Dcaf15 (DDB1 and CUL4 associated factor 15) - Rat Genome Database
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Gene: Dcaf15 (DDB1 and CUL4 associated factor 15) Mus musculus
Analyze
Symbol: Dcaf15
Name: DDB1 and CUL4 associated factor 15
RGD ID: 1312576
MGI Page MGI
Description: Predicted to have small molecule binding activity. Predicted to be involved in protein polyubiquitination and regulation of natural killer cell activation. Predicted to localize to Cul4-RING E3 ubiquitin ligase complex. Orthologous to human DCAF15 (DDB1 and CUL4 associated factor 15); INTERACTS WITH 1,2-dimethylhydrazine; pentachlorophenol; valproic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6720484B16; DDB1- and CUL4-associated factor 15; MGC66593
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,823,698 - 84,831,426 (-)NCBIGRCm39mm39
GRCm38884,097,069 - 84,104,797 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,097,072 - 84,104,768 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,620,971 - 86,628,661 (-)NCBIGRCm37mm9NCBIm37
MGSCv36886,987,180 - 86,994,878 (-)NCBImm8
Celera888,392,962 - 88,401,747 (-)NCBICelera
Cytogenetic Map8C2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15782199   PMID:16141072   PMID:16141073   PMID:21267068  
PMID:21873635   PMID:30111536  


Genomics

Comparative Map Data
Dcaf15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,823,698 - 84,831,426 (-)NCBIGRCm39mm39
GRCm38884,097,069 - 84,104,797 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,097,072 - 84,104,768 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,620,971 - 86,628,661 (-)NCBIGRCm37mm9NCBIm37
MGSCv36886,987,180 - 86,994,878 (-)NCBImm8
Celera888,392,962 - 88,401,747 (-)NCBICelera
Cytogenetic Map8C2NCBI
DCAF15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1913,952,492 - 13,961,449 (+)EnsemblGRCh38hg38GRCh38
GRCh381913,952,474 - 13,961,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371914,063,319 - 14,072,256 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,924,319 - 13,933,256 (+)NCBINCBI36hg18NCBI36
Celera1913,956,945 - 13,965,882 (+)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1913,634,587 - 13,643,524 (+)NCBIHuRef
CHM1_11914,063,859 - 14,072,796 (+)NCBICHM1_1
Dcaf15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01925,212,469 - 25,219,803 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,212,661 - 25,220,010 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,189,603 - 36,197,003 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,737,953 - 25,745,353 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11925,742,787 - 25,750,170 (+)NCBI
Celera1923,602,012 - 23,609,354 (+)NCBICelera
Cytogenetic Map19q11NCBI
Dcaf15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,701,701 - 32,710,051 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,701,701 - 32,710,051 (+)NCBIChiLan1.0ChiLan1.0
DCAF15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11914,243,793 - 14,252,804 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,243,793 - 14,252,804 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01913,514,672 - 13,523,689 (+)NCBIMhudiblu_PPA_v0panPan3
DCAF15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2048,519,464 - 48,527,363 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12048,519,435 - 48,527,701 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dcaf15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366592,656,072 - 2,663,237 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCAF15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,205,657 - 65,213,518 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,205,657 - 65,213,514 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,479,797 - 65,487,661 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCAF15
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1612,607,738 - 12,617,046 (+)NCBI
ChlSab1.1 Ensembl612,607,753 - 12,619,717 (+)Ensembl
Dcaf15
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249011,223,417 - 1,230,947 (+)NCBI

Position Markers
AI385641  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,096,680 - 84,096,812UniSTSGRCm38
MGSCv37886,620,579 - 86,620,711UniSTSGRCm37
Celera888,392,570 - 88,392,702UniSTS
Cytogenetic Map8C3UniSTS
cM Map838.0UniSTS
Whitehead/MRC_RH81001.6UniSTS
UniSTS:235953  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,097,165 - 84,097,352UniSTSGRCm38
MGSCv37886,621,064 - 86,621,251UniSTSGRCm37
Celera888,393,055 - 88,393,242UniSTS
Cytogenetic Map8C3UniSTS
cM Map838.0UniSTS
PMC356977P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,100,536 - 84,101,366UniSTSGRCm38
MGSCv37886,624,435 - 86,625,265UniSTSGRCm37
Celera888,397,518 - 88,398,348UniSTS
Celera888,396,426 - 88,396,954UniSTS
Cytogenetic Map8C3UniSTS
RH36280  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,098,001 - 84,098,261UniSTSGRCm38
MGSCv37886,621,900 - 86,622,160UniSTSGRCm37
Celera888,393,891 - 88,394,151UniSTS
Cytogenetic Map8C3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:268
Count of miRNA genes:206
Interacting mature miRNAs:223
Transcripts:ENSMUST00000041367
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000041367   ⟹   ENSMUSP00000038568
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,097,072 - 84,104,762 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210279   ⟹   ENSMUSP00000147690
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,097,072 - 84,104,763 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210625   ⟹   ENSMUSP00000147657
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,102,754 - 84,104,768 (-)Ensembl
RefSeq Acc Id: NM_001357322   ⟹   NP_001344251
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,823,698 - 84,831,426 (-)NCBI
GRCm38884,097,069 - 84,104,797 (-)NCBI
Sequence:
RefSeq Acc Id: NM_172502   ⟹   NP_766090
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,823,698 - 84,831,426 (-)NCBI
GRCm38884,097,069 - 84,104,797 (-)NCBI
MGSCv37886,620,971 - 86,628,661 (-)RGD
Celera888,392,962 - 88,401,747 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011248336   ⟹   XP_011246638
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,823,703 - 84,831,392 (-)NCBI
GRCm38884,097,074 - 84,104,763 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243400   ⟹   XP_030099260
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,823,703 - 84,831,421 (-)NCBI
GRCm38884,097,074 - 84,104,792 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036153861   ⟹   XP_036009754
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,823,703 - 84,831,392 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_766090   ⟸   NM_172502
- Peptide Label: isoform 1
- UniProtKB: Q6PFH3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011246638   ⟸   XM_011248336
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001344251   ⟸   NM_001357322
- Peptide Label: isoform 2
RefSeq Acc Id: XP_030099260   ⟸   XM_030243400
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000147657   ⟸   ENSMUST00000210625
RefSeq Acc Id: ENSMUSP00000147690   ⟸   ENSMUST00000210279
RefSeq Acc Id: ENSMUSP00000038568   ⟸   ENSMUST00000041367
RefSeq Acc Id: XP_036009754   ⟸   XM_036153861
- Peptide Label: isoform X2

Promoters
RGD ID:8667645
Promoter ID:EPDNEW_M11853
Type:initiation region
Name:Dcaf15_1
Description:Mus musculus DDB1 and CUL4 associated factor 15 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38884,104,752 - 84,104,812EPDNEW
RGD ID:6848878
Promoter ID:MM_TRO:9601
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:MTR060238.8.1513.7
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36886,622,306 - 86,622,806 (-)MPROMDB
RGD ID:6848262
Promoter ID:MM_ACW:48199
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour
Transcripts:BC057552.DSEP07,   BC057552.ISEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36886,622,676 - 86,623,176 (-)MPROMDB
RGD ID:6848266
Promoter ID:MM_ACW:48200
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Lung
Transcripts:BC057552.FSEP07-UNSPLICED,   BC057552.HSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36886,625,626 - 86,626,126 (-)MPROMDB
RGD ID:6842846
Promoter ID:MM_KWN:55051
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000041367,   UC009MLX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36886,628,226 - 86,629,177 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2684420 AgrOrtholog
Ensembl Genes ENSMUSG00000037103 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000038568 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000147657 UniProtKB/TrEMBL
  ENSMUSP00000147690 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000041367 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000210279 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000210625 UniProtKB/TrEMBL
InterPro DCAF15 UniProtKB/Swiss-Prot
  DCAF15_WD40 UniProtKB/Swiss-Prot
KEGG Report mmu:212123 UniProtKB/Swiss-Prot
MGD MGI:2684420 ENTREZGENE
NCBI Gene 212123 ENTREZGENE
PANTHER PTHR28541 UniProtKB/Swiss-Prot
Pfam DCAF15_WD40 UniProtKB/Swiss-Prot
PhenoGen Dcaf15 PhenoGen
UniGene Mm.260557 ENTREZGENE
UniProt A0A1B0GRT7_MOUSE UniProtKB/TrEMBL
  DCA15_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3U305 UniProtKB/Swiss-Prot
  Q8BMB2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Dcaf15  DDB1 and CUL4 associated factor 15  BC057552  cDNA sequence BC057552  Symbol and/or name change 5135510 APPROVED