SMIM8 (small integral membrane protein 8) - Rat Genome Database

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Gene: SMIM8 (small integral membrane protein 8) Homo sapiens
Analyze
Symbol: SMIM8
Name: small integral membrane protein 8
RGD ID: 1313022
HGNC Page HGNC:21401
Description: Located in mitochondrion.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C6orf162; dJ102H19.2; DKFZp586E1923; hypothetical protein LOC57150; UPF0708 protein C6orf162
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38687,322,588 - 87,342,329 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl687,322,583 - 87,399,749 (+)EnsemblGRCh38hg38GRCh38
GRCh37688,032,306 - 88,052,047 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36688,089,025 - 88,108,762 (+)NCBINCBI36Build 36hg18NCBI36
Build 34688,103,443 - 88,108,193NCBI
Celera688,450,980 - 88,470,715 (+)NCBICelera
Cytogenetic Map6q15NCBI
HuRef685,248,760 - 85,268,498 (+)NCBIHuRef
CHM1_1688,129,829 - 88,149,562 (+)NCBICHM1_1
T2T-CHM13v2.0688,531,398 - 88,551,191 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
mitochondrion  (HTP)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14574404   PMID:15489334   PMID:16344560   PMID:17207965   PMID:24324551   PMID:27609421   PMID:28514442   PMID:33961781   PMID:34800366  


Genomics

Comparative Map Data
SMIM8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38687,322,588 - 87,342,329 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl687,322,583 - 87,399,749 (+)EnsemblGRCh38hg38GRCh38
GRCh37688,032,306 - 88,052,047 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36688,089,025 - 88,108,762 (+)NCBINCBI36Build 36hg18NCBI36
Build 34688,103,443 - 88,108,193NCBI
Celera688,450,980 - 88,470,715 (+)NCBICelera
Cytogenetic Map6q15NCBI
HuRef685,248,760 - 85,268,498 (+)NCBIHuRef
CHM1_1688,129,829 - 88,149,562 (+)NCBICHM1_1
T2T-CHM13v2.0688,531,398 - 88,551,191 (+)NCBIT2T-CHM13v2.0
Smim8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39434,768,664 - 34,778,398 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl434,768,664 - 34,778,423 (-)EnsemblGRCm39 Ensembl
GRCm38434,768,664 - 34,778,396 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl434,768,664 - 34,778,423 (-)EnsemblGRCm38mm10GRCm38
MGSCv37434,715,921 - 34,725,586 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36434,957,559 - 34,967,224 (-)NCBIMGSCv36mm8
Celera434,492,856 - 34,502,531 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map416.86NCBI
Smim8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8554,132,905 - 54,141,940 (-)NCBIGRCr8
mRatBN7.2549,336,617 - 49,345,625 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl549,336,617 - 49,345,441 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx551,529,891 - 51,538,899 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0553,130,124 - 53,139,132 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0553,041,051 - 53,050,110 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0550,230,617 - 50,239,651 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl550,230,619 - 50,239,458 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0554,799,571 - 54,808,583 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4551,387,269 - 51,396,269 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1551,387,753 - 51,389,891 (-)NCBI
Celera548,083,152 - 48,092,156 (-)NCBICelera
Cytogenetic Map5q21NCBI
SMIM8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25107,414,195 - 107,429,631 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16105,298,455 - 105,316,806 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0685,199,698 - 85,218,051 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1688,475,495 - 88,493,123 (+)NCBIpanpan1.1PanPan1.1panPan2
SMIM8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11246,835,228 - 46,845,614 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1246,835,832 - 46,845,445 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1246,643,539 - 46,653,995 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01247,640,426 - 47,650,873 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1247,640,463 - 47,652,337 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11246,933,105 - 46,943,543 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01246,860,372 - 46,870,819 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01247,049,790 - 47,060,236 (+)NCBIUU_Cfam_GSD_1.0
Smim8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494681,958,401 - 81,971,964 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365104,500,413 - 4,509,213 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365104,491,692 - 4,512,400 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMIM8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl155,753,910 - 55,765,079 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1155,753,912 - 55,763,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2162,447,071 - 62,455,902 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SMIM8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11311,812,903 - 11,826,175 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1311,813,166 - 11,827,560 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040188,070,512 - 188,084,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smim8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247997,030,326 - 7,031,897 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247997,029,153 - 7,040,532 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SMIM8
7 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q14.1-16.1(chr6:82569098-93753476)x1 copy number loss See cases [RCV000052192] Chr6:82569098..93753476 [GRCh38]
Chr6:83278815..94463194 [GRCh37]
Chr6:83335534..94519915 [NCBI36]
Chr6:6q14.1-16.1		 pathogenic
GRCh37/hg19 6q14.1-16.1(chr6:78911022-98909173)x1 copy number loss See cases [RCV002292710] Chr6:78911022..98909173 [GRCh37]
Chr6:6q14.1-16.1		 uncertain significance
GRCh38/hg38 6q14.2-16.1(chr6:83838303-98822313)x1 copy number loss See cases [RCV000135773] Chr6:83838303..98822313 [GRCh38]
Chr6:84548022..99270189 [GRCh37]
Chr6:84604741..99376910 [NCBI36]
Chr6:6q14.2-16.1		 pathogenic
GRCh38/hg38 6q14.3-16.1(chr6:85804273-93189258)x1 copy number loss See cases [RCV000135450] Chr6:85804273..93189258 [GRCh38]
Chr6:86513991..93898976 [GRCh37]
Chr6:86570710..93955697 [NCBI36]
Chr6:6q14.3-16.1		 pathogenic
GRCh38/hg38 6q14.3-15(chr6:85370716-90669793)x1 copy number loss See cases [RCV000136757] Chr6:85370716..90669793 [GRCh38]
Chr6:86080434..91379512 [GRCh37]
Chr6:86137153..91436233 [NCBI36]
Chr6:6q14.3-15		 pathogenic
GRCh38/hg38 6q14.3-15(chr6:84926864-87365441)x1 copy number loss See cases [RCV000137766] Chr6:84926864..87365441 [GRCh38]
Chr6:85636582..88075159 [GRCh37]
Chr6:85693301..88131878 [NCBI36]
Chr6:6q14.3-15		 likely pathogenic
GRCh38/hg38 6q13-24.1(chr6:74382807-142040500)x3 copy number gain See cases [RCV000139729] Chr6:74382807..142040500 [GRCh38]
Chr6:75092523..142361637 [GRCh37]
Chr6:75149243..142403330 [NCBI36]
Chr6:6q13-24.1		 pathogenic
GRCh38/hg38 6q14.3-15(chr6:87050381-87535518)x1 copy number loss See cases [RCV000140956] Chr6:87050381..87535518 [GRCh38]
Chr6:87760099..88245236 [GRCh37]
Chr6:87816818..88301955 [NCBI36]
Chr6:6q14.3-15		 uncertain significance
GRCh38/hg38 6q14.1-16.1(chr6:75926199-92710793)x1 copy number loss See cases [RCV000143505] Chr6:75926199..92710793 [GRCh38]
Chr6:76635916..93420511 [GRCh37]
Chr6:76692636..93477232 [NCBI36]
Chr6:6q14.1-16.1		 pathogenic
GRCh37/hg19 6q14.3-22.31(chr6:85988428-120548687)x1 copy number loss See cases [RCV000445666] Chr6:85988428..120548687 [GRCh37]
Chr6:6q14.3-22.31		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6q14.1-16.1(chr6:81261418-97796269)x3 copy number gain not provided [RCV000682688] Chr6:81261418..97796269 [GRCh37]
Chr6:6q14.1-16.1		 pathogenic
Single allele deletion not provided [RCV000677932] Chr6:83319012..91907669 [GRCh37]
Chr6:6q14.1-15		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6q14.3-16.1(chr6:87627836-93698486)x1 copy number loss not provided [RCV000848967] Chr6:87627836..93698486 [GRCh37]
Chr6:6q14.3-16.1		 uncertain significance
GRCh37/hg19 6q14.3-15(chr6:86024761-90023713)x1 copy number loss not provided [RCV001005826] Chr6:86024761..90023713 [GRCh37]
Chr6:6q14.3-15		 pathogenic
NM_001042493.3(SMIM8):c.14C>T (p.Pro5Leu) single nucleotide variant not specified [RCV004684050] Chr6:87337045 [GRCh38]
Chr6:88046763 [GRCh37]
Chr6:6q15		 uncertain significance
GRCh37/hg19 6q12-16.1(chr6:69938252-94379210) copy number gain not specified [RCV002053581] Chr6:69938252..94379210 [GRCh37]
Chr6:6q12-16.1		 pathogenic
GRCh37/hg19 6q14.3-22.31(chr6:85988428-120548687) copy number loss not specified [RCV002053595] Chr6:85988428..120548687 [GRCh37]
Chr6:6q14.3-22.31		 pathogenic
GRCh37/hg19 6q14.3-15(chr6:86098133-88663964)x3 copy number gain not provided [RCV002474634] Chr6:86098133..88663964 [GRCh37]
Chr6:6q14.3-15		 uncertain significance
NM_001042493.3(SMIM8):c.232T>C (p.Tyr78His) single nucleotide variant not specified [RCV004169707] Chr6:87340212 [GRCh38]
Chr6:88049930 [GRCh37]
Chr6:6q15		 uncertain significance
NM_001042493.3(SMIM8):c.167C>T (p.Thr56Ile) single nucleotide variant not specified [RCV004360240] Chr6:87340147 [GRCh38]
Chr6:88049865 [GRCh37]
Chr6:6q15		 uncertain significance
NM_001042493.3(SMIM8):c.89C>T (p.Thr30Ile) single nucleotide variant not specified [RCV004360768] Chr6:87337120 [GRCh38]
Chr6:88046838 [GRCh37]
Chr6:6q15		 uncertain significance
GRCh37/hg19 6q15-16.1(chr6:88018122-94565168)x1 copy number loss not provided [RCV003482926] Chr6:88018122..94565168 [GRCh37]
Chr6:6q15-16.1		 pathogenic
GRCh37/hg19 6q15(chr6:88039867-88305895)x1 copy number loss not specified [RCV003986612] Chr6:88039867..88305895 [GRCh37]
Chr6:6q15		 pathogenic
NM_001042493.3(SMIM8):c.188A>G (p.Tyr63Cys) single nucleotide variant not specified [RCV004461979] Chr6:87340168 [GRCh38]
Chr6:88049886 [GRCh37]
Chr6:6q15		 uncertain significance
NM_001042493.3(SMIM8):c.185C>T (p.Ala62Val) single nucleotide variant not specified [RCV004461978] Chr6:87340165 [GRCh38]
Chr6:88049883 [GRCh37]
Chr6:6q15		 uncertain significance
NM_001042493.3(SMIM8):c.4T>A (p.Ser2Thr) single nucleotide variant not specified [RCV004667878] Chr6:87337035 [GRCh38]
Chr6:88046753 [GRCh37]
Chr6:6q15		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:577
Count of miRNA genes:320
Interacting mature miRNAs:338
Transcripts:ENST00000608353, ENST00000608525, ENST00000608868
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407367247GWAS1016223_Happendicular lean mass QTL GWAS1016223 (human)9e-13appendicular lean mass68732848087328481Human
1298426BFD3_HBody fluid distribution QTL 3 (human)2.790.01Body fluid distributionimpedance ratio684873647110873647Human
407098264GWAS747240_HPR interval QTL GWAS747240 (human)0.000002PR intervalPR interval (CMO:0000233)68732267287322673Human
406945917GWAS594893_Hpregnancy disorder QTL GWAS594893 (human)0.000009pregnancy disorder68734232687342327Human

Markers in Region
RH102579  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37688,051,127 - 88,051,249UniSTSGRCh37
Build 36688,107,846 - 88,107,968RGDNCBI36
Celera688,469,799 - 88,469,921RGD
Cytogenetic Map6q15-q16.1UniSTS
HuRef685,267,582 - 85,267,704UniSTS
GeneMap99-GB4 RH Map6384.93UniSTS
RH47881  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37688,049,996 - 88,050,170UniSTSGRCh37
Build 36688,106,715 - 88,106,889RGDNCBI36
Celera688,468,668 - 88,468,842RGD
Cytogenetic Map6q15-q16.1UniSTS
HuRef685,266,451 - 85,266,625UniSTS
GeneMap99-GB4 RH Map6383.9UniSTS
STS-N24194  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37688,051,715 - 88,051,945UniSTSGRCh37
Build 36688,108,434 - 88,108,664RGDNCBI36
Celera688,470,387 - 88,470,617RGD
Cytogenetic Map6q15-q16.1UniSTS
HuRef685,268,170 - 85,268,400UniSTS
GeneMap99-GB4 RH Map6384.55UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENST00000229570   ⟹   ENSP00000229570
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl687,322,593 - 87,342,322 (+)Ensembl
Ensembl Acc Id: ENST00000369570
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl687,397,122 - 87,399,749 (+)Ensembl
Ensembl Acc Id: ENST00000369572
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl687,322,620 - 87,399,599 (+)Ensembl
Ensembl Acc Id: ENST00000392863   ⟹   ENSP00000376603
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl687,322,588 - 87,342,329 (+)Ensembl
Ensembl Acc Id: ENST00000448282   ⟹   ENSP00000476881
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl687,322,605 - 87,399,741 (+)Ensembl
Ensembl Acc Id: ENST00000608353   ⟹   ENSP00000477133
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl687,322,583 - 87,341,759 (+)Ensembl
Ensembl Acc Id: ENST00000608525   ⟹   ENSP00000476709
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl687,322,609 - 87,341,778 (+)Ensembl
Ensembl Acc Id: ENST00000608535
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl687,374,688 - 87,378,602 (+)Ensembl
Ensembl Acc Id: ENST00000608868   ⟹   ENSP00000476945
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl687,322,632 - 87,340,504 (+)Ensembl
RefSeq Acc Id: NM_001042493   ⟹   NP_001035958
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38687,322,588 - 87,342,329 (+)NCBI
GRCh37688,032,306 - 88,052,043 (+)RGD
Build 36688,089,025 - 88,108,762 (+)NCBI Archive
Celera688,450,980 - 88,470,715 (+)RGD
HuRef685,248,760 - 85,268,501 (+)NCBI
CHM1_1688,129,829 - 88,149,565 (+)NCBI
T2T-CHM13v2.0688,531,398 - 88,551,191 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001287445   ⟹   NP_001274374
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38687,322,588 - 87,342,329 (+)NCBI
HuRef685,248,760 - 85,268,501 (+)NCBI
CHM1_1688,129,829 - 88,149,565 (+)NCBI
T2T-CHM13v2.0688,531,398 - 88,551,191 (+)NCBI
Sequence:
RefSeq Acc Id: NM_020425   ⟹   NP_065158
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38687,322,588 - 87,342,329 (+)NCBI
GRCh37688,032,306 - 88,052,043 (+)RGD
Build 36688,089,025 - 88,108,762 (+)NCBI Archive
Celera688,450,980 - 88,470,715 (+)RGD
HuRef685,248,760 - 85,268,501 (+)NCBI
CHM1_1688,129,829 - 88,149,565 (+)NCBI
T2T-CHM13v2.0688,531,398 - 88,551,191 (+)NCBI
Sequence:
RefSeq Acc Id: NP_065158   ⟸   NM_020425
- Peptide Label: isoform 1
- UniProtKB: Q6NSD2 (UniProtKB/Swiss-Prot),   Q5TEZ3 (UniProtKB/Swiss-Prot),   E1P505 (UniProtKB/Swiss-Prot),   B2R4V6 (UniProtKB/Swiss-Prot),   Q8IZ10 (UniProtKB/Swiss-Prot),   Q96KF7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001035958   ⟸   NM_001042493
- Peptide Label: isoform 1
- UniProtKB: Q6NSD2 (UniProtKB/Swiss-Prot),   Q5TEZ3 (UniProtKB/Swiss-Prot),   E1P505 (UniProtKB/Swiss-Prot),   B2R4V6 (UniProtKB/Swiss-Prot),   Q8IZ10 (UniProtKB/Swiss-Prot),   Q96KF7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001274374   ⟸   NM_001287445
- Peptide Label: isoform 2
- UniProtKB: V9GYF9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000229570   ⟸   ENST00000229570
Ensembl Acc Id: ENSP00000376603   ⟸   ENST00000392863
Ensembl Acc Id: ENSP00000476881   ⟸   ENST00000448282
Ensembl Acc Id: ENSP00000476945   ⟸   ENST00000608868
Ensembl Acc Id: ENSP00000476709   ⟸   ENST00000608525
Ensembl Acc Id: ENSP00000477133   ⟸   ENST00000608353

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96KF7-F1-model_v2 AlphaFold Q96KF7 1-97 view protein structure

Promoters
RGD ID:7208645
Promoter ID:EPDNEW_H10068
Type:initiation region
Name:SMIM8_1
Description:small integral membrane protein 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38687,322,593 - 87,322,653EPDNEW
RGD ID:6803834
Promoter ID:HG_KWN:54287
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001042493,   NM_020425,   UC003PLR.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36688,088,846 - 88,089,346 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:21401 AgrOrtholog
COSMIC SMIM8 COSMIC
Ensembl Genes ENSG00000111850 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000229570 ENTREZGENE
  ENST00000229570.9 UniProtKB/Swiss-Prot
  ENST00000392863 ENTREZGENE
  ENST00000392863.6 UniProtKB/Swiss-Prot
  ENST00000448282.6 UniProtKB/TrEMBL
  ENST00000608353.5 UniProtKB/Swiss-Prot
  ENST00000608525 ENTREZGENE
  ENST00000608525.5 UniProtKB/TrEMBL
  ENST00000608868.2 UniProtKB/Swiss-Prot
GTEx ENSG00000111850 GTEx
HGNC ID HGNC:21401 ENTREZGENE
Human Proteome Map SMIM8 Human Proteome Map
InterPro UPF0708 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:57150 UniProtKB/Swiss-Prot
NCBI Gene 57150 ENTREZGENE
PANTHER PTHR14274 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMALL INTEGRAL MEMBRANE PROTEIN 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF4500 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134961667 PharmGKB
UniProt B2R4V6 ENTREZGENE
  E1P505 ENTREZGENE
  Q5TEZ3 ENTREZGENE
  Q6NSD2 ENTREZGENE
  Q8IZ10 ENTREZGENE
  Q96KF7 ENTREZGENE, UniProtKB/Swiss-Prot
  V9GYF9 ENTREZGENE, UniProtKB/TrEMBL
  V9GYL2_HUMAN UniProtKB/TrEMBL
UniProt Secondary B2R4V6 UniProtKB/Swiss-Prot
  E1P505 UniProtKB/Swiss-Prot
  Q5TEZ3 UniProtKB/Swiss-Prot
  Q6NSD2 UniProtKB/Swiss-Prot
  Q8IZ10 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-28 SMIM8  small integral membrane protein 8  C6orf162  chromosome 6 open reading frame 162  Symbol and/or name change 5135510 APPROVED