Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-quinic acid | multiple interactions | ISO | POLD2 (Homo sapiens) | 6480464 | [Hydrogen Peroxide co-treated with Quinic Acid analog] results in increased expression of POLD2 mRNA | CTD | PMID:21751221 | (1->4)-beta-D-glucan | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of POLD2 mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | increases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of POLD2 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of POLD2 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLD2 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of POLD2 mRNA | CTD | PMID:17555576 | 17beta-estradiol | increases expression | ISO | POLD2 (Homo sapiens) | 6480464 | Estradiol results in increased expression of POLD2 mRNA | CTD | PMID:19167446 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | EXP | | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of POLD2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of POLD2 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of POLD2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Pold2 (Rattus norvegicus) | 6480464 | AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of POLD2 mRNA] | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of POLD2 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLD2 mRNA | CTD | PMID:17942748 | 2,4-dinitrotoluene | affects expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of POLD2 mRNA | CTD | PMID:21346803 | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of POLD2 mRNA | CTD | PMID:18648102 | acetamide | increases expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | acetamide results in increased expression of POLD2 mRNA | CTD | PMID:31881176 | acrylamide | decreases expression | ISO | POLD2 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of POLD2 mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of POLD2 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | Aflatoxin B1 results in increased expression of POLD2 mRNA | CTD | PMID:23630614 | all-trans-retinoic acid | decreases expression | ISO | POLD2 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of POLD2 mRNA | CTD | PMID:33167477 | aristolochic acid A | decreases expression | ISO | POLD2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of POLD2 protein | CTD | PMID:33212167 | benzo[a]pyrene | increases methylation | ISO | POLD2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of POLD2 promoter | CTD | PMID:27901495 | benzo[e]pyrene | increases methylation | ISO | POLD2 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of POLD2 exon | CTD | PMID:30157460 | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of POLD2 mRNA] | CTD | PMID:19850644 | bis(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in increased expression of POLD2 mRNA | CTD | PMID:19850644 | bisphenol A | affects expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of POLD2 mRNA | CTD | PMID:25181051 and PMID:32145629 | bisphenol A | decreases expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of POLD2 mRNA | CTD | PMID:34947998 | bisphenol A | decreases expression | ISO | POLD2 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of POLD2 mRNA | CTD | PMID:29275510 | Bisphenol A diglycidyl ether | affects splicing | EXP | | 6480464 | 2 and 2-bis(4-glycidyloxyphenyl)propane affects the splicing of POLD2 mRNA | CTD | PMID:36464114 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | cobalt dichloride | decreases expression | ISO | POLD2 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of POLD2 mRNA | CTD | PMID:19320972 and PMID:19376846 | coumarin | increases expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | coumarin results in increased expression of POLD2 mRNA | CTD | PMID:18480146 | coumestrol | multiple interactions | ISO | POLD2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 more ... | CTD | PMID:19167446 | coumestrol | increases expression | ISO | POLD2 (Homo sapiens) | 6480464 | Coumestrol results in increased expression of POLD2 mRNA | CTD | PMID:19167446 | Cuprizon | increases expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | Cuprizone results in increased expression of POLD2 mRNA | CTD | PMID:26577399 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of POLD2 mRNA | CTD | PMID:17361019 and PMID:21266533 | dioxygen | decreases expression | ISO | POLD2 (Homo sapiens) | 6480464 | Oxygen deficiency results in decreased expression of POLD2 mRNA | CTD | PMID:26516004 | Enterolactone | multiple interactions | ISO | POLD2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of POLD2 mRNA | CTD | PMID:19167446 | fenthion | increases expression | EXP | | 6480464 | Fenthion results in increased expression of POLD2 mRNA | CTD | PMID:34813904 | furan | increases methylation | ISO | Pold2 (Rattus norvegicus) | 6480464 | furan results in increased methylation of POLD2 gene | CTD | PMID:22079235 | furan | increases expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | furan results in increased expression of POLD2 mRNA | CTD | PMID:25539665 | guanine | multiple interactions | ISO | POLD2 (Homo sapiens) | 6480464 | Guanine metabolite results in decreased activity of [POLD1 protein binds to POLD2 protein binds to POLD3 protein binds to POLD4 protein] and Guanine metabolite results in decreased activity of [POLD1 protein binds to POLD2 protein binds to POLD4 protein] | CTD | PMID:26010525 | hydrogen peroxide | multiple interactions | ISO | POLD2 (Homo sapiens) | 6480464 | [Hydrogen Peroxide co-treated with Quinic Acid analog] results in increased expression of POLD2 mRNA and chromium histidinate inhibits the reaction [Hydrogen Peroxide results in increased expression of POLD2 mRNA] | CTD | PMID:19902159 and PMID:21751221 | ivermectin | decreases expression | ISO | POLD2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of POLD2 protein | CTD | PMID:32959892 | mercury atom | affects expression | ISO | POLD2 (Homo sapiens) | 6480464 | Mercury affects the expression of POLD2 mRNA | CTD | PMID:16823088 | mercury(0) | affects expression | ISO | POLD2 (Homo sapiens) | 6480464 | Mercury affects the expression of POLD2 mRNA | CTD | PMID:16823088 | methapyrilene | increases methylation | ISO | POLD2 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of POLD2 exon | CTD | PMID:30157460 | methidathion | increases expression | EXP | | 6480464 | methidathion results in increased expression of POLD2 mRNA | CTD | PMID:34813904 | miconazole | increases expression | EXP | | 6480464 | Miconazole results in increased expression of POLD2 mRNA | CTD | PMID:27462272 | mifepristone | decreases expression | ISO | POLD2 (Homo sapiens) | 6480464 | Mifepristone results in decreased expression of POLD2 mRNA | CTD | PMID:17584828 | oxaliplatin | decreases expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | oxaliplatin results in decreased expression of POLD2 mRNA | CTD | PMID:25729387 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of POLD2 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of POLD2 mRNA | CTD | PMID:33387578 | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of POLD2 mRNA | CTD | PMID:36331819 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of POLD2 mRNA | CTD | PMID:18445702 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of POLD2 mRNA | CTD | PMID:17950772 and PMID:18301758 | pirinixic acid | multiple interactions | EXP | | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in increased expression of POLD2 mRNA] | CTD | PMID:17950772 | quercetin | decreases expression | ISO | POLD2 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of POLD2 mRNA | CTD | PMID:15309432 | resveratrol | multiple interactions | ISO | POLD2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of POLD2 mRNA | CTD | PMID:19167446 | rimonabant | multiple interactions | EXP | | 6480464 | Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of POLD2 mRNA] | CTD | PMID:19030233 | SB 431542 | multiple interactions | ISO | POLD2 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in increased expression of POLD2 protein | CTD | PMID:37664457 | sirolimus | decreases expression | EXP | | 6480464 | Sirolimus results in decreased expression of POLD2 mRNA | CTD | PMID:11355896 | sodium arsenite | decreases expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | sodium arsenite results in decreased expression of POLD2 mRNA | CTD | PMID:35314868 | sodium dichromate | increases expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | sodium bichromate results in increased expression of POLD2 mRNA | CTD | PMID:22110744 and PMID:25993096 | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of POLD2 mRNA | CTD | PMID:17555576 | thioacetamide | increases expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of POLD2 mRNA | CTD | PMID:23411599 and PMID:34492290 | topotecan | decreases expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | Topotecan results in decreased expression of POLD2 mRNA | CTD | PMID:25729387 | trichloroethene | increases expression | ISO | Pold2 (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of POLD2 mRNA | CTD | PMID:33387578 | trimellitic anhydride | increases expression | EXP | | 6480464 | trimellitic anhydride results in increased expression of POLD2 mRNA | CTD | PMID:19042947 | triptonide | decreases expression | EXP | | 6480464 | triptonide results in decreased expression of POLD2 mRNA | CTD | PMID:33045310 | |