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Gene: SEMA7A (semaphorin 7A (John Milton Hagen blood group)) Homo sapiens
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Symbol: SEMA7A
Name: semaphorin 7A (John Milton Hagen blood group)
Description: This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; JMH blood group antigen; John Milton Hagen blood group H-Sema K1; john-Milton-Hargen human blood group Ag; MGC126692; MGC126696; sema domain, immunoglobulin domain (ig), and gpi membrane anchor, (semaphorin) 7a; sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group); sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A; sema K1; sema L; SEMAK1; SEMAL; semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group); semaphorin K1; semaphorin L; semaphorin-7A; semaphorin-K1; semaphorin-L
Orthologs:
Mus musculus (house mouse) : Sema7a (sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sema7a (semaphorin 7A (John Milton Hagen blood group))  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sema7a (semaphorin 7A (John Milton Hagen blood group))
Pan paniscus (bonobo/pygmy chimpanzee) : SEMA7A (semaphorin 7A (John Milton Hagen blood group))
Canis lupus familiaris (dog) : SEMA7A (semaphorin 7A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sema7a (semaphorin 7A (John Milton Hagen blood group))
Sus scrofa (pig) : SEMA7A (semaphorin 7A (John Milton Hagen blood group))
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381574,409,284 - 74,433,959 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371574,701,630 - 74,726,299 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,489,376 - 72,513,329 (-)NCBINCBI36hg18NCBI36
Build 341572,489,375 - 72,513,329NCBI
Celera1551,648,857 - 51,673,527 (-)NCBI
Cytogenetic Map15q24.1NCBI
HuRef1551,497,440 - 51,522,110 (-)NCBIHuRef
CHM1_11574,819,747 - 74,844,422 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SEMA7A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313074
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.