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Gene: Mars (methionine-tRNA synthetase) Mus musculus
Symbol: Mars
Name: methionine-tRNA synthetase
Description: The encoded protein belongs to the class I family of tRNA synthetases, a class of enzymes that charge tRNAs with their cognate amino acids. The related human gene product is essential for the translation initiation of mRNAs. This gene has an overlapping 3' UTR tail-to-tail arrangement with an adjacent gene on the opposite strand that encodes an inhibitor of the CCAAT/enhancer-binding protein's DNA binding activity. This arrangement, conserved in human and mouse, may be involved in mRNA stability and possible functional and regulatory interaction of these adjacent overlapping genes. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: methionine tRNA ligase; methionine--tRNA ligase; methionine--tRNA ligase, cytoplasmic; methionyl-tRNA synthetase, cytoplasmic; MetRS; MGC90747; MTRNS
Homo sapiens (human) : MARS (methionyl-tRNA synthetase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mars (methionyl-tRNA synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mars (methionyl-tRNA synthetase)
Pan paniscus (bonobo/pygmy chimpanzee) : MARS (methionyl-tRNA synthetase)
Canis lupus familiaris (dog) : MARS (methionyl-tRNA synthetase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mars (methionyl-tRNA synthetase)
Sus scrofa (pig) : MARS (methionyl-tRNA synthetase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3810127,296,221 - 127,311,786 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710126,733,277 - 126,748,842 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610126,699,175 - 126,714,588 (-)NCBImm8
Celera10129,688,532 - 129,704,394 (-)NCBICelera
Cytogenetic Map10 D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Mars
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313281
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-03-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.