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Gene: OPTC (opticin) Homo sapiens
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Symbol: OPTC
Name: opticin
Description: Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: oculoglycan; OPT
Orthologs:
Mus musculus (house mouse) : Optc (opticin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Optc (opticin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Optc (opticin)
Pan paniscus (bonobo/pygmy chimpanzee) : OPTC (opticin)
Canis lupus familiaris (dog) : OPTC (opticin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Optc (opticin)
Sus scrofa (pig) : OPTC (opticin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381203,494,153 - 203,508,949 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371203,463,271 - 203,478,077 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,729,894 - 201,744,700 (+)NCBINCBI36hg18NCBI36
Build 341200,194,927 - 200,209,734NCBI
Celera1176,592,905 - 176,608,331 (+)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1174,628,320 - 174,643,467 (+)NCBIHuRef
CHM1_11204,886,108 - 204,900,814 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on OPTC
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312631
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.