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Gene: TMPRSS4 (transmembrane serine protease 4) Homo sapiens
Symbol: TMPRSS4
Name: transmembrane serine protease 4
Description: Predicted to have scavenger receptor activity and serine-type endopeptidase activity. Involved in negative regulation of growth rate and regulation of gene expression. Localizes to secretory granule.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CAPH2; channel-activating protease 2; membrane-type serine protease 2; MT-SP2; TMPRSS3; transmembrane protease serine 4; transmembrane protease, serine 4; transmembrane serine protease 3; type II membrane serine protease
Mus musculus (house mouse) : Tmprss4 (transmembrane protease, serine 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tmprss4 (transmembrane serine protease 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tmprss4 (transmembrane serine protease 4)
Pan paniscus (bonobo/pygmy chimpanzee) : TMPRSS4 (transmembrane serine protease 4)
Canis lupus familiaris (dog) : TMPRSS4 (transmembrane serine protease 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tmprss4 (transmembrane serine protease 4)
Sus scrofa (pig) : TMPRSS4 (transmembrane serine protease 4)
Chlorocebus sabaeus (African green monkey) : TMPRSS4 (transmembrane serine protease 4)
Heterocephalus glaber (naked mole-rat) : Tmprss4 (transmembrane serine protease 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl11118,077,012 - 118,121,890 (+)EnsemblGRCh38hg38GRCh38
GRCh3811118,077,012 - 118,125,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711117,947,727 - 117,996,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611117,452,937 - 117,495,768 (+)NCBINCBI36hg18NCBI36
Build 3411117,452,975 - 117,494,380NCBI
Celera11115,105,578 - 115,148,408 (+)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11113,881,375 - 113,924,217 (+)NCBIHuRef
CHM1_111117,833,208 - 117,876,364 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TMPRSS4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312821
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.