UST (uronyl 2-sulfotransferase) - Rat Genome Database

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Gene: UST (uronyl 2-sulfotransferase) Homo sapiens
Analyze
Symbol: UST
Name: uronyl 2-sulfotransferase
RGD ID: 1312363
HGNC Page HGNC
Description: Predicted to have sulfotransferase activity. Predicted to be involved in dermatan sulfate biosynthetic process and protein sulfation. Predicted to localize to Golgi membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2OST; dermatan/chondroitin sulfate 2-sulfotransferase; uronyl-2-sulfotransferase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6148,747,030 - 149,076,990 (+)EnsemblGRCh38hg38GRCh38
GRCh386148,745,891 - 149,076,990 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376149,068,166 - 149,398,126 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366149,110,157 - 149,439,818 (+)NCBINCBI36hg18NCBI36
Build 346149,110,156 - 149,439,818NCBI
Celera6149,804,170 - 150,133,178 (+)NCBI
Cytogenetic Map6q25.1NCBI
HuRef6146,637,095 - 146,966,117 (+)NCBIHuRef
CHM1_16149,333,029 - 149,662,873 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10187838   PMID:12477932   PMID:14574404   PMID:15489334   PMID:16192264   PMID:17227754   PMID:19240061   PMID:19322201   PMID:20360315   PMID:20379614   PMID:21145461   PMID:21873635  
PMID:23620144   PMID:25456346   PMID:27511124   PMID:28298427   PMID:28514442   PMID:30021884  


Genomics

Comparative Map Data
UST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6148,747,030 - 149,076,990 (+)EnsemblGRCh38hg38GRCh38
GRCh386148,745,891 - 149,076,990 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376149,068,166 - 149,398,126 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366149,110,157 - 149,439,818 (+)NCBINCBI36hg18NCBI36
Build 346149,110,156 - 149,439,818NCBI
Celera6149,804,170 - 150,133,178 (+)NCBI
Cytogenetic Map6q25.1NCBI
HuRef6146,637,095 - 146,966,117 (+)NCBIHuRef
CHM1_16149,333,029 - 149,662,873 (+)NCBICHM1_1
Ust
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39108,068,499 - 8,394,701 (-)NCBIGRCm39mm39
GRCm39 Ensembl108,080,520 - 8,394,589 (-)Ensembl
GRCm38108,204,753 - 8,518,825 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl108,204,756 - 8,518,825 (-)EnsemblGRCm38mm10GRCm38
MGSCv37107,924,551 - 8,238,623 (-)NCBIGRCm37mm9NCBIm37
MGSCv36107,897,457 - 8,208,962 (-)NCBImm8
Celera108,087,930 - 8,411,124 (-)NCBICelera
Cytogenetic Map10A1NCBI
Ust
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.212,666,983 - 2,962,276 (-)NCBI
Rnor_6.0 Ensembl12,333,778 - 2,627,747 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.012,330,631 - 2,627,654 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.014,022,062 - 4,313,796 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.412,868,196 - 3,158,231 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.112,868,195 - 3,158,231 (-)NCBI
Celera11,217,279 - 1,507,424 (-)NCBICelera
Cytogenetic Map1p13NCBI
Ust
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543912,125,591 - 12,406,271 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543912,122,935 - 12,406,368 (-)NCBIChiLan1.0ChiLan1.0
UST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16151,270,358 - 151,600,651 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6151,270,505 - 151,597,779 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06146,562,541 - 146,895,450 (+)NCBIMhudiblu_PPA_v0panPan3
UST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1139,633,276 - 39,922,361 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl139,633,501 - 39,921,289 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha140,532,475 - 40,759,827 (+)NCBI
ROS_Cfam_1.0139,810,126 - 40,102,153 (+)NCBI
UMICH_Zoey_3.1139,687,116 - 39,978,672 (+)NCBI
UNSW_CanFamBas_1.0139,553,715 - 39,843,184 (+)NCBI
UU_Cfam_GSD_1.0139,893,472 - 40,184,349 (+)NCBI
Ust
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946134,614,740 - 134,881,624 (+)NCBI
SpeTri2.0NW_0049364891,866,792 - 2,133,558 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl116,840,530 - 17,138,393 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1116,840,422 - 17,138,088 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2119,294,997 - 19,463,194 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UST
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11322,595,088 - 22,934,184 (-)NCBI
Vero_WHO_p1.0NW_023666040198,605,207 - 198,921,153 (-)NCBI
Ust
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247859,061,753 - 9,388,794 (-)NCBI

Position Markers
D6S1564  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,188,406 - 149,188,639UniSTSGRCh37
Build 366149,230,099 - 149,230,332RGDNCBI36
Celera6149,924,306 - 149,924,537RGD
Cytogenetic Map6q25.1UniSTS
HuRef6146,757,013 - 146,757,244UniSTS
Marshfield Genetic Map6149.13RGD
Marshfield Genetic Map6149.13UniSTS
Genethon Genetic Map6150.2UniSTS
deCODE Assembly Map6152.08UniSTS
Stanford-G3 RH Map65945.0UniSTS
GeneMap99-GB4 RH Map6594.98UniSTS
NCBI RH Map61600.4UniSTS
GeneMap99-G3 RH Map66248.0UniSTS
SGC44468  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,113,967 - 149,114,223UniSTSGRCh37
Build 366149,155,660 - 149,155,916RGDNCBI36
Celera6149,849,868 - 149,850,124RGD
Cytogenetic Map6q25.1UniSTS
HuRef6146,682,571 - 146,682,827UniSTS
GeneMap99-GB4 RH Map6594.98UniSTS
Whitehead-RH Map6809.4UniSTS
NCBI RH Map61594.6UniSTS
RH46094  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,114,203 - 149,114,348UniSTSGRCh37
Build 366149,155,896 - 149,156,041RGDNCBI36
Celera6149,850,104 - 149,850,249RGD
Cytogenetic Map6q25.1UniSTS
HuRef6146,682,807 - 146,682,952UniSTS
GeneMap99-GB4 RH Map6594.98UniSTS
D6S1148E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,397,971 - 149,398,071UniSTSGRCh37
Build 366149,439,664 - 149,439,764RGDNCBI36
Celera6150,133,023 - 150,133,123RGD
Cytogenetic Map6q25.1UniSTS
HuRef6146,965,962 - 146,966,062UniSTS
GeneMap99-GB4 RH Map6595.53UniSTS
RH92645  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,348,471 - 149,348,551UniSTSGRCh37
Build 366149,390,164 - 149,390,244RGDNCBI36
Celera6150,083,527 - 150,083,607RGD
Cytogenetic Map6q25.1UniSTS
HuRef6146,916,419 - 146,916,499UniSTS
GeneMap99-GB4 RH Map6594.87UniSTS
SHGC-58640  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,135,897 - 149,136,018UniSTSGRCh37
Build 366149,177,590 - 149,177,711RGDNCBI36
Celera6149,871,798 - 149,871,919RGD
Cytogenetic Map6q25.1UniSTS
HuRef6146,704,502 - 146,704,623UniSTS
SHGC-146752  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,294,232 - 149,294,579UniSTSGRCh37
Build 366149,335,925 - 149,336,272RGDNCBI36
Celera6150,029,290 - 150,029,637RGD
Cytogenetic Map6q25.1UniSTS
HuRef6146,862,176 - 146,862,523UniSTS
SHGC-148649  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,294,088 - 149,294,398UniSTSGRCh37
Build 366149,335,781 - 149,336,091RGDNCBI36
Celera6150,029,146 - 150,029,456RGD
Cytogenetic Map6q25.1UniSTS
HuRef6146,862,032 - 146,862,342UniSTS
SHGC-152794  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,188,474 - 149,188,573UniSTSGRCh37
Build 366149,230,167 - 149,230,266RGDNCBI36
Celera6149,924,372 - 149,924,471RGD
Cytogenetic Map6q25.1UniSTS
HuRef6146,757,079 - 146,757,178UniSTS
TNG Radiation Hybrid Map371115.0UniSTS
SHGC-111955  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,254,770 - 149,255,043UniSTSGRCh37
Build 366149,296,463 - 149,296,736RGDNCBI36
Celera6149,989,820 - 149,990,093RGD
Cytogenetic Map6q25.1UniSTS
HuRef6146,822,715 - 146,822,988UniSTS
SHGC-83979  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,335,193 - 149,335,477UniSTSGRCh37
Build 366149,376,886 - 149,377,170RGDNCBI36
Celera6150,070,248 - 150,070,532RGD
Cytogenetic Map6q25.1UniSTS
HuRef6146,903,134 - 146,903,418UniSTS
D6S1329  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,229,965 - 149,230,140UniSTSGRCh37
Build 366149,271,658 - 149,271,833RGDNCBI36
Celera6149,965,015 - 149,965,190RGD
Cytogenetic Map6q25.1UniSTS
HuRef6146,797,914 - 146,798,089UniSTS
Whitehead-YAC Contig Map6 UniSTS
SHGC-44468  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,114,184 - 149,114,292UniSTSGRCh37
Build 366149,155,877 - 149,155,985RGDNCBI36
Celera6149,850,085 - 149,850,193RGD
Cytogenetic Map6q25.1UniSTS
HuRef6146,682,788 - 146,682,896UniSTS
UST__5057  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376149,397,355 - 149,398,200UniSTSGRCh37
Build 366149,439,048 - 149,439,893RGDNCBI36
Celera6150,132,407 - 150,133,252RGD
HuRef6146,965,346 - 146,966,191UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2825
Count of miRNA genes:936
Interacting mature miRNAs:1094
Transcripts:ENST00000367463, ENST00000466695, ENST00000473631
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1313 849 894 14 333 8 2105 649 1565 109 753 1110 9 545 1220 1
Low 1065 1745 657 435 1154 283 2194 1442 2139 287 676 472 161 659 1513 1
Below cutoff 46 391 171 170 438 170 56 102 27 21 24 29 4 1 55 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_005715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001743088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB020316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI570697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ420554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL357992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL359252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL589705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL590485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL807246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA842761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB496757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000367463   ⟹   ENSP00000356433
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6148,747,030 - 149,076,990 (+)Ensembl
RefSeq Acc Id: ENST00000466695
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6149,066,176 - 149,074,250 (+)Ensembl
RefSeq Acc Id: ENST00000473631
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6148,953,907 - 149,005,588 (+)Ensembl
RefSeq Acc Id: NM_005715   ⟹   NP_005706
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386148,747,030 - 149,076,990 (+)NCBI
GRCh376149,068,063 - 149,398,126 (+)NCBI
Build 366149,110,157 - 149,439,818 (+)NCBI Archive
Celera6149,804,170 - 150,133,178 (+)RGD
HuRef6146,637,095 - 146,966,117 (+)ENTREZGENE
CHM1_16149,333,029 - 149,662,873 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011535378   ⟹   XP_011533680
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386148,747,427 - 149,006,138 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017010152   ⟹   XP_016865641
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386148,745,891 - 148,964,403 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001743088
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386148,747,427 - 149,012,827 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005706   ⟸   NM_005715
- UniProtKB: Q9Y2C2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011533680   ⟸   XM_011535378
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016865641   ⟸   XM_017010152
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000356433   ⟸   ENST00000367463

Promoters
RGD ID:7209385
Promoter ID:EPDNEW_H10438
Type:initiation region
Name:UST_1
Description:uronyl 2-sulfotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386148,747,418 - 148,747,478EPDNEW
RGD ID:6804987
Promoter ID:HG_KWN:55358
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Lymphoblastoid
Transcripts:NM_005715
Position:
Human AssemblyChrPosition (strand)Source
Build 366149,109,554 - 149,110,054 (+)MPROMDB
RGD ID:6804988
Promoter ID:HG_KWN:55363
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000043365
Position:
Human AssemblyChrPosition (strand)Source
Build 366149,428,776 - 149,429,276 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q24.1-27(chr6:141132990-169339571)x3 copy number gain See cases [RCV000050604] Chr6:141132990..169339571 [GRCh38]
Chr6:141454127..169739666 [GRCh37]
Chr6:141495820..169481591 [NCBI36]
Chr6:6q24.1-27
pathogenic
GRCh38/hg38 6q24.3-25.1(chr6:146481119-151427629)x1 copy number loss See cases [RCV000051005] Chr6:146481119..151427629 [GRCh38]
Chr6:146802255..151748764 [GRCh37]
Chr6:146843948..151790457 [NCBI36]
Chr6:6q24.3-25.1
pathogenic
GRCh38/hg38 6q24.2-25.2(chr6:144932561-152985364)x1 copy number loss See cases [RCV000052206] Chr6:144932561..152985364 [GRCh38]
Chr6:145253697..153306499 [GRCh37]
Chr6:145295390..153348192 [NCBI36]
Chr6:6q24.2-25.2
pathogenic
NM_005715.2(UST):c.291+11313T>G single nucleotide variant Lung cancer [RCV000096599] Chr6:148898342 [GRCh38]
Chr6:149219478 [GRCh37]
Chr6:6q25.1
uncertain significance
NM_005715.2(UST):c.681+21077G>T single nucleotide variant Lung cancer [RCV000096600] Chr6:148985640 [GRCh38]
Chr6:149306776 [GRCh37]
Chr6:6q25.1
uncertain significance
NM_005715.2(UST):c.937+19234G>A single nucleotide variant Lung cancer [RCV000096601] Chr6:149040715 [GRCh38]
Chr6:149361851 [GRCh37]
Chr6:6q25.1
uncertain significance
GRCh38/hg38 6q24.3-25.1(chr6:147805119-150893715)x1 copy number loss See cases [RCV000135408] Chr6:147805119..150893715 [GRCh38]
Chr6:148126255..151214851 [GRCh37]
Chr6:148167948..151256544 [NCBI36]
Chr6:6q24.3-25.1
pathogenic
GRCh38/hg38 6q24.3-25.1(chr6:148112335-149649984)x1 copy number loss See cases [RCV000136969] Chr6:148112335..149649984 [GRCh38]
Chr6:148433471..149971120 [GRCh37]
Chr6:148475164..150012813 [NCBI36]
Chr6:6q24.3-25.1
pathogenic
GRCh38/hg38 6q23.3-25.3(chr6:135358150-155455117)x3 copy number gain See cases [RCV000136826] Chr6:135358150..155455117 [GRCh38]
Chr6:135679288..155776251 [GRCh37]
Chr6:135720981..155817943 [NCBI36]
Chr6:6q23.3-25.3
pathogenic
GRCh38/hg38 6q24.3-25.1(chr6:147580351-150227963)x3 copy number gain See cases [RCV000138362] Chr6:147580351..150227963 [GRCh38]
Chr6:147901487..150549099 [GRCh37]
Chr6:147943180..150590792 [NCBI36]
Chr6:6q24.3-25.1
uncertain significance
GRCh38/hg38 6q25.1(chr6:149056723-149435037)x1 copy number loss See cases [RCV000141698] Chr6:149056723..149435037 [GRCh38]
Chr6:149377859..149756173 [GRCh37]
Chr6:149419552..149797866 [NCBI36]
Chr6:6q25.1
uncertain significance
GRCh38/hg38 6q23.2-27(chr6:133537271-165875545)x3 copy number gain See cases [RCV000143444] Chr6:133537271..165875545 [GRCh38]
Chr6:133858409..166289033 [GRCh37]
Chr6:133900102..166209023 [NCBI36]
Chr6:6q23.2-27
pathogenic
GRCh37/hg19 6q24.2-25.1(chr6:144075695-152337005)x1 copy number loss See cases [RCV000448815] Chr6:144075695..152337005 [GRCh37]
Chr6:6q24.2-25.1
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q24.3-25.1(chr6:148364229-149928368)x1 copy number loss See cases [RCV000511918] Chr6:148364229..149928368 [GRCh37]
Chr6:6q24.3-25.1
likely pathogenic
GRCh37/hg19 6q24.1-25.1(chr6:139513020-150389231)x1 copy number loss See cases [RCV000510942] Chr6:139513020..150389231 [GRCh37]
Chr6:6q24.1-25.1
pathogenic
GRCh37/hg19 6q24.2-25.1(chr6:144947731-150266155)x1 copy number loss not provided [RCV000682729] Chr6:144947731..150266155 [GRCh37]
Chr6:6q24.2-25.1
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q24.3-25.1(chr6:148690764-150494873)x1 copy number loss See cases [RCV000790589] Chr6:148690764..150494873 [GRCh37]
Chr6:6q24.3-25.1
pathogenic
GRCh37/hg19 6q24.3-25.3(chr6:148195086-160127254)x3 copy number gain not provided [RCV000846496] Chr6:148195086..160127254 [GRCh37]
Chr6:6q24.3-25.3
pathogenic
NM_005715.3(UST):c.1113C>T (p.Pro371=) single nucleotide variant not provided [RCV000961768] Chr6:149074008 [GRCh38]
Chr6:149395144 [GRCh37]
Chr6:6q25.1
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17223 AgrOrtholog
COSMIC UST COSMIC
Ensembl Genes ENSG00000111962 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000356433 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000367463 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000111962 GTEx
HGNC ID HGNC:17223 ENTREZGENE
Human Proteome Map UST Human Proteome Map
InterPro Heparan_SO4_2-O-STrfase UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Sulfotransferase UniProtKB/Swiss-Prot
KEGG Report hsa:10090 UniProtKB/Swiss-Prot
NCBI Gene 10090 ENTREZGENE
OMIM 610752 OMIM
PANTHER PTHR12129 UniProtKB/Swiss-Prot
Pfam Sulfotransfer_2 UniProtKB/Swiss-Prot
PharmGKB PA38213 PharmGKB
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt Q9Y2C2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2RCX6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-21 UST  uronyl 2-sulfotransferase  UST  uronyl-2-sulfotransferase  Symbol and/or name change 5135510 APPROVED