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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | ISO | RGD:1305542 | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of FBL mRNA] | CTD | PMID:31150632 | (R,R,R)-alpha-tocopherol | decreases expression | ISO | RGD:1305542 | 6480464 | alpha-Tocopherol deficiency results in decreased expression of FBL protein | CTD | PMID:15247049 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of FBL mRNA | CTD | PMID:22206623 | 17beta-estradiol | affects expression | EXP | | 6480464 | Estradiol affects the expression of FBL mRNA | CTD | PMID:15598610 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | EXP | | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | RGD:1313628 | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1313628 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of FBL mRNA | CTD | PMID:19684285 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1305542 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of FBL mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1313628 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of FBL mRNA | CTD | PMID:19684285 | 2,4,6-tribromophenol | decreases expression | ISO | RGD:1313628 | 6480464 | 2 more ... | CTD | PMID:31675489 | 3,3',5,5'-tetrabromobisphenol A | increases expression | ISO | RGD:1313628 | 6480464 | tetrabromobisphenol A results in increased expression of FBL protein | CTD | PMID:31675489 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of FBL mRNA | CTD | PMID:20188158 | 3-chloropropane-1,2-diol | increases expression | ISO | RGD:1305542 | 6480464 | alpha-Chlorohydrin results in increased expression of FBL protein | CTD | PMID:34915118 | actinomycin D | affects localization | ISO | RGD:1313628 | 6480464 | Dactinomycin analog affects the localization of FBL protein | CTD | PMID:10942594 | all-trans-retinoic acid | decreases expression | ISO | RGD:1313628 | 6480464 | Tretinoin results in decreased expression of FBL mRNA | CTD | PMID:33167477 | arsenite(3-) | multiple interactions | ISO | RGD:1313628 | 6480464 | arsenite promotes the reaction [G3BP1 protein binds to FBL mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | increases methylation | ISO | RGD:1313628 | 6480464 | Benzo(a)pyrene results in increased methylation of FBL promoter | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | RGD:1313628 | 6480464 | Benzo(a)pyrene affects the methylation of FBL 3' UTR | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RGD:1313628 | 6480464 | 7 more ... | CTD | PMID:20382639 | biochanin A | increases expression | ISO | RGD:1313628 | 6480464 | biochanin A results in increased expression of FBL mRNA | CTD | PMID:12111696 | bisphenol A | increases expression | ISO | RGD:1305542 | 6480464 | bisphenol A results in increased expression of FBL mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | RGD:1313628 | 6480464 | bisphenol A results in decreased expression of FBL mRNA, bisphenol A results in decreased expression of FBL protein | CTD | PMID:29275510, PMID:31675489 | cadmium atom | multiple interactions | ISO | RGD:1313628 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of FBL mRNA | CTD | PMID:35301059 | cadmium dichloride | affects localization | ISO | RGD:1313628 | 6480464 | Cadmium Chloride affects the localization of FBL protein | CTD | PMID:10942594 | cadmium dichloride | multiple interactions | ISO | RGD:1313628 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of FBL mRNA | CTD | PMID:35301059 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chromium(6+) | affects expression | EXP | | 6480464 | chromium hexavalent ion affects the expression of FBL mRNA | CTD | PMID:28472532 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of FBL mRNA | CTD | PMID:21151649 | cisplatin | affects localization | ISO | RGD:1313628 | 6480464 | Cisplatin analog affects the localization of FBL protein | CTD | PMID:10942594 | clobetasol | increases expression | EXP | | 6480464 | Clobetasol results in increased expression of FBL mRNA | CTD | PMID:27462272 | clofibrate | decreases expression | EXP | | 6480464 | Clofibrate results in decreased expression of FBL mRNA | CTD | PMID:17585979 | cycloheximide | multiple interactions | ISO | RGD:1313628 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of FBL mRNA | CTD | PMID:19684285 | cyclosporin A | increases expression | ISO | RGD:1313628 | 6480464 | Cyclosporine results in increased expression of FBL mRNA | CTD | PMID:20106945, PMID:27989131 | decabromodiphenyl ether | increases expression | ISO | RGD:1313628 | 6480464 | decabromobiphenyl ether results in increased expression of FBL protein | CTD | PMID:31675489 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of FBL mRNA | CTD | PMID:17361019 | Didecyldimethylammonium | decreases expression | ISO | RGD:1313628 | 6480464 | didecyldimethylammonium results in decreased expression of FBL protein | CTD | PMID:32763356 | disodium selenite | increases expression | ISO | RGD:1313628 | 6480464 | Sodium Selenite results in increased expression of FBL mRNA | CTD | PMID:18175754 | doxorubicin | decreases expression | ISO | RGD:1313628 | 6480464 | Doxorubicin results in decreased expression of FBL mRNA | CTD | PMID:29803840 | enzyme inhibitor | multiple interactions | ISO | RGD:1313628 | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of FBL protein | CTD | PMID:23301498 | etoposide | affects localization | ISO | RGD:1313628 | 6480464 | Etoposide analog affects the localization of FBL protein | CTD | PMID:10942594 | fenpyroximate | increases expression | ISO | RGD:1313628 | 6480464 | fenpyroximate results in increased expression of FBL mRNA | CTD | PMID:33512557 | flutamide | increases expression | ISO | RGD:1305542 | 6480464 | Flutamide results in increased expression of FBL mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | EXP | | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of FBL mRNA | CTD | PMID:22206623 | folpet | decreases expression | EXP | | 6480464 | folpet results in decreased expression of FBL mRNA | CTD | PMID:31558096 | gentamycin | increases expression | ISO | RGD:1305542 | 6480464 | Gentamicins results in increased expression of FBL mRNA | CTD | PMID:22061828 | glafenine | increases expression | ISO | RGD:1305542 | 6480464 | Glafenine results in increased expression of FBL mRNA | CTD | PMID:24136188 | ivermectin | decreases expression | ISO | RGD:1313628 | 6480464 | Ivermectin results in decreased expression of FBL protein | CTD | PMID:32959892 | ketamine | decreases expression | ISO | RGD:1305542 | 6480464 | Ketamine results in decreased expression of FBL mRNA | CTD | PMID:20080153 | lead diacetate | affects localization | ISO | RGD:1313628 | 6480464 | lead acetate affects the localization of FBL protein | CTD | PMID:10942594 | mercury dichloride | affects localization | ISO | RGD:1313628 | 6480464 | Mercuric Chloride affects the localization of FBL protein | CTD | PMID:10942594 | mercury dichloride | affects localization | EXP | | 6480464 | Mercuric Chloride affects the localization of FBL protein | CTD | PMID:10942594, PMID:12388758 | mercury dichloride | decreases activity | EXP | | 6480464 | Mercuric Chloride results in decreased activity of FBL protein | CTD | PMID:19077085 | mercury dichloride | increases cleavage | EXP | | 6480464 | Mercuric Chloride results in increased cleavage of FBL protein | CTD | PMID:10925315 | mercury dichloride | multiple interactions | EXP | | 6480464 | CD28 protein affects the reaction [Mercuric Chloride results in decreased activity of FBL protein] more ... | CTD | PMID:19077085 | methylisothiazolinone | increases expression | ISO | RGD:1313628 | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of FBL protein | CTD | PMID:31629900 | miconazole | increases expression | EXP | | 6480464 | Miconazole results in increased expression of FBL mRNA | CTD | PMID:27462272 | mitomycin C | affects localization | ISO | RGD:1313628 | 6480464 | Mitomycin analog affects the localization of FBL protein | CTD | PMID:10942594 | Monobutylphthalate | decreases expression | EXP | | 6480464 | monobutyl phthalate results in decreased expression of FBL protein | CTD | PMID:20553848 | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of FBL protein | CTD | PMID:26558463 | nefazodone | increases expression | ISO | RGD:1305542 | 6480464 | nefazodone results in increased expression of FBL mRNA | CTD | PMID:24136188 | nimesulide | increases expression | ISO | RGD:1305542 | 6480464 | nimesulide results in increased expression of FBL mRNA | CTD | PMID:24136188 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of FBL mRNA | CTD | PMID:17562736 | paraquat | increases expression | ISO | RGD:1305542 | 6480464 | Paraquat results in increased expression of FBL mRNA | CTD | PMID:32680482 | PCB138 | increases expression | ISO | RGD:1305542 | 6480464 | 2 more ... | CTD | PMID:23829299 | perfluorooctanoic acid | decreases expression | ISO | RGD:1313628 | 6480464 | perfluorooctanoic acid results in decreased expression of FBL protein | CTD | PMID:26879310 | picoxystrobin | increases expression | ISO | RGD:1313628 | 6480464 | picoxystrobin results in increased expression of FBL mRNA | CTD | PMID:33512557 | pyrimidifen | increases expression | ISO | RGD:1313628 | 6480464 | pyrimidifen results in increased expression of FBL mRNA | CTD | PMID:33512557 | rotenone | increases expression | ISO | RGD:1313628 | 6480464 | Rotenone results in increased expression of FBL mRNA | CTD | PMID:33512557 | rotenone | increases expression | ISO | RGD:1305542 | 6480464 | Rotenone results in increased expression of FBL protein | CTD | PMID:35544339 | silver(1+) nitrate | decreases activity | EXP | | 6480464 | Silver Nitrate results in decreased activity of FBL protein | CTD | PMID:19077085 | silver(1+) nitrate | multiple interactions | EXP | | 6480464 | CD28 protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein] more ... | CTD | PMID:19077085 | sodium aurothiomalate | affects localization | ISO | RGD:1313628 | 6480464 | Gold Sodium Thiomalate affects the localization of FBL protein | CTD | PMID:10942594 | sodium aurothiomalate | decreases activity | EXP | | 6480464 | Gold Sodium Thiomalate results in decreased activity of FBL protein | CTD | PMID:19077085 | sodium aurothiomalate | multiple interactions | EXP | | 6480464 | CD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein] more ... | CTD | PMID:19077085 | sodium dichromate | increases expression | ISO | RGD:1305542 | 6480464 | sodium bichromate results in increased expression of FBL mRNA | CTD | PMID:25993096 | sodium fluoride | decreases expression | EXP | | 6480464 | Sodium Fluoride results in decreased expression of FBL protein | CTD | PMID:28918527 | Soman | increases expression | ISO | RGD:1305542 | 6480464 | Soman results in increased expression of FBL mRNA | CTD | PMID:19281266 | tebufenpyrad | increases expression | ISO | RGD:1313628 | 6480464 | 4-chloro-N-((4-(1, 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in increased expression of FBL mRNA | CTD | PMID:33512557 | tetrachloromethane | multiple interactions | ISO | RGD:1305542 | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of FBL mRNA] | CTD | PMID:31150632 | tetrachloromethane | increases expression | ISO | RGD:1305542 | 6480464 | Carbon Tetrachloride results in increased expression of FBL mRNA | CTD | PMID:31150632 | thioacetamide | increases expression | ISO | RGD:1305542 | 6480464 | Thioacetamide results in increased expression of FBL mRNA | CTD | PMID:34492290 | valdecoxib | increases expression | ISO | RGD:1305542 | 6480464 | valdecoxib results in increased expression of FBL mRNA | CTD | PMID:24136188 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of FBL mRNA | CTD | PMID:17292431 | valproic acid | increases methylation | ISO | RGD:1313628 | 6480464 | Valproic Acid results in increased methylation of FBL gene | CTD | PMID:29154799 | |