Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Xpot | Mouse | (+)-schisandrin B | multiple interactions | ISO | Xpot (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of XPOT mRNA] | CTD | PMID:31150632 | Xpot | Mouse | 1-nitropyrene | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | 1-nitropyrene results in increased expression of XPOT mRNA | CTD | PMID:19041380 | Xpot | Mouse | 17beta-estradiol | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | Estradiol results in increased expression of XPOT mRNA | CTD | PMID:20106945 and PMID:31614463 | Xpot | Mouse | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | Xpot | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of XPOT mRNA | CTD | PMID:16214954 | Xpot | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of XPOT mRNA | CTD | PMID:20106945 and PMID:21632981 | Xpot | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of XPOT mRNA | CTD | PMID:19465110 | Xpot | Mouse | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:26705709 | Xpot | Mouse | 2,4-dinitrotoluene | affects expression | ISO | Xpot (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of XPOT mRNA | CTD | PMID:21346803 | Xpot | Mouse | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | XPOT (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of XPOT mRNA | CTD | PMID:28628672 | Xpot | Mouse | 6-propyl-2-thiouracil | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of XPOT mRNA | CTD | PMID:30047161 | Xpot | Mouse | acetamide | decreases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | acetamide results in decreased expression of XPOT mRNA | CTD | PMID:31881176 | Xpot | Mouse | acrylamide | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | Acrylamide results in increased expression of XPOT mRNA | CTD | PMID:32763439 | Xpot | Mouse | actinomycin D | multiple interactions | ISO | XPOT (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of XPOT protein | CTD | PMID:38460933 | Xpot | Mouse | aflatoxin B1 | affects expression | ISO | XPOT (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of XPOT protein | CTD | PMID:20106945 | Xpot | Mouse | aflatoxin B1 | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of XPOT mRNA | CTD | PMID:21632981 | Xpot | Mouse | all-trans-retinoic acid | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of XPOT mRNA | CTD | PMID:15498508 more ... | Xpot | Mouse | amitrole | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | Amitrole results in increased expression of XPOT mRNA | CTD | PMID:30047161 | Xpot | Mouse | antirheumatic drug | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of XPOT mRNA | CTD | PMID:24449571 | Xpot | Mouse | aristolochic acid A | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of XPOT mRNA | CTD | PMID:33212167 | Xpot | Mouse | arsenite(3-) | multiple interactions | ISO | XPOT (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to XPOT mRNA] | CTD | PMID:32406909 | Xpot | Mouse | arsenous acid | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of XPOT protein | CTD | PMID:25419056 | Xpot | Mouse | benzo[a]pyrene | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of XPOT mRNA | CTD | PMID:17879257 | Xpot | Mouse | benzo[a]pyrene | increases methylation | ISO | XPOT (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of XPOT 5' UTR | CTD | PMID:27901495 | Xpot | Mouse | benzo[a]pyrene | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of XPOT mRNA | CTD | PMID:20106945 and PMID:21632981 | Xpot | Mouse | bisphenol A | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of XPOT mRNA | CTD | PMID:25181051 | Xpot | Mouse | bisphenol A | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of XPOT protein | CTD | PMID:32981897 and PMID:37567409 | Xpot | Mouse | bisphenol A | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | bisphenol A results in increased expression of XPOT mRNA | CTD | PMID:29275510 and PMID:33670352 | Xpot | Mouse | bisphenol A | affects expression | ISO | XPOT (Homo sapiens) | 6480464 | bisphenol A affects the expression of XPOT mRNA | CTD | PMID:30903817 | Xpot | Mouse | bisphenol A | decreases methylation | EXP | | 6480464 | bisphenol A results in decreased methylation of XPOT promoter | CTD | PMID:27312807 | Xpot | Mouse | Bisphenol B | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | bisphenol B results in increased expression of XPOT protein | CTD | PMID:34186270 | Xpot | Mouse | bisphenol F | multiple interactions | ISO | XPOT (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of XPOT mRNA | CTD | PMID:28628672 | Xpot | Mouse | bisphenol F | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | bisphenol F results in increased expression of XPOT protein | CTD | PMID:34186270 | Xpot | Mouse | cadmium dichloride | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of XPOT mRNA | CTD | PMID:38568856 | Xpot | Mouse | calcitriol | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of XPOT mRNA | CTD | PMID:16847355 and PMID:18614847 | Xpot | Mouse | carbamazepine | affects expression | ISO | XPOT (Homo sapiens) | 6480464 | Carbamazepine affects the expression of XPOT mRNA | CTD | PMID:25979313 | Xpot | Mouse | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of XPOT mRNA | CTD | PMID:37019170 | Xpot | Mouse | clofibrate | multiple interactions | EXP | | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of XPOT mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of XPOT mRNA] | CTD | PMID:17585979 | Xpot | Mouse | cobalt dichloride | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | cobaltous chloride results in increased expression of XPOT mRNA | CTD | PMID:24386269 | Xpot | Mouse | cyclosporin A | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of XPOT mRNA | CTD | PMID:20106945 more ... | Xpot | Mouse | dexamethasone | multiple interactions | ISO | XPOT (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of XPOT mRNA | CTD | PMID:28628672 | Xpot | Mouse | diarsenic trioxide | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of XPOT protein | CTD | PMID:25419056 | Xpot | Mouse | endosulfan | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | Endosulfan results in increased expression of XPOT mRNA | CTD | PMID:29391264 | Xpot | Mouse | enzyme inhibitor | multiple interactions | ISO | XPOT (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of XPOT protein | CTD | PMID:23301498 | Xpot | Mouse | fenthion | decreases expression | EXP | | 6480464 | Fenthion results in decreased expression of XPOT mRNA | CTD | PMID:34813904 | Xpot | Mouse | flutamide | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of XPOT mRNA | CTD | PMID:24136188 | Xpot | Mouse | genistein | increases methylation | ISO | Xpot (Rattus norvegicus) | 6480464 | Genistein results in increased methylation of XPOT gene | CTD | PMID:28505145 | Xpot | Mouse | gentamycin | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of XPOT mRNA | CTD | PMID:22061828 | Xpot | Mouse | hydrazine | increases expression | EXP | | 6480464 | hydrazine results in increased expression of XPOT mRNA | CTD | PMID:15282401 | Xpot | Mouse | indometacin | multiple interactions | ISO | XPOT (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of XPOT mRNA | CTD | PMID:28628672 | Xpot | Mouse | ivermectin | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of XPOT protein | CTD | PMID:32959892 | Xpot | Mouse | ketoconazole | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | Ketoconazole results in decreased expression of XPOT mRNA | CTD | PMID:36621641 | Xpot | Mouse | lead diacetate | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | lead acetate results in increased expression of XPOT mRNA | CTD | PMID:11578147 | Xpot | Mouse | methapyrilene | decreases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | Methapyrilene results in decreased expression of XPOT mRNA | CTD | PMID:30467583 | Xpot | Mouse | methidathion | decreases expression | EXP | | 6480464 | methidathion results in decreased expression of XPOT mRNA | CTD | PMID:34813904 | Xpot | Mouse | methimazole | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | Methimazole results in increased expression of XPOT mRNA | CTD | PMID:30047161 | Xpot | Mouse | methylmercury chloride | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of XPOT mRNA | CTD | PMID:28001369 | Xpot | Mouse | methylparaben | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | methylparaben results in increased expression of XPOT mRNA | CTD | PMID:31745603 | Xpot | Mouse | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of XPOT protein | CTD | PMID:26558463 | Xpot | Mouse | N-methyl-4-phenylpyridinium | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of XPOT mRNA | CTD | PMID:28801915 | Xpot | Mouse | N-methyl-4-phenylpyridinium | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of XPOT mRNA | CTD | PMID:24810058 | Xpot | Mouse | nefazodone | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | nefazodone results in increased expression of XPOT mRNA | CTD | PMID:24136188 | Xpot | Mouse | nimesulide | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | nimesulide results in increased expression of XPOT mRNA | CTD | PMID:24136188 | Xpot | Mouse | Nutlin-3 | multiple interactions | ISO | XPOT (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of XPOT protein | CTD | PMID:38460933 | Xpot | Mouse | paracetamol | multiple interactions | EXP | | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of XPOT mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of XPOT mRNA] | CTD | PMID:17585979 | Xpot | Mouse | paracetamol | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of XPOT mRNA | CTD | PMID:29067470 | Xpot | Mouse | paracetamol | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of XPOT mRNA | CTD | PMID:22230336 | Xpot | Mouse | perfluorononanoic acid | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in increased expression of XPOT mRNA | CTD | PMID:32588087 | Xpot | Mouse | phenobarbital | affects expression | ISO | XPOT (Homo sapiens) | 6480464 | Phenobarbital affects the expression of XPOT mRNA | CTD | PMID:19159669 | Xpot | Mouse | piroxicam | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | Piroxicam results in decreased expression of XPOT mRNA | CTD | PMID:21858171 | Xpot | Mouse | progesterone | affects expression | EXP | | 6480464 | Progesterone affects the expression of XPOT mRNA | CTD | PMID:17251523 | Xpot | Mouse | quercetin | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | Quercetin results in decreased expression of XPOT mRNA | CTD | PMID:21632981 | Xpot | Mouse | silicon dioxide | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of XPOT mRNA | CTD | PMID:25895662 | Xpot | Mouse | sodium arsenite | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of XPOT mRNA | CTD | PMID:28595984 and PMID:34032870 | Xpot | Mouse | sodium arsenite | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of XPOT mRNA | CTD | PMID:38568856 | Xpot | Mouse | sulfadimethoxine | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in increased expression of XPOT mRNA | CTD | PMID:30047161 | Xpot | Mouse | sulforaphane | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | sulforaphane results in increased expression of XPOT mRNA | CTD | PMID:31838189 | Xpot | Mouse | sunitinib | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | Sunitinib results in increased expression of XPOT mRNA | CTD | PMID:31533062 | Xpot | Mouse | tamibarotene | decreases expression | ISO | XPOT (Homo sapiens) | 6480464 | tamibarotene results in decreased expression of XPOT mRNA | CTD | PMID:15498508 | Xpot | Mouse | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of XPOT mRNA | CTD | PMID:27339419 and PMID:31919559 | Xpot | Mouse | tetrachloromethane | multiple interactions | ISO | Xpot (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of XPOT mRNA] | CTD | PMID:31150632 | Xpot | Mouse | tetrachloromethane | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in increased expression of XPOT mRNA | CTD | PMID:31150632 | Xpot | Mouse | thapsigargin | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | Thapsigargin results in increased expression of XPOT mRNA | CTD | PMID:22378314 | Xpot | Mouse | thioacetamide | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of XPOT mRNA | CTD | PMID:34492290 | Xpot | Mouse | titanium dioxide | decreases expression | EXP | | 6480464 | titanium dioxide results in decreased expression of XPOT mRNA | CTD | PMID:29264374 | Xpot | Mouse | titanium dioxide | decreases methylation | EXP | | 6480464 | titanium dioxide results in decreased methylation of XPOT gene | CTD | PMID:35295148 | Xpot | Mouse | trichloroethene | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of XPOT mRNA | CTD | PMID:33387578 | Xpot | Mouse | triphenyl phosphate | affects expression | ISO | XPOT (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of XPOT mRNA | CTD | PMID:37042841 | Xpot | Mouse | trovafloxacin | decreases expression | EXP | | 6480464 | trovafloxacin results in decreased expression of XPOT mRNA | CTD | PMID:35537566 | Xpot | Mouse | tunicamycin | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of XPOT mRNA and Tunicamycin results in increased expression of XPOT protein | CTD | PMID:22378314 and PMID:29453283 | Xpot | Mouse | valdecoxib | increases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | valdecoxib results in increased expression of XPOT mRNA | CTD | PMID:24136188 | Xpot | Mouse | valproic acid | increases expression | ISO | XPOT (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of XPOT mRNA | CTD | PMID:29154799 | Xpot | Mouse | vinclozolin | decreases expression | ISO | Xpot (Rattus norvegicus) | 6480464 | vinclozolin results in decreased expression of XPOT mRNA | CTD | PMID:23555832 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Biological Process
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 2. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 3. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 4. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:8889548 | PMID:10349636 | PMID:10725249 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:11544199 | PMID:12466851 | PMID:12477932 | PMID:12520002 | PMID:12904583 |
| PMID:14610273 | PMID:14691545 | PMID:15489334 | PMID:15741177 | PMID:15782199 | PMID:16141072 | PMID:16141073 | PMID:16783635 | PMID:17967808 | PMID:18799693 | PMID:21267068 | PMID:21873635 |
| PMID:24194600 | PMID:24457600 | PMID:27626380 | PMID:34255829 | PMID:36114006 | PMID:38355793 |
Genomics
Comparative Map Data
| Xpot (Mus musculus - house mouse) |
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| XPOT (Homo sapiens - human) |
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| Xpot (Rattus norvegicus - Norway rat) |
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| Xpot (Chinchilla lanigera - long-tailed chinchilla) |
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| XPOT (Pan paniscus - bonobo/pygmy chimpanzee) |
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| XPOT (Canis lupus familiaris - dog) |
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| Xpot (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| XPOT (Sus scrofa - pig) |
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| XPOT (Chlorocebus sabaeus - green monkey) |
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| Xpot (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Xpot
1692 total Variants 
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