Tktl2 (transketolase-like 2) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Tktl2 (transketolase-like 2) Mus musculus
Analyze
Symbol: Tktl2
Name: transketolase-like 2
RGD ID: 1312402
MGI Page MGI
Description: Predicted to have thiamine pyrophosphate binding activity and transketolase activity. Predicted to localize to cytoplasm. Orthologous to human TKTL2 (transketolase like 2); PARTICIPATES IN pentose phosphate pathway; INTERACTS WITH folic acid; sodium fluoride; aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4933401I19Rik; transketolase-like protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39866,964,392 - 66,971,851 (+)NCBIGRCm39mm39
GRCm38866,511,740 - 66,519,199 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl866,511,756 - 66,518,335 (+)EnsemblGRCm38mm10GRCm38
MGSCv37869,035,639 - 69,037,677 (+)NCBIGRCm37mm9NCBIm37
MGSCv36869,440,745 - 69,442,765 (+)NCBImm8
Celera869,067,813 - 69,069,849 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14681479   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:28245920   PMID:31201419   PMID:32325033  


Genomics

Comparative Map Data
Tktl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39866,964,392 - 66,971,851 (+)NCBIGRCm39mm39
GRCm38866,511,740 - 66,519,199 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl866,511,756 - 66,518,335 (+)EnsemblGRCm38mm10GRCm38
MGSCv37869,035,639 - 69,037,677 (+)NCBIGRCm37mm9NCBIm37
MGSCv36869,440,745 - 69,442,765 (+)NCBImm8
Celera869,067,813 - 69,069,849 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
TKTL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4163,471,095 - 163,473,754 (-)EnsemblGRCh38hg38GRCh38
GRCh384163,471,095 - 163,473,754 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374164,392,245 - 164,395,047 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364164,611,697 - 164,614,497 (-)NCBINCBI36hg18NCBI36
Celera4161,724,510 - 161,727,310 (-)NCBI
Cytogenetic Map4q32.2NCBI
HuRef4160,146,102 - 160,148,902 (-)NCBIHuRef
CHM1_14164,368,688 - 164,371,488 (-)NCBICHM1_1
Tktl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01624,944,197 - 24,951,478 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1624,949,425 - 24,951,612 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01624,828,047 - 24,835,320 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41624,919,470 - 24,921,481 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11624,919,484 - 24,921,445 (-)NCBI
Celera1623,323,959 - 23,325,970 (-)NCBICelera
Cytogenetic Map16p14NCBI
Tktl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540341,526,398 - 41,528,281 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540341,526,329 - 41,528,591 (+)NCBIChiLan1.0ChiLan1.0
TKTL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14167,526,340 - 167,529,135 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4167,527,100 - 167,529,268 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04155,738,002 - 155,740,740 (-)NCBIMhudiblu_PPA_v0panPan3
Tktl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365552,134,509 - 2,136,421 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TKTL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl852,326,545 - 52,329,300 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1852,325,782 - 52,328,286 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2855,453,371 - 55,455,876 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TKTL2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17109,922,068 - 109,925,412 (-)NCBI
Tktl2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475813,364,668 - 13,367,294 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83383736267837502Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:813
Count of miRNA genes:475
Interacting mature miRNAs:553
Transcripts:ENSMUST00000002025, ENSMUST00000183187
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000002025   ⟹   ENSMUSP00000002025
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl866,511,756 - 66,513,776 (+)Ensembl
RefSeq Acc Id: ENSMUST00000183187   ⟹   ENSMUSP00000138388
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl866,511,759 - 66,518,335 (+)Ensembl
RefSeq Acc Id: NM_001271574   ⟹   NP_001258503
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39866,964,392 - 66,971,851 (+)NCBI
GRCm38866,511,740 - 66,519,199 (+)NCBI
Celera869,067,813 - 69,075,259 (+)NCBI
Sequence:
RefSeq Acc Id: NM_028927   ⟹   NP_083203
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39866,964,392 - 66,966,430 (+)NCBI
GRCm38866,511,740 - 66,513,778 (+)NCBI
MGSCv37869,035,639 - 69,037,677 (+)RGD
Celera869,067,813 - 69,075,259 (+)NCBI
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_083203   ⟸   NM_028927
- UniProtKB: Q9D4D4 (UniProtKB/Swiss-Prot),   A0A0R4J2A3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258503   ⟸   NM_001271574
- UniProtKB: Q9D4D4 (UniProtKB/Swiss-Prot),   A0A0R4J2A3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000138388   ⟸   ENSMUST00000183187
RefSeq Acc Id: ENSMUSP00000002025   ⟸   ENSMUST00000002025
Protein Domains
Transket_pyr

Promoters
RGD ID:8667187
Promoter ID:EPDNEW_M11625
Type:initiation region
Name:Tktl2_1
Description:Mus musculus transketolase-like 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38866,511,759 - 66,511,819EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921669 AgrOrtholog
Ensembl Genes ENSMUSG00000025519 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000002025 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000138388 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000002025 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000183187 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro THDP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketo_C/PFOR_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase-like_Pyr-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:74419 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1921669 ENTREZGENE
NCBI Gene 74419 ENTREZGENE
Pfam Transket_pyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tktl2 PhenoGen
PROSITE TRANSKETOLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Transket_pyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52922 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.159193 ENTREZGENE
  Mm.483407 ENTREZGENE
UniProt A0A0R4J2A3 ENTREZGENE, UniProtKB/TrEMBL
  Q9D4D4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2RSH3 UniProtKB/Swiss-Prot