Hs2st1 (heparan sulfate 2-O-sulfotransferase 1) - Rat Genome Database

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Gene: Hs2st1 (heparan sulfate 2-O-sulfotransferase 1) Mus musculus
Analyze
Symbol: Hs2st1
Name: heparan sulfate 2-O-sulfotransferase 1
RGD ID: 1313349
MGI Page MGI
Description: Exhibits heparan sulfate 2-O-sulfotransferase activity. Involved in several processes, including heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; heparin metabolic process; and ureteric bud formation. Predicted to localize to Golgi apparatus and integral component of membrane. Is expressed in brain and future brain. Orthologous to human HS2ST1 (heparan sulfate 2-O-sulfotransferase 1); PARTICIPATES IN heparan sulfate biosynthetic pathway; INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2-O-sulfotransferase; 2-OST; 2OST; AW214369; Hs2; Hs2st; mKIAA0448
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393144,135,462 - 144,275,977 (-)NCBIGRCm39mm39
GRCm39 Ensembl3144,135,467 - 144,275,942 (-)Ensembl
GRCm383144,429,701 - 144,570,216 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3144,429,706 - 144,570,181 (-)EnsemblGRCm38mm10GRCm38
MGSCv373144,094,071 - 144,233,180 (-)NCBIGRCm37mm9NCBIm37
MGSCv363144,368,496 - 144,507,524 (-)NCBImm8
Celera3150,868,350 - 150,902,535 (-)NCBICelera
Cytogenetic Map3H2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:9153262   PMID:9637690   PMID:10349636   PMID:10677367   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11331020   PMID:11457822   PMID:11687650   PMID:12417414  
PMID:12460940   PMID:12477932   PMID:12676797   PMID:12904583   PMID:12975615   PMID:14610273   PMID:14654220   PMID:15317737   PMID:15489334   PMID:15782199   PMID:16075368   PMID:16141072  
PMID:16141073   PMID:16807321   PMID:16919269   PMID:17405882   PMID:18799693   PMID:19889634   PMID:20059993   PMID:21307234   PMID:21357686   PMID:21586278   PMID:21677750   PMID:21873635  
PMID:21951307   PMID:22745308   PMID:22791291   PMID:24501377   PMID:24753163   PMID:24924191   PMID:25284049   PMID:26075383   PMID:26393505   PMID:27048738   PMID:29158323   PMID:30617207  
PMID:32201365   PMID:32636266  


Genomics

Comparative Map Data
Hs2st1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393144,135,462 - 144,275,977 (-)NCBIGRCm39mm39
GRCm39 Ensembl3144,135,467 - 144,275,942 (-)Ensembl
GRCm383144,429,701 - 144,570,216 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3144,429,706 - 144,570,181 (-)EnsemblGRCm38mm10GRCm38
MGSCv373144,094,071 - 144,233,180 (-)NCBIGRCm37mm9NCBIm37
MGSCv363144,368,496 - 144,507,524 (-)NCBImm8
Celera3150,868,350 - 150,902,535 (-)NCBICelera
Cytogenetic Map3H2NCBI
HS2ST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl186,914,635 - 87,109,982 (+)EnsemblGRCh38hg38GRCh38
GRCh38186,914,635 - 87,109,982 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37187,380,318 - 87,575,665 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36187,152,950 - 87,348,252 (+)NCBINCBI36hg18NCBI36
Build 34187,092,382 - 87,287,685NCBI
Celera185,623,706 - 85,821,380 (+)NCBI
Cytogenetic Map1p22.3NCBI
HuRef185,491,509 - 85,689,310 (+)NCBIHuRef
CHM1_1187,495,264 - 87,690,587 (+)NCBICHM1_1
Hs2st1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22233,508,018 - 233,641,769 (-)NCBI
Rnor_6.0 Ensembl2250,467,429 - 250,600,517 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02250,467,428 - 250,600,517 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02268,996,210 - 269,129,114 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42242,622,270 - 242,760,095 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12242,610,982 - 242,746,835 (-)NCBI
Celera2225,501,220 - 225,634,734 (-)NCBICelera
Cytogenetic Map2q44NCBI
Hs2st1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554237,090,246 - 7,253,608 (-)NCBIChiLan1.0ChiLan1.0
HS2ST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1188,283,486 - 88,480,498 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl188,283,872 - 88,475,198 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01119,432,583 - 119,630,472 (+)NCBIMhudiblu_PPA_v0panPan3
HS2ST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1661,124,393 - 61,298,912 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha663,838,125 - 64,012,670 (-)NCBI
ROS_Cfam_1.0661,664,708 - 61,838,267 (-)NCBI
UMICH_Zoey_3.1661,198,888 - 61,372,107 (-)NCBI
UNSW_CanFamBas_1.0661,155,168 - 61,335,473 (-)NCBI
UU_Cfam_GSD_1.0661,660,387 - 61,834,150 (-)NCBI
Hs2st1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505897,492,076 - 97,666,113 (+)NCBI
SpeTri2.0NW_0049367321,773,043 - 1,947,081 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HS2ST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.14129,101,900 - 129,258,372 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24141,550,206 - 141,705,780 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HS2ST1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12046,346,009 - 46,546,363 (-)NCBI
ChlSab1.1 Ensembl2046,350,496 - 46,386,791 (-)Ensembl
Vero_WHO_p1.0NW_02366603371,286,322 - 71,488,665 (+)NCBI
Hs2st1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474210,472,607 - 10,695,939 (-)NCBI

Position Markers
AF060178  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383144,433,839 - 144,433,984UniSTSGRCm38
MGSCv373144,096,803 - 144,096,948UniSTSGRCm37
Celera3150,871,082 - 150,871,227UniSTS
Cytogenetic Map3H2UniSTS
Whitehead/MRC_RH31579.04UniSTS
AW214369  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383144,431,333 - 144,431,418UniSTSGRCm38
MGSCv373144,094,297 - 144,094,382UniSTSGRCm37
Celera3150,868,576 - 150,868,661UniSTS
Cytogenetic Map3H2UniSTS
Whitehead/MRC_RH31577.52UniSTS
Hs2st1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3H2UniSTS
cM Map3 UniSTS
UniSTS:234839  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383144,564,075 - 144,564,386UniSTSGRCm38
MGSCv373144,227,039 - 144,227,350UniSTSGRCm37
Celera3151,005,225 - 151,005,536UniSTS
Cytogenetic Map3H2UniSTS
PMC316906P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383144,444,365 - 144,444,522UniSTSGRCm38
MGSCv373144,107,329 - 144,107,486UniSTSGRCm37
Celera3150,881,608 - 150,881,765UniSTS
Cytogenetic Map3H2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300753Eae10_msusceptibility to experimental allergic encephalomyelitis 10 (mouse)Not determined3132030856148745542Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107469620147599053Mouse
4142449Tgq14_mtriglyceride QTL 14 (mouse)Not determined119612825153612825Mouse
1301347Fpli_mfasting plasma insulin (mouse)Not determined3126754753160039680Mouse
1301221Hrtfm2_mheart failure modifier 2 (mouse)Not determined3143564487147339967Mouse
4141935Tgq15_mtriglyceride QTL 15 (mouse)Not determined119612825153612825Mouse
1301381Bomb1_mbone marrow pre-B 1 (mouse)Not determined3111339594145339768Mouse
1302151Lprm2_mlymphoproliferation modifier 2 (mouse)Not determined3120073096154073283Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100465596147339967Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
10412240Alpq6_malcohol preference QTL 6 (mouse)Not determined3121066317155066317Mouse
1301563Alcp3_malcohol preference locus 3 (mouse)Not determined3131031299160039680Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396700000148100000Mouse
10412120Ccs3_mcolon cancer susceptibility 3 (mouse)Not determined3132048775146311914Mouse
10043919Afpq8_mabdominal fat percent QTL 8 (mouse)Not determined3119351571153351695Mouse
1301528Loco1_mlocomotor activity 1 (mouse)Not determined3133756256160039680Mouse
11039523Tbbr1_mTrypanosoma brucei brucei response 1 (mouse)3131143739160039680Mouse
1558868Ses9_msalmonella enteritidis susceptibility 9 (mouse)Not determined3119351571153351695Mouse
1301218Letohc1_mlow ethanol consumption 1 (mouse)Not determined3126647225160039680Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101400000150100000Mouse
4142245Pstc1_mperiosteal circumference 1 (mouse)Not determined3126564487160039680Mouse
1301222Scc7_mcolon tumor susceptibility 7 (mouse)Not determined3143647225156658471Mouse
1301100Bdt2_mbone density traits 2 (mouse)Not determined3115030856149031023Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1375
Count of miRNA genes:646
Interacting mature miRNAs:806
Transcripts:ENSMUST00000043325, ENSMUST00000160690
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000043325   ⟹   ENSMUSP00000043066
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3144,429,706 - 144,570,181 (-)Ensembl
RefSeq Acc Id: ENSMUST00000160690   ⟹   ENSMUSP00000123816
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3144,453,963 - 144,569,881 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199680
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3144,567,838 - 144,570,158 (-)Ensembl
RefSeq Acc Id: NM_001355234   ⟹   NP_001342163
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393144,135,462 - 144,275,977 (-)NCBI
GRCm383144,429,701 - 144,570,216 (-)NCBI
Sequence:
RefSeq Acc Id: NM_011828   ⟹   NP_035958
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393144,135,462 - 144,275,977 (-)NCBI
GRCm383144,429,701 - 144,570,216 (-)NCBI
MGSCv373144,094,071 - 144,233,180 (-)RGD
Celera3150,868,350 - 150,902,535 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006501450   ⟹   XP_006501513
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393144,135,467 - 144,275,473 (-)NCBI
GRCm383144,433,448 - 144,569,716 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035958   ⟸   NM_011828
- Peptide Label: isoform 2
- UniProtKB: Q8R3H7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006501513   ⟸   XM_006501450
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001342163   ⟸   NM_001355234
- Peptide Label: isoform 1
RefSeq Acc Id: ENSMUSP00000123816   ⟸   ENSMUST00000160690
RefSeq Acc Id: ENSMUSP00000043066   ⟸   ENSMUST00000043325

Promoters
RGD ID:6833964
Promoter ID:MM_KWN:36312
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000088088
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363144,128,336 - 144,128,836 (-)MPROMDB
RGD ID:6833967
Promoter ID:MM_KWN:36313
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000106211,   NM_011828,   OTTMUST00000050336,   OTTMUST00000050338,   UC008RPP.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363144,232,421 - 144,233,787 (-)MPROMDB
RGD ID:6882544
Promoter ID:EPDNEW_M4723
Type:initiation region
Name:Hs2st1_1
Description:Mus musculus heparan sulfate 2-O-sulfotransferase 1 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383144,570,199 - 144,570,259EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346049 AgrOrtholog
Ensembl Genes ENSMUSG00000040151 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000043066 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000123816 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000043325 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000160690 UniProtKB/TrEMBL
InterPro Heparan_SO4_2-O-STrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot
  Sulfotransferase UniProtKB/Swiss-Prot
KEGG Report mmu:23908 UniProtKB/Swiss-Prot
MGD MGI:1346049 ENTREZGENE
NCBI Gene 23908 ENTREZGENE
PANTHER PTHR12129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sulfotransfer_2 UniProtKB/Swiss-Prot
PhenoGen Hs2st1 PhenoGen
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt E0CYX6_MOUSE UniProtKB/TrEMBL
  HS2ST_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O88464 UniProtKB/Swiss-Prot
  Q3TNP7 UniProtKB/Swiss-Prot
  Q9JLK2 UniProtKB/Swiss-Prot