Gene: SEMA7A (semaphorin 7A (John Milton Hagen blood group)) Homo sapiens
Analyze
Symbol:
SEMA7A
Name:
semaphorin 7A (John Milton Hagen blood group)
Description:
This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; JMH blood group antigen; John Milton Hagen blood group H-Sema K1; john-Milton-Hargen human blood group Ag; MGC126692; MGC126696; sema domain, immunoglobulin domain (ig), and gpi membrane anchor, (semaphorin) 7a; sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group); sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A; sema K1; sema L; SEMAK1; SEMAL; semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group); semaphorin K1; semaphorin L; semaphorin-7A; semaphorin-K1; semaphorin-L
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Sema7a (sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Sema7a (semaphorin 7A (John Milton Hagen blood group)) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Sema7a (semaphorin 7A (John Milton Hagen blood group)) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
SEMA7A (semaphorin 7A (John Milton Hagen blood group)) NCBI
Ortholog
Canis lupus familiaris (dog):
SEMA7A (semaphorin 7A) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Sema7a (semaphorin 7A (John Milton Hagen blood group)) NCBI
Ortholog
Sus scrofa (pig):
SEMA7A (semaphorin 7A (John Milton Hagen blood group)) HGNC
EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Sema7a (semaphorin 7A (John Milton Hagen blood group))
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Sema7a (sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
sema7a (semaphorin 7A)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, ZFIN)
Danio rerio (zebrafish):
si:ch211-113g11.6
Alliance
DIOPT (OrthoFinder, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
smp-2
Alliance
DIOPT (Ensembl Compara, OMA, PANTHER)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 15 74,409,284 - 74,433,959 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 15 74,701,630 - 74,726,299 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 15 72,489,376 - 72,513,329 (-) NCBI NCBI36 hg18 NCBI36 Build 34 15 72,489,375 - 72,513,329 NCBI Celera 15 51,648,857 - 51,673,527 (-) NCBI Cytogenetic Map 15 q24.1 NCBI HuRef 15 51,497,440 - 51,522,110 (-) NCBI HuRef CHM1_1 15 74,819,747 - 74,844,422 (-) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol increases expression ISO RGD:1313075 6480464 Ethinyl Estradiol results in increased expression of SEMA7A mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:1313075 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SEMA7A mRNA CTD PMID:17942748 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of SEMA7A mRNA CTD PMID:30165855 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1313075 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SEMA7A mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1313075 6480464 Tetrachlorodibenzodioxin affects the expression of SEMA7A mRNA CTD PMID:24680724 2,4-diaminotoluene increases expression ISO RGD:1313075 6480464 2, 4-diaminotoluene results in increased expression of SEMA7A mRNA CTD PMID:20713471 3,3',5,5'-tetrabromobisphenol A increases expression ISO RGD:1313075 6480464 tetrabromobisphenol A results in increased expression of SEMA7A mRNA CTD PMID:25172293 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1313075 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of SEMA7A mRNA CTD PMID:20188158 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of SEMA7A mRNA CTD PMID:28628672 3-methylcholanthrene increases expression ISO RGD:1313075 6480464 Methylcholanthrene results in increased expression of SEMA7A mRNA CTD PMID:20713471 4,4'-diaminodiphenylmethane increases expression ISO RGD:1313075 6480464 4, 4'-diaminodiphenylmethane results in increased expression of SEMA7A mRNA CTD PMID:18648102 4-hydroxyphenyl retinamide increases expression ISO RGD:1313075 6480464 Fenretinide results in increased expression of SEMA7A mRNA CTD PMID:28973697 6-propyl-2-thiouracil decreases expression ISO RGD:1305192 6480464 Propylthiouracil results in decreased expression of SEMA7A mRNA CTD PMID:24780913 more ... aflatoxin B1 increases methylation EXP 6480464 Aflatoxin B1 results in increased methylation of SEMA7A intron CTD PMID:30157460 benzo[a]pyrene increases expression ISO RGD:1313075 6480464 Benzo(a)pyrene results in increased expression of SEMA7A mRNA CTD PMID:21569818 benzo[a]pyrene diol epoxide I decreases expression EXP 6480464 7 more ... CTD PMID:20382639 benzo[b]fluoranthene increases expression ISO RGD:1313075 6480464 benzo(b)fluoranthene results in increased expression of SEMA7A mRNA CTD PMID:26377693 bisphenol A affects expression ISO RGD:1305192 6480464 bisphenol A affects the expression of SEMA7A mRNA CTD PMID:25181051 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SEMA7A mRNA CTD PMID:29275510 Brodifacoum increases expression ISO RGD:1305192 6480464 bromfenacoum results in increased expression of SEMA7A protein CTD PMID:28903499 buta-1,3-diene increases expression ISO RGD:1313075 6480464 1, 3-butadiene results in increased expression of SEMA7A mRNA CTD PMID:29038090 butanal increases expression EXP 6480464 butyraldehyde results in increased expression of SEMA7A mRNA CTD PMID:26079696 C60 fullerene decreases expression ISO RGD:1305192 6480464 fullerene C60 results in decreased expression of SEMA7A mRNA CTD PMID:19167457 carbon nanotube increases expression ISO RGD:1313075 6480464 Nanotubes, Carbon analog results in increased expression of SEMA7A mRNA, Nanotubes, Carbon results in increased expression of SEMA7A mRNA CTD PMID:25554681 chloroprene increases expression ISO RGD:1313075 6480464 Chloroprene results in increased expression of SEMA7A mRNA CTD PMID:23125180 chlorpyrifos decreases expression ISO RGD:1313075 6480464 Chlorpyrifos results in decreased expression of SEMA7A mRNA CTD PMID:20350560 cisplatin multiple interactions EXP 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of SEMA7A mRNA CTD PMID:27392435 cocaine affects expression ISO RGD:1305192 6480464 Cocaine affects the expression of SEMA7A mRNA CTD PMID:15691709 dexamethasone decreases expression ISO RGD:1313075 6480464 Dexamethasone results in decreased expression of SEMA7A mRNA CTD PMID:22733784 dexamethasone multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of SEMA7A mRNA CTD PMID:28628672 diazinon increases methylation EXP 6480464 Diazinon results in increased methylation of SEMA7A gene CTD PMID:22964155 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of SEMA7A mRNA CTD PMID:29803840 fluoranthene decreases expression ISO RGD:1313075 6480464 fluoranthene results in decreased expression of SEMA7A mRNA CTD PMID:28329830 formaldehyde decreases expression EXP 6480464 Formaldehyde results in decreased expression of SEMA7A mRNA CTD PMID:28937961 indometacin multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of SEMA7A mRNA CTD PMID:28628672 leflunomide decreases expression EXP 6480464 leflunomide results in decreased expression of SEMA7A mRNA CTD PMID:28988120 methotrexate increases expression EXP 6480464 Methotrexate results in increased expression of SEMA7A mRNA CTD PMID:21678067 microcystin increases expression ISO RGD:1305192 6480464 Microcystins results in increased expression of SEMA7A protein CTD PMID:22430071 naphthalene increases expression ISO RGD:1313075 6480464 naphthalene results in increased expression of SEMA7A mRNA CTD PMID:18978301 nickel sulfate decreases expression EXP 6480464 nickel sulfate results in decreased expression of SEMA7A mRNA CTD PMID:22714537 ozone increases expression ISO RGD:1305192 6480464 Ozone results in increased expression of SEMA7A mRNA CTD PMID:28623178 potassium chromate decreases expression EXP 6480464 potassium chromate(VI) results in decreased expression of SEMA7A mRNA CTD PMID:22714537 potassium dichromate decreases expression EXP 6480464 Potassium Dichromate results in decreased expression of SEMA7A protein CTD PMID:23718831 silicon dioxide increases expression EXP 6480464 Silicon Dioxide analog results in increased expression of SEMA7A mRNA CTD PMID:25895662 sodium arsenate affects methylation ISO RGD:1313075 6480464 sodium arsenate affects the methylation of SEMA7A promoter CTD PMID:20667999 sodium arsenate increases expression ISO RGD:1313075 6480464 sodium arsenate results in increased expression of SEMA7A mRNA CTD PMID:20667999 succimer multiple interactions ISO RGD:1313075 6480464 [Succimer binds to Magnetite Nanoparticles] which results in increased expression of SEMA7A mRNA CTD PMID:21641980 titanium dioxide increases expression ISO RGD:1313075 6480464 titanium dioxide results in increased expression of SEMA7A mRNA CTD PMID:27760801 triclosan increases expression EXP 6480464 Triclosan results in increased expression of SEMA7A mRNA CTD PMID:30510588 troglitazone decreases expression ISO RGD:1313075 6480464 troglitazone results in decreased expression of SEMA7A mRNA CTD PMID:28973697 urethane increases expression EXP 6480464 Urethane results in increased expression of SEMA7A mRNA CTD PMID:28818685 valproic acid increases methylation EXP 6480464 Valproic Acid results in increased methylation of SEMA7A gene CTD PMID:29154799 
Gene-Chemical Interaction Annotations
