Nek4 (NIMA (never in mitosis gene a)-related expressed kinase 4) - Rat Genome Database

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Gene: Nek4 (NIMA (never in mitosis gene a)-related expressed kinase 4) Mus musculus
Analyze
Symbol: Nek4
Name: NIMA (never in mitosis gene a)-related expressed kinase 4
RGD ID: 1312758
MGI Page MGI
Description: Enables manganese ion binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including DNA damage response; positive regulation of DNA-templated transcription; and regulation of cellular senescence. Predicted to act upstream of or within cell division and phosphorylation. Located in cytoplasm. Is expressed in seminiferous tubule; spermatid; spermatocyte; and testis. Orthologous to human NEK4 (NIMA related kinase 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: never in mitosis A-related kinase 4; NIMA-related expressed kinase 4; NIMA-related kinase 4; nimA-related protein kinase 4; serine/threonine-protein kinase 2; serine/threonine-protein kinase Nek4; Stk2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,673,334 - 30,710,778 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,673,334 - 30,710,778 (+)EnsemblGRCm39 Ensembl
GRCm381430,951,377 - 30,988,821 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,951,377 - 30,988,821 (+)EnsemblGRCm38mm10GRCm38
MGSCv371431,764,674 - 31,800,587 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,780,497 - 29,816,410 (+)NCBIMGSCv36mm8
Celera1427,208,772 - 27,245,215 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10393247   PMID:10529384   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12819135   PMID:14610273   PMID:15747579   PMID:16141072  
PMID:16141073   PMID:18799693   PMID:20103636   PMID:21267068   PMID:21677750   PMID:21873635   PMID:32325033  


Genomics

Comparative Map Data
Nek4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,673,334 - 30,710,778 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,673,334 - 30,710,778 (+)EnsemblGRCm39 Ensembl
GRCm381430,951,377 - 30,988,821 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,951,377 - 30,988,821 (+)EnsemblGRCm38mm10GRCm38
MGSCv371431,764,674 - 31,800,587 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,780,497 - 29,816,410 (+)NCBIMGSCv36mm8
Celera1427,208,772 - 27,245,215 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
NEK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,708,444 - 52,770,940 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,708,444 - 52,770,946 (-)EnsemblGRCh38hg38GRCh38
GRCh37352,742,460 - 52,804,956 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,719,840 - 52,779,991 (-)NCBINCBI36Build 36hg18NCBI36
Build 34352,719,841 - 52,779,979NCBI
Celera352,723,506 - 52,783,686 (-)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef352,806,323 - 52,866,636 (-)NCBIHuRef
CHM1_1352,696,967 - 52,757,147 (-)NCBICHM1_1
T2T-CHM13v2.0352,741,355 - 52,803,847 (-)NCBIT2T-CHM13v2.0
Nek4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,151,292 - 6,200,280 (+)NCBIGRCr8
mRatBN7.2166,144,900 - 6,185,376 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,144,959 - 6,188,932 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,156,495 - 6,197,248 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,301,957 - 7,342,710 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,163,758 - 6,204,437 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,035,002 - 7,080,272 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,035,068 - 7,075,554 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,961,142 - 7,009,810 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,386,850 - 6,422,465 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,386,924 - 6,422,453 (+)NCBI
Celera169,003,955 - 9,044,746 (-)NCBICelera
Cytogenetic Map16p16NCBI
Nek4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554302,696,493 - 2,733,392 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554302,695,674 - 2,733,204 (-)NCBIChiLan1.0ChiLan1.0
NEK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,704,488 - 52,765,747 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,707,159 - 52,770,529 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,649,280 - 52,712,645 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,877,257 - 53,938,520 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,878,760 - 53,938,520 (-)Ensemblpanpan1.1panPan2
NEK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,056,852 - 37,091,977 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,056,754 - 37,092,686 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,039,095 - 37,073,987 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,407,881 - 37,442,744 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,407,885 - 37,440,616 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12036,771,452 - 36,806,315 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,179,859 - 37,214,937 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,457,447 - 37,492,395 (+)NCBIUU_Cfam_GSD_1.0
Nek4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,361,288 - 170,389,366 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,499,754 - 3,528,329 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,499,858 - 3,527,918 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,841,366 - 34,896,565 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,844,972 - 34,909,028 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,065,216 - 38,081,875 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NEK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,083,583 - 14,152,775 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,121,073 - 14,152,547 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,745,104 - 152,816,427 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nek4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,453,379 - 4,502,579 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,454,040 - 4,500,031 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nek4
1163 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:73
Interacting mature miRNAs:75
Transcripts:ENSMUST00000050171
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301991Wta3_mweight adult 3 (mouse)Not determined14388747337887650Mouse
4141550Dbm3_mdiabetes modifier 3 (mouse)Not determined514347339143596Mouse
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
1300779Dyscalc4_mdystrophic cardiac calcinosis 4 (mouse)Not determined141221287146213007Mouse
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)141376927346737457Mouse
27226752Femd4_mfemur midshaft diameter 4, 5 week (mouse)141376927347237457Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226775Tibl7_mtibia length 7, 5 week (mouse)143032195748837457Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse

Markers in Region
px-31f3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B5UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map16C3.3UniSTS
Cytogenetic Map10A4UniSTS
Cytogenetic Map10A3-A4UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map9E3.1UniSTS
Cytogenetic Map10A1UniSTS
Cytogenetic Map17CUniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map16B5UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map10C3UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map5C3.1UniSTS
Cytogenetic Map10B5.1UniSTS
Cytogenetic Map18E4UniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map18D1UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map17B3UniSTS
Cytogenetic Map12C2UniSTS
Cytogenetic Map13B2UniSTS
Cytogenetic Map15A1UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map10D1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map4C3UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map18D3UniSTS
cM Map1060.0UniSTS
cM Map154.6UniSTS
cM Map439.4UniSTS
cM Map1170.0UniSTS
cM Map1336.0UniSTS
cM Map518.2UniSTS
cM Map1229.0UniSTS
cM MapX42.0UniSTS
cM Map1347.01UniSTS
px-38e3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D1UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map18D3UniSTS
Cytogenetic Map5B3UniSTS
Cytogenetic Map17B3UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map16B5UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map1H4UniSTS
Cytogenetic Map7F2UniSTS
Cytogenetic Map10D2UniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic MapYA1UniSTS
Cytogenetic Map11A3.2UniSTS
Cytogenetic Map3A1UniSTS
Cytogenetic Map13C3UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map10D1UniSTS
Cytogenetic Map10A1UniSTS
cM Map1060.0UniSTS
cM Map1106.6UniSTS
cM Map1936.5UniSTS
cM Map520.0UniSTS
cM Map1340.0UniSTS
D11Bhm20  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F1UniSTS
Cytogenetic Map5E2UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map19D1UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map12D1UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map7B4UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map4E1UniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map16C1.1UniSTS
Cytogenetic Map3BUniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map2E2UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map10A3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map1C1.3UniSTS
Cytogenetic Map13D2UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map6A2UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map16C4UniSTS
Cytogenetic Map3G1UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map7B1-B2UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic Map11B1.1UniSTS
Cytogenetic Map15B3.1UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic Map10D2UniSTS
Cytogenetic Map15E3UniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map7E3UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXC-DUniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map11A3.2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map16B4UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map19BUniSTS
cM Map1144.15UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001308328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011245068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011245069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF099067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ223071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP762751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN526970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT025528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y09234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000050171   ⟹   ENSMUSP00000057915
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1430,673,415 - 30,709,371 (+)Ensembl
GRCm38.p6 Ensembl1430,951,458 - 30,987,414 (+)Ensembl
RefSeq Acc Id: ENSMUST00000226146   ⟹   ENSMUSP00000153710
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1430,678,872 - 30,709,401 (+)Ensembl
GRCm38.p6 Ensembl1430,956,915 - 30,987,444 (+)Ensembl
RefSeq Acc Id: ENSMUST00000226551   ⟹   ENSMUSP00000154678
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1430,673,334 - 30,710,775 (+)Ensembl
GRCm38.p6 Ensembl1430,951,377 - 30,988,818 (+)Ensembl
RefSeq Acc Id: ENSMUST00000226833   ⟹   ENSMUSP00000154606
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1430,673,435 - 30,681,535 (+)Ensembl
GRCm38.p6 Ensembl1430,951,478 - 30,959,578 (+)Ensembl
RefSeq Acc Id: ENSMUST00000227199
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1430,673,473 - 30,686,275 (+)Ensembl
GRCm38.p6 Ensembl1430,951,516 - 30,964,318 (+)Ensembl
RefSeq Acc Id: ENSMUST00000227602
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1430,673,456 - 30,675,857 (+)Ensembl
GRCm38.p6 Ensembl1430,951,499 - 30,953,900 (+)Ensembl
RefSeq Acc Id: ENSMUST00000228328   ⟹   ENSMUSP00000154090
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1430,673,334 - 30,710,778 (+)Ensembl
GRCm38.p6 Ensembl1430,951,377 - 30,988,821 (+)Ensembl
RefSeq Acc Id: ENSMUST00000228392
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1430,673,368 - 30,709,544 (+)Ensembl
GRCm38.p6 Ensembl1430,951,411 - 30,987,587 (+)Ensembl
RefSeq Acc Id: NM_001308328   ⟹   NP_001295257
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391430,673,334 - 30,710,778 (+)NCBI
GRCm381430,951,377 - 30,988,821 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011849   ⟹   NP_035979
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391430,673,334 - 30,710,778 (+)NCBI
GRCm381430,951,377 - 30,988,821 (+)NCBI
MGSCv371431,764,674 - 31,800,587 (+)RGD
Celera1427,208,772 - 27,245,215 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011245068   ⟹   XP_011243370
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391430,674,372 - 30,710,433 (+)NCBI
GRCm381430,952,412 - 30,988,476 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011245069   ⟹   XP_011243371
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391430,673,456 - 30,710,433 (+)NCBI
GRCm381430,951,441 - 30,988,476 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_035979   ⟸   NM_011849
- Peptide Label: isoform 1
- UniProtKB: Q9R1J1 (UniProtKB/Swiss-Prot),   O35673 (UniProtKB/Swiss-Prot),   Q9Z1J2 (UniProtKB/Swiss-Prot),   Q6GTE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011243371   ⟸   XM_011245069
- Peptide Label: isoform X2
- UniProtKB: Q9Z1J2 (UniProtKB/Swiss-Prot),   Q9R1J1 (UniProtKB/Swiss-Prot),   O35673 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011243370   ⟸   XM_011245068
- Peptide Label: isoform X1
- UniProtKB: F8WGA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295257   ⟸   NM_001308328
- Peptide Label: isoform 2
- UniProtKB: Q9R1J1 (UniProtKB/Swiss-Prot),   O35673 (UniProtKB/Swiss-Prot),   Q9Z1J2 (UniProtKB/Swiss-Prot),   Q3UED6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000154090   ⟸   ENSMUST00000228328
RefSeq Acc Id: ENSMUSP00000154678   ⟸   ENSMUST00000226551
RefSeq Acc Id: ENSMUSP00000153710   ⟸   ENSMUST00000226146
RefSeq Acc Id: ENSMUSP00000154606   ⟸   ENSMUST00000226833
RefSeq Acc Id: ENSMUSP00000057915   ⟸   ENSMUST00000050171
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1J2-F1-model_v2 AlphaFold Q9Z1J2 1-792 view protein structure

Promoters
RGD ID:8681794
Promoter ID:EPDNEW_M18928
Type:initiation region
Name:Nek4_1
Description:Mus musculus NIMA -related expressed kinase 4 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381430,951,461 - 30,951,521EPDNEW
RGD ID:6825212
Promoter ID:MM_KWN:16077
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000050171,   ENSMUST00000112124,   UC007SWA.1,   UC007SWB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361431,764,226 - 31,764,726 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1344404 AgrOrtholog
Ensembl Genes ENSMUSG00000021918 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000050171.10 UniProtKB/TrEMBL
  ENSMUST00000226146 ENTREZGENE
  ENSMUST00000226146.2 UniProtKB/TrEMBL
  ENSMUST00000226551 ENTREZGENE
  ENSMUST00000226551.2 UniProtKB/Swiss-Prot
  ENSMUST00000226833.2 UniProtKB/TrEMBL
  ENSMUST00000228328 ENTREZGENE
  ENSMUST00000228328.2 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:23955 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1344404 ENTREZGENE
NCBI Gene 23955 ENTREZGENE
PANTHER CAMK FAMILY PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nek4 PhenoGen
PIRSF Integrin-linked_kinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2I3BPM0_MOUSE UniProtKB/TrEMBL
  F8WGA9 ENTREZGENE, UniProtKB/TrEMBL
  NEK4_MOUSE UniProtKB/Swiss-Prot
  O35673 ENTREZGENE
  Q3THY0_MOUSE UniProtKB/TrEMBL
  Q3UED6 ENTREZGENE, UniProtKB/TrEMBL
  Q3UF09_MOUSE UniProtKB/TrEMBL
  Q6GTE9 ENTREZGENE, UniProtKB/TrEMBL
  Q9R1J1 ENTREZGENE
  Q9Z1J2 ENTREZGENE
UniProt Secondary O35673 UniProtKB/Swiss-Prot
  Q9R1J1 UniProtKB/Swiss-Prot