAGP)
decreased circulating total protein level  (IAGP)
decreased DNA replication  (IAGP)
decreased embryo size  (IAGP)
decreased heart weight  (IAGP)
decreased muscle cell glucose uptake  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased small intestinal microvillus size  (IAGP)
diarrhea  (IAGP)
dilated heart right ventricle  (IAGP)
diluted coat color  (IAGP)
disheveled coat  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
embryonic lethality before implantation, incomplete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
hunched posture  (IAGP)
impaired glucose tolerance  (IAGP)
increased adipocyte glucose uptake  (IAGP)
increased body weight  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased eosinophil cell number  (IAGP)
increased fat cell size  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased heart right atrium size  (IAGP)
increased interleukin-13 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased renal fat pad weight  (IAGP)
increased susceptibility to age related obesity  (IAGP)
increased susceptibility to type I hypersensitivity reaction  (IAGP)
increased total body fat amount  (IAGP)
insulin resistance  (IAGP)
intestinal fibrosis  (IAGP)
intestinal inflammation  (IAGP)
kidney degeneration  (IAGP)
lethality, incomplete penetrance  (IAGP)
lethargy  (IAGP)
melena  (IAGP)
no abnormal phenotype detected  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
pulmonary vascular congestion  (IAGP)
reduced hair shaft melanin granule number  (IAGP)
small heart  (IAGP)
spleen hypoplasia  (IAGP)
thymus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9858586   PMID:10349636   PMID:10419465   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11112776   PMID:11123925   PMID:11285266   PMID:11706043   PMID:12270933   PMID:12904583  
PMID:14530284   PMID:14610273   PMID:14681479   PMID:15018809   PMID:15368895   PMID:15546921   PMID:16141072   PMID:16141073   PMID:16512683   PMID:17475247   PMID:17556371   PMID:17967808  
PMID:18287559   PMID:18799693   PMID:18950639   PMID:19056739   PMID:19840946   PMID:19841139   PMID:19951917   PMID:20513353   PMID:20841379   PMID:21267068   PMID:21349843   PMID:21737449  
PMID:21873635   PMID:22028665   PMID:22621786   PMID:22696681   PMID:22988430   PMID:23047693   PMID:23068606   PMID:23297396   PMID:23322734   PMID:23673157   PMID:23680464   PMID:23793062  
PMID:24600036   PMID:25178411   PMID:25619930   PMID:25754822   PMID:25925170   PMID:26232680   PMID:26825532   PMID:26934981   PMID:27008179   PMID:27273882   PMID:27623384   PMID:28396567  
PMID:28533230   PMID:28779020   PMID:29584722   PMID:29661845   PMID:30295876   PMID:31427458   PMID:31692073   PMID:32188273   PMID:32325033   PMID:33378226   PMID:35275098   PMID:35708031  
PMID:35760104   PMID:36754049   PMID:37248430   PMID:37380769   PMID:38942798  


Genomics

Comparative Map Data
Pikfyve
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,225,796 - 65,317,855 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,225,842 - 65,317,854 (+)EnsemblGRCm39 Ensembl
GRCm38165,186,640 - 65,278,696 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,186,683 - 65,278,695 (+)EnsemblGRCm38mm10GRCm38
MGSCv37165,233,259 - 65,325,270 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36165,120,978 - 65,208,034 (+)NCBIMGSCv36mm8
Celera165,677,339 - 65,769,254 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map132.94NCBI
PIKFYVE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382208,266,056 - 208,358,746 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2208,266,255 - 208,358,746 (+)EnsemblGRCh38hg38GRCh38
GRCh372209,130,979 - 209,223,470 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,839,236 - 208,931,720 (+)NCBINCBI36Build 36hg18NCBI36
Celera2202,898,915 - 202,991,410 (+)NCBICelera
Cytogenetic Map2q34NCBI
HuRef2200,978,970 - 201,070,591 (+)NCBIHuRef
CHM1_12209,136,843 - 209,229,320 (+)NCBICHM1_1
T2T-CHM13v2.02208,744,537 - 208,838,556 (+)NCBIT2T-CHM13v2.0
Pikfyve
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8974,057,488 - 74,151,610 (+)NCBIGRCr8
mRatBN7.2966,563,747 - 66,657,873 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,563,727 - 66,657,868 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0971,911,744 - 72,005,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,915,421 - 72,005,838 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0970,566,016 - 70,660,374 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,798,743 - 63,890,905 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera963,959,029 - 64,052,994 (+)NCBICelera
Cytogenetic Map9q32NCBI
Pikfyve
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554576,748,534 - 6,842,489 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554576,749,226 - 6,841,855 (-)NCBIChiLan1.0ChiLan1.0
PIKFYVE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213110,875,873 - 110,968,489 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B110,891,072 - 110,983,465 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B95,505,376 - 95,597,792 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B213,628,997 - 213,721,299 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B213,628,997 - 213,721,299 (+)Ensemblpanpan1.1panPan2
PIKFYVE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13716,537,095 - 16,620,427 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3716,541,562 - 16,619,554 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3717,419,766 - 17,503,074 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03716,472,780 - 16,556,108 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3716,472,913 - 16,554,451 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13716,416,782 - 16,500,119 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03716,390,154 - 16,473,467 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03716,399,401 - 16,482,715 (+)NCBIUU_Cfam_GSD_1.0
Pikfyve
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303164,903,831 - 164,987,854 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936950242,522 - 320,078 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936950242,071 - 323,204 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIKFYVE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15111,372,173 - 111,467,899 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115111,372,148 - 111,468,720 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215122,893,751 - 122,991,762 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIKFYVE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11094,051,096 - 94,144,968 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1094,056,923 - 94,145,268 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040105,226,813 - 105,319,971 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pikfyve
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247657,681,875 - 7,790,704 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247657,684,770 - 7,806,381 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:78
Interacting mature miRNAs:83
Transcripts:ENSMUST00000081154, ENSMUST00000097707
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
12910788Pwgrq9_mpost-weaning growth rate QTL 9 (mouse)14086800867270256Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
12910786Pwgrq10_mpost-weaning growth rate QTL 10 (mouse)14086800867270256Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15672692290727077Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15597494889975057Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15626621490266360Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15672692290727077Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14541777372975057Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15626621490266360Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
4142307Shali1_msurvival time to hyperoxic acute lung injury 1 (mouse)Not determined5196402570406589Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
12910780Pwgrq11_mpost-weaning growth rate QTL 11 (mouse)14086800867270256Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse

Markers in Region
D1Mit327  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38165,265,339 - 65,265,478UniSTSGRCm38
MGSCv37165,311,913 - 65,312,052UniSTSGRCm37
Celera165,755,906 - 65,756,045UniSTS
Cytogenetic Map1C2UniSTS
cM Map132.8UniSTS
Whitehead Genetic132.8UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001310624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011238454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC164079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF102777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK173077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY271210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000081154   ⟹   ENSMUSP00000079926
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,225,861 - 65,317,854 (+)Ensembl
GRCm38.p6 Ensembl165,186,702 - 65,278,695 (+)Ensembl
Ensembl Acc Id: ENSMUST00000097707   ⟹   ENSMUSP00000095314
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,225,909 - 65,313,171 (+)Ensembl
GRCm38.p6 Ensembl165,186,750 - 65,274,012 (+)Ensembl
Ensembl Acc Id: ENSMUST00000185263   ⟹   ENSMUSP00000140932
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,225,872 - 65,231,346 (+)Ensembl
GRCm38.p6 Ensembl165,186,713 - 65,192,187 (+)Ensembl
Ensembl Acc Id: ENSMUST00000185317
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,225,842 - 65,244,865 (+)Ensembl
GRCm38.p6 Ensembl165,186,683 - 65,205,706 (+)Ensembl
Ensembl Acc Id: ENSMUST00000186404
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,225,863 - 65,272,443 (+)Ensembl
GRCm38.p6 Ensembl165,186,704 - 65,233,284 (+)Ensembl
Ensembl Acc Id: ENSMUST00000187579
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,225,853 - 65,231,642 (+)Ensembl
GRCm38.p6 Ensembl165,186,694 - 65,192,483 (+)Ensembl
Ensembl Acc Id: ENSMUST00000188799
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,225,852 - 65,265,276 (+)Ensembl
GRCm38.p6 Ensembl165,186,693 - 65,226,117 (+)Ensembl
Ensembl Acc Id: ENSMUST00000189925
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,225,855 - 65,245,333 (+)Ensembl
GRCm38.p6 Ensembl165,186,696 - 65,206,174 (+)Ensembl
Ensembl Acc Id: ENSMUST00000190058   ⟹   ENSMUSP00000140204
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,225,848 - 65,286,057 (+)Ensembl
GRCm38.p6 Ensembl165,186,689 - 65,246,898 (+)Ensembl
Ensembl Acc Id: ENSMUST00000190847
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,235,919 - 65,255,421 (+)Ensembl
GRCm38.p6 Ensembl165,196,760 - 65,216,262 (+)Ensembl
Ensembl Acc Id: ENSMUST00000213081
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,225,863 - 65,248,558 (+)Ensembl
GRCm38.p6 Ensembl165,186,704 - 65,209,399 (+)Ensembl
RefSeq Acc Id: NM_001310624   ⟹   NP_001297553
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,844 - 65,317,855 (+)NCBI
GRCm38165,186,685 - 65,278,696 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011086   ⟹   NP_035216
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,844 - 65,317,855 (+)NCBI
GRCm38165,186,685 - 65,278,696 (+)NCBI
MGSCv37165,233,259 - 65,325,270 (+)RGD
Celera165,677,339 - 65,769,254 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006495776   ⟹   XP_006495839
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
GRCm38165,186,640 - 65,278,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006495777   ⟹   XP_006495840
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
GRCm38165,186,640 - 65,278,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006495779   ⟹   XP_006495842
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
GRCm38165,186,640 - 65,278,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006495781   ⟹   XP_006495844
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
GRCm38165,186,640 - 65,278,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006495782   ⟹   XP_006495845
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
GRCm38165,186,640 - 65,278,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011238454   ⟹   XP_011236756
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,796 - 65,294,287 (+)NCBI
GRCm38165,186,640 - 65,255,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030252267   ⟹   XP_030108127
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
GRCm38165,186,640 - 65,278,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030252271   ⟹   XP_030108131
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
GRCm38165,186,640 - 65,278,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162776   ⟹   XP_036018669
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162778   ⟹   XP_036018671
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162779   ⟹   XP_036018672
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,225,797 - 65,317,843 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035216   ⟸   NM_011086
- Peptide Label: isoform 2
- UniProtKB: D3Z5N5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006495839   ⟸   XM_006495776
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006495845   ⟸   XM_006495782
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006495842   ⟸   XM_006495779
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006495840   ⟸   XM_006495777
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006495844   ⟸   XM_006495781
- Peptide Label: isoform X3
- UniProtKB: Q69ZU1 (UniProtKB/Swiss-Prot),   Q3UTT6 (UniProtKB/Swiss-Prot),   Q3TNE4 (UniProtKB/Swiss-Prot),   E9QL40 (UniProtKB/Swiss-Prot),   Q9CU94 (UniProtKB/Swiss-Prot),   Q9Z1T6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011236756   ⟸   XM_011238454
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: NP_001297553   ⟸   NM_001310624
- Peptide Label: isoform 1
- UniProtKB: Q69ZU1 (UniProtKB/Swiss-Prot),   Q3UTT6 (UniProtKB/Swiss-Prot),   Q3TNE4 (UniProtKB/Swiss-Prot),   E9QL40 (UniProtKB/Swiss-Prot),   Q9CU94 (UniProtKB/Swiss-Prot),   Q9Z1T6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030108131   ⟸   XM_030252271
- Peptide Label: isoform X7
RefSeq Acc Id: XP_030108127   ⟸   XM_030252267
- Peptide Label: isoform X2
Ensembl Acc Id: ENSMUSP00000140932   ⟸   ENSMUST00000185263
Ensembl Acc Id: ENSMUSP00000140204   ⟸   ENSMUST00000190058
Ensembl Acc Id: ENSMUSP00000079926   ⟸   ENSMUST00000081154
Ensembl Acc Id: ENSMUSP00000095314   ⟸   ENSMUST00000097707
RefSeq Acc Id: XP_036018669   ⟸   XM_036162776
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036018671   ⟸   XM_036162778
- Peptide Label: isoform X5
RefSeq Acc Id: XP_036018672   ⟸   XM_036162779
- Peptide Label: isoform X7
Protein Domains
DEP   FYVE-type   PIPK

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1T6-F1-model_v2 AlphaFold Q9Z1T6 1-2097 view protein structure

Promoters
RGD ID:6873964
Promoter ID:EPDNEW_M433
Type:initiation region
Name:Pikfyve_1
Description:Mus musculus phosphoinositide kinase, FYVE type zinc finger containing, transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38165,186,692 - 65,186,752EPDNEW
RGD ID:6817968
Promoter ID:MM_KWN:1016
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001111320,   NM_011086,   UC007BHO.1,   UC007BHP.1,   UC007BHQ.1,   UC007BHR.1,   UC007BHT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36165,232,246 - 65,233,412 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1335106 AgrOrtholog
Ensembl Genes ENSMUSG00000025949 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000081154 ENTREZGENE
  ENSMUST00000081154.14 UniProtKB/TrEMBL
  ENSMUST00000097707 ENTREZGENE
  ENSMUST00000097707.5 UniProtKB/Swiss-Prot
  ENSMUST00000185263.7 UniProtKB/TrEMBL
  ENSMUST00000190058.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2-Layer Sandwich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.800.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.7.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cpn60/TCP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GroEL-like_apical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIKfyve UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIKfyve_DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIKfyve_PIPKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PInositol-4-P-4/5-kinase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PInositol-4-P-5-kinase_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PInositol-4-P-5-kinase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCP-1-like_intermed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18711 UniProtKB/Swiss-Prot
MGD MGI:1335106 ENTREZGENE
NCBI Gene 18711 ENTREZGENE
PANTHER 1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46715 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cpn60_TCP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIP5K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pikfyve PhenoGen
PROSITE DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIPK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIPKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SAICAR synthase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52029 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54849 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57903 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WQI1_MOUSE UniProtKB/TrEMBL
  A0A087WS78_MOUSE UniProtKB/TrEMBL
  D3Z5N5 ENTREZGENE, UniProtKB/TrEMBL
  E9QL40 ENTREZGENE
  FYV1_MOUSE UniProtKB/Swiss-Prot
  Q3TNE4 ENTREZGENE
  Q3TR41_MOUSE UniProtKB/TrEMBL
  Q3UTT6 ENTREZGENE
  Q69ZU1 ENTREZGENE
  Q9CU94 ENTREZGENE
  Q9Z1T6 ENTREZGENE
UniProt Secondary E9QL40 UniProtKB/Swiss-Prot
  Q3TNE4 UniProtKB/Swiss-Prot
  Q3UTT6 UniProtKB/Swiss-Prot
  Q69ZU1 UniProtKB/Swiss-Prot
  Q9CU94 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-09 Pikfyve  phosphoinositide kinase, FYVE type zinc finger containing    phosphoinositide kinase, FYVE finger containing  Symbol and/or name change 5135510 APPROVED