Serpina9 (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9) - Rat Genome Database

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Gene: Serpina9 (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9) Mus musculus
Analyze
Symbol: Serpina9
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
RGD ID: 1312436
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain. Orthologous to human SERPINA9 (serpin family A member 9).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310014L03Rik; AW049635; Cent; Centerin; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9; serpin A9
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912103,962,877 - 103,979,911 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12103,961,002 - 103,980,014 (-)EnsemblGRCm39 Ensembl
GRCm3812103,996,615 - 104,013,652 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12103,994,743 - 104,013,755 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712105,234,830 - 105,251,862 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612104,397,670 - 104,414,702 (-)NCBIMGSCv36mm8
Celera12105,214,012 - 105,231,660 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1252.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12659817   PMID:16141072   PMID:16141073   PMID:19111575   PMID:21267068   PMID:21873635   PMID:24172014  
PMID:24952961  


Genomics

Comparative Map Data
Serpina9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912103,962,877 - 103,979,911 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12103,961,002 - 103,980,014 (-)EnsemblGRCm39 Ensembl
GRCm3812103,996,615 - 104,013,652 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12103,994,743 - 104,013,755 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712105,234,830 - 105,251,862 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612104,397,670 - 104,414,702 (-)NCBIMGSCv36mm8
Celera12105,214,012 - 105,231,660 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1252.98NCBI
SERPINA9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381494,462,721 - 94,476,197 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1494,462,717 - 94,479,689 (-)EnsemblGRCh38hg38GRCh38
GRCh371494,929,058 - 94,942,534 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361493,998,811 - 94,012,423 (-)NCBINCBI36Build 36hg18NCBI36
Build 341494,000,715 - 94,012,423NCBI
Celera1474,984,948 - 74,998,549 (-)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1475,109,316 - 75,122,913 (-)NCBIHuRef
CHM1_11494,866,855 - 94,880,458 (-)NCBICHM1_1
T2T-CHM13v2.01488,692,234 - 88,705,726 (-)NCBIT2T-CHM13v2.0
Serpina9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,683,650 - 128,700,784 (-)NCBIGRCr8
mRatBN7.26122,918,819 - 122,936,000 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,918,880 - 122,936,000 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6123,059,784 - 123,076,902 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,355,064 - 123,372,182 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,691,927 - 122,709,053 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,662,348 - 127,680,232 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,662,813 - 127,679,951 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06136,881,410 - 136,898,530 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46128,052,256 - 128,069,518 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16128,056,362 - 128,072,771 (-)NCBI
Celera6120,398,966 - 120,416,084 (-)NCBICelera
Cytogenetic Map6q32NCBI
Serpina9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543817,866,796 - 17,875,104 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543817,862,064 - 17,875,490 (+)NCBIChiLan1.0ChiLan1.0
SERPINA9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21595,610,914 - 95,624,365 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11494,827,419 - 94,840,870 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01475,085,874 - 75,099,381 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11494,418,728 - 94,431,999 (-)NCBIpanpan1.1PanPan1.1panPan2
SERPINA9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1863,473,622 - 63,487,720 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl863,473,687 - 63,488,556 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha863,050,176 - 63,064,142 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0863,740,521 - 63,754,568 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl863,740,505 - 63,754,602 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1863,415,783 - 63,429,810 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0863,468,110 - 63,482,144 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0863,798,760 - 63,812,804 (-)NCBIUU_Cfam_GSD_1.0
SERPINA9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12472,247,517 - 72,255,199 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2472,248,001 - 72,254,999 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605359,473,350 - 59,485,363 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpina9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247347,162,235 - 7,173,654 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247347,165,467 - 7,181,908 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Serpina9
544 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:932
Count of miRNA genes:512
Interacting mature miRNAs:609
Transcripts:ENSMUST00000058464, ENSMUST00000164023
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse
25823169Hrsq8_mhost response to SARS QTL 8, log titer (mouse)1281696245108495368Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
12910790Pwgrq7_mpre-weaning growth rate QTL 7 (mouse)1290937367108645308Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
10412192Bbaa27_mB.burgdorferi-associated arthritis 27 (mouse)Not determined1291254220107308393Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
11039526Ccc1_mcolitis susceptibility in the Collaborative Cross 1 (mouse)1293528334111028223Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
25394546Skmw76_mskeletal muscle weight 76, TA (mouse)12102593095106941888Mouse

Markers in Region
AW049635  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812103,996,904 - 103,997,018UniSTSGRCm38
MGSCv3712105,235,114 - 105,235,228UniSTSGRCm37
Celera12105,214,296 - 105,214,410UniSTS
Cytogenetic Map12EUniSTS
Whitehead/MRC_RH12955.45UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000058464   ⟹   ENSMUSP00000058535
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12103,961,002 - 103,979,911 (-)Ensembl
GRCm38.p6 Ensembl12103,994,743 - 104,013,652 (-)Ensembl
RefSeq Acc Id: ENSMUST00000164023   ⟹   ENSMUSP00000130064
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12103,974,535 - 103,980,014 (-)Ensembl
GRCm38.p6 Ensembl12104,008,276 - 104,013,755 (-)Ensembl
RefSeq Acc Id: NM_001361910   ⟹   NP_001348839
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912103,962,877 - 103,979,911 (-)NCBI
GRCm3812103,996,615 - 104,013,652 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001361912   ⟹   NP_001348841
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912103,962,877 - 103,979,911 (-)NCBI
GRCm3812103,996,615 - 104,013,652 (-)NCBI
Sequence:
RefSeq Acc Id: NM_027997   ⟹   NP_082273
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912103,962,877 - 103,979,911 (-)NCBI
GRCm3812103,996,615 - 104,013,652 (-)NCBI
MGSCv3712105,234,830 - 105,251,862 (-)RGD
Celera12105,214,012 - 105,231,660 (-)RGD
cM Map12 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_082273   ⟸   NM_027997
- Peptide Label: precursor
- UniProtKB: Q9D7D2 (UniProtKB/Swiss-Prot),   A2RSX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001348839   ⟸   NM_001361910
- Peptide Label: precursor
- UniProtKB: Q9D7D2 (UniProtKB/Swiss-Prot),   A2RSX5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001348841   ⟸   NM_001361912
- Peptide Label: precursor
- UniProtKB: Q9D7D2 (UniProtKB/Swiss-Prot),   A2RSX5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000130064   ⟸   ENSMUST00000164023
RefSeq Acc Id: ENSMUSP00000058535   ⟸   ENSMUST00000058464
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D7D2-F1-model_v2 AlphaFold Q9D7D2 1-418 view protein structure

Promoters
RGD ID:8679118
Promoter ID:EPDNEW_M17590
Type:multiple initiation site
Name:Serpina9_1
Description:Mus musculus serine peptidase inhibitor, clade A (alpha-1 antiproteinase,antitrypsin), member 9 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812104,013,652 - 104,013,712EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919157 AgrOrtholog
Ensembl Genes ENSMUSG00000058260 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000058464 ENTREZGENE
  ENSMUST00000058464.5 UniProtKB/Swiss-Prot
  ENSMUST00000164023.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpins superfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:71907 UniProtKB/Swiss-Prot
MGD MGI:1919157 ENTREZGENE
NCBI Gene 71907 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERPIN A9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Serpina9 PhenoGen
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2RSX5 ENTREZGENE, UniProtKB/TrEMBL
  E9Q865_MOUSE UniProtKB/TrEMBL
  Q9D7D2 ENTREZGENE, UniProtKB/Swiss-Prot