Ttll12 (tubulin tyrosine ligase-like family, member 12)

Gene: Ttll12 (tubulin tyrosine ligase-like family, member 12) Mus musculus

Analyze

Symbol:

Ttll12

Name:

tubulin tyrosine ligase-like family, member 12

RGD ID:

1313277

MGI Page

MGI

Description:

Predicted to enable H4K20me3 modified histone binding activity and tubulin binding activity. Predicted to be involved in negative regulation of type I interferon-mediated signaling pathway and regulation of mitotic cell cycle. Predicted to act upstream of or within innate immune response. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in liver; medulla oblongata basal plate mantle layer; metanephros; submandibular gland primordium; and thymus primordium. Orthologous to human TTLL12 (tubulin tyrosine ligase like 12).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

BC055368; D430005B17; inactive tubulin--tyrosine ligase-like protein 12; TTL domain protein; tubulin--tyrosine ligase-like protein 12

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TTLL12 (tubulin tyrosine ligase like 12)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Ttll12 (tubulin tyrosine ligase like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ttll12 (tubulin tyrosine ligase like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TTLL12 (tubulin tyrosine ligase like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TTLL12 (tubulin tyrosine ligase like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ttll12 (tubulin tyrosine ligase like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TTLL12 (tubulin tyrosine ligase like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TTLL12 (tubulin tyrosine ligase like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ttll12 (tubulin tyrosine ligase like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Ttll12 (tubulin tyrosine ligase like 12)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TTLL12 (tubulin tyrosine ligase like 12)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ttll12 (tubulin tyrosine ligase-like family, member 12)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	TTLL12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ttll-12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ttll12	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	83,459,295 - 83,479,358 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	83,459,291 - 83,479,358 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	83,575,094 - 83,595,157 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	83,575,090 - 83,595,157 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	83,405,524 - 83,425,587 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	83,403,576 - 83,422,878 (-)	NCBI		MGSCv36	mm8
Celera	15	85,701,912 - 85,721,975 (-)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	39.4	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Developmental Delay with Variable Intellectual Impairment and Behavioral Abnormalities (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Phelan-McDermid syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (EXP)

1,2-dimethylhydrazine (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (ISO)

2-butoxyethanol (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (EXP)

bisphenol A (EXP,ISO)

butan-1-ol (ISO)

cadmium dichloride (ISO)

carbon nanotube (EXP)

clobetasol (EXP)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

decabromodiphenyl ether (ISO)

diazinon (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

enzyme inhibitor (ISO)

ethanol (EXP)

ethyl methanesulfonate (ISO)

fenthion (EXP)

folic acid (EXP)

formaldehyde (ISO)

genistein (ISO)

glafenine (ISO)

glyphosate (EXP)

ivermectin (ISO)

lead(0) (ISO)

methamphetamine (ISO)

methidathion (EXP)

methyl methanesulfonate (ISO)

ozone (EXP,ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (EXP)

phenobarbital (EXP,ISO)

progesterone (ISO)

rotenone (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

thioacetamide (ISO)

trimellitic anhydride (EXP)

tunicamycin (ISO)

urethane (ISO)

valproic acid (EXP,ISO)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

immune system process (IEA)

innate immune response (IEA)

negative regulation of type I interferon-mediated signaling pathway (ISO)

protein modification process (IEA)

regulation of mitotic cell cycle (ISO)

Cellular Component

cytoplasm (IBA,ISO)

cytoskeleton (IEA)

cytosol (ISO)

nucleus (IEA)

plasma membrane (ISO)

Molecular Function

ATP binding (IEA)

H4K20me3 modified histone binding (ISO)

histone H4K20 trimethyltransferase activity (ISO)

nucleotide binding (IEA)

protein binding (ISO)

tubulin binding (ISO)

tubulin-tyrosine ligase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	MGDs mouse GO annotations	MGD data from the GO Consortium
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:10349636	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12466851	PMID:12477932	PMID:14610273	PMID:15782199	PMID:16141072	PMID:16141073	PMID:17499049
PMID:20360068	PMID:21267068	PMID:21677750	PMID:21873635	PMID:24457600	PMID:26496610	PMID:32325033	PMID:36114006

Genomics

Comparative Map Data

Ttll12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	83,459,295 - 83,479,358 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	83,459,291 - 83,479,358 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	83,575,094 - 83,595,157 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	83,575,090 - 83,595,157 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	83,405,524 - 83,425,587 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	83,403,576 - 83,422,878 (-)	NCBI		MGSCv36	mm8
Celera	15	85,701,912 - 85,721,975 (-)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	39.4	NCBI

TTLL12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	43,166,622 - 43,187,134 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	43,166,622 - 43,187,134 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	43,562,628 - 43,583,140 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	41,892,572 - 41,913,051 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	22	27,473,015 - 27,493,525 (-)	NCBI		Celera
Cytogenetic Map	22	q13.2	NCBI
HuRef	22	26,520,840 - 26,541,320 (-)	NCBI		HuRef
CHM1_1	22	43,521,891 - 43,542,376 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	43,647,474 - 43,667,938 (-)	NCBI		T2T-CHM13v2.0

Ttll12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	116,612,609 - 116,631,244 (-)	NCBI		GRCr8
mRatBN7.2	7	114,731,890 - 114,751,237 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	114,731,892 - 114,751,356 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	116,479,632 - 116,498,238 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	118,705,346 - 118,723,851 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	118,674,816 - 118,693,321 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	124,472,758 - 124,491,004 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	124,472,758 - 124,491,004 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	124,461,238 - 124,479,484 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	121,601,492 - 121,620,937 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	121,634,544 - 121,655,280 (-)	NCBI
Celera	7	111,043,936 - 111,062,464 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

Ttll12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	28,316,936 - 28,333,508 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	28,316,936 - 28,333,423 (-)	NCBI	ChiLan1.0	ChiLan1.0

TTLL12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	52,977,557 - 53,009,632 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	55,669,517 - 55,702,553 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	24,038,128 - 24,070,135 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	42,248,276 - 42,270,232 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	42,249,660 - 42,271,318 (-)	Ensembl	panpan1.1		panPan2

TTLL12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	22,367,590 - 22,385,167 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	22,367,367 - 22,386,617 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	22,304,290 - 22,321,864 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	23,112,096 - 23,129,643 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	23,111,562 - 23,129,625 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	22,831,432 - 22,848,971 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	23,150,355 - 23,167,934 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	23,326,241 - 23,343,803 (+)	NCBI		UU_Cfam_GSD_1.0

Ttll12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	5,966,837 - 5,983,407 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936718	996,000 - 1,010,342 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936718	996,758 - 1,013,372 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TTLL12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	5,701,583 - 5,720,724 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	5,687,895 - 5,719,003 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	3,124,019 - 3,141,730 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TTLL12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	25,693,844 - 25,714,386 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	25,692,610 - 25,714,342 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	99,724,252 - 99,744,802 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ttll12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	5,796,958 - 5,813,075 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	5,796,935 - 5,813,078 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ttll12
580 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	2026
Count of miRNA genes:	663
Interacting mature miRNAs:	849
Transcripts:	ENSMUST00000016901, ENSMUST00000134334, ENSMUST00000136066
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
27226734	Tibmd5_m	tibia midshaft diameter 5, 10 week (mouse)					15	6129481	86684201	Mouse
26884442	Sklq6_m	skull length QTL 6, 5 week (mouse)					15	6129481	100797881	Mouse
27226777	Tibl8_m	tibia length 8, 5 week (mouse)					15	6929481	84584201	Mouse
1357526	Hyplip2_m	hyperlipidemia 2 (mouse)			Not determined		15	12402203	102896555	Mouse
26884425	Cvht2_m	cranial vault height 2, 5 week (mouse)					15	28800146	102008435	Mouse
1558985	Eae32_m	experimental allergic encephalomyelitis susceptibility 32 (mouse)			Not determined		15	32578416	103425899	Mouse
27226729	Tibmd2_m	tibia midshaft diameter 2, 5 week (mouse)					15	38000244	86684201	Mouse
26884402	Cvht9_m	cranial vault height 9, 16 week (mouse)					15	42163396	95497881	Mouse
26884397	Humsd5_m	humerus midshaft diameter 5, 10 week (mouse)					15	48363396	98397881	Mouse
26884399	Humsd1_m	humerus midshaft diameter 1, 5 week (mouse)					15	48363396	101708435	Mouse
4142198	Hbtq_m	habituation QTL (mouse)			Not determined		15	51160708	85160833	Mouse
10045637	Heal27_m	wound healing/regeneration 29 (mouse)			Not determined		15	51418361	85418511	Mouse
10412067	Pain2_m	pain 2 (mouse)			Not determined		15	51645339	85645626	Mouse
1302080	Szs13_m	seizure susceptibility 13 (mouse)			Not determined		15	51685832	85694449	Mouse
1301708	Cocrb14_m	cocaine related behavior 14 (mouse)			Not determined		15	51806515	85806651	Mouse
38501067	Tip3_m	tuberculosis immunophenotype 3, IFN-g level (mouse)					15	53563396	89584203	Mouse
13504731	Cath5_m	carotid atherosclerosis 5 (mouse)					15	54789129	88789129	Mouse
1302074	Bmd4_m	bone mineral density 4 (mouse)			Not determined		15	56186708	103425899	Mouse
27095936	Ulnl4_m	ulna length 4, 5 week (mouse)					15	56763396	87684201	Mouse
1300800	Ses3_m	salmonella enteritidis susceptibility 3 (mouse)			Not determined		15	57117005	91117153	Mouse
1357407	Pfat4_m	predicted fat percentage 4 (mouse)	8.6		Body fat amount	predicted fat percentage	15	57117005	91117153	Mouse
12880420	V25Dq8_m	vitamin D inactive form serum level QTL 8 (mouse)					15	61584200	95584200	Mouse
1301601	Faq9_m	fluctuating asymmetry QTL 9 (mouse)			Not determined		15	63163903	97163995	Mouse
1302197	Bhr2_m	bronchial hyperresponsiveness 2 (mouse)			Not determined		15	64306334	103425899	Mouse
4141135	Cia35_m	collagen induced arthritis 35 (mouse)			Not determined		15	64811826	98811946	Mouse
1301119	Drb7_m	dopamine receptor binding 7 (mouse)			Not determined		15	65336578	99341028	Mouse
1301171	Brm2_m	brachyury modifier 2 (mouse)			Not determined		15	65525376	99525499	Mouse
4141921	Pstc3_m	periosteal circumference 3 (mouse)			Not determined		15	67270698	101270847	Mouse
1300627	Sluc26_m	susceptibility to lung cancer 26 (mouse)			Not determined		15	70345653	104073951	Mouse
1300648	Dbsty4_m	diabesity 4 (mouse)			Not determined		15	70349271	104073951	Mouse
1300726	Pitm4_m	prion incubation time 4 (mouse)			Not determined		15	70349271	104073951	Mouse
14747011	Mancz13_m	mandible centroid size 13 (mouse)					15	72382669	104073951	Mouse
12791003	Aath8_m	aortic arch atherosclerosis 8 (mouse)					15	73430144	104073951	Mouse
1301472	Pain1_m	pain 1 (mouse)			Not determined		15	75320846	90813185	Mouse
1300851	Heal4_m	wound healing/regeneration 4 (mouse)			Not determined		15	77527592	104073951	Mouse
4142060	W3q6_m	weight 3 weeks QTL 6 (mouse)			Not determined			78601103	102901704	Mouse
1357894	Epfpq3_m	epididymal fat percentage QTL 3 (mouse)			Not determined		15	78601103	102901704	Mouse
14928306	Manh79_m	mandible shape 79 (mouse)					15	78847557	104073951	Mouse
12880411	V125Dq11_m	vitamin D active form serum level QTL 11 (mouse)					15	78897881	104073951	Mouse
10402490	Dipa5_m	drug induced psychomotor activation 5 (mouse)			Not determined		15	79163411	104073951	Mouse
4141897	Imrfq2_m	immune response to Factor IX QTL 2 (mouse)			Not determined			79908940	104073951	Mouse
1301284	Cosz3_m	cocaine seizure 3 (mouse)			Not determined		15	80313634	104073951	Mouse
4141902	Cia37_m	collagen induced arthritis 37 (mouse)			Not determined		15	80884933	104073951	Mouse
1300974	Pgia9_m	proteoglycan induced arthritis 9 (mouse)			Not determined		15	80884933	104073951	Mouse
4141511	Gdcr1_m	glycerolphosphate dehydrogenase regulator 1 (mouse)			Not determined			82615474	104073951	Mouse
11532732	Pitm5_m	prion incubation time 5 (mouse)					15	82964061	87054388	Mouse

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_183017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK084879	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK134345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK143496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK150116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK179941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK190517	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK191515	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK202581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL583887	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AM690756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC055368	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000016901 ⟹ ENSMUSP00000016901

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	15	83,459,291 - 83,479,358 (-)	Ensembl
GRCm38.p6 Ensembl	15	83,575,090 - 83,595,157 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000134334

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	15	83,465,968 - 83,471,093 (-)	Ensembl
GRCm38.p6 Ensembl	15	83,581,767 - 83,586,892 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000136066 ⟹ ENSMUSP00000117161

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	15	83,459,320 - 83,479,358 (-)	Ensembl
GRCm38.p6 Ensembl	15	83,575,119 - 83,595,157 (-)	Ensembl

RefSeq Acc Id:

NM_183017 ⟹ NP_898838

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	15	83,459,295 - 83,479,358 (-)	NCBI
GRCm38	15	83,575,094 - 83,595,157 (-)	ENTREZGENE
MGSCv37	15	83,405,524 - 83,425,587 (-)	RGD
Celera	15	85,701,912 - 85,721,975 (-)	RGD
cM Map	15		ENTREZGENE

Sequence:

show sequence

GTCCGCTTAAATCCTGCGGTGGGCGGCGCCGTGCTCTTCCGAGCACTATGGAGATCCAGTCCGG
GCCGCAGCCTGGCAGTCCCGGCCGCGCCGAGAGGCTGAACGCGCGGCTGCTGGACGAGTTCGTG
TCGCTGCACGGCCCTACGCTGCGCGCCTCGGGAGTCCCAGAGCGACTATGGGGCCGCCTTCTGC
ACAAGCTGGAGCACGAGGTTTTCGATGCCGGGGAGATGTTTGGGATAATGCAGGTGGAGGAGGT
GGAGGAGGCTGAGGACGAGGCCGCCAGGGAGGCTCAGAGGAAGCAGCCCAACCCTGGGGGCGAG
CTGTGCTACAAGGTCATTGTGACCAGTGAGAGCGGCGTCCGGGCTGACGACCCCAACAGCATCT
TCCTCATCGACCATGCCTGGACGTGCCGTGTGGAGCATGCACGCAAACAGCTGCAGCAGGTACC
TGGACTCCTGCACCGGATGGCCAACCTCATGGGCATCGAGTTCCATGGGGAAGTGCCCAGCCCA
GAGGTTGTGGCCCTAGTGCTGGAGGAGATGTGGAAATTCAACCAGACCTATCAGCTGGCCCATG
GGACAGCCGAAGAGAAGGTGCCAGTGTGGTACATCATGGACGAGTTTGGCTCGAGGATCCAGCA
CTCAGACATGCCCAGCTTCGCCACTGCTCCCTTCTTCTACATGCCCCAGCAGGTGGCATACACG
CTGCTGTGGCCCCTAAGGGACCTAGACACAGGCGAGGAGGTGACCCGGGACTTTGCCTACGGAG
AGGCAGACCCTCTGATCCGGAAATGCATGCTGCTGCCCTGGGCCCCCGCCGACATGCTGGACCT
CAGCTTCTCTACGCCTGAGCCTCCTGCCAAGTACTACCAGGCCATTTTGGAGGAGAACAAGGAG
AAACTGCCGCTCGCCATTAGCCCAGTGGCACGTCCCCAGGGCCACGTCTTCAGAGTCCACTGCG
ACGTGCAGCAGGTGCTCGGCCACCTTACCCACCCTCGCTTCACCTTCACTGATAGCGAGGCTGA
TGCCGACATCTTCTTCCACTTCTCACACTTCAAGGACTACATGAAACTCAGCCAAGAGAGCCCA
CAGGTGCTACTCAACCAGTTCCCCTGTGAGAATCTGCTGACTGTTAAGGACTGTCTGGCCTCCA
TCGCTCGCCGGGCTGGGGGTCCTGAGGGTCCCCCCTGGCTACCCCGAACCTTCAACCTGCGCAC
TGAGCTGCCCCAGTTTGTCAGCTATTTCCAGCACCGGGAGAGGCGGGGTGAAGACAACCACTGG
ATCTGCAAGCCCTGGAACCTGGCCCGCAGCCTGGACACTCACGTCACCAACAACCTCCACAGTA
TCATTCGGCACCGAGAGAGCACCCCCAAGGTTGTGTCCAAGTACATCGAAAGTCCCGTCTTGTT
CCTCCGAGAAGATGTGGGGAACGTCAAGTTTGACATCCGCTACATTGTGCTGCTGCGCTCAGTG
AGGCCGCTGAGGTTGTTTGCTTACGATGTGTTTTGGCTACGCTTCTCCAATCGGCCCTTCGCCC
TCGATGACCTAGACGACTATGAGAAGCATTTCACCGTCATGAACTATGACCCGGATGTGGTGCT
GAAGCAGGTGCACTATAATGAGTTCATCCCTCAGTTTGAGAAGCAGTACCCAGAGTTTCCCTGG
AGTGATGTTCAGGCTGAGATCTTCAAGGCCTTCACGGAGCTGTTCCAAGTGGCATGTGCCAAGC
CACCGCCCATGGGCCTCTGTGACTACCCCTCATCCCGGGCCATGTATGCCATTGATCTCATGCT
CAACTGGGACAACCACCCAGATGGAAAGCGGGTGATGCAGCCCCAAATCCTGGAGGTGAACTTC
AACCCCGACTGCGAGCGAGCCTGCAGATACCACCCCTCATTCTTCAATGATGTCTTCAGCACTT
TGTTTCTGGACGAGACTGACAACTGCCATGTCACCCGCATCATCTAGGTGCCCAGAGTTCTGCC
TGTTCTCATAGCCAGTTCCAGCCGGTTCCAGCCGGTCCAGCCTCTGCTCACAGAACTGCCTTTG
CAGTCCCAGGCTTCTCCCTCCCTCCCTCTCTCCCCTCCTTCCTTCCTCAGCCAGAGCCTTGGCC
TAAGTTATACTCAACCCTCCTGAGCCGTGTTCCTGCTCCATATGTGGGATATCAGGTCCATGTG
TGGCAGAGCTGGACAGTGAGTGGTGTCCCAAGGACTGGGCTCCGACCAGCTGTACCTGGTCTCT
GTACCTCTTAACGCCCTCTCTTCTCTGAAGAGTCTGCAGCTCAGCTAAGGGCTTTTCTCCTGGC
ATCCAGAAAGTTCGCAGACCAAGAAATGTTCTGCAGAAACAGGGTTCGACGAGGGAAGTGTTTG
GGAACCCGGTATCCACAAGGGCCAGGGAGTACTCTCAGAATCTCTGCCCTCCTGTCCCATGGCT
GCTGCAAGCAGGGTACGGGAACCCTGTGTTGCACCCACAGGCCCCAGAACAGCCAAGGGGAAAC
ATTTGCCAACCCGGCCTTATGCCTCGGCATCCTCCGCCAGAGCCTTCACCAGCAGACTTCTCAG
CCATGCCTACCCTGGGTGTTTCCCTTCTGGGAAGCTGGGCTATGCAGAGTCCCATGGTCTCTGC
ATGTTGGTACCTCACCAAGTCCCACTGTGCTCTTGTGGTAGACAGGGTGCTAGGTTGCTCTAGG
GCTGTGACATTTCATGGCAGAATCCAAGCAGGAGTGGCTGTGGAAATGCCAGAGCGGCTAAGAT
GGCTCTGGAGAGAACTTCATGTGGGAATCAGGCTGCCTCTTGCCAAAGTTCAGAGTCCTAGTGT
TAAGGTTTTGGGTTTGGTTTTCCTTCAACCTGCAGGAAAGACAATGTTACGTGGAGTTCCTAAT
TTTGTTGCTGGAATTTGAAGTCAGCCACCATTGCTTCTGTAACTGCTGGGCGCTGGGATCCTGC
CCCCAGGAAGTTAAGAGTGGGCAGGAGCTCCTTCCAGATGTCCTACTGTTCGGGTGGGACACTG
TGGTGGCTGTTGTACTTGTGAAGGTAAAAGTGACCTTCTCTTAGCATGACTGGACATGGTTCTT
CCTGCTCATCTCTGGGCTTGTAGGCCACCTGTTAGGGAGCCTGCCCCCGCCACCATCAGGGTCA
GGGTAGAGACACTTGTGGTGGTCGCACCCCTGGAAAGCGGCTGGCATCTGCCCTTTTATACTGC
AGTAAAATACGCCTCCTTTCCACCTGGTCTTTTCTCTTTGGGGCCCTAGAGGCCTGGGCTGGGC
TGGCAGGGCGGCTGTGTCCCTCCAAGGTTGCAAGCAGACCCAACATGTCACCACGTGTGCTTTG
AGAAATGAGAAGGAAAAGAAAGACCTCCGAGCTCCCTAAGGCAGTCTAGCTTCCTAGTTAGAGT
CCCAGTTCCAAGCTGGAGAAGAGATCTGACCTGACCAGTCCACACTACCAACCCAAGGGGGCGT
TGGGGGCCGCAGGGTCTGAGGCTTGGTCCCACCTGGTGGCCTTGAGAAATAGCATTCTCTATGT
TACCTCCTTGTTCTGGAGTGGGGATGAGAGGCCATAATTCATGAGGTAGTCAAGAGGCTCTGGG
GGCTGGCAGAGGACCAGCAAGACAGCTCACCGAGTAAAAATGCCTGCTGCCAAGCCTGAAGACT
TCCCTGGGAGCTACAGGAGAGAGAACCAACTCCCACGGGTTGTCCTCTGACCTCCATGTGTATA
CCATGGGACATGTGACTGGACAGGCATGTACACACAAAAATATAATTTAAAAGTCTTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_898838	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH55368	(Get FASTA)	NCBI Sequence Viewer
	BAE29319	(Get FASTA)	NCBI Sequence Viewer
	CAM84333	(Get FASTA)	NCBI Sequence Viewer
	EDL04467	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000016901
	ENSMUSP00000016901.4
	ENSMUSP00000117161.2
GenBank Protein	Q3UDE2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_898838 ⟸ NM_183017

- UniProtKB:

Q7TPC3 (UniProtKB/Swiss-Prot), Q3UDE2 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MEIQSGPQPGSPGRAERLNARLLDEFVSLHGPTLRASGVPERLWGRLLHKLEHEVFDAGEMFGI
MQVEEVEEAEDEAAREAQRKQPNPGGELCYKVIVTSESGVRADDPNSIFLIDHAWTCRVEHARK
QLQQVPGLLHRMANLMGIEFHGEVPSPEVVALVLEEMWKFNQTYQLAHGTAEEKVPVWYIMDEF
GSRIQHSDMPSFATAPFFYMPQQVAYTLLWPLRDLDTGEEVTRDFAYGEADPLIRKCMLLPWAP
ADMLDLSFSTPEPPAKYYQAILEENKEKLPLAISPVARPQGHVFRVHCDVQQVLGHLTHPRFTF
TDSEADADIFFHFSHFKDYMKLSQESPQVLLNQFPCENLLTVKDCLASIARRAGGPEGPPWLPR
TFNLRTELPQFVSYFQHRERRGEDNHWICKPWNLARSLDTHVTNNLHSIIRHRESTPKVVSKYI
ESPVLFLREDVGNVKFDIRYIVLLRSVRPLRLFAYDVFWLRFSNRPFALDDLDDYEKHFTVMNY
DPDVVLKQVHYNEFIPQFEKQYPEFPWSDVQAEIFKAFTELFQVACAKPPPMGLCDYPSSRAMY
AIDLMLNWDNHPDGKRVMQPQILEVNFNPDCERACRYHPSFFNDVFSTLFLDETDNCHVTRII

hide sequence

RefSeq Acc Id:

ENSMUSP00000016901 ⟸ ENSMUST00000016901

RefSeq Acc Id:

ENSMUSP00000117161 ⟸ ENSMUST00000136066

Protein Domains

TTL

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q3UDE2-F1-model_v2	AlphaFold	Q3UDE2	1-639	view protein structure

Promoters

RGD ID:

6826582

Promoter ID:

MM_KWN:19259

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

NM_183017, OTTMUST00000057651

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	15	83,425,364 - 83,425,864 (-)	MPROMDB

RGD ID:

8684576

Promoter ID:

EPDNEW_M20319

Type:

single initiation site

Name:

Ttll12_2

Description:

Mus musculus tubulin tyrosine ligase-like family, member 12 ,mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M20320

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	15	83,594,583 - 83,594,643	EPDNEW

RGD ID:

8684578

Promoter ID:

EPDNEW_M20320

Type:

initiation region

Name:

Ttll12_1

Description:

Mus musculus tubulin tyrosine ligase-like family, member 12 ,mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M20319

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	15	83,595,122 - 83,595,182	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:3039573	AgrOrtholog
Ensembl Genes	ENSMUSG00000016757	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000016901	ENTREZGENE
	ENSMUST00000016901.5	UniProtKB/Swiss-Prot
	ENSMUST00000136066.8	UniProtKB/TrEMBL
Gene3D-CATH	ATP-grasp fold, B domain	UniProtKB/Swiss-Prot
InterPro	TTL/TTLL_fam	UniProtKB/Swiss-Prot
	TTLL12	UniProtKB/Swiss-Prot
KEGG Report	mmu:223723	UniProtKB/Swiss-Prot
MGD	MGI:3039573	ENTREZGENE
NCBI Gene	223723	ENTREZGENE
PANTHER	PTHR46088	UniProtKB/Swiss-Prot
	TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12	UniProtKB/Swiss-Prot
Pfam	TTL	UniProtKB/Swiss-Prot
PhenoGen	Ttll12	PhenoGen
PROSITE	TTL	UniProtKB/Swiss-Prot
UniProt	F2Z423_MOUSE	UniProtKB/TrEMBL
	Q3UDE2	ENTREZGENE
	Q7TPC3	ENTREZGENE
	TTL12_MOUSE	UniProtKB/Swiss-Prot
UniProt Secondary	Q7TPC3	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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