Gene: TRPM1 (transient receptor potential cation channel subfamily M member 1) Homo sapiens
Symbol: TRPM1
Name: transient receptor potential cation channel subfamily M member 1
Description: This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CSNB1C; long transient receptor potential channel 1; LTRPC1; melastatin 1; melastatin-1; MLSN1; OTTHUMP00000159584; transient receptor potential cation channel, subfamily M, member 1; transient receptor potential melastatin family
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381531,001,061 - 31,161,273 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371531,293,264 - 31,453,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361529,080,829 - 29,181,216 (-)NCBINCBI36hg18NCBI36
Build 341529,080,844 - 29,181,216NCBI
Celera159,019,006 - 9,119,394 (-)NCBI
Cytogenetic Map15q13.3NCBI
HuRef158,470,226 - 8,630,487 (-)NCBIHuRef
CHM1_11531,284,115 - 31,444,331 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TRPM1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312607
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2018-02-06
Status: ACTIVE