Lpar2 (lysophosphatidic acid receptor 2) - Rat Genome Database
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Gene: Lpar2 (lysophosphatidic acid receptor 2) Mus musculus
Analyze
Symbol: Lpar2
Name: lysophosphatidic acid receptor 2
RGD ID: 1312932
MGI Page MGI
Description: Exhibits PDZ domain binding activity. Involved in G protein-coupled receptor signaling pathway; activation of MAPK activity; and positive regulation of Rho protein signal transduction. Localizes to glutamatergic synapse and integral component of presynaptic active zone membrane. Predicted to colocalize with endocytic vesicle. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; hemolymphoid system gland; and sensory organ. Orthologous to human LPAR2 (lysophosphatidic acid receptor 2); INTERACTS WITH 1,1-dichloroethene; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Edg4; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4; IPA2; L; LPA receptor 2; LPA-2; LPA2; lysophosphatidic acid receptor Edg-4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,275,215 - 70,283,752 (+)NCBIGRCm39mm39
GRCm38869,822,565 - 69,831,102 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl869,822,429 - 69,831,102 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,346,464 - 72,355,001 (+)NCBIGRCm37mm9NCBIm37
MGSCv36872,751,418 - 72,760,091 (+)NCBImm8
Celera872,373,530 - 72,382,072 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map833.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:6765731   PMID:10349636   PMID:10729222   PMID:11042159   PMID:11076861   PMID:11087877   PMID:11093753   PMID:11217851   PMID:11313151   PMID:11544199   PMID:12123830   PMID:12215548  
PMID:12401212   PMID:12477932   PMID:12730698   PMID:14625558   PMID:15195086   PMID:15755723   PMID:16141072   PMID:16141073   PMID:16434032   PMID:16504475   PMID:16602821   PMID:16782887  
PMID:16829511   PMID:17965021   PMID:18448840   PMID:18703779   PMID:18723828   PMID:18762810   PMID:18924241   PMID:19147812   PMID:19293149   PMID:19328876   PMID:19766573   PMID:19800338  
PMID:19930563   PMID:20458606   PMID:20495828   PMID:20505096   PMID:20724530   PMID:21267068   PMID:21319224   PMID:21677750   PMID:21873635   PMID:21900594   PMID:22015657   PMID:22427635  
PMID:22465231   PMID:22885106   PMID:23808384   PMID:24429286   PMID:24602016   PMID:25542932   PMID:26027517   PMID:26248018   PMID:26830463   PMID:27453502   PMID:27760754   PMID:27909001  
PMID:29518331   PMID:29724718   PMID:30804442   PMID:30847983   PMID:31633020  


Genomics

Comparative Map Data
Lpar2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,275,215 - 70,283,752 (+)NCBIGRCm39mm39
GRCm38869,822,565 - 69,831,102 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl869,822,429 - 69,831,102 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,346,464 - 72,355,001 (+)NCBIGRCm37mm9NCBIm37
MGSCv36872,751,418 - 72,760,091 (+)NCBImm8
Celera872,373,530 - 72,382,072 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map833.91NCBI
LPAR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1919,623,655 - 19,628,930 (-)EnsemblGRCh38hg38GRCh38
GRCh381919,623,655 - 19,628,395 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371919,734,464 - 19,739,039 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361919,595,477 - 19,600,017 (-)NCBINCBI36hg18NCBI36
Build 341919,595,476 - 19,600,017NCBI
Celera1919,638,539 - 19,643,114 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1919,296,769 - 19,301,344 (-)NCBIHuRef
CHM1_11919,735,551 - 19,740,126 (-)NCBICHM1_1
Lpar2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01621,343,313 - 21,348,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1621,344,456 - 21,348,391 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01621,257,145 - 21,262,902 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41620,079,826 - 20,085,307 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1619,783,465 - 19,789,027 (-)NCBICelera
Cytogenetic Map16p14NCBI
Lpar2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555242,390,598 - 2,394,877 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555242,390,354 - 2,395,436 (+)NCBIChiLan1.0ChiLan1.0
LPAR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11920,057,179 - 20,062,171 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1920,057,179 - 20,061,260 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01919,060,927 - 19,065,792 (-)NCBIMhudiblu_PPA_v0panPan3
LPAR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2043,647,653 - 43,650,710 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12043,646,642 - 43,650,270 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lpar2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365961,872,919 - 1,878,304 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPAR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl258,298,271 - 58,300,844 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1258,296,381 - 58,300,869 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2258,395,164 - 58,399,454 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q2.1NCBI
LPAR2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1618,082,907 - 18,088,240 (-)NCBI
ChlSab1.1 Ensembl618,082,784 - 18,087,145 (-)Ensembl
Lpar2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249082,349,783 - 2,357,969 (-)NCBI

Position Markers
Edg4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8B3.3UniSTS
cM Map833.5UniSTS
UniSTS:235915  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38869,827,654 - 69,827,887UniSTSGRCm38
MGSCv37872,351,553 - 72,351,786UniSTSGRCm37
Celera872,378,623 - 72,378,856UniSTS
Cytogenetic Map8B3.3UniSTS
PMC134025P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38869,823,986 - 69,824,296UniSTSGRCm38
MGSCv37872,347,885 - 72,348,195UniSTSGRCm37
Celera872,374,951 - 72,375,261UniSTS
Cytogenetic Map8B3.3UniSTS
PMC134025P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38869,823,804 - 69,824,296UniSTSGRCm38
MGSCv37872,347,703 - 72,348,195UniSTSGRCm37
Celera872,374,769 - 72,375,261UniSTS
Cytogenetic Map8B3.3UniSTS
PMC134025P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38869,823,804 - 69,824,053UniSTSGRCm38
MGSCv37872,347,703 - 72,347,952UniSTSGRCm37
Celera872,374,769 - 72,375,018UniSTS
Cytogenetic Map8B3.3UniSTS
Edg4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8B3.3UniSTS
cM Map833.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3382
Count of miRNA genes:754
Interacting mature miRNAs:945
Transcripts:ENSMUST00000034325, ENSMUST00000164890
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034325   ⟹   ENSMUSP00000034325
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl869,822,429 - 69,831,102 (+)Ensembl
RefSeq Acc Id: ENSMUST00000164890   ⟹   ENSMUSP00000128261
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl869,822,429 - 69,831,101 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238452   ⟹   ENSMUSP00000158853
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl869,822,584 - 69,824,775 (+)Ensembl
RefSeq Acc Id: NM_020028   ⟹   NP_064412
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,275,215 - 70,283,752 (+)NCBI
GRCm38869,822,565 - 69,831,102 (+)ENTREZGENE
MGSCv37872,346,464 - 72,355,001 (+)RGD
Celera872,373,530 - 72,382,072 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_064412   ⟸   NM_020028
- UniProtKB: Q6P290 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000128261   ⟸   ENSMUST00000164890
RefSeq Acc Id: ENSMUSP00000034325   ⟸   ENSMUST00000034325
RefSeq Acc Id: ENSMUSP00000158853   ⟸   ENSMUST00000238452
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:8667245
Promoter ID:EPDNEW_M11654
Type:initiation region
Name:Lpar2_1
Description:Mus musculus lysophosphatidic acid receptor 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38869,822,607 - 69,822,667EPDNEW
RGD ID:6843073
Promoter ID:MM_KWN:54642
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000034325,   UC009LXV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36872,345,921 - 72,346,557 (+)MPROMDB
RGD ID:6843402
Promoter ID:MM_KWN:54643
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000066018
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36872,346,636 - 72,347,907 (+)MPROMDB
RGD ID:6848298
Promoter ID:MM_ACW:47784
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:EDG4.CSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36872,350,171 - 72,350,671 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1858422 AgrOrtholog
Ensembl Genes ENSMUSG00000031861 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034325 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000128261 UniProtKB/TrEMBL
  ENSMUSP00000158853 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034325 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000164890 UniProtKB/TrEMBL
  ENSMUST00000238452 UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LPA_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LPA_rcpt_EDG4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:53978 UniProtKB/TrEMBL
MGD MGI:1858422 ENTREZGENE
NCBI Gene 53978 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lpar2 PhenoGen
PRINTS EDG4RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LPARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.23253 ENTREZGENE
UniProt A0A571BEW5_MOUSE UniProtKB/TrEMBL
  LPAR2_MOUSE UniProtKB/Swiss-Prot
  Q6P290 ENTREZGENE, UniProtKB/TrEMBL
  Q9JL06 ENTREZGENE