PLA2G3 (phospholipase A2 group III) - Rat Genome Database

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Gene: PLA2G3 (phospholipase A2 group III) Homo sapiens
Analyze
Symbol: PLA2G3
Name: phospholipase A2 group III
RGD ID: 1313284
HGNC Page HGNC
Description: Enables calcium-dependent phospholipase A2 activity. Involved in several processes, including glycerophospholipid metabolic process; plasma lipoprotein particle remodeling; and regulation of vesicle-mediated transport. Acts upstream of or within negative regulation of gene expression. Located in centriole and recycling endosome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GIII sPLA2; GIII-SPLA2; group 3 secretory phospholipase A2; group III secreted phospholipase A2; group III secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 3; phosphatidylcholine 2-acylhydrolase GIII; phospholipase A2, group III; sPLA2-III; SPLA2III
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2231,134,807 - 31,140,508 (-)EnsemblGRCh38hg38GRCh38
GRCh382231,134,807 - 31,140,508 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372231,530,793 - 31,536,494 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,860,793 - 29,866,469 (-)NCBINCBI36hg18NCBI36
Build 342229,855,346 - 29,861,023NCBI
Celera2215,330,868 - 15,336,544 (-)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2214,492,451 - 14,498,127 (-)NCBIHuRef
CHM1_12231,490,658 - 31,496,334 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:9377118   PMID:9745929   PMID:10591208   PMID:10713052   PMID:12127976   PMID:12477932   PMID:12522102   PMID:15489334   PMID:15863501   PMID:17868035   PMID:17980167   PMID:18801741  
PMID:19371233   PMID:19541351   PMID:19805624   PMID:19851296   PMID:20056178   PMID:20198315   PMID:20393563   PMID:20492356   PMID:20654644   PMID:20930276   PMID:21701769   PMID:21848517  
PMID:21988832   PMID:23624557   PMID:23685814   PMID:23776197   PMID:23793742   PMID:24508801   PMID:24692702   PMID:25230085   PMID:25286228   PMID:25964585   PMID:26637123   PMID:27146384  
PMID:28947740   PMID:33961781  


Genomics

Comparative Map Data
PLA2G3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2231,134,807 - 31,140,508 (-)EnsemblGRCh38hg38GRCh38
GRCh382231,134,807 - 31,140,508 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372231,530,793 - 31,536,494 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,860,793 - 29,866,469 (-)NCBINCBI36hg18NCBI36
Build 342229,855,346 - 29,861,023NCBI
Celera2215,330,868 - 15,336,544 (-)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2214,492,451 - 14,498,127 (-)NCBIHuRef
CHM1_12231,490,658 - 31,496,334 (-)NCBICHM1_1
Pla2g3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,438,158 - 3,449,346 (+)NCBIGRCm39mm39
GRCm39 Ensembl113,438,284 - 3,449,350 (+)Ensembl
GRCm38113,488,158 - 3,499,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,488,284 - 3,499,350 (+)EnsemblGRCm38mm10GRCm38
MGSCv37113,388,230 - 3,394,169 (+)NCBIGRCm37mm9NCBIm37
MGSCv36113,388,302 - 3,399,353 (+)NCBImm8
Celera113,979,003 - 3,985,078 (+)NCBICelera
Cytogenetic Map11A1NCBI
Pla2g3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21478,367,625 - 78,373,913 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1478,368,105 - 78,373,913 (+)Ensembl
Rnor_6.01483,724,828 - 83,730,614 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,724,933 - 83,730,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,412,999 - 84,418,680 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,119,872 - 84,125,552 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11484,130,645 - 84,143,800 (+)NCBI
Celera1477,281,569 - 77,287,249 (+)NCBICelera
Cytogenetic Map14q21NCBI
Pla2g3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554555,315,450 - 5,320,053 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554555,314,520 - 5,320,151 (-)NCBIChiLan1.0ChiLan1.0
PLA2G3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12229,995,364 - 30,001,160 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,995,364 - 30,001,160 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02212,158,589 - 12,164,441 (-)NCBIMhudiblu_PPA_v0panPan3
PLA2G3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12624,127,074 - 24,132,508 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2624,128,005 - 24,132,508 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,994,204 - 24,002,589 (-)NCBI
ROS_Cfam_1.02624,506,855 - 24,515,226 (-)NCBI
UMICH_Zoey_3.12624,210,260 - 24,218,645 (-)NCBI
UNSW_CanFamBas_1.02624,472,253 - 24,480,619 (-)NCBI
UU_Cfam_GSD_1.02624,533,532 - 24,541,902 (-)NCBI
Pla2g3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118117,049,648 - 117,058,557 (-)NCBI
SpeTri2.0NW_004936755307,166 - 312,683 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,923,787 - 47,928,810 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,923,005 - 47,928,762 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21451,034,721 - 51,040,254 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11914,025,373 - 14,033,214 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1914,025,742 - 14,030,643 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045112,087,770 - 112,093,291 (+)NCBIVero_WHO_p1.0
Pla2g3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247477,602,848 - 7,607,872 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH70642  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372231,530,431 - 31,530,654UniSTSGRCh37
GRCh372231,530,431 - 31,531,232UniSTSGRCh37
Build 362229,860,431 - 29,860,654RGDNCBI36
Celera2215,330,506 - 15,331,307UniSTS
Celera2215,330,506 - 15,330,729RGD
Cytogenetic Map22q12.2UniSTS
HuRef2214,492,089 - 14,492,312UniSTS
HuRef2214,492,089 - 14,492,890UniSTS
A009F03  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372231,530,488 - 31,530,676UniSTSGRCh37
Build 362229,860,488 - 29,860,676RGDNCBI36
Celera2215,330,563 - 15,330,751RGD
Cytogenetic Map22q12.2UniSTS
HuRef2214,492,146 - 14,492,334UniSTS
GeneMap99-GB4 RH Map2287.46UniSTS
STS-R40003  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372231,530,470 - 31,530,657UniSTSGRCh37
Build 362229,860,470 - 29,860,657RGDNCBI36
Celera2215,330,545 - 15,330,732RGD
Cytogenetic Map22q12.2UniSTS
HuRef2214,492,128 - 14,492,315UniSTS
GeneMap99-GB4 RH Map2288.01UniSTS
G32496  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372231,530,488 - 31,530,676UniSTSGRCh37
Celera2215,330,563 - 15,330,751UniSTS
Cytogenetic Map22q12.2UniSTS
HuRef2214,492,146 - 14,492,334UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:495
Count of miRNA genes:398
Interacting mature miRNAs:425
Transcripts:ENST00000215885
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 22 6 12 4 1304 10 11 4 81 134 12 1 634
Low 242 21 637 94 66 6 202 27 518 88 601 1048 88 7 77 1
Below cutoff 1628 1901 584 183 613 122 1786 1271 2668 143 494 295 62 690 1370 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000215885   ⟹   ENSP00000215885
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2231,134,807 - 31,140,508 (-)Ensembl
RefSeq Acc Id: NM_015715   ⟹   NP_056530
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382231,134,807 - 31,140,508 (-)NCBI
GRCh372231,530,793 - 31,536,469 (-)ENTREZGENE
Build 362229,860,793 - 29,866,469 (-)NCBI Archive
HuRef2214,492,451 - 14,498,127 (-)ENTREZGENE
CHM1_12231,490,658 - 31,496,458 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011530204   ⟹   XP_011528506
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382231,134,807 - 31,140,485 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011530205   ⟹   XP_011528507
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382231,134,807 - 31,140,485 (-)NCBI
Sequence:
RefSeq Acc Id: XR_937865
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382231,135,845 - 31,140,508 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_056530   ⟸   NM_015715
- Peptide Label: precursor
- UniProtKB: Q9NZ20 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011528507   ⟸   XM_011530205
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011528506   ⟸   XM_011530204
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000215885   ⟸   ENST00000215885

Promoters
RGD ID:6800231
Promoter ID:HG_KWN:42383
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562
Transcripts:ENST00000215885
Position:
Human AssemblyChrPosition (strand)Source
Build 362229,866,266 - 29,866,766 (-)MPROMDB
RGD ID:13603750
Promoter ID:EPDNEW_H28059
Type:initiation region
Name:PLA2G3_1
Description:phospholipase A2 group III
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382231,140,508 - 31,140,568EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 22q11.21-12.3(chr22:18178957-31821193)x3 copy number gain See cases [RCV000050768] Chr22:18178957..31821193 [GRCh38]
Chr22:18661724..32217179 [GRCh37]
Chr22:17041724..30547179 [NCBI36]
Chr22:22q11.21-12.3
pathogenic
GRCh38/hg38 22q12.1-12.3(chr22:26979579-33992220)x3 copy number gain See cases [RCV000050553] Chr22:26979579..33992220 [GRCh38]
Chr22:27375542..34388209 [GRCh37]
Chr22:25705542..32718209 [NCBI36]
Chr22:22q12.1-12.3
pathogenic
GRCh38/hg38 22q12.1-12.2(chr22:28278805-31742328)x1 copy number loss See cases [RCV000052870] Chr22:28278805..31742328 [GRCh38]
Chr22:28674793..32138314 [GRCh37]
Chr22:27004793..30468314 [NCBI36]
Chr22:22q12.1-12.2
pathogenic
NM_015715.4(PLA2G3):c.882C>T (p.Ser294=) single nucleotide variant Malignant melanoma [RCV000072943] Chr22:31137894 [GRCh38]
Chr22:31533880 [GRCh37]
Chr22:29863880 [NCBI36]
Chr22:22q12.2
not provided
GRCh38/hg38 22q11.1-13.33(chr22:16916608-50739836)x3 copy number gain See cases [RCV000133646] Chr22:16916608..50739836 [GRCh38]
Chr22:17397498..51178264 [GRCh37]
Chr22:15777498..49525130 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916743-50739785)x3 copy number gain See cases [RCV000134730] Chr22:16916743..50739785 [GRCh38]
Chr22:17397633..51178213 [GRCh37]
Chr22:15777633..49525079 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
GRCh38/hg38 22q11.23-12.3(chr22:23279231-36247369)x3 copy number gain See cases [RCV000138172] Chr22:23279231..36247369 [GRCh38]
Chr22:23621418..36643415 [GRCh37]
Chr22:21951418..34973361 [NCBI36]
Chr22:22q11.23-12.3
pathogenic
GRCh38/hg38 22q11.21-12.3(chr22:20907226-37187347)x3 copy number gain See cases [RCV000137926] Chr22:20907226..37187347 [GRCh38]
Chr22:21261514..37583387 [GRCh37]
Chr22:19591514..35913333 [NCBI36]
Chr22:22q11.21-12.3
pathogenic
GRCh38/hg38 22q12.1-12.2(chr22:26451042-31451926)x1 copy number loss See cases [RCV000143415] Chr22:26451042..31451926 [GRCh38]
Chr22:26847008..31847912 [GRCh37]
Chr22:25177008..30177912 [NCBI36]
Chr22:22q12.1-12.2
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237518)x3 copy number gain See cases [RCV000240091] Chr22:16054691..51237518 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51220902)x3 copy number gain See cases [RCV000446956] Chr22:16054691..51220902 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237463)x3 copy number gain See cases [RCV000448847] Chr22:16054691..51237463 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q12.1-12.3(chr22:28349854-33013062)x3 copy number gain See cases [RCV000510523] Chr22:28349854..33013062 [GRCh37]
Chr22:22q12.1-12.3
likely pathogenic
GRCh37/hg19 22q11.23-12.3(chr22:23637907-36614412)x3 copy number gain See cases [RCV000511098] Chr22:23637907..36614412 [GRCh37]
Chr22:22q11.23-12.3
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838) copy number gain See cases [RCV000510873] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838)x3 copy number gain See cases [RCV000512333] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.22-12.3(chr22:22460754-35198232)x3 copy number gain not provided [RCV000684530] Chr22:22460754..35198232 [GRCh37]
Chr22:22q11.22-12.3
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054667-51243435)x3 copy number gain not provided [RCV000741689] Chr22:16054667..51243435 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51195728)x3 copy number gain not provided [RCV000741691] Chr22:16114244..51195728 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51211392)x3 copy number gain not provided [RCV000741692] Chr22:16114244..51211392 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q12.2-13.33(chr22:30654764-51197838)x3 copy number gain not provided [RCV001007181] Chr22:30654764..51197838 [GRCh37]
Chr22:22q12.2-13.33
pathogenic
inv(22)(q12.2q12.2) inversion Anaplastic ependymoma [RCV000785873] Chr22:29684716..31740655 [GRCh37]
Chr22:22q12.2
likely pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888899-51197838)x3 copy number gain not provided [RCV000846344] Chr22:16888899..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16197005-51224252)x3 copy number gain See cases [RCV001263056] Chr22:16197005..51224252 [GRCh37]
Chr22:22q11.1-13.33
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17934 AgrOrtholog
COSMIC PLA2G3 COSMIC
Ensembl Genes ENSG00000100078 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000215885 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000215885 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.90.10 UniProtKB/Swiss-Prot
GTEx ENSG00000100078 GTEx
HGNC ID HGNC:17934 ENTREZGENE
Human Proteome Map PLA2G3 Human Proteome Map
InterPro PLipase_A2_dom UniProtKB/Swiss-Prot
  PLipase_A2_dom_sf UniProtKB/Swiss-Prot
  PLipase_A2_His_AS UniProtKB/Swiss-Prot
KEGG Report hsa:50487 UniProtKB/Swiss-Prot
NCBI Gene 50487 ENTREZGENE
OMIM 611651 OMIM
Pfam Phospholip_A2_2 UniProtKB/Swiss-Prot
PharmGKB PA38267 PharmGKB
PROSITE PA2_HIS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48619 UniProtKB/Swiss-Prot
UniProt PA2G3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O95768 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 PLA2G3  phospholipase A2 group III    phospholipase A2, group III  Symbol and/or name change 5135510 APPROVED
2011-08-17 PLA2G3  phospholipase A2, group III  PLA2G3  phospholipase A2, group III  Symbol and/or name change 5135510 APPROVED