Foxb1 (forkhead box B1) - Rat Genome Database

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Gene: Foxb1 (forkhead box B1) Mus musculus
Analyze
Symbol: Foxb1
Name: forkhead box B1
RGD ID: 1313113
MGI Page MGI
Description: Enables sequence-specific DNA binding activity. Involved in several processes, including mammary gland development; nervous system development; and visual learning. Acts upstream of or within spinal cord development; thalamus development; and urogenital system development. Located in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; limb; paraxial mesenchyme; and tail bud. Orthologous to human FOXB1 (forkhead box B1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C43; Fkh5; forkhead box B1a; forkhead box B1b; forkhead box protein B1; Foxb; Foxb1a; Foxb1b; Hfh-e5.1; mesoderm/mesenchyme forkhead 3; Mf3; MGC130499; transcription factor FKH-5; Twh
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39969,664,992 - 69,668,222 (-)NCBIGRCm39mm39
GRCm39 Ensembl969,664,992 - 69,668,222 (-)Ensembl
GRCm38969,757,710 - 69,760,940 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl969,757,710 - 69,760,940 (-)EnsemblGRCm38mm10GRCm38
MGSCv37969,605,517 - 69,608,747 (-)NCBIGRCm37mm9NCBIm37
MGSCv36969,556,916 - 69,559,991 (-)NCBImm8
Celera966,973,932 - 66,977,157 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map938.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7689224   PMID:8306889   PMID:8325367   PMID:8375339   PMID:8661058   PMID:8861101   PMID:9118797   PMID:9136764   PMID:9409663   PMID:9441664   PMID:9767163   PMID:9878737  
PMID:10662642   PMID:11170346   PMID:11298452   PMID:11486040   PMID:12477932   PMID:12663500   PMID:14594209   PMID:14681479   PMID:15654859   PMID:16291793   PMID:16376864   PMID:16547111  
PMID:17151600   PMID:18064677   PMID:18206388   PMID:18287559   PMID:18662545   PMID:18697938   PMID:18973680   PMID:19046377   PMID:19244520   PMID:19474326   PMID:19640321   PMID:20059953  
PMID:20211142   PMID:20436479   PMID:20932939   PMID:21122108   PMID:21267068   PMID:21625468   PMID:21873635   PMID:22371696   PMID:22639370   PMID:24146773   PMID:24576653   PMID:24952961  
PMID:25002511   PMID:25804738   PMID:28560839   PMID:29214672   PMID:30063881   PMID:30642949   PMID:32868762   PMID:33567285   PMID:34095148  


Genomics

Comparative Map Data
Foxb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39969,664,992 - 69,668,222 (-)NCBIGRCm39mm39
GRCm39 Ensembl969,664,992 - 69,668,222 (-)Ensembl
GRCm38969,757,710 - 69,760,940 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl969,757,710 - 69,760,940 (-)EnsemblGRCm38mm10GRCm38
MGSCv37969,605,517 - 69,608,747 (-)NCBIGRCm37mm9NCBIm37
MGSCv36969,556,916 - 69,559,991 (-)NCBImm8
Celera966,973,932 - 66,977,157 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map938.76NCBI
FOXB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381560,004,311 - 60,007,444 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1560,004,234 - 60,061,730 (+)EnsemblGRCh38hg38GRCh38
GRCh371560,296,510 - 60,299,643 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361558,083,713 - 58,085,434 (+)NCBINCBI36hg18NCBI36
Build 341558,084,426 - 58,085,434NCBI
Celera1537,184,381 - 37,186,102 (+)NCBI
Cytogenetic Map15q22.2NCBI
HuRef1537,118,460 - 37,120,181 (+)NCBIHuRef
CHM1_11560,414,763 - 60,416,484 (+)NCBICHM1_1
T2T-CHM13v2.01557,805,997 - 57,809,133 (+)NCBI
Foxb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2870,407,221 - 70,409,841 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl870,408,186 - 70,409,781 (-)Ensembl
Rnor_6.0875,992,751 - 75,995,371 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl875,992,755 - 75,995,371 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0880,317,629 - 80,320,249 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4874,200,271 - 74,202,891 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1874,219,330 - 74,221,945 (-)NCBI
Celera871,314,793 - 71,317,413 (+)NCBICelera
Cytogenetic Map8q24NCBI
Foxb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545014,867,941 - 14,902,990 (-)NCBIChiLan1.0ChiLan1.0
FOXB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11557,283,337 - 57,286,487 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1557,284,077 - 57,285,054 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01538,979,727 - 38,983,040 (+)NCBIMhudiblu_PPA_v0panPan3
FOXB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13024,822,137 - 24,825,833 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3024,823,815 - 24,824,792 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3024,797,514 - 24,798,713 (+)NCBI
ROS_Cfam_1.03024,992,213 - 24,994,850 (+)NCBI
ROS_Cfam_1.0 Ensembl3024,992,421 - 24,993,398 (+)Ensembl
UMICH_Zoey_3.13024,917,815 - 24,920,448 (+)NCBI
UNSW_CanFamBas_1.03025,000,424 - 25,003,058 (+)NCBI
UU_Cfam_GSD_1.03025,187,647 - 25,190,278 (+)NCBI
Foxb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640103,085,950 - 103,088,987 (+)NCBI
SpeTri2.0NW_00493647120,934,524 - 20,935,584 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1111,997,640 - 112,000,550 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11111,997,638 - 112,000,550 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21123,861,407 - 123,864,342 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FOXB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12623,502,048 - 23,505,390 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2623,503,545 - 23,504,522 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048117,818,793 - 117,822,194 (+)NCBIVero_WHO_p1.0
Foxb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478112,183,444 - 12,185,185 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462478112,182,728 - 12,185,228 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
X92592  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38969,758,757 - 69,758,961UniSTSGRCm38
MGSCv37969,606,564 - 69,606,768UniSTSGRCm37
Celera966,974,979 - 66,975,178UniSTS
Cytogenetic Map9DUniSTS
cM Map941.0UniSTS
Whitehead_YAC9 UniSTS
AU047864  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38969,762,322 - 69,762,534UniSTSGRCm38
MGSCv37969,610,129 - 69,610,341UniSTSGRCm37
Celera966,978,535 - 66,978,739UniSTS
Cytogenetic Map9DUniSTS
cM Map941.0UniSTS
Foxb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38969,758,143 - 69,759,253UniSTSGRCm38
MGSCv37969,605,950 - 69,607,060UniSTSGRCm37
Celera966,974,365 - 66,975,470UniSTS
Cytogenetic Map9DUniSTS
cM Map941.0UniSTS
UniSTS:489236  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38969,759,020 - 69,760,652UniSTSGRCm38
MGSCv37969,606,827 - 69,608,459UniSTSGRCm37
Celera966,975,237 - 66,976,869UniSTS
Cytogenetic Map9DUniSTS
cM Map941.0UniSTS
Foxb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95455996088559960Mouse
10043877Adip21_madiposity 21 (mouse)Not determined95643910890439255Mouse
1301549Bbaa9_mB.burgdorferi-associated arthritis 9 (mouse)Not determined95780504771481754Mouse
4141676Neogq1_mneonatal growth QTL 1 (mouse)Not determined95780504786121973Mouse
1301803Stheal9_msoft tissue heal 9 (mouse)Not determined95902438793024534Mouse
1301172Fembrs6_mfemur breaking strength 6 (mouse)Not determined95902438793024534Mouse
1301456Adip5_madiposity 5 (mouse)Not determined95936994693370128Mouse
1300848Skull13_mskull morphology 13 (mouse)Not determined95936994693370128Mouse
5491195Mobq8_mmultigenic obesity QTL 8 (mouse)Not determined95936994693370128Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959897283109089068Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96214976796149881Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
11081165Psl6_mpromotion susceptibility QTL 6 (mouse)96504119195522808Mouse
1301290Smgd1_msubmucosal gland distribution 1 (mouse)Not determined96583105686577967Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966089077100089175Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967006220101006220Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968779563102779705Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968779563102779705Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969121898103121973Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96926774798701707Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969428566103428698Mouse
14700779Syncq8_msynovial calcification QTL 8 (mouse)96951428270692282Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:423
Count of miRNA genes:323
Interacting mature miRNAs:345
Transcripts:ENSMUST00000071281
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000071281   ⟹   ENSMUSP00000096197
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl969,664,992 - 69,668,222 (-)Ensembl
GRCm38.p6 Ensembl969,757,710 - 69,760,940 (-)Ensembl
RefSeq Acc Id: NM_022378   ⟹   NP_071773
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39969,664,992 - 69,668,222 (-)NCBI
GRCm38969,757,710 - 69,760,940 (-)ENTREZGENE
MGSCv37969,605,517 - 69,608,747 (-)RGD
Celera966,973,932 - 66,977,157 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_071773   ⟸   NM_022378
- UniProtKB: Q64732 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000096197   ⟸   ENSMUST00000071281

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64732-F1-model_v2 AlphaFold Q64732 1-325 view protein structure

Promoters
RGD ID:8670074
Promoter ID:EPDNEW_M13068
Type:multiple initiation site
Name:Foxb1_1
Description:Mus musculus forkhead box B1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38969,760,874 - 69,760,934EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1927549 AgrOrtholog
Ensembl Genes ENSMUSG00000059246 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000096197 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000071281 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
InterPro Fork_head_dom UniProtKB/Swiss-Prot
  TF_fork_head_CS_1 UniProtKB/Swiss-Prot
  TF_fork_head_CS_2 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report mmu:64290 UniProtKB/Swiss-Prot
MGD MGI:1927549 ENTREZGENE
NCBI Gene 64290 ENTREZGENE
Pfam Forkhead UniProtKB/Swiss-Prot
PhenoGen Foxb1 PhenoGen
PRINTS FORKHEAD UniProtKB/Swiss-Prot
PROSITE FORK_HEAD_1 UniProtKB/Swiss-Prot
  FORK_HEAD_2 UniProtKB/Swiss-Prot
  FORK_HEAD_3 UniProtKB/Swiss-Prot
SMART SM00339 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt FOXB1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O08753 UniProtKB/Swiss-Prot
  Q2M2M4 UniProtKB/Swiss-Prot