Tmem59l (transmembrane protein 59-like) - Rat Genome Database
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Gene: Tmem59l (transmembrane protein 59-like) Mus musculus
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Symbol: Tmem59l
Name: transmembrane protein 59-like
RGD ID: 1313654
MGI Page MGI
Description: Predicted to localize to Golgi apparatus and integral component of membrane. Is expressed in several structures, including liver; lung; nervous system; retina; and ureteric tip. Orthologous to human TMEM59L (transmembrane protein 59 like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; ethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5330410G16Rik; brain-specific membrane-anchored protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,936,505 - 70,939,998 (-)NCBIGRCm39mm39
GRCm38870,483,855 - 70,487,348 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,483,867 - 70,487,358 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,007,766 - 73,011,257 (-)NCBIGRCm37mm9NCBIm37
MGSCv36873,412,856 - 73,416,347 (-)NCBImm8
Celera873,040,279 - 73,043,770 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
ovarian cyst  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15226823   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:18287559   PMID:21267068   PMID:21677750   PMID:28705898   PMID:32017326  


Genomics

Comparative Map Data
Tmem59l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,936,505 - 70,939,998 (-)NCBIGRCm39mm39
GRCm38870,483,855 - 70,487,348 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,483,867 - 70,487,358 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,007,766 - 73,011,257 (-)NCBIGRCm37mm9NCBIm37
MGSCv36873,412,856 - 73,416,347 (-)NCBImm8
Celera873,040,279 - 73,043,770 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
TMEM59L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1918,607,430 - 18,621,039 (+)EnsemblGRCh38hg38GRCh38
GRCh381918,612,870 - 18,621,040 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371918,723,682 - 18,731,849 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,584,682 - 18,592,849 (+)NCBINCBI36hg18NCBI36
Build 341918,584,711 - 18,592,822NCBI
Celera1918,625,877 - 18,634,029 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1918,286,195 - 18,294,347 (+)NCBIHuRef
CHM1_11918,723,794 - 18,731,960 (+)NCBICHM1_1
Tmem59l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01620,691,956 - 20,695,701 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,691,978 - 20,695,701 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,547,447 - 20,551,180 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,448,403 - 19,452,133 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11619,448,409 - 19,452,106 (+)NCBI
Celera1619,133,030 - 19,136,753 (+)NCBICelera
Cytogenetic Map16p14NCBI
Tmem59l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555242,981,909 - 2,988,080 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555242,983,699 - 2,988,080 (-)NCBIChiLan1.0ChiLan1.0
TMEM59L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11919,059,627 - 19,068,171 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1919,059,660 - 19,067,669 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01918,089,605 - 18,097,943 (+)NCBIMhudiblu_PPA_v0panPan3
TMEM59L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2044,450,349 - 44,455,933 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12044,450,164 - 44,455,983 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tmem59l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365962,679,689 - 2,685,323 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM59L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,210,792 - 59,223,004 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,211,404 - 59,223,017 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2258,965,371 - 58,970,420 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM59L
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1617,080,955 - 17,093,524 (+)NCBI
ChlSab1.1 Ensembl617,080,093 - 17,093,574 (+)Ensembl
Tmem59l
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,767,673 - 1,772,145 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:236
Count of miRNA genes:190
Interacting mature miRNAs:202
Transcripts:ENSMUST00000045286
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000045286   ⟹   ENSMUSP00000043659
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,483,867 - 70,487,358 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210365
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,485,171 - 70,487,324 (-)Ensembl
RefSeq Acc Id: NM_001368366   ⟹   NP_001355295
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,936,505 - 70,939,998 (-)NCBI
GRCm38870,483,855 - 70,487,348 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001368367   ⟹   NP_001355296
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,936,505 - 70,939,998 (-)NCBI
GRCm38870,483,855 - 70,487,348 (-)NCBI
Sequence:
RefSeq Acc Id: NM_182991   ⟹   NP_892036
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,936,505 - 70,939,998 (-)NCBI
GRCm38870,483,855 - 70,487,348 (-)NCBI
MGSCv37873,007,766 - 73,011,257 (-)RGD
Celera873,040,279 - 73,043,770 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001355295 (Get FASTA)   NCBI Sequence Viewer  
  NP_001355296 (Get FASTA)   NCBI Sequence Viewer  
  NP_892036 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH56172 (Get FASTA)   NCBI Sequence Viewer  
  EDL28822 (Get FASTA)   NCBI Sequence Viewer  
  Q7TNI2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_892036   ⟸   NM_182991
- Peptide Label: isoform 1 precursor
- UniProtKB: Q7TNI2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001355296   ⟸   NM_001368367
- Peptide Label: isoform 3 precursor
RefSeq Acc Id: NP_001355295   ⟸   NM_001368366
- Peptide Label: isoform 2 precursor
RefSeq Acc Id: ENSMUSP00000043659   ⟸   ENSMUST00000045286

Promoters
RGD ID:8667311
Promoter ID:EPDNEW_M11686
Type:initiation region
Name:Tmem59l_1
Description:Mus musculus transmembrane protein 59-like , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38870,487,321 - 70,487,381EPDNEW
RGD ID:6843825
Promoter ID:MM_KWN:54706
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_182991
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,010,911 - 73,011,411 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915187 AgrOrtholog
Ensembl Genes ENSMUSG00000035964 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000043659 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000045286 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Uncharacterised_TMEM59 UniProtKB/Swiss-Prot
KEGG Report mmu:67937 UniProtKB/Swiss-Prot
MGD MGI:1915187 ENTREZGENE
NCBI Gene 67937 ENTREZGENE
PANTHER PTHR28652 UniProtKB/Swiss-Prot
Pfam BSMAP UniProtKB/Swiss-Prot
PhenoGen Tmem59l PhenoGen
UniGene Mm.23002 ENTREZGENE
UniProt Q7TNI2 ENTREZGENE, UniProtKB/Swiss-Prot