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Gene: EXOSC3 (exosome component 3) Homo sapiens
Symbol: EXOSC3
Name: exosome component 3
Description: Predicted to have RNA binding activity. Involved in nucleic acid metabolic process. Localizes to the cytoplasmic exosome (RNase complex); nuclear lumen; and transcriptionally active chromatin. Implicated in pontocerebellar hypoplasia type 1B.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bA3J10.7; CGI-102; exosome complex component RRP40; exosome complex exonuclease RRP40; exosome component Rrp40; hRrp-40; hRrp40p; MGC15120; MGC723; p10; PCH1B; ribosomal RNA-processing protein 40; RP11-3J10.8; RRP40; Rrp40p
Mus musculus (house mouse) : Exosc3 (exosome component 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Exosc3 (exosome component 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Exosc3 (exosome component 3)
Pan paniscus (bonobo/pygmy chimpanzee) : EXOSC3 (exosome component 3)
Canis lupus familiaris (dog) : EXOSC3 (exosome component 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Exosc3 (exosome component 3)
Sus scrofa (pig) : EXOSC3 (exosome component 3)
Chlorocebus sabaeus (African green monkey) : EXOSC3 (exosome component 3)
Heterocephalus glaber (naked mole-rat) : Exosc3 (exosome component 3)
more info ...
Related Pseudogenes: EXOSC3P1   EXOSC3P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl937,766,978 - 37,801,437 (-)Ensembl
GRCh38937,779,714 - 37,785,092 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37937,779,711 - 37,785,089 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36937,770,308 - 37,775,067 (-)NCBINCBI36hg18NCBI36
Build 34937,770,307 - 37,775,065NCBI
Celera937,713,503 - 37,718,262 (-)NCBI
Cytogenetic Map9p13.2NCBI
HuRef937,732,052 - 37,737,430 (-)NCBIHuRef
CHM1_1937,781,396 - 37,786,774 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on EXOSC3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312357
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.