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Gene: MRTFA (myocardin related transcription factor A) Homo sapiens
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Symbol: MRTFA
Name: myocardin related transcription factor A
Description: Exhibits actin binding activity and leucine zipper domain binding activity. Involved in positive regulation of transcription via serum response element binding activity; smooth muscle cell differentiation; and wound healing, spreading of cells. Localizes to cytosol and nucleoplasm. Implicated in megakaryocytic leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basic, SAP and coiled-coil domain; BSAC; MAL; megakaryoblastic leukemia (translocation) 1; megakaryoblastic leukemia 1 protein; megakaryocytic acute leukemia protein; MKL; MKL/myocardin-like protein 1; MKL1; Mkl1 variant 1 Mkl1_S; MRTF-A; myocardin-related transcription factor A; RBM15/MKL1 fusion; RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein
Orthologs:
Mus musculus (house mouse) : Mrtfa (myocardin related transcription factor A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mrtfa (myocardin related transcription factor A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mrtfa (myocardin related transcription factor A)
Pan paniscus (bonobo/pygmy chimpanzee) : MRTFA (myocardin related transcription factor A)
Canis lupus familiaris (dog) : MRTFA (myocardin related transcription factor A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mrtfa (myocardin related transcription factor A)
Sus scrofa (pig) : MRTFA (myocardin related transcription factor A)
Chlorocebus sabaeus (African green monkey) : MRTFA (myocardin related transcription factor A)
Heterocephalus glaber (naked mole-rat) : Mrtfa (myocardin related transcription factor A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: MAL (Gene ID: 4118), TIRAP (Gene ID: 114609), and MKL1 (Gene ID: 57591) share the MAL symbol/alias in common. MAL is a widely used alternative name for TIR domain containing adaptor protein (TIRAP) and megakaryoblastic leukemia (translocation) 1 (MKL1). [23 May 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2240,410,281 - 40,636,719 (-)EnsemblGRCh38hg38GRCh38
GRCh382240,410,289 - 40,636,719 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372240,806,292 - 41,032,690 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,136,238 - 39,362,636 (-)NCBINCBI36hg18NCBI36
Build 342239,130,791 - 39,357,190NCBI
Celera2224,608,353 - 24,836,358 (-)NCBI
Cytogenetic Map22q13.1-q13.2NCBI
HuRef2223,769,395 - 23,994,500 (-)NCBIHuRef
CHM1_12240,765,188 - 40,992,736 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MRTFA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312564
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.